The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.

Background: Obesity has emerged as a critical global public health challenge. Postmenopausal women experience significantly elevated risks of metabolic disorders and a marked increase in obesity prevalence due to declining estrogen levels. The uric acid to high-density lipoprotein cholesterol ratio (UHR), an emerging biomarker for metabolic syndrome, is gaining clinical recognition.

Analysis of potential profiles of health literacy in chronic heart failure patients.

Purpose: This study aimed to explore health literacy profiles in patients with heart failure and identify heterogeneous subgroups within the chronic heart failure population. Through investigating the health literacy of heart failure patients, we analyzed the factors influencing patients' health literacy levels, aiming to provide evidence-based guidance for improving health literacy in this patient population.

Methods: This study employed a cross-sectional design.

Integrative bulk and single-cell transcriptomic analysis identifies a migrasome-associated lncRNA signature predictive of prognosis and immune landscape in clear cell renal cell carcinoma.

Introduction: Clear cell renal cell carcinoma (ccRCC) is characterized by high recurrence and metastasis rates, leading to poor prognosis. Migrasomes, a class of organelles mediating intercellular communication, and long noncoding RNAs (lncRNAs) both play critical roles in tumor progression; however, the prognostic significance of migrasome-associated lncRNAs in ccRCC remains unclear.

Methods: Migrasome-associated lncRNAs were identified using The Cancer Genome Atlas (TCGA) dataset, and a prognostic risk signature was constructed.

Nano-Biosensors for mRNA-Based Cell Sorting Using Intracellular Markers at the Early Stage of Cell Reprogramming.

Cell reprogramming and manufacturing have broad applications in tissue regeneration and disease treatment. However, many derived cell types lack unique cell surface markers for protein-based cell sorting, making it difficult to isolate these cells from mixed populations. Additionally, there is a need to identify and isolate cells of interest at the early stages of cell expansion.

Assessment of surgical precision and safety in oncoplastic breast-conserving surgery for breast cancer under the guidance of imaging.

Background: Oncoplastic breast-conserving surgery (OBCS) has become an essential component of breast cancer treatment. Imaging guidance in breast surgery has the potential to enhance surgical precision. Despite increasing recognition, a comprehensive evaluation of its specific impact on OBCS for breast cancer is needed.

Insulin resistance, left atrial anatomical remodeling, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation.

Background: Insulin resistance (IR) is associated with both the anatomical remodeling of the left atrium and the pathogenesis of atrial fibrillation (AF). However, the exact extent of this correlation and its influence on AF recurrence in individuals undergoing radiofrequency catheter ablation (RFCA) remains unclear.

Methods: A total of 910 patients with AF who underwent RFCA were included in this analysis.

Septal LYVE1 macrophages control adipocyte stem cell adipogenic potential.

Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose tissue macrophages (sATMs), marked by CD209b and lymphatic vessel endothelial hyaluronan receptor 1, were long-lived and positioned in close proximity to adipocyte stem cells (ASCs) within the WAT septum.

Validation of the Longitudinal Effect of an Integrated Nursing Intervention Based on the Integrated Theory of Health Behavior Change (ITHBC) on Multidimensional Health Indicators in Older Radiotherapy Patients.

Introduction: The Integrated Theory of Health Behavior Change (ITHBC) offers a structured framework for promoting sustained health behavior change through cognitive beliefs, self-regulation, and social facilitation. However, its application in geriatric oncology remains unexplored.

Methods: This quasi-experimental study enrolled 291 older adult patients who underwent radiotherapy at the Jiangsu Cancer Hospital.

Methionine enkephalin upregulates the immune function of RAW264.7 cells to inhibit the infection of Nelson Bay orthoreoviruses.

Preliminary research has found that MENK can upregulate the antiviral state of macrophages to inhibit influenza virus infection. To further study the immunomodulatory mechanism of MENK in macrophages against reovirus, we used RNA-Seq technology to analyze the genomic changes between macrophages infected with Nelson Bay orthoreoviruses (Miyazaki) after MENK pretreatment and those infected with Miyazaki alone. A total of 3,624 genes were screened, with 1,817 genes upregulated and 1,447 genes downregulated.

Multi-Omics Profiling of the 42-Day Infant Gut as a Pilot Predictor of Atopic Dermatitis at One Year: A Birth Cohort Study in China.

Background: Early-life gut microbiota and metabolism are increasingly linked to immune development and atopic diseases. However, predictive microbial and metabolic markers present during the neonatal period for later atopic dermatitis (AD) remain poorly defined. This study aimed to identify early-life gut microbiome and metabolite signatures associated with the development of AD by one year of age.

Graph-sequence enhanced transformer for template-free prediction of natural product biosynthesis.

Natural products (NPs) play a vital role in drug discovery, with many FDA-approved drugs derived from these compounds. Despite their significance, the biosynthetic pathways of NPs remain poorly characterized due to their inherent complexity and the limitations of traditional retrosynthesis methods in predicting such intricate reactions. While template-free machine learning models have demonstrated promise in organic synthesis, their application to biosynthetic pathways is still in its infancy.

Harnessing Biomaterials for Gene Therapy in Autoimmune Disease.

The integration of biomaterials and gene therapy heralds a transformative approach for treating autoimmune diseases, which are characterized by immune dysregulation and chronic inflammation. Conventional therapies often suffer from systemic toxicity and nonspecific immunosuppression, highlighting the need for precision medicine strategies. This review highlights recent breakthroughs in biomaterial-assisted delivery of gene therapy tools, such as small interfering RNA (siRNA), messenger RNA (mRNA), and clustered regularly interspaced short palindromic repeats-CRISPR-associated 9 (CRISPR-Cas9).

Research hotspots and global trends in respiratory syncytial virus over past five years.

Respiratory syncytial virus (RSV) is the main cause of acute lower respiratory tract infections in children under 2 years old. This bibliometric analysis is used to determine the characteristics, hotspots, and frontiers of RSV global scientific output over the past 5 years. In this study, the Science Citation Index Expanded (SCI-Expanded) version from the Web of Science Core Collection (WoSCC) for publications and record information published from 2020 to 2024 was retrieved.

Antipsychotic-Related Prolactin Changes: A Systematic Review and Dose-Response Meta-analysis.

Background: Prolactin increase is a common and potentially problematic adverse event of antipsychotics. We aimed to discover the relationship between antipsychotic doses and changes in prolactin levels.

Objective: To examine the relationship between antipsychotic doses and changes in prolactin levels in adults with acutely exacerbated schizophrenia.

The impact of glycemic variability on the 28-day prognosis of patients with cardiogenic shock with or without diabetes mellitus: A retrospective cohort study.

Unlabelled: Glycaemic variability (GV) may reflect sharp rises and acute fluctuations in blood glucose, which are associated with adverse cardiovascular events. The aim of this study was to investigate the effect of GV on 28-day outcome in patients with cardiogenic shock (CS) with or without diabetes mellitus (DM).

Methods: This retrospective cohort study adhered to the RECORD (REporting of studies Conducted using Observational Routinely-collected Data) guidelines.

Spatial distribution characteristics and tourism response of intangible cultural heritage in coastal areas of China.

The coastal regions of China are abundant in intangible cultural heritage (ICH) resources characterized by distinct maritime features. The comprehensive integration and development of these resources with tourism represent a critical strategy for the scientific protection and sustainable development of coastal ICH. This study examines the spatial distribution of ICH across China's coastal regions.

Conjugate-dual clusters.

Discovery of clusters with high symmetrical geometry, such as C60 fullerene, always attracts lots of interest because of their diverse nature. However, most of such interesting clusters were sporadically discovered; is there any systematic method to explore all possible high symmetrical clusters? Herein, we propose an idea to systematically construct high symmetrical structures based on a novel conjugate-dual (co-dual) concept. A co-dual structure would be constructed by conjugately combining one high symmetrical polyhedron and its corresponding dual.

A Segmentation Network with Two Distinct Attention Modules for the Segmentation of Multiple Renal Structures in Ultrasound Images.

: Ultrasound imaging is widely employed to assess kidney health and diagnose renal diseases. Accurate segmentation of renal structures in ultrasound images plays a critical role in the diagnosis and treatment of related kidney diseases. However, challenges such as speckle noise and low contrast still hinder precise segmentation.

Photonic generation of frequency-doubled microwave waveforms based on time-domain processing.

A photonic approach for a frequency-doubled microwave waveforms generator based on time-domain processing is proposed and experimentally demonstrated. This approach achieves the generation of various frequency-doubled microwave waveforms by overlapping optical envelopes and performing mathematical operations on optical envelopes. Detailed theoretical analysis and simulations are provided.

Correction: Evaluation of a novel chemiluminescent immunoassay for autoantibody detection in pemphigus and bullous pemphigoid.

[This corrects the article DOI: 10.3389/fimmu.2025.

Comparing Regional Saturation Biopsy and Targeted Biopsy: Is Perilesional Biopsy Necessary for High-Prostate-Specific Antigen Patients?

Background: Previous studies have indicated that regional saturation prostate biopsy (RSB) is more effective than targeted biopsy (TB) or systematic biopsy (SB) for patients with prostate-specific antigen (PSA) levels between 4 and 20 ng/mL. However, its efficacy in patients with PSA levels ≥ 20 ng/mL remains unclear.

Patients And Methods: In this prospective, single-center, randomized controlled trial, we enrolled patients with PSA levels greater than 20 ng/mL and suspicious magnetic resonance imaging (MRI) findings from January 2021 to August 2023.

Development and Evaluation of Antioxidant Postbiotics from Bacillus amyloliquefaciens C-1 to Alleviate DSS-Induced Colitis.

Bacillus amyloliquefaciens has been recognized as a next-generation probiotic with a qualified presumption of safety (QPS) status by the European Food Safety Authority (EFSA), indicating its promising application potential in postbiotic development. This study aimed to investigate the probiotic characteristics of B. amyloliquefaciens strain C-1, isolated from ready-to-eat fruit salads.

Multifunctional dynamic cerium-polypeptide hydrogel with antibacterial antioxidative anti-inflammatory for multidrug-resistant bacterial infected wound healing.

Bacterial infection, especially multidrug-resistant (MDR) bacterial infection, is a great challenge in clinical wound repair, highlighting the urgent to develop antibacterial hydrogel dressing. In this work, a multifunctional cerium-polypeptide hydrogel (FEPC) with comprehensive antibacterial, antioxidant, anti-inflammatory and angiogenesis ability was developed for the treatment of methicillin-resistant (MRSA) infected wounds. The FEPC hydrogel was constructed using Ce and antibacterial polypeptide co-crosslinked γ-polyglutamic acid (γ-PGA) through double dynamic electrostatic and coordination interaction.

What should we focus on in pregnancy complicated by pheochromocytoma? a bibliometric analysis (1990-2024).

Purpose Of Review: The incidence of pheochromocytoma and paraganglioma (PPGL) in pregnancy is extremely low, yet it poses a significant threat to maternal and fetal safety. While studies are published annually, progress in this field remains slow. A key question is how researchers can better utilize limited case data to gain valuable insights.