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With the aging of the population, diseases of aging such as Alzheimer's disease, diabetes and coronary heart disease are gradually becoming a key concern in global health. Dietary polyphenols, as a natural antioxidant with biological activities such as anti-inflammatory, anti-glycation, and anticancer, can effectively prevent and treat these diseases through a variety of mechanisms. However, the current means of prevention and control for these age-related diseases are still insufficient, especially the lack of reviews and studies on systematic regulation from a dietary perspective. Therefore, in this paper, we will review the bioactivity of dietary polyphenols and their regulatory mechanisms on aging-related diseases, the relationship between dietary polyphenols and cell signaling pathways and the microbiome, and the creation of polyphenol-based functional anti-aging foods, so as to provide new ideas and methods for the intervention of geriatric diseases from the perspective of dietary regulation.
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http://dx.doi.org/10.1016/j.crfs.2025.101163 | DOI Listing |
Vet Res Commun
September 2025
Department of Physiology, Faculty of Veterinary Medicine, Cairo University, PO 11221, Giza, Egypt.
This comprehensive review examines the versatile applications and effects of Moringa oleifera across multiple fish species in aquaculture systems amid growing challenges of rising feed costs and antimicrobial resistance. M. oleifera, commonly called the Miracle tree, contains an exceptional nutritional profile with high protein content (22.
View Article and Find Full Text PDFFood Funct
September 2025
Department of Chemistry, King Saud University, 11451, Riyadh, Saudi Arabia.
Consumption of mango has been associated with a number of beneficial effects on health which have been attributed to phenolic catabolites originating from (poly)phenols following ingestion. To investigate the origins of potentially bioactive phenolic catabolites, ileostomists and subjects with a full gastrointestinal tract on a low(poly)phenol diet ingested a mango pulp purée containing 426 μmol of (poly)phenols consisting mainly of gallotannins and cinnamic acids, along with 231 μmol of the aromatic amino acids phenylalanine and tyrosine. Over a 24 h period post-mango intake plasma and urine were collected and analysed by UHPLC-HRMS.
View Article and Find Full Text PDFFront Nutr
August 2025
Emergency Department, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, Guizhou Province, China.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a rising health issue linked to poor diet and gut microbiota dysbiosis. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, high in polyphenols and anti-inflammatory nutrients, may help protect against MASLD. This study examined how adherence to the MIND diet relates to MASLD severity, focusing on hepatic steatosis, fibrosis, insulin resistance, inflammation, and gut microbiota diversity.
View Article and Find Full Text PDFFood Sci Nutr
September 2025
Panvascular Diseases Research Center, Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China.
Date fruit ( L.) is a highly nutritious and therapeutic food with substantial potential to improve human health. This review emphasizes the nutritional and therapeutic traits of date fruit, focusing on its role as a functional food and dietary supplement.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China.
Resistant starches with additional functionalities, such as starch-polyphenol complexes, are generating great interest due to the increasing incidence of diet-related diseases. However, preparing these complexes remains a major challenge due to the incompatible structures of many natural phenolic compounds. Herein, three protocols were compared for preparing novel amylose (AM) complexes with polyphenol quercetin (Q) in the presence of lauric acid (LA).
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