The public's perceptions and attitudes of male nursing postgraduate professional identity on Chinese social media: Qualitative study based on machine learning.

Background: Professional identity plays a critical role in the career development of male postgraduate nursing students, particularly in contexts where gender imbalance and social stereotypes persist.

Objective: This study explores how the clinical professional identity of male nursing postgraduates is perceived and constructed through social media discourse in China.

Design: A qualitative study using content analysis of social media discourse, supported by sentiment classification and clustering algorithms.

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic Loss.

Somatic retinoblastoma 1 () loss is prevalent across different cancer types and is enriched in treatment-refractory tumors, such as castration-resistant prostate cancer (CRPC) and small-cell lung cancer, but cannot be considered as a direct druggable target. In this study, we revealed that the close proximity of nudix hydrolase 15 () and may result in their common somatic codeletion or epigenomic cosilencing in different cancer types and subsequent significant positive correlations of their expressions at the bulk transcriptional and single-cell levels. With clinical CRPC samples, co-loss of and were commonly observed (14 out of 21).

Fungal symbiont Mycena complements impaired nitrogen utilization in Gastrodia elata and supplies indole-3-acetic acid to facilitate its seed germination.

Nitrogen and auxin uptake plays pivotal roles in seed germination and development. Gastrodia elata, a fully mycoheterotrophic plant, depends entirely on its symbiotic association with Mycena for early growth and seed germination. The process by which Mycena enables the supply of nitrogen nutrients and auxin, which are deficient in G.

DiffRaman: A conditional latent denoising diffusion probabilistic model for enhancing bacterial identification via Raman spectra generation under limited data.

Raman spectroscopy has attracted significant attention in various biochemical detection fields, especially in the rapid identification of pathogenic bacteria. The integration of this technology with deep learning to facilitate automated bacterial Raman spectroscopy diagnosis has emerged as a key focus in recent research. However, the diagnostic performance of existing deep learning methods largely depends on a sufficient dataset, and in scenarios where there is a limited availability of Raman spectroscopy data, it is inadequate to fully optimize the numerous parameters of deep neural networks.

[Current status and progress of health economics research on allergen specific immunotherapy].

Allergen specific immunotherapy（AIT）, as an effective treatment for allergic rhinitis, asthma, and other allergic diseases, has received widespread attention in the field of health economic evaluation in recent years. This article reviews the current status and progress of economic research on AIT, mainly discussing the socioeconomic burden of allergic rhinitis, the results of health economic studies from different countries, and the primary methods used in health economic research on allergic rhinitis. Existing studies indicate that, although AIT involves high initial costs, it offers significant long-term economic benefits by reducing healthcare resource utilization, improving patient quality of life, and decreasing medication dependence.

A dual-responsive polyacrylamide sensor for colorimetric and fluorescent detection of Cu.

Polyacrylamide, a classic polymer material, has been extensively applied in both industrial production and daily life, owing to its outstanding physical and chemical properties. However, the absence of a conjugated π-electron system in its molecular structure severely restricts its application in the field of fluorescence. In this study, a novel fluorescent polyacrylamide sensor (P) was synthesized via free-radical precipitation polymerization using acrylamide and 3-[(Allylaminothiocarbonyl)hydrazinecarbonyl]-7-(diethylamino)-2H-chromen-2-one as monomers.

ZGS521 attenuates colitis by regulating intestinal epithelial proliferation and differentiation and the gut microbiota.

Inflammatory bowel disease (IBD) is a persistent and relapsing intestinal disorder that significantly harms health. ZGS521 isolated from fermented pickles was identified through Gram staining, physiological and biochemical assays and 16S rDNA sequencing. The gene of ZGS521 was annotated through sequence alignment.

Signal Detection Based on Separable CNN for OTFS Communication Systems.

This paper proposes a low-complexity signal detection method for orthogonal time frequency space (OTFS) communication systems, based on a separable convolutional neural network (SeCNN), termed SeCNN-OTFS. A novel SeparableBlock architecture is introduced, which integrates residual connections and a channel attention mechanism to enhance feature discrimination and training stability under high Doppler conditions. By decomposing standard convolutions into depthwise and pointwise operations, the model achieves a substantial reduction in computational complexity.

Uncertainty-aware Cross-training for Semi-supervised Medical Image Segmentation.

Semi-supervised learning has gained considerable popularity in medical image segmentation tasks due to its capability to reduce reliance on expert-examined annotations. Several mean-teacher (MT) based semi-supervised methods utilize consistency regularization to effectively leverage valuable information from unlabeled data. However, these methods often heavily rely on the student model and overlook the potential impact of cognitive biases within the model.

Superior High-Temperature Energy Storage Performance in All-Organic Composite Dielectrics Achieved by Synergistic Regulation of Free Volume and Charge Distribution.

Developing polymer dielectrics with stable high-temperature energy storage performance remains a pivotal challenge for next-generation electrical systems. However, the exponentially increasing conduction loss at elevated temperatures results in a decline in both energy storage density and efficiency. Herein, a cross-scale synergistic regulation strategy that integrates mesoscale free volume and molecular-scale charge trap, effectively addressing the issue of free volume collapse and space charge accumulation under thermal-electric coupling stress is proposed.

Application of Sodium Bicarbonate Prereduction in Regional Citrate Anticoagulation for Continuous Veno-Venous Hemofiltration.

Introduction: This study aimed to explore the effectiveness of sodium bicarbonate prereduction during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA).

Methods: Patients undergoing CVVH with RCA were randomly divided into a control group and a prereduction group, with the latter receiving reduced sodium bicarbonate concentration levels to achieve the desired level after three hours of treatment. The investigation focused on variations in pH, bicarbonate ion levels and the frequency of sodium bicarbonate dosage adjustments at different intervals during CVVH.

Adjunctive treatment of symmetrical peripheral gangrene with phenolamine wet compress.

Rationale: Symmetrical peripheral gangrene (SPG) is a rare and life-threatening condition characterized by symmetrical distal ischemic damage that can progress to gangrene at 2 or more anatomical sites, without involvement of a large vessel obstruction or vasculitis. We report the case of an older adult female who developed septic shock and disseminated intravascular coagulation (DIC) postoperatively, complicated by the onset of SPG.

Patient Concerns: A 66-year-old female was transferred to the intensive care unit for postoperative management.

Flexible fibre-shaped fuel cells with gel-mediated internal pressure encapsulation.

The development of flexible fuel cells has been hindered by the rigid components and stringent requirements for pressure encapsulation and fuel sealing. Here we report an adaptive internal pressure encapsulation strategy that leverages the dynamic swelling behaviour of woven cotton fibres enclosed in a gel matrix in methanol. This strategy achieves simultaneous interfacial self-reinforcement and pressure modulation, enabling the fabrication of fibre-shaped direct methanol fuel cells.

Short-term outcomes of percutaneous versus subcutaneous fascial flap fixation in cubital tunnel syndrome surgery: A retrospective cohort study.

Objective: Percutaneous external suturing has been proposed as an alternative approach to fascial flap fixation during anterior subcutaneous transposition for cubital tunnel syndrome (CuTS), with the aim of minimizing deep tissue disruption and reducing postoperative complications. This study compared short-term outcomes between percutaneous external fixation and traditional subcutaneous fixation of fascial flaps in CuTS surgery.

Methods: In this retrospective cohort study, 114 patients who underwent anterior ulnar nerve transposition with fascial flap coverage were enrolled between January 2020 and December 2023.

Global burden of lower respiratory infections attributable to PM across global, regional, national level and China from 1990 to 2021 and predictions to 2035: A cross-sectional study.

Background: Particulate matter (PM) based air pollution closely linked to lower respiratory infections (LRIs). PM air pollution is identified as the leading risk factor for LRIs. This study examined deaths and disability-adjusted life years (DALYs) associated with PM-related LRIs to understand and prevent their impact.

Effect of electroacupuncture intervention before and after operation on perioperative neurocognitive disorders in elderly patients with hip fractures: A randomized controlled trial.

Introduction: The incidence of postoperative neurocognitive disorder (PND) in elderly patients with hip fractures poses a significant clinical challenge, with current management strategies offering limited efficacy in prevention or resolution. This prospective study evaluated the effectiveness of pre-and postoperative electroacupuncture (EA) intervention in mitigating PND in this patient cohort.

Methods: A double-masked, randomized controlled trial was conducted involving 60 elderly patients (≥65 years) with fragility hip fractures scheduled for surgical repair.

Value of intravoxel incoherent motion and diffusion kurtosis imaging to differentiate hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Background: The differential diagnosis between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is crucial. The individual differences of patients increase the complexity of diagnosis. Currently, imaging diagnosis mainly relies on conventional computed tomography and magnetic resonance imaging (MRI), but few studies have investigated MRI functional imaging.

GA-DELLA-OsMYB48-1 module-mediated regulation of inorganic phosphate uptake in rice.

Inorganic phosphate (Pi) is essential for plant growth and development, yet the regulatory role of gibberellic acid (GA) in Pi uptake in rice remains poorly understood. Here, we identified a major quantitative trait locus (QTL) for phosphorus and nitrogen concentrations, which corresponds to an allele of the Green Revolution gene Semi-Dwarf 1 (SD1), encoding GA20-oxidase, a key enzyme in GA biosynthesis. Through functional analyses of near-isogenic lines, genetic complementation, overexpression, and knockout transgenic lines, we demonstrated that SD1 enhances Pi uptake in rice.

Identification and functional analysis of novel precursor genes in cyclic peptide biosynthesis in Pseudostellaria heterophylla.

Background: , a member of the Caryophyllaceae family, is widely used in traditional Chinese medicine due to its bioactive cyclic peptides (CPs) with immunomodulatory functions. Caryophyllaceae- like CPs, one of the largest types plant-derived CPs, typically consist of 5–12 amino acids and are derived from ribosomally synthesized peptide precursors. The diversity of CPs arises from variations in their core peptide sequences.

Strain-induced lead-free morphotropic phase boundary.

Enhanced susceptibilities in ferroelectrics often arise near phase boundaries between competing ground states. While chemically-induced phase boundaries have enabled ultrahigh electrical and electromechanical responses in lead-based ferroelectrics, precise chemical tuning in lead-free alternatives, such as (K,Na)NbO thin films, remains challenging due to the high volatility of alkali metals. Here, we demonstrate strain-induced morphotropic phase boundary-like polymorphic nanodomain structures in chemically simple, lead-free, epitaxial NaNbO thin films.

Population transcriptomic and metabolomic profiling provide novel insights into evolutionary mechanisms of metabolomic diversity between divergent lineages of Rheum palmatum complex.

The quality of traditional Chinese medicine (TCM) greatly relies on the accumulation of medicinal compounds. As a crucial TCM, rhubarb (dahuang) exhibits significant quality variations across different geographical production regions. However, the insufficient knowledge on metabolic diversity and metabolic pathways of specialized metabolites across distinct geographical regions fundamentally constrains our ability to decipher the mechanisms driving quality differences among different production areas in rhubarb.

Clinical characteristics and caloric testing in patients with light or heavy cupula of the horizontal semicircular canal.

Objectives: Persistent direction-changing positional nystagmus (DCPN) and null point (NP) are characteristic of cupulopathy of the horizontal semicircular canal (HSC). The cupulopathy can manifest as HSC-light cupula (HSC-Lcu) (geotropic DCPN) and HSC-heavy cupula (HSC-Hcu) (apogeotropic DCPN) in the supine roll test (SRT). Whether the affected side of cupulopathy could be based on the nystagmus intensity in the SRT is controversial.

Understanding risk factors and prognosis in diabetic foot ulcers.

Diabetic foot ulcer (DFU) is a severe and prevalent complication of diabetes mellitus, posing substantial risks to patient health and increasing healthcare burdens globally. These chronic wounds often result from a complex interplay of factors, including neuropathy, ischemia, infection, immune dysregulation, and vascular dysfunction, leading to significant morbidity and, in severe cases, amputation. Effective management of DFUs necessitates a comprehensive understanding of their risk factors and prognostic indicators.

Unconventional phase metal heteronanostructures with tunable exposed interface for efficient tandem nitrate electroreduction to ammonia.

Tandem catalysis is an effective approach to achieve highly selective and high-rate multi-electron/proton transfer reactions, such as nitrate electroreduction, which are important for various physicochemical and biological processes. However, present tandem catalysts suffer from uncontrollable interface, limited crystal phase, and complex synthesis protocols. Here, we report facile seed-mediated synthesis of unconventional phase 4H/fcc Au-Cu heterostructures with a unique beaded-bracelet nanostructure (BBN).

Multi-grayscale driving system for a passive-matrix alternating current electroluminescence display with low crosstalk by an asymmetric half-voltage driving strategy.

Alternating current electroluminescence (ACEL) devices have been investigated for their applications in flexible displays, particularly in textile displays. The current driving system for passive-matrix alternating current electroluminescence (PMACEL) still suffers from crosstalk, which significantly affects the display quality. In this study, a circuit model of ACEL is proposed, which is used to simulate the optoelectronic characteristics of ACEL devices as well as the crosstalk of PMACEL by the Simulation Program with Integrated Circuit Emphasis (SPICE).