[Simultaneous identification and detection of four novel isoxazoline drugs in bovine-origin foods using ultra-high performance liquid chromatography coupled to quadrupole/linear ion trap mass spectrometry].

Isoxazoline drugs （ISOs） are a class of five-membered heterocyclic compounds containing N and O atoms. They can inhibit -aminobutyric acid gated chloride channels and are widely used in the treatment of parasitic diseases in poultry. The intake of animal-derived foods by humans is an important way to come into contact with ISOs.

Global research trends on ALK-TKIs in non-small cell lung cancer: a bibliometric analysis.

Background: Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide. Non-small cell lung cancer (NSCLC) constitutes the most prevalent histological subtype of lung cancer. A notable proportion of NSCLC patients harbor mutations in the anaplastic lymphoma kinase (ALK) gene, and treatment with ALK-TKIs has demonstrated favorable therapeutic efficacy in ALK-positive patients.

Characterization of the key aroma-active compounds causing the Douchi aroma in high-temperature Daqu via integrated molecular sensory science, metabolomics, and molecular docking.

"Qu is the backbone of Baijiu", and the production of premium Baijiu depends on high-quality Daqu. The Douchi aroma is a key sensory indicator of Daqu quality. However, the specific aroma-active compounds responsible for this characteristic remain unclear.

AI-Empowered Electrochemical Sensors for Biomedical Applications: Technological Advances and Future Challenges.

Biomarkers play a pivotal role in disease diagnosis, therapeutic efficacy evaluation, prognostic assessment, and drug screening. However, the trace concentrations of these markers in complex physiological environments pose significant challenges to efficient detection. It is necessary to avoid interference from non-specific signals, which may lead to misjudgment of other substances as biomarkers and affect the accuracy of detection results.

Reoperation for the implantation of Corheart 6 biventricular assist devices due to severe right ventricular failure and aortic regurgitation following left ventricular assist device implantation.

Background: We present the case of a 68-year-old patient who underwent secondary thoracotomy, implantation of a continuous-flow ventricular assist device (VAD) in a biventricular configuration, and aortic valve replacement (AVR) 2 years after receiving a continuous-flow left ventricular assist device (LVAD) and coronary artery bypass grafting (CABG), due to right ventricular failure, moderate aortic insufficiency, and damage to the original LVAD device cable.

Case Report: The patient initially received a Corheart 6 LVAD, CABG, and tricuspid annuloplasty due to end-stage heart failure resulting from ischemic cardiomyopathy and severe tricuspid regurgitation. Following the surgery, the patient was discharged with favorable outcomes.

Carbon dots: translating versatile physicochemistry into multidisciplinary application frameworks.

Carbon dots (CDs), as a novel class of carbon-based fluorescent nanomaterials, exhibit significant potential in bioimaging, optoelectronic devices, and environmental monitoring due to their tunable optical properties, biocompatibility, and environmental stability. This review systematically summarizes the physicochemical properties and developmental history of CDs. Beginning with structural features such as core-shell composition and surface functionalization, we analyze the intrinsic relationships governing their optical, electrochemical, and interfacial properties.

Dual-Dielectric-Layer-Based Iontronic Pressure Sensor Coupling Ultrahigh Sensitivity and Wide-Range Detection for Temperature/Pressure Dual-Mode Sensing.

Iontronic pressure sensors are widely used in human motion monitoring and human-machine interactions owing to their high sensitivity, wide measurement range, and excellent resolution. However, conventional dielectric layer designs often involve complex fabrication processes, high costs, and limited performances. This paper proposes a novel sensor structure, the dual-dielectric-layer iontronic pressure sensor (DLIPS), which integrates high- and low-permittivity layers.

Development of a Starvation Response-Based Model and Its Application in Prognostic Assessment of Liver Hepatocellular Carcinoma.

Hepatocellular carcinoma (LIHC) is a highly prevalent and poorly prognostic malignancy worldwide, and nutrient deprivation in the tumor microenvironment activates the starvation response in tumor cells. Starvation response-related genes (SRRGs) play critical roles in maintaining energy metabolism and promoting tumor development, but their value in prognostic prediction of LIHC has not been clarified. We based on public databases to obtain transcriptome and single-cell RNA sequencing (scRNA-seq) data for LIHC and SRRG from previous studies.

Trends in enhanced recovery after surgery (ERAS) in thoracic surgery from a bibliometric insight.

Background: In thoracic surgery, the concept of Enhanced Recovery After Surgery (ERAS) has been extensively implemented. Although numerous studies have investigated ERAS in thoracic surgery, bibliometric analyses remain limited. In this study, the developmental trajectory, current research status, and prospective trends of ERAS in thoracic surgery were systematically analyzed through bibliometric and visual analysis techniques.

[The research on the mechanism of GBP2 promoting the progression of silicosis by inducing macrophage polarization and epithelial cell transformation].

Objective This study aims to investigate the expression, phenotypic changes, and mechanisms of action of guanylate-binding protein 2 (GBP2) in the process of silica-induced pulmonary fibrosis. Methods The expression and localization of GBP2 in silicotic lung tissue were detected by immunohistochemical staining and immunofluorescence. An in vitro cell model was constructed, and methods such as Western blot and real-time quantitative reverse transcription polymerasechain reaction were utilized to investigate the function of GBP2 in different cell lines following silica stimulation.

Application of targeted metagenomic next-generation sequencing in pneumonia patients.

After the coronavirus disease 2019 (COVID-19) pandemic, the incidence rate of mixed infections, especially in critically ill patients with severe pneumonia, increases due to the immunity gap and has also been proven to be associated with mortality, increasing the difficulty in accurate and rapid diagnoses. Here, we evaluated the performance of targeted metagenomic next-generation sequencing (mNGS), including capture hybridization-based mNGS (chNGS) and multiplex PCR-based targeted mNGS (tNGS), in diagnosing pneumonia. Patients admitted to the Pulmonary and Critical Care Medicine, Beijing Aerospace General Hospital, and diagnosed as suspected pulmonary infections from April 2022 to March 2024 were retrospectively evaluated, and 110 patients were finally enrolled.

Enhancing health risk assessment for soil heavy metal (loid)s using a copula-based monte carlo simulation method.

In probabilistic health risk assessment (HRA) of multiple soil heavy metal(loid)s (HMs), Monte Carlo Simulation (MCS) typically ignores inter-element correlations during concentration simulation, potentially compromising risk estimation accuracy. In this study, a total of 109 surface soil samples collected in 2023 from a mining area in Chizhou, China, were analyzed for HM concentrations, which followed the order Zn > Cr > Cu > Pb > As > Ni > Hg > Cd. An enhanced HRA model by integrating Copula functions with MCS was employed to account for HM interdependencies.

Correction: TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates.

Correction for 'TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates' by Jingbin Huang , , 2025, , 4860-4865, https://doi.org/10.1039/d5ob00410a.

Biomimetic Coacervates Protocells for Dual Delivery Pathways and Apoptosis/Pyroptosis Based Drug-Free Therapeutics.

Current drug delivery still faces the challenge of limited capacity of loading cargos and the risk of undesired drug leakage before reaching the target sites, limiting its therapeutic efficacy. As an alternative, liquid-liquid phase separation-based coacervates protocells may facilitate cellular uptake and improve organelle-targeted delivery efficiency. Here, a drug-free protocell system is proposed by using peptide-polyphenol network shells wrapped nucleic acid coacervates (NC@PPNs), which can specifically and sequentially target breast cancer cells and their organelles.

Electrooxidation-induced arylsulfonylation of xanthene derivatives with DABSO as an SO surrogate.

An electrochemical redox C(sp)-H arylsulfonylation of xanthenes has been developed using aryl diazonium tetrafluoroborates and DABSO as the arylsulfone source. This radical reaction proceeds the formation of arylsulfonyl radicals from the reaction between aryl diazonium tetrafluoroborates and DABSO, followed by a radical cross-coupling process. Notably, the reaction occurs in the absence of any catalyst or external oxidant, providing efficient sulfonylation of xanthenes with broad functional group compatibility.

TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates.

A practical protocol has been established to access 2-aminoquinazolin-4(3)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C-N bonds under mild conditions without metal catalysts or external oxidants. The practicability of this strategy is demonstrated by its broad substrate scope, good functional group compatibility, and scale-up synthesis.

Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway.

Background: Triple-negative breast cancer (TNBC) is characterized by high invasiveness, high potential for metastasis, easy recurrence, and poor prognosis. There is an urgent need to develop new clinical treatments.

Methods: This study utilized TNBC tissue microarrays to detect Peroxiredoxin 2 (PRDX2) expression levels and analyzed the correlation between PRDX2 and tumor invasion as well as invasion-related gene expression through the TCGA database.

The Hydrochemical Characteristics and Evolution Process of Coal Reservoir Drainage Water in the Fukang Mining Area.

Coalbed water participates in the whole process of coalbed gas generation, migration, accumulation, and exploitation, and its hydrogeochemical characteristics play a crucial role in the exploration and development of coalbed gas in mining areas. Taking the Fukang mining area in Xinjiang as the research object, this study tested the conventional cations, anions, trace elements, pH value, and TDS of its aquifer and analyzed the hydrochemical characteristics and evolution process of coalbed gas drainage water. The results show that the drainage water of coalbed gas is generally weakly alkaline, with significant changes in TDS and ion concentrations over time.

Ingenol ameliorates silicosis via targeting the PTGS2/PI3K/AKT signaling axis: Implications for therapeutic intervention.

Silicosis, formerly known as silico, is an irreversible disease caused by prolonged inhalation of substantial amounts of free crystalline silica dust, characterized by pulmonary inflammation and extensive nodular fibrosis. The etiology of the disease remains unclear, which currently hinders the development of effective therapeutic drugs and interventions. Ingenol (Ing), a terpenoid active ingredient found in plants of the Euphorbiaceae family, including the entire herb of Euphorbia helioscopia, Euphorbia kansui, or Euphorbia lathyris, demonstrates significant anti-inflammatory and antiviral activities.

L-methionine promotes CD8 T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling.

Background: Liver cancer has consistently high incidence and mortality rates among malignant tumors. PCSK9, a target for hypercholesterolemia therapy, has recently been identified as an inhibitor of anti-tumor immunity, and targeting PCSK9 effectively inhibits tumor progression. However, small molecule inhibitors are lacking due to its flat protein structure.

MiR-221-3p Attenuates IL-33-Induced Mast Cell Cytokine Expression by Targeting KIT.

Background: Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)-33 stimulation. MiR-221 is reported to be an important regulator of MCs, and miR-221-3p can be expressed in CRSwNP. However, the role of miR-221-3p in CRSwNP is unclear.

The multifaceted role of m5C RNA methylation in digestive system tumorigenesis.

5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2. The m5C modification not only impacts RNA structure and stability but also governs post-transcriptional regulation by influencing RNA transport, translation, and protein interactions. Recently, the functional importance of m5C in complex diseases, including cancer, has gained substantial attention.

Piperine as a promising therapeutic agent for silicosis: Targeting the JAK2-STAT3 signaling pathway and alleviating inflammation and fibrosis.

Silicosis, a pervasive and life-threatening occupational respiratory disease, poses a substantial global health burden, particularly affecting those in impacted communities and their families. Characterized by irreversible pulmonary fibrosis, the disease's complex pathogenesis remains poorly elucidated, presenting significant challenges for therapeutic intervention. This study integrates bioinformatics, network pharmacology, and experimental validation to explore the potential mechanisms and therapeutic drugs for silicosis.

TFCP2 is recognized as a dynamic monitoring index of pneumoconiosis by combining radiomics with transcriptomics.

Objective: Herein, we employed a novel integrated radiomics and transcriptomics approach to identify key biomarkers for pneumoconiosis. Specifically, we combined thoracic Computed Tomography (CT) imaging-based phenomics and peripheral blood gene expression analysis to improve early diagnosis and risk stratification of pneumoconiosis.

Methods: The study cohort comprised individuals with diagnosed pneumoconiosis and healthy coal miners.

Discrepancy on the quality characteristics of soluble dietary fiber in wild Rosa roxburghii Tratt fruits from different regions.

To minimize waste and maximize the utilization of wild Rosa roxburghii Tratt fruits, the quality characteristics of soluble dietary fiber (SDF) extracted from wild Rosa roxburghii Tratt fruits sourced from ten regions were assessed in this study through an in-depth analysis. This analysis included the evaluation of chemical composition, physicochemical properties, structural elucidation, antioxidant capacity, and functional properties in yogurt applications. Communally, these SDFs are acidic heteropolysaccharides mainly composed of glucose, galacturonic acid, galactose, arabinose, and rhamnose, and all of them showed the infrared spectrum and high molecular weight (Mw) characteristics of polysaccharides.