Hybrid epigenome unveils parental genetic divergence shaping salt-tolerant heterosis in Brassica napus.

Heterosis holds great potential for improving yield, quality, and environmental adaptability in crop breeding, which suggests that hybrids can exhibit better performance in adapting to extreme environments. However, the epigenetic mechanisms of salt-tolerant heterosis in allopolyploid crop Brassica napus (AACC, 2n = 38), particularly chromatin accessibility, remain largely unexplored. We investigated the dynamics of chromatin accessibility and transcriptional reprogramming during a time course of salt exposure in Brassica napus hybridization.

Comparison of SPECT/CT, AEEG, and 3D-pCASL in people with epilepsy.

Objective: To analyze the clinical value of single-photon emission computed tomography (SPECT)/computed tomography (CT), ambulatory electroencephalogram (AEEG) and three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) in people with epilepsy (PWE).

Methods: The study included 98 PWE who were treated in The General Hospital of Ningxia Medical University from December 2021 to September 2023. The positive detection rates and characteristics of SPECT/CT, AEEG and 3D-pCASL were compared.

Explainable mortality prediction models incorporating social health determinants and physical frailty for heart failure patients.

There is limited evidence on how social determinants of health (SDOH) and physical frailty (PF) influence mortality prediction in heart failure (HF), particularly for in-hospital, 90-day, and 1-year outcomes. This study aims to develop explainable machine learning (ML) models to assess the prognostic value of SDOH and PF at multiple time points. We analyzed data from adult patients admitted to the intensive care unit (ICU) for the first time with a diagnosis of HF.

Pipkin type III fractures: a narrative review of literature and comparative opinion on ORIF vs. arthroplasty.

Pipkin Type III is extremely rare and is associated with worse prognosis and several complications. There is still no consensus on the management of injuries and whether these fractures should be treated surgically with ORIF or arthroplasty. Pipkin type III involves a combination of ipsilateral femoral head and neck fractures.

Construction of high-density bin genetic map and QTL mapping of fruit aroma in longan ( Lour.).

Aroma is a crucial factor influencing the flavor quality and economic value of longan fruits. This study employed a mapping population consisting of 98 F progeny of 'Shixia × Xiangcui' (exhibiting broad segregation in fruit aroma trait) and their parents. We performed the SNP genotyping through whole-genome resequencing to construct a high-density linkage map, followed by QTL mapping and candidate gene screening for aroma trait.

Neodymium-doped mesoporous silica nanoparticles promote bone regeneration via autophagy-mediated macrophage immunomodulation.

Rare earth nanomaterials, especially those incorporating neodymium, hold great potential for bone regeneration, but their clinical application is limited by insufficient understanding of immunomodulatory effects and potential toxicity concerns. To address this, we developed neodymium-doped mesoporous silica nanoparticles (NDMSN) to modulate macrophage autophagy and polarization. NDMSN exhibited uniform dispersion with an average size of 103 nm.

Hydrogel Formation of Enzymatically Solubilized Corn Bran Feruloylated Arabinoxylan by Laccase-Catalyzed Cross-Linking.

In order to upgrade the potential of cereal bran arabinoxylan for advanced hydrogel applications, a deep understanding of its gelation process is required. This work provides a comprehensive and systematic analysis of the laccase-catalyzed cross-linking of feruloylated arabinoxylan (FAX) to establish a clear link between processing conditions and final hydrogel properties. Endo-1,4-xylanase was used to obtain corn bran FAX rich in ferulic acid moieties, and then we demonstrated that gel formation is driven by the oxidative coupling of these feruloyl monomers into diferulic acid bridges, e.

Correction: Liu et al. GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways. 2015, , 21897-21910.

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CD4 T Cell Subsets and as Novel Biomarkers of Immune Dysregulation in Dilated Cardiomyopathy.

Recent multiomics advancements have improved our understanding of immune dysregulation in dilated cardiomyopathy (DCM). However, specific immune cell subsets and their regulatory genes are still ambiguous. This study aimed to explore immune cell imbalances and regulatory genes in DCM, discover diagnostic biomarkers, and identify potential therapeutic targets.

Engineering noncentrosymmetry in 2D atomic crystals chemical vapor deposition.

In contrast to extensively studied centrosymmetric 2D materials, noncentrosymmetric 2D atomic crystals (2DACs) exhibit unique properties-such as nonlinear optical responses, ferroelectricity, and piezoelectricity-making them promising for next-generation optoelectronics and quantum devices. Despite their potential, the controlled synthesis and scalable fabrication of these materials remain challenging, limiting further exploration of their physics and applications. This Feature Article highlights our group's recent advances in engineering noncentrosymmetry in 2DACs chemical vapor deposition (CVD).

Wearable Device-Based Respiratory Complexity Analysis for Detecting Pulmonary Congestion in Patients With Heart Failure: Observational Exploratory Study.

Background: Excessive pulmonary congestion (PC) is a major contributor to heart failure (HF) deterioration and often necessitates emergency hospitalization. Early detection of PC-related respiratory abnormalities via wearable devices could enable prompt intervention and reduce admissions. However, the feasibility of using wearables to detect specific respiratory biomarkers of PC remains unclear.

Achieving Long-Term Cyclability in Sodium-Ion Batteries: Site-Selective Doping to Inhibit Irreversible Phase Transitions in P2-NaNiMnO Cathode.

The typical P2-type NaNiMnO exhibits a high theoretical capacity for sodium-ion batteries (SIBs). However, its P2-O2 phase transition during deep charging causes severe structural degradation and capacity decay. In this work, we propose a site-selective doping strategy based on multielement synergy to suppress irreversible phase transitions.

Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study.

Background And Aims: Epidemiological data on bacterial infections in cirrhosis in China remain limited. Therefore, we aimed to conduct a multicenter study to investigate the characteristics and outcomes of patients with cirrhosis and bacterial infections in China.

Methods: We retrospectively enrolled 1,438 hospitalized adult patients with cirrhosis and bacterial or fungal infections from 24 hospitals across China between January 2018 and September 2024.

Thoracic duct obstruction leading to chylous mesenteric cyst in an female obese adolescent: a case report.

Introduction And Importance: Mesenteric cysts are rare intra-abdominal lesions, with a prevalence of approximately 1 in 100 000 to 1 in 250 000 adults. Clinical presentation can range from asymptomatic to severe. Chylous mesenteric cysts caused by thoracic duct obstruction are particularly rare and have not been previously reported in obese adolescents.

Prognostic value of the co-stimulatory molecule OX40 expression in Extranodal Natural Killer/T-cell Lymphoma.

Objective: To explore the clinicopathological features and the prognostic values of the co-stimulatory molecules OX40 and the inducible T-cell co-stimulator (ICOS) in Extranodal Natural Killer/T-cell Lymphoma (ENKTL).

Methods: 82 participants (median age 51 years, 26.8% female) were included in this study.

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha.

Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of action remains unclear. Here, we employ artificial intelligence, molecular docking, and molecular dynamics simulations to elucidate the molecular mechanism of Bufalin.

Virome characteristics of small mammals and their associated environments in pastoral areas on the Qinghai-Tibet Plateau.

The Qinghai-Tibet Plateau (QTP), known for its rich biodiversity and unique ecological niche, harbors numerous endemic species and serves as a reservoir for both established human pathogens and numerous poorly characterized pathogens. Despite certain advances, virological research on small mammals in this region is still limited. In this study, we investigated the diversity and evolution of viral communities in plateau voles, plateau pikas, and their associated environmental samples collected near pastoral settlements on the QTP.

Machine learning-assisted Ru-N bond regulation for ammonia synthesis.

Ruthenium-bearing intermetallics (Ru-IMCs) featured with well-defined structures and variable compositions offer new opportunities to develop ammonia synthesis catalysts under mild conditions. However, their complex phase nature and the numerous controlling parameters pose major challenges for catalyst design and exploration. Herein, we demonstrate that a combination of machine learning (ML) and model mining techniques can effectively address these challenges.

Duckweed Evolution: from Land back to Water.

Terrestialization is an important evolutionary process that plants experienced. However, little is known about how land plants acquired aquatic growth behaviors. Here we integrate multiproxy evidence to elucidate the evolution of the aquatic plant duckweed.

Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO.

Background: Necrosis by sodium overload (NECSO) is a poorly understood, novel form of cell death implicated in cancer. TRPM4 is the only protein currently linked to NECSO and is downregulated in bortezomib-resistant multiple myeloma (MM) patients and cell lines.

Purpose: To investigate the potential of cinobufagin to overcome bortezomib resistance in MM and elucidate its underlying mechanism of action, particularly regarding TRPM4 and NECSO induction.

A chain mediation model for physical exercise and sleep quality.

In recent years, there has been a significant increase in academic interest regarding the sleep quality of university students. Physical exercise has been extensively studied for its association with sleep quality in this population. However, the roles of anxiety and subjective well-being in mediating the relationship between physical exercise and sleep quality require further investigation.

Design and Development of Potent SOS1 Inhibitors with Effective Antitumor Activities /.

KRAS inhibitors encounter significant resistance, which may be partially mitigated through combination with SOS1 inhibitors. The structural diversity of SOS1 inhibitors presents potential solutions, offering a means to enhance treatment outcomes for KRAS mutant tumors. Herein, we report the discovery of potent SOS1 inhibitors and their antitumor activity both and .

Dietary-related characteristics and cataract risk: evidence from a mendelian randomization study.

Cataract is the leading cause of blindness globally, imposing a significant socioeconomic burden. While diet is associated with various eye diseases, the causal relationship between dietary-related characteristics (DRCs) and cataract remains unclear. This study investigates the causal associations between DRCs and cataract using Mendelian randomization (MR) to provide insights into potential dietary interventions for cataract prevention.

Gender differences in neurocognitive impairment among first-episode, drug-naïve schizophrenia patients: a cross-sectional study.

Introduction: Cognitive impairment is a core feature of first-episode schizophrenia (FES), yet the influence of biological sex on its manifestation remains under characterized. Existing evidence suggests sex differences in cognitive profiles among chronic schizophrenia patients, but whether these patterns emerge in drug-naïve FES patients-and how they relate to clinical symptoms-requires clarification.

Methods: We recruited 382 drug-naïve FES patients and 522 healthy controls (HCs) matched for age and education.

A spatial-temporal trend-aware neural network model for accurate water quality prediction in river.

Accurate prediction of river water quality is crucial for environmental management and ecological preservation, but it remains challenging due to the nonlinear, dynamic, and non-stationary nature of water quality data. Existing studies often struggle with long-term prediction and fail to jointly capture complex spatiotemporal dependencies across monitoring networks. To address these challenges, this study proposes a novel deep learning model, the Spatial-Temporal Trend Neural Network (STTNN), designed to capture complex spatiotemporal dependencies across multiple water quality monitoring stations.