Impact of Acute High-Altitude Exposure on the Timing of Tranexamic Acid Administration in Rabbits with Traumatic Hemorrhagic Shock.

Liu, Zhen, Chao Nie, Lijia Yuan, Hui Jiang, Chuanchuan Liu, Yi Zhang, and Minghua Liu.Impact of Acute High-Altitude Exposure on the Timing of Tranexamic Acid Administration in Rabbits with Traumatic Hemorrhagic Shock. 00:00-00, 2025.

Convergent Electrochemical-Chemical Tandem Catalysis Synthesis of Ethylene Oxide from CO and Water at Ambient Conditions.

Ethylene oxide (EO) is an important commodity chemical, and its production currently relies on fossil fuel-based energy-intensive thermocatalysis associated with substantial CO emissions or the usage of toxic/corrosive precursors (e.g., Cl).

NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway.

Sorafenib, a tyrosine kinase inhibitor, has demonstrated efficacy in the treatment of hepatocellular carcinoma and clear cell renal carcinoma. However, its clinical application is limited by cardiotoxicity. Here, we show that NFE2L2, a transcription factor that regulates oxidative stress and iron homeostasis, mitigates Sorafenib-induced cardiotoxicity.

Bacterial-Fungal Interactions: Mutualism, Antagonism, and Competition.

The interaction between bacteria and fungi is one of the key interactions of microbial ecology, including mutualism, antagonism, and competition, which profoundly affects the balance and functions of animal microbial ecosystems. This article reviews the interactive dynamics of bacteria and fungi in more concerned microenvironments in animals, such as gut, rumen, and skin. Moreover, we summarize the molecular mechanisms and ecological functions of the interaction between bacteria and fungi.

AI-Empowered Electrochemical Sensors for Biomedical Applications: Technological Advances and Future Challenges.

Biomarkers play a pivotal role in disease diagnosis, therapeutic efficacy evaluation, prognostic assessment, and drug screening. However, the trace concentrations of these markers in complex physiological environments pose significant challenges to efficient detection. It is necessary to avoid interference from non-specific signals, which may lead to misjudgment of other substances as biomarkers and affect the accuracy of detection results.

Study on the thermal radiation tolerance characteristics of lithium-ion batteries.

With the extensive use of lithium-ion batteries (LIBs) in electrochemical energy storage systems and electric vehicles, their safety concerns have gradually emerged. Once LIBs undergo thermal runaway (TR), they can potentially trigger fire and explosion accidents, presenting substantial safety hazards. Regarding the issue that LIBs may experience TR due to external fires or other high-temperature conditions, the study of their thermal runaway tolerance characteristics under different degrees of external thermal radiation triggering conditions is of great significance in guiding the safe design and operation of LIB systems.

Integrated self-assembling multi-enzyme display platform on Candida tropicalis surface for efficient degradation of PET waste.

The bioprocess of recycling polyethylene terephthalate (PET) has been extensively studied; however, challenges remain due to its process complexity, low enzymatic performance, and high costs. Here, we devised a strategy termed the Integrated Self-Assembling Multi-Enzyme Display Platform (ISA-MEDP) to directly and efficiently degrade postconsumer PET (pc-PET). We developed a novel surface display system for the unconventional and robust yeast Candida tropicalis, enabling FAST-PETase and MHETase to be functionally anchored onto the cell wall.

Genistein ameliorates thoracic aortic dissection by inhibiting CB1 receptor hyperactivation and modulating its-mediated cAMP-PKA signaling.

Background: Thoracic aortic dissection (TAD) is a fatal cardiovascular disease characterized by vascular smooth muscle cell (VSMC) phenotypic remodeling and inflammation. Cannabinoid 1 (CB1/Cnr1) receptor has been implicated in cardiovascular diseases, but its role in TAD and its downstream signaling remains unclear. Genistein (Gen), an isoflavone abundant in legumes, has demonstrated promising therapeutic potential in cardiovascular diseases such as vascular calcification, hypertension, and atherosclerosis due to its anti-inflammatory, antioxidant, and metabolic regulatory properties.

TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation.

Cells adapt to nutrient limitation by activating catabolic and inhibiting anabolic pathways, yet prolonged stress may lead to cell death. How cells orchestrate metabolic adaptation and cell death to nutrient stress is poorly understood. We conduct a genome-wide CRISPR-Cas9 screen to identify regulators in glucose-starvation-induced cell death and find a group of genes in lysosomal pathway is enriched following glucose starvation.

Visualization of Met dimerization and cell migration interference by aptamer terminated tripodal DNA coacervates.

As a family member of receptor tyrosine kinases, mesenchymal-epithelial transition receptor (Met) promotes cell proliferation and tumor metastasis by binding to growth factors to form specific dimers. The sensitive and efficient detection of Met dimerization and monomerization is essential in medical diagnosis and intervention. Herein, we proposed a visual method for Met dimerization by using a single stranded DNA named Met-Apt-G4 (MA), which contains a Met aptamer and G-quadruplex precursor sequences.

A novel sequence-based transformer model architecture for integrating multi-omics data in preterm birth risk prediction.

Preterm birth (PTB) significantly contributes to maternal and perinatal mortality and lifelong morbidity. While large language models (LLM) offer considerable potential for disease risk prediction and early detection, their application to PTB prediction using multi-omics data remains limited. We developed a novel transformer-based architecture for integrating cell free (cfDNA) and cfRNA sequencing data for PTB risk prediction.

Identifying Parameters Associated with Delayed Diagnosis in Thrombotic Antiphospholipid Syndrome: Data from China Prospective APS Cohort.

Introduction: The aim of this study was to  evaluate the rate of delayed diagnosis in patients with thrombotic antiphospholipid syndrome (tAPS) and explore potential risk factors and prognosis of delayed diagnosis.

Methods: This single-center, prospective study included consecutive patients with tAPS fulfilling the 2006 Sydney Revised Classification Criteria referred to Peking Union Medical College Hospital from June 2012 to September 2022. Patients diagnosed after more than two aPL-related clinical events had occurred were defined as having delayed diagnosis.

The distinct subtypes and prognosis of acute myocardial infarction in antiphospholipid syndrome patients.

Introduction: Acute myocardial infarction (AMI) can be divided into myocardial infarction with coronary artery disease (MICAD) or with nonobstructive coronary arteries (MINOCA) according to the severity of artery stenosis. Antiphospholipid syndrome (APS) can present with AMI, but the subtype and prognosis are not fully understood.

Methods: The study was conducted based on the APS cohort in Peking Union Medical College Hospital.

Stripe Rust Effector Pst4121 Targets and Suppresses TaSnRK1.3 Protein Kinase Activity to Promote Infection in Wheat.

Pathogens secrete a variety of effectors to compromise host immunity and promote nutrient absorption. The molecular mechanisms by which effectors interfere with plant resistance need to be continuously explored to develop effective strategies for disease prevention and control. In this study, we characterized an effector protein Pst4121 from Puccinia striiformis f.

Engineering Bienzymatic Cascade for Efficient Biosynthesis of Citronellal and Citronellol.

Citronellal and citronellol are monoterpenoids that serve as key ingredients in the flavor and fragrance industry and hold significant potential for pharmaceutical applications. Currently, these compounds are primarily obtained through chemical synthesis or extraction from plant essential oils. However, these methods raise concerns regarding environmental sustainability, carbon emissions, and the growing attentions for natural production.

Long noncoding RNA NONRATT007487.2 drives cancer-induced bone pain progression through direct interaction with CXCL1.

Background: Cancer-induced bone pain (CIBP) is a significant and challenging comorbidity closely related to cancer metastasis. Long noncoding RNAs (lncRNAs) have been implicated in both cancer progression and pain modulation, however, their specific role in CIBP remains unclear. The present study aims to elucidate the potential mechanisms by which lncRNA NONRATT007487.

Unveiling research landscapes in erectile dysfunction: a bibliometric analysis comparing basic scientific research and clinical studies.

Introduction: Erectile dysfunction (ED) is a highly prevalent male sexual disorders, affecting million of men worldwide. Given the volume of literature in ED, bibliometric analyses will provide an important resource to highlight landmark articles.

Objectives: To evaluate the publication trends and impacts between basic scientific research and clinical studies through bibliometric analysis of ED literature between 1998 and 2023.

Warming coupled with uranium exposure can alter the marine microbial community and induce toxin accumulation in shellfish.

This study explores the coupled effects of warming and uranium exposure on marine microbial communities and assesses their potential impact on shellfish toxicity. Different temperature conditions (20 °C and 30 °C) and uranium exposure levels (a controlled setting, 25 μM, and 50 μM) were simulated in an artificial climate chamber. The results indicate that the coupling of warming and uranium exposure significantly altered the water system's properties, including its pH, dissolved oxygen, redox potential, and conductivity.

SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia.

Mitochondria-driven histone lysine succinylation is emerging as a critical signaling system that links cellular metabolism to the pathogenesis of diseases, including cancer. Here, we report that a global increase in protein/histone succinylation is associated with mitochondrial tricarboxylic acid cycle defects in acute myeloid leukemia (AML). Depletion of the succinyl-coenzyme A (CoA) synthetase alpha subunit SUCLG1 causes protein/histone hypersuccinylation in leukemia cells, which impairs cell proliferation and leukemia progression in xenograft models.

Research Progress in the Detection of Mycotoxins in Cereals and Their Products by Vibrational Spectroscopy.

Grains and their derivatives play a crucial role as staple foods for the global population. Identifying grains in the food chain that are free from mycotoxin contamination is essential. Researchers have explored various traditional detection methods to address this concern.

Design of a polarization beam splitter based on a thin-film lithium niobate and grating-assisted contra-directional coupler.

A polarization beam splitter (PBS) is a key device for controlling the polarization state of light in photonic integrated circuits (PICs). In this paper, a compact TM-pass/TE-divide PBS based on a thin-film lithium niobate (TFLN) and grating-assisted contra-directional coupler (GACDC) is proposed. The device makes the contra-directional coupling satisfy the phase-matching condition by etching the corrugated strip waveguide on the waveguide sidewall.

Phase-Space Generalized Brillouin Zone For Spatially Inhomogeneous Non-Hermitian Systems.

The generalized Brillouin zone (GBZ) is highly successful in characterizing the topology and band structure of non-Hermitian systems. However, its applicability ischallenged in spatially inhomogeneous settings, where the non-locality of non-Hermitian pumping competes with Wannier-Stark localization and quantum interference, potentially leading to highly non-exponential state accumulation. To transcend this major conceptual bottleneck, a general phase-space GBZ formalism is developed that encodes non-Bloch deformations in both position and momentum space, such as to accurately represent spatially inhomogeneous non-Hermitian pumping.

A comparative evaluation of EEG Power spectrum characteristics between two methods for alleviating preoperative anxiety in breast cancer patients.

Introduction: Women with breast cancer are prone to moderate to severe preoperative anxiety. Effective measures for preventing and managing preoperative anxiety include drug therapy and non-drug intervention. The main evaluation method is scale assessment, which has certain limitations and may involve human concealment or evaluation errors.