Synergistic Coupling of Interfacial Oxidation Sites and S-Scheme Heterojunction in CuWS@SnInS Core-Shell Nanocomposites Boosting CO Photoreduction Efficiency.

Photocatalytic CO reduction offers a dual solution to mitigate the energy crisis and reduce carbon emissions. In situ synthesis of the CuWS@SnInS (CWS@SIS) composite has established S-S bonds at the interface, which act as atomic-scale interfacial "bridges" to stabilize the heterojunction interface. SnInS nanosheets are uniformly dispersed on the CuWS surface, activating the (101) crystal plane of CuWS to consume photogenerated holes.

Enhanced hydrophobicity of the current collector modifier for Zn anode endows improved longevity.

Though zinc-ion batteries have gained intensive attention recently, their application prospects have long been hampered by Zn dendrite evolution and water-involved side reactions, especially for thin and highly utilized Zn anodes. Coating a modified layer on the current collector is a common strategy to improve the reversibility of Zn plating/stripping. Hydrophilic modifier with high zincophilicity, usually affords uniform Zn deposition but exhibits intrinsic limitations in repelling water molecules, while hydrophobic modifiers shows excellent water-resistance.

Integrated Experimental-Numerical Analysis of HTPB Propellant Casting Optimization and Droplet Dynamics.

The rheological properties of the propellant slurry and droplet dynamics during the casting process play a critical role in the manufacturing of propellants. This study systematically investigated the rheological characteristics of a hydroxyl-terminated polybutadiene (HTPB)-based composite solid propellant slurry and optimized the vacuum casting process through integrated experimental and numerical simulation approaches. Rheological tests revealed shear-thinning behavior, with the Herschel-Bulkley model parameters confirming non-Newtonian fluid characteristics.

Development and validation of an LC-MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma.

The pharmacokinetics of LXT-101 sustained-release suspension, an anti-prostate cancer polypeptide, were studied on beagle dogs using a high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Samples were prepared by the protein precipitation, evaporation and reconstitution. Chromatographic separation was performed using a Hypersil GOLD C18 column (50 mm × 2.

Manganese octacyanomolybdate/carbon nanotube hybrids as novel cathode materials for aqueous zinc-ion batteries.

Prussian blue analogues (PBAs) exhibit strong competitiveness as cathode materials in aqueous zinc-ion batteries (AZIBs) due to their ideal three-dimensional open framework structure based on hexacyanometallate building blocks. However, the intriguing open frameworks based on octacyanometallates have not been explored for AZIBs cathodes to date. In this paper, we demonstrate that manganese octacyanomolybdate (MnMo(CN)·nHO), a typical octacyanometallate-based complex, is also a feasible cathode material for AZIBs.

Coronary heart disease prediction method fusing domain-adaptive transfer learning with graph convolutional networks (GCN).

Graph convolutional networks (GCNs) have achieved impressive results in many medical scenarios involving graph node classification tasks. However, there are difficulties in transfer learning for graph representation learning and graph network models. Most GNNs work only in a single domain and cannot transfer the learned knowledge to other domains.

Acute coronary syndrome risk prediction based on gradient boosted tree feature selection and recursive feature elimination: A dataset-specific modeling study.

Acute coronary syndrome (ACS) is a serious cardiovascular disease that can lead to cardiac arrest if not diagnosed promptly. However, in the actual diagnosis and treatment of ACS, there will be a large number of redundant related features that interfere with the judgment of professionals. Further, existing methods have difficulty identifying high-quality ACS features from these data, and the interpretability work is insufficient.

All-Cause Death Prediction Method for CHD Based on Graph Convolutional Networks.

Coronary heart disease (CHD) has become one of the most serious public health issues due to its high morbidity and mortality rates. Most of the existing coronary heart disease risk prediction models manually extract features based on shallow machine learning methods. It only focuses on the differences between local patient features and ignores the interaction modeling between global patients.

Morphology-Dependent Electrocatalytic Performance of a Two-Dimensional Nickel-Iron MOF for Oxygen Evolution Reaction.

Developing highly efficient, low-cost, and durable oxygen evolution reaction (OER) electrocatalysts is extraordinarily desirable for achieving clean and sustainable hydrogen energy. Metal-organic frameworks (MOFs) are emerging as attractive candidates for OER electrocatalysts. Herein, a two-dimensional Fe-Ni MOF of Fe(py)Ni(CN) (py = pyridine) is synthesized controllably to generate various nanostructures, including nanoboxes, nanocubes, nanoplates, and nanosheets.

Decoration of nickel hexacyanoferrate nanocubes onto reduced graphene oxide sheets as high-performance cathode material for rechargeable aqueous zinc-ion batteries.

Prussian blue analogues (PBA) have attracted much attention in energy research due to their unique three-dimensional open framework structure, adjustable metal ions, and facile synthesis. However, the application of PBA as a cathode material for aqueous zinc-ion batteries (ZIBs) is restricted by its poor cycling performance and lower capacity. In this paper, we develop a new PBA-based hybrid cathode material for aqueous ZIBs by loading uniform nickel hexacyanoferrate (NiHCF) nanocubes onto reduced graphene oxide (RGO) sheets.

Pharmacokinetic Study of Hypaphorine, a Potential Agent for Treating Osteoclast-based Bone Loss, on Rats Using LC-MS/MS.

Aims And Objectives: A high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determining hypaphorine, a potential agent for treating osteoclast- based bone loss, was developed and validated in rat plasma.

Materials And Methods: Plasma samples were pretreated by the protein precipitation. Chromatographic separation was performed using an Inertsil ODS-3 column (50 mm × 4.

[Analysis on quality value transmitting of substance benchmarks of Linggui Zhugan Decoction].

By preparing 10 batches of the material reference of Linggui Zhugan Decoction,the methodology of the characteristic spectrum of the material reference was created. The creaming rate range,the contents and the transfer rate range of cinnamaldehyde,glycyrrhizin and glycyrrhizic acid,the characteristic peaks and the similarity range of the characteristic spectrum of Linggui Zhugan Decoction were determined to clarify key quality attributes of the material reference of Linggui Zhugan Decoction. In the 10 batches of the material reference of Linggui Zhugan Decoction,the similarity of characteristic spectrum was higher than 0.

Pharmaceutical excipient salts effect on micellization and drug solubilization of PEO-PPO-ph-PPO-PEO block copolymer.

Hydrophobic modification PEO-PPO copolymer BP123 was synthesized, with two aromatic rings in the centre linked to PEO-PPO blocks, and the identical PEO and PPO block numbers were possessed with commercial copolymer P123. The influence of three common pharmaceutical excipient salts sodium chloride (NaCl), sodium citrate (NaCA) and sodium benzoate (NaBZ) on self-assembly behaviors of BP123 and P123 was investigated via cloud point, surface tension, pyrene fluorescence and dynamic light scattering. Solubilization for hydrophobic drug simvastatin (SV) and in vitro drug release behavior were assessed accordingly.

Microneedle-Assisted Percutaneous Delivery of Paeoniflorin-Loaded Ethosomes.

Paeoniflorin, the main component of total glucosides of paeony (TGP), shows good therapeutic effects in arthritis, but has low bioavailability when administered orally. Avoiding such a deficiency for topical administration would expand its clinical application. This study aimed to avoid these limitations by using nanotechnology (ethosomes) and a physical approach (microneedles).

Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats.

Objective To investigate whether red ginseng extract can affect the pharmacokinetics of aspirin in Sprague Dawley (SD) rats.Methods Totally, 12 male SD rats were randomly and uniformly divided into the aspirin group (aspirin 10.42 mg·kg ) and the combined group (red ginseng extraction 0.

[Effect of paeoniflorin and menthol on membrane fluidity, Na⁺-K⁺-ATPase activity and Ca²⁺-ATPase activity during transport of puerarin in Calu-3 cell].

The aim of this research is to investigate the effects of paeoniflorin and menthol on the physiological function of Calu-3 cell membrane during the transport of puerarin. Calu-3 cell was used as the cell model to simulate nasal mucosa tissues, and the cell membrane fluidity, Na⁺-K⁺-ATPase activity and Ca²⁺-ATPase activity were detected by fluorescence recovery after photobleaching(FRAP) and ultramicro enzyme activity testing, in order to explore the mechanism of compatible drugs on promoting puerarin transport. The results showed that when puerarin associated with low, middle and high concentration of menthol or both paeoniflorin and menthol, the fluorescence recovery rate was increased significantly, while Na⁺-K⁺-ATPase activity had no significant change and Ca²⁺-ATPase activity was enhanced significantly as compared with puerarin alone.

[The molecular identification of licorice species and the quality evaluation of licorice slices].

Licorice is one of the most common herbs in traditional Chinese medicine, and classified as top grade in Shen Nong Ben Cao Jing. There are three different original plants of licorice stipulated in Chinese Pharmacopeia, Glycyrrhiza uralensis Fisch., Glycyrrhiza glabra L.