Impact of social-psychological factors on anxiety before gastrointestinal endoscopy and quality of life.

Introduction: This study aimed to examine the impact of social-psychological factors on anxiety before gastrointestinal endoscopy and its effect on patients' quality of life (QoL).

Methods: Patients scheduled for gastrointestinal endoscopy were recruited for the study. Demographic characteristics, social factors, lifestyle information and endoscopy-related data were obtained through self-reports and the hospital information system.

Comparative efficacy of balloon dilatation duration on patients with choledocholithiasis: a Bayesian network meta-analysis and systematic review.

Objective: To evaluate the application effects of different balloon dilation durations in endoscopic papillary balloon dilation (EPBD) and small endoscopic sphincterotomy with balloon dilation (ESBD) for biliary duct calculi by network meta-analysis and find the most appropriate dilation durations for both.

Methods: PubMed, Web of Science, Cochrane Library, Embase, and other databases were searched for relevant randomized controlled trials (RCTs) published up to August 2024. Data were analyzed using R (V.

Effect of particle size variation of stabilized wheat germ on dough processing characteristics and steamed bread quality.

Wheat germ is a by-product of wheat flour milling and processing, and is valued for being the nutrient-rich center of wheat grains. In this study, hot air-stabilized wheat germ with five different particle sizes (coarse, medium, fine, ultrafine, and very fine) was prepared and mixed with wheat flour (WF) in a ratio of 8:92. The study focused on the effect of particle size of stabilized wheat germ on the thermomechanical, dynamic rheological, and fermentation properties of wheat flour and the quality of steamed bread.

FED-UNet++: An Improved Nested UNet for Hippocampus Segmentation in Alzheimer's Disease Diagnosis.

The hippocampus is a key structure involved in the early pathological progression of Alzheimer's disease. Accurate segmentation of this region is vital for the quantitative assessment of brain atrophy and the support of diagnostic decision-making. To address limitations in current MRI-based hippocampus segmentation methods-such as indistinct boundaries, small target size, and limited feature representation-this study proposes an enhanced segmentation framework called FED-UNet++.

Peripheral nerve injury mediated by JEV strain NX1889 infection and impairment of Schwann cells.

Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus primarily associated with central nervous system disorders. Recent studies have indicated that JEV infection can lead to Guillain-Barré syndrome (GBS), a peripheral nervous system (PNS) disorder; however, the underlying mechanisms remain unclear. In this study, we investigated the tropism of different genotypes of JEV strains for peripheral nerves and their potential impact on peripheral nerves.

Impact of maternal iron and zinc intake on low birth weight risk: a nested case-control study.

Background: The association between maternal iron/zinc intake and the risk of low birth weight (LBW) in infants is still unclear. This study aimed to investigate the effects of iron and zinc daily intake preconception and during pregnancy on the risk of delivering LBW babies and to assess whether there is an interaction between iron and zinc intake on the risk of LBW.

Methods: A nested case-control study was performed, including 565 cases and 7,510 controls in Lanzhou City, China.

Clustering of chemical profiles of cultivars, grown in greenhouses, allows grouping of metabolites with similar production trends.

(L.) Urban (also known as "gotu kola") is a perennial plant, used in traditional medicine for promoting resilience to central nervous system (CNS) disorders. is a tropical medicinal herb from the family and is native to Southeast Asian countries.

The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations.

The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present genome-wide data from 74 Middle Neolithic genetic samples from these regions, showing marked genetic differentiation but bidirectional gene flow, supporting a demic diffusion model of mixed farming. Yellow River populations exhibit distinct genetic substructures resulting from interactions with surrounding groups during the mid-Neolithic expansion of millet agriculture.

Factors influencing adherence to oral nutritional supplementation in patients with gastrointestinal neoplasms: a mixed methods systematic review.

Objective: To explore specific determinants influencing oral nutritional supplementation (ONS) adherence in gastrointestinal neoplasm patients.

Methods: This PROSPERO-registered (CRD42024611358) systematic review followed PRISMA 2020 guidelines. Databases including PubMed, Web of Science, and CNKI were searched from inception to April 2025.

Construction of a multimodal esophageal cancer prognostic model with screening of key genes and investigation of their biological functions.

Purpose: Despite decreased esophageal carcinoma incidence, its prognosis remains challenging. We aimed to develop a multimodal prognostic model to optimize treatment strategies and elucidate biological mechanisms of key regulatory genes.

Methods: Pivotal prognostic genes were screened using integrated bioinformatics and immunohistochemistry.

Development and validation of the time perspective scale of perceived benefits and harms of internet gaming among adolescents in China.

Background And Aims: Gaming-specific maladaptive cognitions were critical determinants of internet gaming disorder (IGD). This study was novel to develop and validate the Time Perspective Scale of Perceived Benefits and Harms of Internet Gaming (TPS-PBHIG) by integrating the concepts of present- and future-oriented time perspectives, perceived benefits, and perceived harms of internet gaming.

Methods: Item generation was conducted by using both inductive (focus group interviews among adolescents) and deductive (comprehensive literature review) approaches.

Psychological Reactions and Coping Strategies in Nurses' Experiences With Workplace Bullying: A Qualitative Study.

Workplace bullying remains a pervasive concern in healthcare, with nurses reporting among the highest rates of exposure across health professions. This study explored nurses' lived experiences of workplace bullying, with particular attention to their psychological reactions, coping responses and the organisational conditions that shaped these processes. A descriptive phenomenological design was employed.

YOLO-Extreme: Obstacle Detection for Visually Impaired Navigation Under Foggy Weather.

Visually impaired individuals face significant challenges in navigating safely and independently, particularly under adverse weather conditions such as fog. To address this issue, we propose YOLO-Extreme, an enhanced object detection framework based on YOLOv12, specifically designed for robust navigation assistance in foggy environments. The proposed architecture incorporates three novel modules: the Dual-Branch Bottleneck Block (DBB) for capturing both local spatial and global semantic features, the Multi-Dimensional Collaborative Attention Module (MCAM) for joint spatial-channel attention modeling to enhance salient obstacle features and reduce background interference in foggy conditions, and the Channel-Selective Fusion Block (CSFB) for robust multi-scale feature integration.

Eomesodermin defines uterine NK cells crucial for pregnancy success in mice.

Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we demonstrate that Eomesodermin is a key transcription factor determining the lineage of tissue-resident NK cells within the uterus both at steady state and during pregnancy. Ablation of Eomesodermin in Ncr1-expressing cells results in the loss of tissue-resident natural killer (NK) cells in both the virgin and pregnant uterus, suggesting that uterine tissue-resident NK cells derive from precursors in the conventional NK cell lineage.

Spatiotemporal evolution and impacts of environment on scrub typhus in northern China, 2006-2019.

Background: Scrub typhus is a significant public health issue with a global distribution. In northern China, Shandong Province is a major endemic area, but its spatiotemporal patterns and influencing factors remain unclear.

Methods: This study collected data on scrub typhus in Shandong Province from the Infectious Disease Reporting System of the Shandong Center for Disease Control and Prevention between 2006 and 2019.

Remnant cholesterol predicts the development of type 2 diabetes in patients with nonalcoholic fatty liver disease.

Background: The predictive value of serum remnant cholesterol in cardiovascular disease has been widely recognized. This value has also been explored in metabolic disorders such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD). However, whether remnant cholesterol can predict the risk of incident diabetes in NAFLD patients remains unclear.

[Spatio-temporal Monitoring and Driving Factor Analysis of Eco-environment Quality in the Loess Plateau of Northern Shaanxi].

Located in the core area， the Loess Plateau of Northern Shaanxi is characterized by a sensitive and fragile eco-environment facing a series of ecological challenges such as soil erosion， desertification， and salinization. Therefore， comprehensive and quantitative monitoring and analysis of the spatio-temporal changes and driving factors of eco-environment quality are critically important for regional eco-environment protection. Based on Google Earth Engine （GEE）， and taking the ecological characteristics into account， an adjusted remote sensing ecological index（RSEI）was constructed by introducing the composite salinity index （CSI） and desertification difference index （DDI） into the classical remote sensing ecological index （RSEI）.

Revolutionizing the Female Reproductive System Research with Additive Manufacturing.

The female reproductive system is highly complex, making it essential for applied research and translational medicine to accurately model its intricate physiological functions or develop strategies for restoring them. However, significant structural and functional differences between human and animal models, along with the limitations of static 2D cell culture technologies, underscore the need for more dynamic and sophisticated platforms, as well as therapies. These advancements are critical for deepening our understanding of reproductive biology and supporting clinical applications.

Prenatal psychological stress mediates vertical transmission of gut microbiome to the next generation affecting offspring depressive-like behaviors and neurotransmitter.

Objective: Prenatal stress has been proven to be associated with dysbiosis of the gut microbiota. Despite the established phenomenon that psychological stress can be transmitted to offspring and the ability of maternal gut microbiota to colonize the offspring's gut through vertical transmission, the intricate relationships linking cross-generational depression with the microbiome remain poorly understood.

Methods: We utilized combined fear stress stimuli to establish a pregnancy psychological stress (PPS) rat model, in which offspring exhibited trans-generational depression-like behavior.

Enhanced Reduction of Nitrate to Ammonia at the Co-N Heteroatomic Interface in MOF-Derived Porous Carbon.

The electrocatalytic reduction of nitrate is an efficient and green method for NH production. In this study, a Co-containing MOF with a stable three-dimensional carbon framework that offers abundant metal active sites is prepared as a precursor to a Co-N-C electrocatalyst. Facile pyrolysis of the three-dimensional MOF affords the desired Co-N-C electrocatalyst, which exhibits excellent stability, an NH yield of 1.

Near-infrared light-activated osmium-complex/UiO-67-bpy composite for enhanced antibacterial activity and wound healing.

Osmium(bpy) complex coordinated with metal-organic framework UiO-67-bpy, photodynamic effect was studied in detail against pathogenic bacteria, under Near-IR (800-810 nm) irradiation. Structural analysis, including XRD, FTIR, and XPS, confirmed successful synthesis of the composite, highlighting Os-N ligation characterized by distinct peak at 623 cm with a slight red shift, and electronic modifications of N in XPS. Os(bpy)/UiO-67-bpy (UOsCb) composite demonstrated significantly enhanced photodynamic antibacterial efficacy, with 10.

Mobilization of mercury, thallium and arsenic in soil hydrological processes in karst catchment, southwest China.

Soils are natural pools of potentially toxic elements (PTEs), and their hydrological processes, such as runoff, infiltration, and groundwater migration, profoundly influence the migration and transformation of PTEs through biogeochemical cycling. These hydrological processes were controlled by multiple factors, including vegetation cover and land uses. This study investigates sources, spatial patterns, and migration mechanisms of mercury (Hg), thallium (Tl), and arsenic (As) in rainfall-runoff and groundwater migration processes in Lanmuchang catchment, a typical karst region in southwest China.

Impact of Intravenous Fish Oil Lipid Emulsion on Short-Term Postoperative Outcomes in Rectal Cancer Patients Following Neoadjuvant Therapy: A Propensity Score-Matched Study.

Purpose: Previous studies lack a consensus on the role of fish oil lipid emulsion in postoperative complications and recovery in rectal cancer patients post-neoadjuvant therapy. This study aimed to evaluate the impact of intravenous fish oil lipid emulsion on short-term clinical outcomes in these patients.

Patients And Methods: This retrospective study included patients who underwent radical surgery for RC after NT between November 2018 and April 2022.

FTO promotes breast cancer development via inhibiting CYP27B1 /1,25-dihydroxyvitamin D3 asis in m6A-dependent manner.

The dynamic regulation of RNA N6-methyladenosine (mA) modification is decisive for tumor initiation, metastasis and recurrence. Whereas, the underlying mechanism that downstream signal regulated by FTO to control breast cancer development through m6A modification needs to be further studied. In this study, we used m6A methylation and RNA sequencing (seq) to verify the role of FTO and its downstream signal in the development of breast cancer.

Ashwagandha () Plant Extracts Affect the Cytochrome P450 System and Cytotoxicity of Primary Human Hepatocytes.

Ashwagandha ( [L] Dunal) is emerging as one of the top 10 botanicals in the market due to its claimed health benefits as an adaptogen. Alongside its popularity, the lack of standardization in botanical dietary supplements and potential interactions with prescription drugs raise safety concerns. This study aimed to investigate the potential of ashwagandha extracts to induce cytochrome P450 (P450) enzymes, which are critical for drug metabolism and implicated in botanical-drug interactions.