Resistance to Silicosis Progression in Mice with Ch25h Downregulation: The Involvement of NLRP3 Inflammasome.

Silicosis is a fatal occupational lung disease characterized by persistent inflammation and irreversible fibrosis. However, the pathogenesis of silicosis is currently unclear. In this study, a mouse model of silicosis was established by intranasal instillation of silica, and transcriptomic alterations in lung tissues were assessed by mRNA-sequencing.

Deep generative models design mRNA sequences with enhanced translational capacity and stability.

Despite the success of mRNA COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that utilizes Transformer architectures tailored for mRNA coding sequences (CDSs) and untranslated regions (UTRs), to design novel mRNAs with enhanced expression and stability. GEMORNA-designed full-length mRNAs exhibited up to a 41-fold increase in firefly luciferase expression compared to an optimized benchmark in vitro.

Multi-Omics Profiling of the 42-Day Infant Gut as a Pilot Predictor of Atopic Dermatitis at One Year: A Birth Cohort Study in China.

Background: Early-life gut microbiota and metabolism are increasingly linked to immune development and atopic diseases. However, predictive microbial and metabolic markers present during the neonatal period for later atopic dermatitis (AD) remain poorly defined. This study aimed to identify early-life gut microbiome and metabolite signatures associated with the development of AD by one year of age.

Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles.

Local electrical stimulation (LES) is a widely used clinical method to treat peripheral nerve injury. However, existing plate electrodes (PE) usually suffer from low electronic transport efficiency, whereas acupuncture electrical stimulation may cause damage to normal tissues. There is an urgent need to develop an innovative LES technique with efficient electronic transport, minimal tissue injury and enhanced biosafety.

True natural orifice transluminal endoscopic surgery-transgastric cholecystectomy and beyond.

Natural orifice transluminal endoscopic surgery (NOTES) represents a revolutionary advancement in minimally invasive surgery, eliminating the need for external incisions and offering faster recovery and improved aesthetics. Endoscopic transgastric cholecystectomy (ETGC), a NOTES-based procedure, stands out for its potential to revolutionize gallbladder removal by offering a truly scarless alternative to traditional laparoscopic cholecystectomy (LC). This review explores the historical development of cholecystectomy, evolution of NOTES, and emergence of ETGC as a feasible alternative to LC.

Endoscopic management of esophagomediastinal fistula following peroral endoscopic myotomy.

Objectives: Esophagomediastinal fistula (EMF) is a rare but important major adverse event (mAE) after peroral endoscopic myotomy (POEM), which is scarcely reported. This study aimed to offer a comprehensive analysis of the evaluation and management of EMF following POEM.

Method: From June 2015 to December 2023, we retrospectively reviewed patients with achalasia receiving POEM.

Impact of free provision of disinfectant wipes combined with bundle management on the prevention of multi-drug resistant organism infections in the respiratory and intensive care unit.

Objective: To explore the role of free provision of disinfectant wipes combined with bundle management in preventing Multi-Drug Resistant Organism (MDRO) infections in the Respiratory and Intensive Care Unit (RICU).

Methods: This study included patients admitted to the RICU between January 2022 and June 2023 (control group) and from July 2023 to June 2024 (intervention group), all of whom met the inclusion criteria. The control group received standard bundle management measures, while the intervention group received unlimited use of disinfectant wipes combined with bundle management.

Diagnostic challenges of rarely well-differentiated adenocarcinoma of the stomach.

Background: Fundic gland tumors are a rare subtype of gastric tumors with fundic gland differentiation. This group of tumors has a low incidence rate and shows indistinctive cellular atypia, obvious structural atypia, special tissue morphology, and clinical prognosis, thus leading to diagnostic challenges.

Aim: We aimed to investigate the clinical and endoscopic characteristics and pathological features of gastric adenocarcinoma of the fundic gland (GA-FG) to provide a better understanding of this disease.

Synergistic integration of oxygen vacancy enrichment and Z-scheme heterojunction in novel BiO/TiO photocatalyst for enhanced tetracycline degradation in wastewater.

The novel Z-scheme heterojunction BiO/TiO photocatalytic system with oxygen-rich vacancies was constructed in this paper, which realized the efficient degradation of tetracycline. The tetracycline was 92.2 % removed by BiO/TiO after 60 min of visible-light driving, which is not only attributed to the high density of oxygen vacancies (0.

Evolution of cooperation under a time-varying peer pressure model in complex networks.

In this paper, based on the traditional prisoner's dilemma model, we introduce time-varying peer pressure and verify the enhancing effect of this time-varying peer pressure model on cooperation in different types of networks. We decompose peer pressure into two aspects: pressure intensity, reflecting the degree of punishment an individual receives due to strategy inconsistency with neighbors, and pressure sensitivity, indicating the likelihood of an individual being influenced by peer pressure, which can be regarded as an individual characteristic. Considering individuals' continuous development over time, it is possible for individual characteristics to change over time.

Knowledge, Attitudes, and Practices Among Patients Undergoing Gastrointestinal Endoscopy in the Endoscopy Unit of a Tertiary-Care Hospital.

Purpose: Gastrointestinal endoscopy is a crucial diagnostic and therapeutic tool, but patients' perspectives and preparation can significantly impact procedure outcomes. Understanding patient knowledge, attitudes, and practices (KAP) is crucial for improving the quality of care in gastrointestinal procedures, fostering informed consent, and enhancing patient outcomes. Our objective was to assess the KAP regarding gastrointestinal endoscopy in the Endoscopy Unit among those referred for diagnostic procedures.

Acidosis-dependent inverse association between partial pressure of arterial carbon dioxide and mortality in acute ischemic stroke.

Background: Acute ischemic stroke (AIS) is a major global health concern with significant economic consequences. While various neuroprotective treatments have been explored, a promising but under-investigated approach involves manipulating partial pressure of arterial carbon dioxide (PaCO) levels. Experimental studies suggest that CO may exert neuroprotective effects through mechanisms such as anti-inflammatory and antioxidant roles.

Developing an NT3-loaded exosomal biodegradable conductive hydrogel combined with EA for targeted treatment of spinal cord injury.

Spinal cord injury (SCI) causes permanent sensory and motor function loss below the injury site, with limited treatment options. Conductive hydrogels have shown promise for SCI repair due to their electrical and mechanical properties, while neurotrophic factors and extracellular vesicles exhibit anti-inflammatory and neurorestorative effects. This study developed a dual-loaded conductive hydrogel (Exo-N/NT3@ICH) containing both neurotrophic factors and extracellular vesicles and evaluated its efficacy combined with electroacupuncture (EA) for SCI treatment.

Feasibility and safety of endoscopic submucosal dissection for the anal canal lesions.

Background And Aims: We aimed to evaluate the technical safety, efficacy, and feasibility of endoscopic submucosal dissection (ESD) for anal canal lesions (ACLs) and compare outcomes between lesions involving the dentate line (IDL) and those above the dentate line (ADL) to guide clinical decision-making.

Methods: We retrospectively investigated 102 patients with ACLs who underwent ESD from August 2010 to August 2023. We collected and analyzed clinicopathologic characteristics, procedure-related parameters, outcomes, and follow-up data.

Metal-carbon dual network reinforced bismuth-based chitosan hydrogels for improved photoresponsiveness, antibacterial activity, and wound healing.

Photodynamic therapy (PDT) is widely recognized as an effective antimicrobial strategy that minimizes the risk of bacterial resistance. Exploiting the intrinsic properties of hydrogels to create a favorable microenvironment for wound healing, researchers integrated bismuth-based metal particles into a chitosan-polyvinyl alcohol gel matrix. Representative gel complexes after metal-gel networks (Bi-gel) and composites introduced by biomass-derived carbon (BC) immobilized by cross-linking are referred to as CP/BC@Bi.

Management of Tunnel Infection Following Upper Gastrointestinal Endoscopic Submucosal Tunneling Procedures.

Objectives: Tunnel infection is a rare but major adverse event after endoscopic submucosal tunneling procedures (ESTPs), which is scarcely reported. This study aims to offer a comprehensive analysis of the evaluation and management of tunnel infection following ESTP.

Method: From August 2010 to December 2023, we retrospectively analyzed 4398 patients with achalasia receiving peroral endoscopic myotomy (POEM) and 2214 patients with upper gastrointestinal tumors receiving submucosal tunneling endoscopic resection (STER).

Bibliometric insights into the top 100 most-cited annual studies on digital health in nursing education (2020-2024).

Aim: This study aims to use bibliometric methods to analyze highly cited nursing education articles on digital health, particularly those 100 top cited publications between 2020 and 2024, from the Web of Science (WOS) Core Collection.

Design: A retrospective bibliometric analysis was conducted.

Methods: A bibliometric analysis of the most-cited digital health articles on nursing education in English with the highest citations.

LACTB promotes cell differentiation and inhibits cell proliferation in colorectal cancer.

This study aims at exploring the role of LACTB on colorectal cancer (CRC) cell differentiation. In this study, 143 colorectal cancer tissue samples were collected for analyzing the correlation between LACTB level and clinical information. Another 24 recent cases and adjacent tissues underwent qPCR, Western blot, and immunohistochemistry (IHC) to detect LACTB expression.

Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway.

White matter lesions (WMLs) caused by chronic cerebral hypoperfusion (CCH) are closely related to the activation of microglia. Inhibition of microglia overactivation is considered as a protective strategy for WMLs. Based on its anti-inflammatory properties and clinical benefits, colchicine has become a hot spot in the drug treatment and research of vascular diseases.

Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis.

Purpose: To investigate the therapeutic and gut microbiota-modulating effects of Qingreliangxuefang (QRLXF) on psoriasis.

Materials And Methods: We used network pharmacology, a computational approach, to identify key bioactive compounds and biological targets, and explored the molecular mechanisms of QRLXF. The effects of QRLXF on keratinocyte proliferation and inflammation were evaluated using a mouse model of psoriasis.

Effects of gestational diabetes mellitus on offspring: A literature review.

Gestational diabetes mellitus (GDM) is a health problem that is becoming increasingly serious worldwide. It has a high incidence and strongly affects both mothers and children. In recent years, more extensive and in-depth studies have been conducted.

Nanoporous Copper-Palladium-Based Catalyst for Electrocatalytic Nitrate-to-Ammonia Conversion.

Electrochemical nitrate reduction reaction (NORR) is a green and environmentally friendly process with great potential for sustainable nitrogen cycle management and ecofriendly ammonia production. Development of catalysts with high Faradaic efficiency (FE) and ammonia yield is still a challenge for the large-scale industrial application of the NORR. In this work, a self-supported nanoporous bimetallic Cu-Pd-based catalyst (np Cu-Pd@ZrCuAl) is prepared by dealloying and galvanic replacement.

miR-29a-3p/ axis modulates high phosphate-induced vascular smooth muscle cell calcification.

Vascular calcification (VC) is a major contributor to the progression of cardiovascular disease (CVD). The VC is characterized by arterial stiffness and impaired blood flow. This pathology is especially prevalent in chronic kidney disease (CKD), where dysregulated mineral metabolism and elevated phosphate levels accelerate calcification of vascular smooth muscle cells (VSMCs).