Virulence-mediated colonization mechanism for TEP as a promising watershed-scale recorder and source-tracking indicator of human pathogens.

Waterborne pathogens related diseases have been a global health concern. Precise source tracking of pathogens in rivers is crucial for understanding and reducing waterborne pathogens transmission risks. Current microbial source tracking techniques are still limited by identifying pathogen indicators at low concentrations, particularly in highly dynamic confluence zones of rivers where the coalescence of microbiomes exacerbates community disturbances.

Obesity hinders the efficacy of adipose-derived stem cells for knee osteoarthritis by reducing the proportion of DPP4+ stem cells.

Osteoarthritis (OA) is the most prevalent and disabling joint disease, while adipose-derived stem cells (ASCs) have emerged as a promising therapeutic option in pre-clinical studies. However, the therapeutic efficacy of ASCs may be influenced by the source of these cells, especially in obese patients. This study compared the effects of intra-articular injections of ASCs from wild-type (WT) and ob/ob (OB) mice.

Chronically Stable, High-Resolution Micro-Electrocorticographic Brain-Computer Interfaces for Real-Time Motor Decoding.

Brain-computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high-resolution micro-electrocorticography (µECoG) BCI based on a flexible, high-density µECoG electrode array, capable of chronically stable and real-time motor decoding. Leveraging micro-nano manufacturing technology, the µECoG BCI achieves a 64-fold increase in electrode density compared to conventional clinical electrode arrays, enhancing spatial resolution while featuring scalability.

Investigating the Potential Effects of 6PPDQ on Clear Cell Renal Cell Carcinoma via Network Toxicology and Molecular Docking Analysis With In Vitro Experimental Validation.

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ), as a recently identified environmental toxicant, has garnered significant attention because of its widespread detection in ecosystems and human habitats. Emerging evidence highlights its potential detrimental effects on various organs. However, its carcinogenic potential remains poorly understood, particularly its role in clear cell renal cell carcinoma (ccRCC).

Phase-Reconstruction of S-Doped (NiCo)WC for Efficient and Stable Oxygen Evolution Reaction Electrocatalysis.

Developing highly active and stable nonprecious electrocatalysts toward sluggish alkaline oxygen evolution reaction (OER) is essential for large-scale green hydrogen production via electrochemical water splitting. Here we report phase and surface co-reconstruction of S-doped (NiCo)WC nanoparticles into (NiCo)C with amorphous electroactive NiCoOOH layer for highly efficient alkaline OER by W dissolution and NiCo surface oxidation. The W dissolution results in the formation of Brønsted base WO ions, which electrostatically accumulate around electrode to promote water dissociation into abundant OH* intermediates, in situ constructing a locally strong alkaline microenvironment to facilitate OH* adsorption on NiCoOOH sites and trigger lattice-oxygen oxidation path.

The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.

Background: Obesity has emerged as a critical global public health challenge. Postmenopausal women experience significantly elevated risks of metabolic disorders and a marked increase in obesity prevalence due to declining estrogen levels. The uric acid to high-density lipoprotein cholesterol ratio (UHR), an emerging biomarker for metabolic syndrome, is gaining clinical recognition.

Longitudinal associations between 24-hour movement behaviors and physical fitness in preschoolers: a compositional isotemporal substitution analysis.

This study investigated the prospective associations between changes in 24-h movement behaviors and physical fitness (PF) components in preschool children; and examined how the reallocation of time between movement behaviours was associated with longitudinal changes in PF. This is a two-year longitudinal study of 200 Chinese children aged 3-4 years old. At baseline and follow-up, 24-h movement behaviors including moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), screen-based sedentary behavior (SSB), non-screen-based sedentary behavior (NSB), and sleep were assessed.

Stimuli-activable hollow CuO@C/N doped paste for the prevention of white spot lesions in orthodontic treatments.

White spot lesions (WSLs) are the most common complication of orthodontic treatment, compromising dental health and significantly affecting aesthetics. To address this clinical challenge, this study aims to develop a dual-functional therapeutic strategy that simultaneously promotes the remineralization of demineralized enamel and inhibits the activity of cariogenic bacteria, thereby achieving effective prevention and treatment of WSLs. A hollow double-shell structured CuO@N/C nanozyme (H-CuO@N/C) was synthesized using a one-step hydrothermal method.

Clinical characterisation of human metapneumovirus infection in 525 patients with respiratory tract infections in Jilin province.

Background: Human metapneumovirus (HMPV) is a common cause of acute respiratory infections. The aim of this study was to analyze the demographic characteristics and treatment outcomes of HMPV virus infection in Jilin province.

Methods: We conducted a retrospective cohort analysis of patients with respiratory tract infections between September 2023 and February 2024 in the Lequn Campus of the First Hospital of Jilin University, using tNGS sequencing.

Advances of bispecific antibodies using/application in dermatology: a review.

Bispecific antibodies represent an important innovation in the field of biomedicine in recent years. Compared to monoclonal antibodies, their specific structure enables a single antibody molecule to bind to two different antigens simultaneously. This characteristic endows bispecific antibodies with more functions, regulating multiple signal pathways simultaneously, enhancing the therapeutic effect, and by infusion of targeted tumor antigens and drug carriers in advance, the contact time between the drug and normal tissues is reduced, and the toxic side effects are greatly reduced.

Microorganisms in mosquitoes for controlling mosquito-borne viral diseases: from lab to field.

Mosquito-borne viral diseases pose a growing global health threat, with over half of the world's population living in high-risk areas. In the absence of effective vaccines or antiviral therapies for most mosquito-borne viruses, vector control remains the primary strategy. However, traditional insecticides face rising resistance and ecological concerns.

Aligning organ-specific toxicities with formulation strategies: a rational design approach to chemotherapy optimization.

Chemotherapy-induced toxicity remains a persistent challenge in oncology, where multi-organ injury continues to limit clinical outcomes despite decades of drug optimization and formulation innovation. Although mechanistic studies have elucidated key pathways of damage, current formulation strategies often overlook organ-specific pathophysiology, resulting in nonspecific mitigation approaches. This review fills a methodological gap by introducing a toxicity-informed framework that integrates organ-specific injury mechanisms with formulation design principles to support rational chemotherapy optimization.

Lewy body dementia promotion by air pollutants.

Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM) exposure raises LBD risk.

Mutant alleles enable a D-glutamate auxotroph to grow with lower requirements for exogenous D-glutamate.

D-glu is a key component of peptidoglycan (PG) and is essential for growth in most bacteria. To assess constraints on PG evolution and bacterial requirements for D-glu, we sought to artificially evolve PG biosynthesis, leading to either replacement of D-glu in the PG peptide or alternative pathways to D-glu incorporation. We previously found that suppression of D-glu auxotrophy in a mutant of grown on lysogeny broth salts (LBS) medium was rare but could be accomplished by mutation of , with restoration of wild-type PG structure.

Ultrabroadband Photosensitivity and Frequency-Mixing in Anisotropic Weyl Semimetal NbNiTe.

Broadband anisotropic photodetectors show great promise for polarization-sensitive imaging and multispectral optoelectronic systems yet face critical challenges in material anisotropy modulation and broadband sensitivity. Weyl semimetals exhibit giant optical anisotropy and tunable heterojunction band alignment, enabling high-performance anisotropic photodetection. Herein, ultrabroadband PDs based on the NbNiTe (niobium nickel telluride), enabled by antenna integration and heterostructure engineering, achieve high sensitivity from visible to Terahertz (THz).

Development of New Blood Immunoassay and Biomarkers for Tau in the Diagnosis of Alzheimer's Disease.

Post-translational modifications, such as truncation facilitated by proteases and phosphorylation mediated by protein kinases, play pivotal roles in Tau protein function and cellular processes. The detection of distinct Tau forms in plasma has garnered significant interest in the scientific and translational communities. We discovered monoclonal antibodies (mAbs) using the hybridoma technique by immunizing mice with different Tau proteins.

SrZnSiS: Shattering the 4.0 eV Threshold toward Dual-Optimized Bandgap and Second-Harmonic Generation.

Infrared (IR) nonlinear optical (NLO) crystals are crucial for mid-IR lasers, yet their intrinsic narrow band gaps cause low laser-induced damage thresholds (LIDTs) and detrimental two-photon absorption, thus limiting their widespread application. Herein, a synergistic strategy involving d-orbital exclusion and polarization motif construction is employed to synthesize novel chalcogenide SrZnSiS by introducing [SiS] and [ZnS] tetrahedral polarization subunits. Performance evaluation demonstrates that SrZnSiS breaks through the "4.

Safety and Diagnostic Yield of Transbronchial Cryobiopsy by Flexible Bronchoscopy Under Conscious Sedation Without Intubation in Diffuse Parenchymal Lung Disease.

Background: Transbronchial cryobiopsy (TBCB) is generally recommended under intubation or rigid bronchoscopy with general anesthesia. However, some patients with diffuse parenchymal lung disease (DPLD) are unable to tolerate general anesthesia, which limits the widespread adoption of TBCB.

Methods: A total of 37 patients with DPLD who underwent TBCB under conscious sedation without intubation were included in this study.

Exploration of the Mechanism of Action of in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.

Purpose: The anti-tumor effects of , as a medicinal and dietary Chinese medicine, have long been documented. However, the mechanism of action for its therapeutic effect has not been fully elucidated.

Methods: The chemical constituents of were screened using PubMed, CNKI, and Wanfang databases.

Ecological pattern of microalgal communities and associated risks in coastal ecosystems.

Eukaryotic harmful and toxic microalgae, along with their derived toxins, pose significant threats to seafood safety, human health, and marine ecosystems. Here, we developed a novel full-length 18S rRNA database for harmful and toxic microalgae and combined metabarcoding with toxin analyses to investigate the ecological patterns of phytoplankton communities and the underlying mechanism of associated toxic microalgae risks. We identified 79 harmful and toxic species in Hong Kong's coastal waters, with dinoflagellates and diatoms representing the majority of toxic and harmful taxa, respectively.

Postoperative Vocal Cord Paralysis After Retrieval of a Fishbone Penetrating the Recurrent Laryngeal Nerve.

A migratory fishbone is not a rare case in otorhinolaryngology clinics in Asia. Deep neck infection is a common complication, and several cases of preoperative vocal cord paralysis have been reported. However, postoperative vocal cord paralysis after the retrieval of a fishbone penetrating the recurrent laryngeal nerve has not been documented.

[Effect and mechanism of Moringa oleifera leaves, seeds, and velamen in improving learning and memory impairments in mice based on transcriptomic and metabolomic].

Moringa oleifera, widely utilized in Ayurvedic medicine, is recognized for its leaves, seeds, and velamen possessing traditional effects such as vātahara(wind alleviation), sirovirecaka(brain clearing), and hridya(mental nourishment). This study aims to identify the medicinal part of ■ in the Sārasvata ghee formulation as described in the Bower Manuscript, while investigating the ameliorative effects of different medicinal parts of M. oleifera on learning and memory deficits in mice and elucidating the underlying molecular mechanisms.

68Ga-NODAGA-SNA006 PET/CT Imaging of Tumor CD8+ T-Cell Infiltration Predicts Immunotherapy Response in Lung Cancer.

Background: This study aimed to evaluate the potential of 68Ga-NODAGA-SNA006 PET/CT imaging as a noninvasive method for assessing immune cell infiltration and predicting treatment response in lung cancer patients undergoing immunotherapy.

Patients And Methods: A prospective study enrolled 8 patients with histologically confirmed lung cancer who received first-line chemotherapy combined with anti-PD-1/PD-L1 immunotherapy. 68Ga-SNA006 PET/CT imaging was performed before treatment.

Assessing the Prognostic Accuracy of the PSS, pSOFA, and SIRS for In-Hospital Mortality in Children with Suspected Infection in Non-ICU Settings: A Multicenter Retrospective Study.

Objectives: To systematically compare the predictive accuracy of the Phoenix Sepsis Score (PSS), the Pediatric Sequential Organ Failure Assessment (pSOFA), and systemic inflammatory response syndrome (SIRS) in assessing in-hospital mortality risk among pediatric sepsis patients in non-ICU wards, thereby providing evidence-based support for clinical risk stratification.

Design: This study employed a multicenter retrospective cohort design, enrolling non-ICU pediatric patients with suspected infections (excluding preterm infants and neonates hospitalized immediately after birth), to construct an overall cohort and a neonatal subgroup cohort. Clinical parameters were collected through a data acquisition system, with parallel calculations of PSS, pSOFA, and SIRS scores.

Organic ultraviolet filters in Irish sediments and biosolids.

This study provides baseline data on the concentrations of selected ultraviolet filters (UVFs) in 81 inland and transitional sediments as well as in 21 agricultural biosolid samples sourced from seven wastewater treatment plants (WWTP) across Ireland. Concentrations of five prominent UVFs were determined: 4-methylbenzylidene camphor (4-MBC); benzophenone-3 (BP-3); 2-ethylhexyl-4-methoxycinnamate (EHMC); homosalate (HMS); and Octocrylene (OC). Mean concentrations in sediments were as follows: OC (3.