Reduced morbidity and mortality of cGVHD in patients who received treatment with mesenchymal stromal cells for steroid-resistant aGVHD: long-term follow-up of a randomized phase 3 trial.

Background: Our open-label, multicenter, randomized, phase 3 trial showed that the incidence and severity of chronic graft-versus-host disease (cGVHD) reduced in steroid-resistant acute graft-versus-host disease (aGVHD) patients who underwent mesenchymal stromal cells (MSCs) treatments, but survival benefit was not received. Here, we present a post-hoc analysis of the 5-year follow-up to explore long-term survival and its underlying mechanism.

Methods: This long-term follow-up trial included steroid-resistant aGVHD patients, who were randomly assigned (1:1) to receive MSCs (MSC group) (1 × 10 cells/kg once weekly for 4 consecutive weeks, 8 doses at most) or without MSCs treatment (control group).

A smart composite film derived from high amylose tigernut starch: Integrating antimicrobial and pH-indicating properties for beef preservation applications.

For consumers and the food industry, monitoring food freshness poses significant challenges. This study successfully developed a smart composite film (PDTS-CEO-Cur) based on high amylose tigernut starch (TNS) to extend beef shelf-life and enable freshness monitoring. After 4 h of debranching TNS with pullulanase, the amylose content reached 48.

Heterogeneous characteristics of γδ T cells in peripheral blood of diffuse large B-cell lymphoma.

Background: Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous disease with variable clinical and molecular features. Studies have highlighted the significant role of γδ T cells in the survival of leukemia patients. However, the heterogeneity of γδ T cells and their impact on clinical correlation in the peripheral blood of patients with DLBCL remain unclear.

Correction: TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates.

Correction for 'TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates' by Jingbin Huang , , 2025, , 4860-4865, https://doi.org/10.1039/d5ob00410a.

The Impact of Different Molecular Weight Hyaluronic Acid on Pasting, Rheological and In Vitro Digestibility of Cyperus esculentus Starch.

Hyaluronic acid (HA), a naturally occurring polysaccharide recognized for its health benefits, has been approved for use in the food industry as a food additive and nutraceutical. This study aimed to explore the influence of HA with varying molecular weights (Mws) on the pasting, rheological properties, and in vitro digestibility of Cyperus esculentus starch (CES). High Mw HA (HHA) exhibited a more pronounced inhibition on starch solubility (15.

TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates.

A practical protocol has been established to access 2-aminoquinazolin-4(3)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C-N bonds under mild conditions without metal catalysts or external oxidants. The practicability of this strategy is demonstrated by its broad substrate scope, good functional group compatibility, and scale-up synthesis.

Comparative Analysis of Treatment Effects of Different Materials on Thin Oil Films.

With the continuous and rapid development of global industries, issues such as offshore oil spills, leakage of organic chemicals, and the direct discharge of industrial oily sewage have caused serious damage to the ecological environment and water resources. Efficient oil-water separation is widely recognized as the solution. However, there is an urgent need to address the difficulties in treating thin oil films on the water surface and the low separation efficiency of existing oil-water separation materials.

Heterogeneity of γδ T-cell subsets and their clinical correlation in patients with AML.

Background: γδ T cells are integral elements of the immune system and have shown therapeutic potential in the treatment of acute myeloid leukemia (AML). Nevertheless, the influence of distinct functional subsets, including the activating marker NKG2D, the immune exhaustion marker TIGIT, and the regulatory marker Foxp3, on therapeutic outcomes in AML patients remains unknown.

Methods: First, we analyzed RNA-seq data from 167 patients in The Cancer Genome Atlas (TCGA) database, concentrating on the correlations between , , and gene expressions and their association with prognosis in AML.

Exploring the feasibility of RS4-type resistant starch as a fat substitute in low-fat mayonnaise: An evaluation of the effects of acylated starches with different chain lengths.

Given the health concerns associated with excessive fat intake, reducing the fat content in lipid-based products such as mayonnaise has become a critical priority. This study aimed to achieve dual objectives: firstly, to prepare RS4-type resistant starch by the modification of starch with acyl groups of varying chain lengths. Secondly, to investigate how different types of acylated starch and varying fat substitution levels (40 % and 80 %) affect the viscoelastic and textural properties of low-fat mayonnaise prepared with these acylated starches.

Metal-Free Alkane Functionalization by Organocatalytic and Photoinduced Methods.

Transforming alkane C-H bonds into carbon-carbon and carbon-heteroatom bonds represents a paramount objective in synthetic chemistry with significant implications for sustainable production. Although transition-metal catalysts such as Pd, Rh etc have dominated this field, recent breakthroughs in metal-free approaches leveraging small-molecule catalysts or photogenerated intermediates have emerged as efficient and sustainable alternatives. These approaches facilitate precise C-H bond activation and selective formation of C-X (e.

Low digestibility characteristics of white kidney bean protein hydrolysate-corn starch complex: Structural and functional transformations induced by heat-moisture treatment.

This study prepared complexes using corn starch and white kidney bean protein (KBP) and its hydrolysates (KBPH60 and KBPH180, hydrolysates derived via enzymatic hydrolysis for 60 and 180 min, respectively) through heat-moisture treatment (HMT). The impact of HMT on the structure, physicochemical properties, and in vitro starch digestibility of these KBP/KBPH-starch complexes was systematically analyzed. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results showed that KBP and its hydrolysates stabilized the starch structure weakened by HMT through hydrogen bonding, promoting a more ordered crystalline arrangement and decreasing starch digestibility.

Effects of different saccharides glycosylation modified soy protein isolate on its structure and film-forming characteristics.

With the serious impact of traditional plastic packaging on the environment, the development of safe, environmentally friendly and degradable packaging materials has become a research hotspot. Glycosylation reaction has been explored by researchers because of its green, efficient and simple. In this study, the film-forming properties of soy protein isolate (SPI) were improved by glycosylation modification.

Electrochemical Synthesis of 2-Amino-1,3-benzoxazines via TBAI-mediated Desulfurative Cyclization of Isothiocyanates and 2-Aminobenzyl Alcohols.

An efficient one-step protocol has been developed to access a variety of 2-amino-1,3-benzoxazine derivatives via tetrabutylammonium iodide-mediated electrochemical desulfurative cyclization of isothiocyanates and 2-aminobenzyl alcohols. The reaction proceeds through a cycle involving iodine generation, desulfurative cyclization, and iodide regeneration, efficiently forming intermolecular C-O and C-N bonds and affording 2-amino-1,3-benzoxazines in moderate to excellent yields. The practical utility of this strategy is evidenced by its broad substrate scope, good functional group compatibility, scalability to gram-scale synthesis, and metal- and oxidant-free conditions.

Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius.

Hispidin (1) is a polyphenolic compound with a wide range of pharmacological activities that is distributed in both plants and fungi. In addition to natural extraction, hispidin can be obtained by chemical or enzymatic synthesis. In this study, the identification and characterization of an undescribed enzyme, PheG, from Phellinus igniarius (P.

Structural, physicochemical and in vitro digestibility of white kidney bean protein-corn starch complexes under various heat treatments.

The presence of exogenous protein can delay starch digestion. However, systematic studies on the effects of protein on starch digestion under various heat treatments still need to be completed. In this study, the effects of exogenous protein and heat treatments on corn starch digestibility were investigated.

Design, synthesis, and biological evaluation of a potent and orally bioavailable FGFRs inhibitor for fibrotic treatment.

Organ fibrosis, such as lung fibrosis and liver fibrosis, is a progressive and fatal disease. Fibroblast growth factor receptors (FGFRs) play an important role in the development and progression of fibrosis. Through scaffold hopping, bioisosteric replacement design, and structure-activity relationship optimization, we developed a series of highly potent FGFRs inhibitors, and the indazole-containing candidate compound A16 showed potent kinase activity comparable to that of AZD4547.

Effect of strengthening agents on properties of dual-modified cassava starch-based degradable films.

Insufficient hydrophobicity and mechanical properties pose significant challenges in the development of starch-based degradable films. This study prepared modified (crosslinked, acetylated, and crosslinked & acetylated) cassava starch films, and different concentrations of strengthening agents (polyvinyl alcohol, sodium alginate, gelatin, and hyaluronic acid) were added to produce modified starch composite films. The physical properties, structure characteristics, and degradability of these films were systematically evaluated.

Biodegradation of imidacloprid and diuron by Simplicillium sp. QHSH-33.

Imidacloprid (IMI) and diuron (DIU) are widely used pesticides in agricultural production. However, their excessive use and high residues have caused harm to the ecological environment and human health. Microbial remediation as an efficient and low-toxic method has become a research hotspot for controlling environmental pollutants.

Assessing Visitor Expectations of AI Nursing Robots in Hospital Settings: Cross-Sectional Study Using the Kano Model.

Background: Globally, the rates at which the aging population and the prevalence of chronic diseases are increasing are substantial. With declining birth rates and a growing percentage of older individuals, the demand for nursing staff is steadily rising. However, the shortage of nursing personnel has been a long-standing issue.

Effect of low degree succinylation on properties of enzyme-induced casein hydrogel.

This study examines the impact of succinic anhydride (SA) modification (0-9 %) on the gel properties of casein. Upon succinylation, the surface hydrophobicity (H) of casein initially increased before decreasing, achieving its peak at a degree of succinylation of 5.22 ± 0.

A Review of Modified Gelatin: Physicochemical Properties, Modification Methods, and Applications in the Food Field.

Gelatin is a significant multifunctional biopolymer that is widely utilized as a component in food, pharmaceuticals, and cosmetics. Numerous functional qualities are displayed by gelatin, such as its exceptional film-forming ability, gelling qualities, foaming and emulsifying qualities, biocompatibility and biodegradable qualities. Due to its unique structural, physicochemical, and biochemical characteristics, which enhance nutritional content and health benefits as well as the stability, consistency, and elasticity of food products, gelatin is utilized extensively in the food business.

Demand Forecasting of Nurse Talents in China Based on the Gray GM (1,1) Model: Model Development Study.

Background: In a global context, the shortage of nursing personnel has emerged as a significant challenge, particularly in countries such as China experiencing population aging. The inadequacy of nursing human resources has become one of the primary threats affecting the quality of health services available to Chinese residents. Therefore, forecasting the demand for nursing personnel has become an important issue.

N-Heterocyclic Carbene Enabled Functionalization of Inert C(Sp)-H Bonds via Hydrogen Atom Transfer (HAT) Processes.

Developing methods to directly transform C(sp) -H bonds is crucial in synthetic chemistry due to their prevalence in various organic compounds. While conventional protocols have largely relied on transition metal catalysis, recent advancements in organocatalysis, particularly with radical NHC catalysis have sparked interest in the direct functionalization of "inert" C(sp) -H bonds for cross C-C coupling with carbonyl moieties. This strategy involves selective cleavage of C(sp) -H bonds to generate key carbon radicals, often achieved via hydrogen atom transfer (HAT) processes.

Intelligent films based on dual-modified starch and microencapsulated Aronia melanocarpa anthocyanins: Functionality, stability and application.

This study aims to enhance the physical properties and color stability of anthocyanin-based intelligent starch films. Three dual-modified starches, namely crosslinked-oxidized starch (COS), acetylated distarch phosphate (ADSP), and hydroxypropyl distarch phosphate (HDSP), were utilized as film matrices. Aronia melanocarpa anthocyanins were incorporated through three different pre-treatments (free, spray-drying microencapsulation, and freeze-drying microencapsulation) to assess the prepared films' functionality, stability, and applicability.

Three nonconventional starch: Comparison of physicochemical properties and in vitro digestibility.

Extraction of starch from waste is also an effective way to recover resources and provide new sources of starch. In this study, starch was isolated from white kidney bean residue, chickpea residue, and tiger nut meal after protein or oil extraction, and the morphology of starch particles was observed to determine their physicochemical properties and in vitro digestibility. All these isolated starches had unique properties, among which white kidney bean starch (KBS) had a high amylose content (43.