Mask protein keeps NF-κB precursor inactive by inducing a closed conformation and isolating it in biomolecular condensates.

Nuclear factor κB (NF-κB) family transcription factors are critical for innate immune responses across a variety of organisms and are frequently dysregulated in diseases. Understanding their homeostatic regulation is essential for developing therapeutic strategies. Relish, a Drosophila homolog of mammalian NF-κB precursors, provides a valuable model for studying these processes.

Anionically-Reinforced Nanocellulose Separator Enables Dual Suppression of Zinc Dendrites and Polyiodide Shuttle for Long-Cycle Zn-I Batteries.

Zn-I batteries have emerged as promising next-generation energy storage systems owing to their inherent safety, environmental compatibility, rapid reaction kinetics, and small voltage hysteresis. Nevertheless, two critical challenges, i.e.

Adaptive metric for knowledge distillation by deep Bregman divergence.

Knowledge distillation (KD) makes it possible to deploy high-accuracy models on devices with limited resources and is an effective means of achieving lightweight models. With the advancement of technology, the methods of knowledge distillation are also continuously developing and improving to adapt to different application scenarios and needs. To facilitate the transfer of knowledge from larger networks to smaller and lighter networks, KD has been employed to bridge the gap in probability outputs or middle-layer representations between teacher and student networks.

Near Infrared-Responsive Xanthene Probes for Dual-Mode Cancer Treatment and Bioimaging.

The incidence of cancer has escalated at a distressing pace, creating an urgent demand for advancements and breakthroughs in medical interventions. Amidst the multitude of approaches for diagnosing and managing cancer, fluorescence imaging, photodynamic therapy, and photothermal therapy have emerged as key approaches due to their unique advantages. Herein, two new xanthene-based probes, namely, and , with D-π-A conjugated structures, are reported.

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic Loss.

Somatic retinoblastoma 1 () loss is prevalent across different cancer types and is enriched in treatment-refractory tumors, such as castration-resistant prostate cancer (CRPC) and small-cell lung cancer, but cannot be considered as a direct druggable target. In this study, we revealed that the close proximity of nudix hydrolase 15 () and may result in their common somatic codeletion or epigenomic cosilencing in different cancer types and subsequent significant positive correlations of their expressions at the bulk transcriptional and single-cell levels. With clinical CRPC samples, co-loss of and were commonly observed (14 out of 21).

Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.

Background: Knee osteoarthritis (KOA) is a major health burden for adults and the elderly globally; however, national radiological and epidemiological data and predictive models for KOA are lacking in China. Most of the existing studies are limited to regional samples, which cannot accurately reflect disease burden and risk factors.

Objectives: This study aimed to systematically analyze the prevalence and risk factors of adult radiology KOA in China for the first time using a national representative sample and to develop a prediction model to provide a basis for public health strategies.

Establishing a long-term predictive model for aggressive behavior in schizophrenia: a 21-year longitudinal study in rural China.

Background: Although identifying factors contributing to aggressive behavior in individuals with schizophrenia is crucial for developing targeted prevention strategies and intervention, most studies were cross-sectional or short-term, and did not take into account the factor of urbanicity. This study aimed to develop a predictive model of aggressive behavior in individuals with schizophrenia in rural China.

Method: A total of 205 individuals with schizophrenia who were identified in 1994 and followed up in 2015 were included in the study.

High-quality whole genome data of .

A high-quality whole genome assembly of (Lepidoptera: Sphingidae) was generated using PacBio HiFi sequencing technology. The assembly, constructed with hifiasm and refined by redundant sequences using Purge_dups, resulted in a genome size of 384.76 Mb with a contig N50 of 14.

Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis.

Thyroid cancer is a common endocrine malignancy associated with various inflammatory factors. This research aimed to explore the causal relationships between 41 inflammatory factors and the risk of thyroid cancer using Mendelian randomisation (MR) analysis. MR analysis was performed using genetic data from two publicly available European genome-wide association studies (GWAS).

Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.

Background: The introduction of novel therapeutics into clinical practice could impact equity in health outcomes.

Methods: This was a retrospective, observational cohort study based on the Get With The Guidelines-Stroke program of the American Heart Association. Two epochs were considered: January 2010 to December 2014 and January 2016 to December 2019.

MiR-126-3p and MiR-195-5p as Novel Therapeutic Attenuators of Liver Fibrosis by Targeting the IRS1/PI3K Signalling Pathway.

Background & Aims: Hepatic fibrosis is a progressive response to chronic liver injury. A key event in the development of hepatic fibrosis is the activation of hepatic stellate cells (HSCs); emerging research indicates that microRNAs play crucial roles in regulating HSCs activation. However, the specific roles of miR-126-3p (miR-126) and miR-195-5p (miR-195) in liver fibrosis remain inadequately understood.

Evaluating ChatGPT's Utility in Biologic Therapy for Systemic Lupus Erythematosus: Comparative Study of ChatGPT and Google Web Search.

Background: Systemic lupus erythematosus (SLE) is a life-threatening, multisystem autoimmune disease. Biologic therapy is a promising treatment for SLE. However, public understanding of this therapy is still insufficient, and the quality of related information on the internet varies, which affects patients' acceptance of this treatment.

Therapeutic Potential of BMX-001 for Preventing Chemotherapy-Induced Peripheral Neuropathic Pain.

: Chemotherapy-induced neuropathic pain (CINP) represents a critical challenge in oncology, emerging as a common and debilitating side effect of widely used chemotherapeutic agents, such as paclitaxel (PTX). Current therapeutic interventions and preventive strategies for CINP are largely insufficient, as they fail to address the underlying peripheral nerve damage, highlighting an urgent need for the development of new drugs. This study aimed to investigate the dual-function effects on normal cell protection and tumor suppression of BMX-001, a redox-active manganese metalloporphyrin that has demonstrated antioxidant and anti-inflammatory properties, which offers potential in protecting central nervous system tissues and treating CINP.

A protocol for organoids from the gynecomastia patients.

Background: Gynecomastia, characterized by benign proliferation of male breast glandular tissue, is a prevalent condition with complex etiologies. However, the absence of effective models has hindered mechanistic investigations and therapeutic development.

Methods: In this study, we established and characterized organoids derived from the breast tissues of six male gynecomastia patients, including physiological, idiopathic, and hormone-related subtypes.

Vestibulo-Ocular Reflex Results in Patients with Intralabyrinthine Schwannomas: Case Series with a Literature Review.

Intralabyrinthine schwannoma (ILS) is a rare benign tumor of the inner ear, often presenting with nonspecific symptoms such as hearing loss, tinnitus and vertigo. Vestibular function in ILS patients remains underexplored. This study aims to evaluate vestibulo-ocular reflex (VOR) function and inner ear magnetic resonance imaging (MRI) signal changes in ILS, and to provide insights into potential mechanisms underlying vestibular dysfunction.

Novel Environmentally-Friendly Process for Selective Extraction and Enrichment of DHA/EPA-Containing Phospholipids from Krill Oil via Differential Temperature-Controlled Crystallization.

This study presents a novel environmentally-friendly process for the selective extraction and enrichment of DHA/EPA-containing phospholipids (PL-DHA/EPA) from krill oil. The methodology leverages differential crystallization behavior between phospholipids and triacylglycerols in ethanolic solutions, exploiting their distinct freezing point thresholds to achieve precise fractionation. Response surface methodology optimization identified optimal extraction parameters: liquid-to-material ratio of 6:1 (/), freezing temperature of -20 °C, freezing duration of 25 h, and rotary evaporation temperature of 45 °C, yielding a final product with 39.

Glycosylated SARS-CoV-2 RBD Antigens Expressed in Glycoengineered Yeast Induce Strong Immune Responses Through High Antigen-Alum Adsorption.

Glycosylation plays a pivotal role in regulating the functions and immunogenicity of antigens. Targeting the receptor-binding domain (RBD) of the spike protein (S protein) of SARS-CoV-2, we examined the impact of different glycoforms on RBD antigen immunogenicity and the underlying mechanisms. IgG-specific antibody titers and pseudovirus neutralization were compared in mice immunized with RBD antigens bearing different glycoforms, which were prepared using glycoengineering-capable and mammalian cell expression systems with distinct glycosylation pathways.

Regulatory Effect of PGE-EP2/EP4 Receptor Pathway on -Induced Inflammatory Factors in Dairy Cow Neutrophils.

Naturally occurring prostaglandin E (PGE) influences cytokine production regulation in bovine neutrophils exposed to Rosenbach. Here, we employed bovine neutrophils as the primary experimental system, and administered specific inhibitors targeting various receptors, which were subsequently exposed to . Cytokine expression levels in dairy cow neutrophils induced by via the endogenous PGE-EP2/4 receptor pathway were investigated, and its effects on P38, extracellular signal-regulated kinase (ERK), P65 activation, and phagocytic function in Rosenbach-induced dairy cow neutrophils, were examined.

Exogenous prostaglandin D as a modulator in bovine endometritis: implications for reducing antibiotic use in dairy cattle.

Introduction: Bovine endometritis is a common postpartum uterine infection that significantly impacts the health and production performance of dairy cows, leading to economic losses for farms. Bovine endometritis is closely associated with pathogenic microorganisms, disturbances in uterine microecology, and localized inflammatory damage. () is the primary pathogenic bacterium responsible for bovine endometritis.

Multidimensional technological advances in cervical cancer screening: From standardized processes to precision medicine.

Cervical cancer is a common malignancy among women worldwide. To address this significant public health issue, the World Health Organization launched the "Eliminating Cervical Cancer" initiative. Effective screening of cervical cancer is crucial for reducing its morbidity and mortality.

GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential.

G protein-coupled estrogen receptor (GPER) significantly influences metabolic regulation by engaging multiple signaling pathways that affect overall metabolic health. Its structure and signaling mechanisms drive its diverse roles. Our team and others have successfully demonstrated that GPER modulates nutrient metabolism, spanning glucose, protein, and lipid metabolism, while also contributing to vitamin and mineral metabolism.

Enrichment of Streptococcus oralis in respiratory microbiome enhance innate immunity and protects against influenza infection.

Respiratory microbial dysbiosis has been implicated in the occurrence and progression of community-acquired pneumonia (CAP). However, the dynamic variation in the respiratory microbiota and its interaction with the host response remain poorly understood. Here, we performed metagenomic analysis of respiratory and gut microbiota, along with blood transcriptomics, using longitudinally collected samples from 38 CAP patients.

Performance Assessment of ChatGPT-4.0 and ChatGLM Series in Traditional Chinese Medicine for Metabolic Associated Fatty Liver Disease: Comparative Study.

Background: ChatGPT-4.0 and the ChatGLM series are novel conversational large language models (LLMs). ChatGLM includes 3 versions: ChatGLM4 (with internet connectivity but no knowledge base pretraining), ChatGLM4+Knowledge base (combining internet search capabilities with knowledge base pretraining), ChatGLM3-6B (offline knowledge base pretraining but no internet connectivity).