Gastrodin ameliorates ulcerative colitis via modulating gut microbial tryptophan metabolism and AhR/NLRP3 pathway.

Background: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disorder, presents persistent therapeutic challenges in clinical management. Gastrodin (GAS) is an active compound isolated from traditional Chinese medicine Gastrodia elata (Tianma), exhibits robust anti-inflammatory bioactivity. However, the role of GAS in UC has not been thoroughly studied.

Attitudes and opinions of pharmacy undergraduates towards the integration of innovation and entrepreneurship programs into professional education.

Background: Innovation and entrepreneurship (I&E) ability has been defined as one of the key elements and expected outcomes of personal and professional development among pharmacy students. As an emerging trend in pharmacy undergraduate training, the organic integration of I&E elements in professional education offers a critical means to cultivate high-quality pharmacy professionals. However, the current methods of doing so have not incorporated adequate consultation with pharmacy undergraduates, who are key stakeholders in I&E and professional education.

Case Report: A rare hyperplastic polyp with synchronous high-grade intraepithelial neoplasia in both glandular and squamous epithelium in autoimmune gastritis.

A 68-year-old man came to evaluate a gastric polyp discovered during a routine gastroscopy. After endoscopic mucosal resection, pathological findings confirmed that it's a hyperplastic polyp. Notably, squamous metaplasia was observed within the hyperplastic polyp, and both squamous and glandular epithelium exhibited high-grade intraepithelial neoplasia.

Knowledge map of self-reported outcomes in patients with prostate cancer: a bibliometric analysis (2014-2023).

Objective: To analyze the related literature of self-reported outcomes of prostate cancer patients using bibliometric methods, and explore the research status and development trend in this field.

Methods: The literature related to self-reported outcomes of prostate cancer was searched in Web of Science core database. The literature on prostate cancer self-reported outcomes was visualized using VOSviewer, CiteSpace and R software packages.

Advances in orofacial pain research: a bibliometric analysis.

Objective: Orofacial pain has become increasingly prevalent with the advancement of society and economy. Bibliometrics, an interdisciplinary field encompassing mathematics, statistics, and information science, offers insights into the trends, research focal points, and knowledge framework of orofacial pain through quantitative analysis of relevant literature. This study aims to systematically map the evolutionary trajectory of orofacial pain research from 2000 to 2024.

The Role of miR-30d-5p in Neutrophil-Derived Exosomes in Promoting Systemic Lupus Erythematosus.

Background: In this study, we investigated the role of neutrophil-derived exosomal miR-30d-5p in systemic lupus erythematosus (SLE).

Methods: We extracted exosomes from the neutrophils collected from SLE patients and healthy donors and analyzed the relative level of miR-30d-5p. The exosomes were characterized by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA).

Factors affecting preoperative sentinel lymph nodes contrast-enhanced ultrasound in breast cancer.

Background: Preoperative evaluation of sentinel lymph nodes is very important in breast cancer patients. This study aimed to explore factors affecting the result of preoperative percutaneous contrast-enhanced ultrasound for sentinel lymph nodes (SLN-CEUS) using Sonovue.

Methods: A total of 176 patients with breast cancer who underwent preoperative SLN-CEUS to trace axillary sentinel lymph nodes were included.

Secreted frizzled-related protein 4 (sFRP4) in cancer - Dual roles in tumorigenesis and therapeutic potential: A review.

Secreted Frizzled-Related Protein 4 (sFRP4), the largest member of the Secreted Frizzled-Related Protein (sFRP) family, contains two functional domains: a cysteine-rich domain (CRD) homologous to the Wnt-binding region of Frizzled (FZD) receptors and a netrin-like (NTR) domain structurally similar to axonal guidance proteins. By modulating the Wingless/Integrated (Wnt) signaling pathway, sFRP4 regulates essential cellular processes including proliferation, differentiation, apoptosis, and tissue homeostasis. This review aims to provide a comprehensive overview of the dualistic roles of sFRP4 in cancer, highlighting its tumor-suppressive and tumor-promoting functions, underlying molecular mechanisms, and therapeutic potential.

Maternal and early postnatal antibiotic exposure may increase the risk of autism spectrum disorder with regression.

Purpose: To analyze if exposure to antibiotics during maternal pregnancy and early postnatal period increases the risk of autism spectrum disorder with regression (ASD-R).

Methods: A total of 483 children with ASD were categorized into ASD-R and ASD without regression (ASD-NR) groups. The caregivers of children completed questionnaires regarding use of antibiotics during maternal pregnancy and early postnatal period.

Knotless backstitching provides comparable strength to conventional knotting in porcine stomach suture biomechanics.

In this biomechanics study, we compared the use of knot fixation or backstitching at the end of a continuous suture with the use of conventional absorbable sutures to close a porcine stomach incision. We then evaluated whether the backstitching method could be considered a novel, surgical, knot-free closure technique. A total of 40 suturing samples were obtained and divided into 20 samples from the posterior wall and 20 from the anterior wall.

Pyrolysis-Controlled Engineering of Nickel-Nitrogen-Carbon Catalytic Sites on Carbon Supports for Robust and Selective CO Electroreduction to CO.

Electrocatalytic carbon dioxide reduction (CORR) to carbon monoxide (CO) represents a sustainable pathway for closing the carbon cycle. In this study, polymerized nickel phthalocyanine (NiPPc) was employed as a molecular precursor and immobilized onto a highly conductive Ketjenblack (KB) carbon support through ultrasonic-assisted deposition, forming a NiPPc-KB composite catalyst. The carbon-nitrogen coordination environment was systematically tailored by controlled annealing to optimize the catalytic performance.

Anti-photoaging activity of cod peptides: structural characterisation and clinical validation.

The role of collagen peptides in anti-photoaging has attracted considerable research attention; however, the structure-activity relationship between their specific structural characteristics and biological efficacy remains poorly defined. In this study, collagen peptides from five sources, cod skin (CP), tilapia skin (TP), cowhide (BP), pig skin (PP), and chicken bone (JP), were selected to systematically compare their anti-photoaging activities in a UVA-induced L929 cell model and to investigate the mechanisms underlying their effects through analysis of molecular weight distributions, amino acid compositions, and sequence features. The results showed that CP, TP, and BP had stronger activities in increasing cell viability, enhancing the expression of , , and HAS-1/2/3, and inhibiting ROS generation and over-activation of MMP-1/3 in UVA-damaged cells, with CP having the most significant effect.

Synergistic Coupling of Interfacial Oxidation Sites and S-Scheme Heterojunction in CuWS@SnInS Core-Shell Nanocomposites Boosting CO Photoreduction Efficiency.

Photocatalytic CO reduction offers a dual solution to mitigate the energy crisis and reduce carbon emissions. In situ synthesis of the CuWS@SnInS (CWS@SIS) composite has established S-S bonds at the interface, which act as atomic-scale interfacial "bridges" to stabilize the heterojunction interface. SnInS nanosheets are uniformly dispersed on the CuWS surface, activating the (101) crystal plane of CuWS to consume photogenerated holes.

Molecular diagnostic technology: beyond analytical accuracy.

Infectious diseases cause high morbidity and mortality, and early, effective antimicrobial therapy improves outcomes. However, conventional microbiology methods like culture are slow and insensitive. Emerging molecular diagnostics-such as multiplex PCR (mPCR), droplet digital PCR (ddPCR), and metagenomic next-generation sequencing (mNGS)-offer rapid, accurate pathogen identification.

Outcomes following hospitalization for diabetic ketoacidosis in patients with cardiovascular disease.

Introduction: Diabetic ketoacidosis (DKA) is a serious complication in patients with diabetes. This study compares the outcomes of hospitalized DKA patients with and without cardiovascular disease (CVD). In addition, we assess outcomes between DKA and hyperosmolar hyperglycemic syndrome (HHS) in diabetes patients with CVD, and between those who developed DKA and those who did not.

HRASLS2 promotes the growth and glycolysis of pancreatic cancer by enhancing the stability of ASPH.

Pancreatic cancer remains one of the deadliest forms, with limited treatment options and a grim prognosis. However, the role of HRASLS2 in pancreatic adenocarcinoma (PAAD) is still not fully understood. This study aimed to investigate the role of HRAS-like suppressor family 2 (HRASLS2) and its potential mechanisms in PAAD.

Influence of six teaching methods on critical thinking ability of nursing students: a protocol for systematic review and network meta-analysis.

Introduction: To enhance nursing students' critical thinking abilities, numerous educators have explored alternative teaching methods. While meta-analyses have confirmed that various approaches are effective in developing critical thinking, consensus regarding their comparative effectiveness remains elusive. Furthermore, few investigations have directly contrasted the outcomes across these methods, highlighting the necessity to undertake a comprehensive evaluation of their impact on nursing students' critical thinking skills.

Integrated Analysis of Bulk and Single-Cell Transcriptomics Identifies Prognostic Biomarkers in Breast Cancer Metastasis.

Breast cancer (BC) remains one of the leading causes of cancer-related mortality among women worldwide, with distant metastasis being the primary contributor to poor prognosis. However, the molecular mechanisms driving BC metastasis are not yet fully understood. We integrated three public microarray datasets (GSE14776, GSE103357, and GSE32489) to identify the differentially expressed genes (DEGs) associated with breast cancer metastasis.

Oviduct-derived C-type natriuretic peptide improves bovine preimplantation embryo development in vitro by attenuating oxidative damage.

It is widely accepted that the poor quality of in vitro-produced (IVP) embryos becomes one of the most intractable issues currently limiting the outcomes of human assisted reproductive technology (ART). Although diverse molecules and pathways may be involved in this process, strategies to optimize culture conditions for the improvement of embryo development potential and the relevant mechanisms remain underexplored. Here, we demonstrate that the supplementation of C-type natriuretic peptide (CNP), a potential embryokine present in the oviduct, can improve the blastocyst formation rate and embryo quality, as evidenced by an increased total cell number and inner cell mass (ICM) cells, elevated embryonic cell proliferation, and reduced embryonic cell apoptosis.

TRGOA: Topological-Aware Residue-Gene Ontology Attention Network for Protein Function Prediction.

Protein function prediction is one of the most important biological problems in the field of bioinformatics. The functions of proteins are generally described by a series of Gene Ontology (GO) terms that have hierarchical relationships. Two factors hinder the effective prediction of protein functions using current methods: 1) they cannot well model and learn the topological semantic similarity between residues and GO terms, resulting in a huge semantic gap; 2) they predict the functions of proteins by calculating the semantic similarity between protein-level embeddings and GO terms, which does not effectively learn the protein-function relationship.

Application of feedforward control management combined with holistic operating room nursing in gynecological laparoscopic surgery.

Objective: This study analyzes the effects of feedforward control management combined with holistic operating room nursing in gynecological laparoscopic surgery.

Methods: Seventy patients undergoing gynecological laparoscopic surgery were enrolled and randomized into two groups: the control group (35 patients) and the observation group (35 patients). The control group received conventional operating room nursing, while the observation group received feedforward control management plus holistic operating room management.

Neural substrates underlying multisensory stiffness perception via active touch and dynamic visual feedback.

Humans perceive the physical properties of objects through active touch to acquire information that is unavailable by passive observation (e.g., pinching an object to estimate its stiffness).

High-quality real-time 3D holographic display for real-world scenes based on the optimized layered angular spectrum method.

Holographic display is ideal for true 3D technology because it provides essential depth cues and motion parallax for the human eye. Real-time computation using deep learning was explored for intensity and depth images, whereas real-time generating holograms from real scenes remains challenging due to the trade-off between the speed and the accuracy of obtaining depth information. Here, we propose a real-time 3D color hologram computation model based on deep learning, realizing stable focusing from monocular image capture to display.

High-quality integral imaging 3D display from a captured monocular image.

Due to the limited space-bandwidth product, three-dimensional (3D) integral imaging (InI) encounters the trade-off between spatial resolution and viewpoint density. This problem significantly impedes the advancement of high quality InI 3D displays. Moreover, the cost and complexity of light field sampling constrain the generation of 3D light fields for real scenes.

Image quality enhancement for an integral imaging display using aperture array and revised pixel mapping method.

The limited space-bandwidth product constrains the performance of an integral imaging three-dimensional (3D) display, highlighting the need for optimization of system structure and display process. In this paper, we propose an image quality enhanced integral imaging 3D display system under a restricted information-capacity. An aperture array corresponding to the microlens array (MLA) is integrated into the system to improve display clarity and minimize crosstalk by controlling the beam diameter entering each microlens.