Case Report: Carcinosarcoma of the common bile duct: a rare case report with literature review.

Carcinosarcoma of the common bile duct is an exceedingly rare and highly aggressive malignancy with uncertain therapeutic outcomes. We present a case of a 70-year-old Asian female presenting with progressive jaundice. Contrast-enhanced computed tomography (CT) identified a tumor in the common bile duct.

Lab-scale investigation of drag reduction for crude oil by oil-soluble polymers.

This study investigates the drag reduction performance of oil-soluble polymers, specifically Polyisobutylene (PIB), in crude oil pipelines. The experiments were conducted using a flow-loop system to simulate turbulent flow conditions. The effects of Reynolds number and polymer concentration on drag reduction were analyzed using Response Surface Methodology (RSM).

Association between magnesium depletion score and overactive bladder among U.S. Adults using data from NHANES 2005-2018.

Overactive bladder (OAB) is a common condition that significantly affects quality of life. Magnesium deficiency may influence muscle and nerve functions, potentially contributing to bladder dysfunction. This study aimed to examine whether magnesium depletion is associated with OAB symptoms among U.

Glycyrrhizin alleviates contrast-induced acute kidney injury via inhibiting HMGB1-mediated renal tubular epithelial cells ferroptosis.

Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of AKI, but there are no effective preventive or therapeutic measures in clinical practice. Glycyrrhizin, a bioactive compound isolated from the L., exhibits anti-inflammatory effects; however, the effects and mechanisms of glycyrrhizin on CI-AKI remain unknown.

Echinacoside mitigates sepsis-associated encephalopathy by inhibiting STING pathway and reducing neuroinflammation.

Purpose: Sepsis-associated encephalopathy (SAE) is a prevalent and severe complication in septic patients, characterized by diffuse brain dysfunction and high mortality rates. Current treatment options are limited, necessitating the exploration of novel therapeutic approaches. Echinacoside (ECH) has demonstrated neuroprotective effects in various neurodegenerative models.

Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle.

Metabolic dysfunction-associated steatotic liver disease (MASLD), potentially ameliorated by bariatric-metabolic surgery, remains a global health concern in the absence of approved drugs. Protein post-translational modifications (PTMs) are crucial for MASLD. However, the functional significance of lysine crotonylation (Kcr) remains unclear.

Ligand-Engineered All-In-One Cu(I) Iodide Complex Enables Near-Unity Photoluminescence and Advanced 3D X-ray Image Reconstruction.

High-performance X-ray detectors are essential for 3D X-ray imaging in computed tomography (CT), but conventional systems require high radiation doses to achieve fine resolution. All-In-One (AIO) Cu(I) halide complexes, capable of forming both ionic and coordinate bonds within a single structure, offer efficient scintillation at lower doses, yet their performance remains limited by nonradiative energy losses during indirect X-ray-to-light conversion. Here, we develop rigid-cation-assisted AIO Cu(I) halide complexes by introducing π-π interactions to suppress the nonradiative pathways, achieving near-unity photoluminescence quantum yield (PLQY).

Correction: Liu et al. GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways. 2015, , 21897-21910.

In the original publication [...

H3K14: A histone site closely related to diseases.

Histone H3K14 is a crucial site for histone H3 modifications, which are intimately connected to processes such as DNA replication, gene expression, and transcription. Modifications at H3K14 can lead to damage within the human body. Specifically, the acetylation of H3K14 influences immune system function, often linking to conditions like tumor inflammation and immune-related diseases.

Mass spectrometry-based metabolomic and lipidomic profiling stratifies stages of diabetic retinopathy.

Aims: Diabetic retinopathy is a metabolic complication of diabetes. This study aimed to elucidate metabolic and lipidomic alterations associated with diabetic retinopathy progression and identify biomarkers for its diagnosis and staging.

Methods: We analyzed serum profiles of 962 molecules, including 653 lipids and 309 polar small metabolites, from 167 individuals: 45 without retinopathy, 69 with non-proliferative diabetic retinopathy of varying severity, and 53 with proliferative diabetic retinopathy.

An MRI study of pancreatic atrophy in children with type 1 diabetes: Heterogeneity, disease duration effects, and progression prediction models.

Aim: To investigate the heterogeneity of pancreatic alterations in children with T1D and the effect of disease duration on the pancreas. To develop predictive models based on clinical and imaging parameters at baseline to determine whether pancreatic atrophy will progress at follow-up.

Methods: This retrospective study included 90 children with T1D and 82 control children.

pH-dependent reaction kinetics between glyoxal and ammonium sulfate in simulated cloud droplets.

Aqueous-phase reactions between carbonyls and reduced nitrogen compounds play a considerable role in the formation of secondary organic aerosols and brown carbon in the atmosphere. However, the reported reaction rate constants for these reactions have largely been limited to bulk aqueous-phase simulations, which may not accurately represent the real state of atmospheric cloud droplets. We employed an integration of optical tweezers and Raman spectroscopy to manipulate and analyze simulated cloud droplets (size range 8000-10,000 nm), comprising a mixture of glyoxal and ammonium sulfate.

Ultrasound-assisted gram-scale synthesis of nano-tubular ag-MOF and its hybridization with yellow/green carbon quantum dots: membrane-based turn-on fluorescence recognition for procaterol.

Procaterol, a third-generation long-acting β₂-adrenergic receptor agonist, is widely used in asthma and chronic obstructive pulmonary disease (COPD) treatment. Rapid and sensitive detection of Procaterol is essential for both clinical monitoring and environmental surveillance. This study presents a facile and gram-scale synthesis of tubular silver-based Metal-organic framework (MOF) MONT by employing an ultrasonic-assisted green synthesis strategy (20 kHz ultrasound, 100 W power, 30 min).

Integrated Analysis of Bulk and Single-Cell Transcriptomics Identifies Prognostic Biomarkers in Breast Cancer Metastasis.

Breast cancer (BC) remains one of the leading causes of cancer-related mortality among women worldwide, with distant metastasis being the primary contributor to poor prognosis. However, the molecular mechanisms driving BC metastasis are not yet fully understood. We integrated three public microarray datasets (GSE14776, GSE103357, and GSE32489) to identify the differentially expressed genes (DEGs) associated with breast cancer metastasis.

Fabrication of a foldable transparent conductive electrode with suppressed silver migration by anchoring fluorinated alkyl passivated silver nanowires on a PET surface.

Tethering silver nanowires (AgNWs) on polymeric membranes is a highly applicable strategy for constructing flexible transparent conductive electrodes (FTCEs) for flexible electronics. However, it remains a challenge to establish reliable connections between AgNWs and polymeric surfaces to enhance the flexibility of FTCEs without altering their transparency. Herein, a bifunctional interfacial engineering strategy was proposed, synergizing covalent anchoring and passivation shielding to concurrently achieve flexibility, silver migration suppression, environmental stability, and retained optical transparency.

A sprayable exosome-loaded hydrogel with controlled release and multifunctional synergistic effects for diabetic wound healing.

Diabetic wound healing is hindered by bacterial infections, oxidative stress, impaired vascularization, and chronic inflammation. Conventional dressings, limited by static drug release and single-functionality, fail to dynamically match the varying demands of different healing stages and dressing replacement frequencies. This study developed a multifunctional sprayable hydrogel dressing (Exo@AMCN) by photocrosslinking methacrylated decellularized dermal matrix co-loaded with human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exo) and β-cyclodextrin-borneol inclusion complexes (CN).

Strain-Rate-Dependent Tensile Behaviour and Viscoelastic Modelling of Kevlar 29 Plain-Woven Fabric for Ballistic Applications.

Aramid fibre has become a critical material for individual soft body armour due to its lightweight nature and exceptional impact resistance. To investigate its energy absorption mechanism, quasi-static and dynamic tensile experiments were conducted on Kevlar 29 plain-woven fabric using a universal material testing machine and a Split Hopkinson Tensile Bar (SHTB) apparatus. Tensile mechanical responses were obtained under various strain rates.

Research on Q-Learning-Based Cooperative Optimization Methodology for Dynamic Task Scheduling and Energy Consumption in Underwater Pan-Tilt Systems.

Given the harsh working conditions of underwater pan-tilt systems, their energy consumption management is particularly crucial. This study proposes an underwater pan-tilt operation method with an automatic wake-up mechanism, which activates only upon target detection, replacing conventional timer-based triggering. Furthermore, departing from fixed-duration observation strategies, we introduce a Q-learning algorithm to optimize operational modes.

Phase Equilibria of Si-C-Cu System at 700 °C and 810 °C and Implications for Composite Processing.

The phase equilibria of the Si-C-Cu ternary system at 700 °C and 810 °C were experimentally investigated for the first time. Fifteen key alloys were prepared via powder metallurgy and analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), and electron probe microanalysis (EPMA). Isothermal sections were constructed based on the identified equilibrium phases.

Ultra compression-ratio distributed acoustic sensing system via combination of envelope extraction and compressed sensing.

Distributed acoustic sensing (DAS) is experiencing significant growth in applications such as seismological observation, urban cable monitoring, and thunder observation, due to its long sensing distance and high accuracy measurement in distributed sensing. The heterodyne coherent DAS system offers a high-fidelity, linear strain response, but its strain range is limited by the LFM pulse bandwidth. This requires a high-performance gigahertz DAQ, which increases data volume, system cost, and real-time processing challenges.

Improving the reconstruction accuracy of tomographic absorption spectroscopy sensor by optimizing laser beam arrangements.

Tomographic absorption spectroscopy (TAS) typically employs multiple projections to reconstruct the spatial distribution of temperature and species concentration, making it a promising method for combustion diagnostics. However, the geometric arrangement of the laser beams significantly affects its accuracy, especially under limited beam conditions. In this work, we propose a beam arrangement optimization method to maximize the utilization efficiency of limited beams, thereby improving reconstruction accuracy in a simpler and more intuitive manner.

Athermalization and large depth of field in endoscopes based on wavefront coding.

Through theoretical analysis, this study validates the feasibility of wavefront coding (WFC) technology for simultaneously extending the depth of field (DOF) and the operational temperature range. We designed and optimized an industrial endoscope with an image space F-number of 8, an effective focal length of 7 mm, a total length of 871 mm, and a field of view of 52°. To achieve a larger DOF and athermalization over a wider temperature range, an expanded quintic phase mask is introduced.

Reconfigurable three-channel terahertz reflective metasurface.

A reconfigurable three-channel terahertz reflective metasurface based on vanadium dioxide, photosensitive silicon, gold, and silica is proposed. The unit of the metasurface adopts a six-layer sandwich structure, which is mainly designed by the composite resonator on the top layer and the back-to-back double E-shaped structure in the middle layer. Based on the geometric phase principle, through rotating the design pattern in plane, the unit in the range of 360° realizes the 3 bit quantization of the compensation phase of the metasurface's cross reflection.

Effectiveness of Radiotherapy in Preventing Heterotopic Ossification: A Meta-analysis of Randomized Controlled Trials Beyond Total Hip Arthroplasty.

Heterotopic ossification (HO) frequently occurs after procedures such as hip replacements, acetabular fractures, and elbow fractures. While radiotherapy (RT) has been a longstanding preventive measure against HO, its efficacy remains controversial, with some studies questioning its effectiveness and noting potential side effects. Previous research has predominantly focused on total hip arthroplasty (THA), leading to a gap in comprehensive evaluation of RT's efficacy and safety across other conditions.