Publications by authors named "Tianxiao Zheng"
Background: ChatGPT-4.0 and the ChatGLM series are novel conversational large language models (LLMs). ChatGLM includes 3 versions: ChatGLM4 (with internet connectivity but no knowledge base pretraining), ChatGLM4+Knowledge base (combining internet search capabilities with knowledge base pretraining), ChatGLM3-6B (offline knowledge base pretraining but no internet connectivity).
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited efficacy of current immunotherapeutic strategies. Immunogenic cell death (ICD), characterized by the release of damage-associated molecular patterns (DAMPs), offers a promising approach to enhance antitumor immunity. Arsenic trioxide (ATO), an ICD inducer, may synergize with PD-1 inhibitors to overcome therapeutic resistance, though the underlying mechanisms remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- Ginsenoside Rh1 (G-Rh1) has potential therapeutic effects on hepatocellular carcinoma (HCC), although its impact was previously unclear, as it has shown effectiveness against other cancers like breast and colon cancer.
- The study used various methods, including bioinformatics and in vitro & in vivo experiments, to examine G-Rh1's effects on HCC cells and the immune environment of tumors.
- Results indicated that G-Rh1 did not significantly impact HCC cell growth but improved the immune response by enhancing the infiltration of key immune cells and increasing MHC-I expression, suggesting its role in fighting cancer by modifying the tumor microenvironment.