Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice.

Aldehyde dehydrogenase 2 (ALDH2) is a critical enzyme involved in the detoxification of acetaldehyde. Although numerous studies have demonstrated the significance of ALDH2 in alcohol-associated liver disease (ALD), its role in alcohol-induced activation of liver progenitor cells (LPCs) has not been thoroughly investigated. Proteomic analysis of serum samples from patients with either normal ALDH2 genotype or ALDH2 mutation following alcohol consumption revealed that ALDH2 deficiency may suppress LPC proliferation.

Impact of social-psychological factors on anxiety before gastrointestinal endoscopy and quality of life.

Introduction: This study aimed to examine the impact of social-psychological factors on anxiety before gastrointestinal endoscopy and its effect on patients' quality of life (QoL).

Methods: Patients scheduled for gastrointestinal endoscopy were recruited for the study. Demographic characteristics, social factors, lifestyle information and endoscopy-related data were obtained through self-reports and the hospital information system.

Mollugin reacts with phenol thiol but not produce modification on cysteine discovered by a phenol thiol probe.

Electrophilic compounds from natural products (NPs) and metabolites can covalently modify the cysteines of target proteins to induce biological activities. To facilitate the discovery of novel NPs and metabolites, chemical probes with various thiol groups-mimicking the reactivity of cysteine-have been developed. These probes are designed to react with electrophilic groups of NPs and metabolites in an electrophilic addition mechanism, with the resulting adducts having molecular masses which equal to the sum of the probe and the target compound.

Janus Asymmetric-Wettability Cellulosic Triboelectric Materials Enabled by Noncovalent Interactions.

High-strength cellulose materials, endowed with both biocompatibility and lightweight characteristics, are accelerating the advancement of artificial intelligence technologies in wearable electronics. However, the abundance of hydroxyl groups on cellulose surfaces imparts pronounced hydrophilicity, severely constraining the cellulose's wet strength. This study proposes a noncovalent bonding strategy based on hydrogen bonding and electrostatic interactions and develops a Janus-type cellulose triboelectric material with an asymmetric wettability.

The defensin-like protein OsCDT5 reduces Cd accumulation in rice (Oryza sativa L.).

Rice (Oryza sativa L.) is one of the most important food crops worldwide, with a strong capacity for Cd accumulation. Cd accumulation in rice is regulated by multiple genes.

Concentration-function coupled electrolytes harmonize thermodynamics and kinetics for stable zinc metal batteries.

The application of zinc-based aqueous batteries (ZABs) is limited by poor thermodynamic stability and sluggish electrochemical kinetics due to the unfavorable bulk phase and interface. Conventional electrolyte strategies struggle to balance these aspects. Here, we present a concentration-function coupled electrolyte strategy that enables the independent yet synergistic regulation of bulk and interfacial behaviors of Zn.

Comparative profiling of splenic phospholipid and sphingolipid during acute infection.

Lipid profile of spleen and bursa of Fabricius (BF) during acute infection remains unknown. Acute infection models of porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and Eimeria tenella (ET) were developed, and spleen samples with African swine fever virus (ASFV) or not were collected. Spleen and BF were examined and characteristic microscopic lesions were observed.

Stroke-Aware CycleGAN: Improving Low-Field MRI Image Quality for Accurate Stroke Assessment.

Low-field portable magnetic resonance imaging (pMRI) devices address a crucial requirement in the realm of healthcare by offering the capability for on-demand and timely access to MRI, especially in the context of routine stroke emergency. Nevertheless, images acquired by these devices often exhibit poor clarity and low resolution, resulting in their reduced potential to support precise diagnostic evaluations and lesion quantification. In this paper, we propose a 3D deep learning based model, named Stroke-Aware CycleGAN (SA-CycleGAN), to enhance the quality of low-field images for further improving diagnosis of routine stroke.

Artificial intelligence in dysphagia since the 21st century: a bibliometric and visualization study.

Background: The fields of dysphagia is progressively acknowledging the transformative capacity of artificial intelligence (AI). The implementation of this technology is profoundly impacting research directions, clinical practices, and healthcare systems. However, existing studies remain scattered and predominantly focus on specific techniques or case applications, lacking a systematic synthesis of global research output, influential contributors, collaboration networks, and evolving thematic trends.

Selenomethionine alleviates OTA-induced kidney injury in broilers by modulating ferroptosis.

Mycotoxin contamination in food and feed poses a significant threat to human and animal health worldwide. OTA is a common mycotoxin. About 20-30% of global feed is contaminated with OTA, and the annual potential contamination amount exceeds 200 million tons, which has become a major problem of local feed safety.

Bioinspired Heterogeneous Wettability Triboelectric Sensors for Sweat Collection and Monitoring.

Triboelectric sweat sensors, endowed with the technical advantages of non-invasive ex vivo and in situ detection, have catalyzed the rapid advancement of personalized medicine and precision health management systems. However, the inherently low secretion rate and rapid evaporation of sweat pose significant challenges for its efficient collection and rapid analytical screening. This study leverages laser cutting and aqueous interfacial self-assembly strategies to develop a biomimetic heterogeneous wettability triboelectric material (HWTM).

Intraplacental choriocarcinoma coexisting with fetomaternal hemorrhage and fetal intrahepatic portosystemic venous shunt in a term pregnancy: A case report.

Rationale: Intraplacental choriocarcinoma (IC) coexisting with fetomaternal hemorrhage (FMH) in term pregnancy is rare and life-threatening for the mother and baby. The limited knowledge of this disease leads to delayed or missed diagnosis. This case report aims to illustrate how to avoid missed diagnosis through a more complicated case by the presence of fetal intrahepatic portosystemic venous shunt (IPSVS).

Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats.

Objectives: Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury. This study aimed to evaluate the apoptosis following SM-induced acute pulmonary injury.

Materials And Methods: Acute pulmonary injury models were established using SM at an equivalent toxicity dose (1 LD50), administered via intraperitoneal injection or intratracheal instillation.

Unveiling the renoprotective mechanisms of self-assembled herbal nanoparticles from and in acute kidney injury: A nano-TCM approach.

Acute kidney injury (AKI) is a critical clinical condition characterized by rapid renal function decline, with high morbidity, mortality, and healthcare costs. Traditional Chinese medicine (TCM) has shown potential effects on mitigating oxidative stress and programmed cell death in AKI models. D.

Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism.

Porcine respiratory disease complex (PRDC) is a common syndrome in the modern swine industry worldwide, and its pathogenesis remains unclear to date. Our study aimed to investigate PRDC-induced pulmonary fibrosis and sphingolipid metabolism, and their relationship. Mouse and cell line (A549 and 3D4/21) models exposed to bleomycin and/or transforming growth factor-β1 (TGF-β1) were developed.

Case Report: A case of tuberculous empyema causing rupture of the diaphragm was misdiagnosed as diaphragmatic hernia.

Tuberculous empyema (TE) is a chronic active infection caused by that invades the pleural cavity. Initially, fluid accumulates in the pleural space, followed by an influx of neutrophils, which gradually develops into purulent fluid. This process can eventually lead to pleural thickening and calcification, restricting lung expansion and impairing lung function.

Identification and Characterization of the Gene Family in Potato.

Carboxypeptidase A inhibitor (CPAI) is a globular polypeptide that specifically inhibits carboxypeptidase A activity in the insect gut, playing a vital role in plant defense against external stimuli. To date, this gene family has not been systematically characterized in potatoes. In this study, we identified the gene family using the potato DM v6.

Enhancing YOLOv11 with Large Kernel Attention and Multi-Scale Fusion for Accurate Small and Multi-Lesion Bone Tumor Detection in Radiographs.

Primary bone tumors such as osteosarcoma and chondrosarcoma are rare but aggressive malignancies that require early and accurate diagnosis. Although X-ray radiography is a widely accessible imaging modality, detecting small or multi lesions remains challenging. Existing deep learning models are often trained on small, single-center datasets and lack generalizability, limiting their clinical effectiveness.

A novel SOX6 + melanoma cell subtype promotes early microsatellite invasion in Asian acral melanoma through fatty acid transport disorder.

Acral melanoma (AM) is the predominant subtype of melanoma in Asians. Early detection and prevention can significantly improve patient outcomes; however, there is a lack of effective early biomarkers for predicting AM metastasis. Here, we employed single-cell and spatial transcriptomics analyses to investigate early microsatellite lesions of AM and identify biomarkers of invasiveness in these lesions.

Dietary as a functional food combined with blood flow restriction to enhance the jump performance of basketball athletes: a randomized crossover study.

Introduction: (TT), a food-derived functional ingredient, may influence neuromuscular function via its bioactive compounds, but its acute effects on BFR-induced PAP and performance remain unknown. This study examined its short-term effects on neuromuscular performance after BFR-primed PAP in elite male basketball athletes ( = 20).

Methods: Participants completed two sessions involving BFR-augmented plyometric protocols with either TT or placebo.

A multifunctional terahertz device based on vanadium dioxide metamaterials that switches between ultra-broadband absorption and ultra-high- narrowband absorption.

Terahertz (THz) absorbers with ultra-broadband and ultra-narrowband absorption capabilities are crucial for integrated and efficient terahertz modulation. This study proposes a dual-mode tunable terahertz absorber based on the phase transition characteristics of vanadium dioxide (VO), enabling dynamic switching between narrowband and broadband absorption through its insulating-to-metallic transition. In the insulating state, the excitation of quasi-bound states in the continuum (Q-BIC) resonance geometric parameter modulation of silicon pillars is investigated, with its physical mechanism elucidated impedance matching theory and multipole analysis.

Lesion Network Mapping for Atrial Fibrillation Newly Detected on ECG or Cardiac Monitoring After Stroke.

Background: Atrial fibrillation detected after stroke is a distinct clinical entity that may stem from cardiogenic-neurogenic interactions. We aimed to illuminate the lesion network mapping of atrial fibrillation newly detected on ECG or cardiac monitoring after stroke and explore the association between the central autonomic network and occurrence of atrial fibrillation.

Methods: We performed voxel-based lesion-symptom mapping, structural disconnection connectome mapping and functional disconnection connectome mapping to locate lesions and networks for atrial fibrillation newly detected on ECG or cardiac monitoring after stroke.

Superior High-Temperature Energy Storage Performance in All-Organic Composite Dielectrics Achieved by Synergistic Regulation of Free Volume and Charge Distribution.

Developing polymer dielectrics with stable high-temperature energy storage performance remains a pivotal challenge for next-generation electrical systems. However, the exponentially increasing conduction loss at elevated temperatures results in a decline in both energy storage density and efficiency. Herein, a cross-scale synergistic regulation strategy that integrates mesoscale free volume and molecular-scale charge trap, effectively addressing the issue of free volume collapse and space charge accumulation under thermal-electric coupling stress is proposed.

Global burden of autism spectrum disorders among population aged 70 years and older from 1990-2021, with projections to 2040: findings from the Global Burden of Disease Study 2021.

Autism spectrum disorders (ASD) is a lifelong neurodevelopmental condition that negatively affects older adults, yet it receives minimal priority and limited attention in research and healthcare services for this population. Using data from Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we estimated the prevalence and disability-adjusted life-years (DALYs) of ASD among population aged ≥70 years globally from 1990-2021, with projections to 2040. Decomposition analysis was conducted.

Low-Cost IMU-Based System for Automated Parkinson's Subtype and Stage Classification to Support Precision Rehabilitation.

Parkinson's disease (PD) is one of the most common progressive neurodegenerative disorder, for which early detection and precise rehabilitation planning are essential to alleviate its impact on quality of life and reduce societal burden. Accurate, automated PD subtype classification and staging play a key role in designing effective rehabilitation strategies while minimizing reliance on intensive expert assessments. Unlike existing automated methods that typically depend on high-cost medical imaging (e.