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Adjunctive treatment of symmetrical peripheral gangrene with phenolamine wet compress. | LitMetric

Adjunctive treatment of symmetrical peripheral gangrene with phenolamine wet compress.

Medicine (Baltimore)

Department of Critical Care Medicine, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing, China.

Published: August 2025


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Article Abstract

Rationale: Symmetrical peripheral gangrene (SPG) is a rare and life-threatening condition characterized by symmetrical distal ischemic damage that can progress to gangrene at 2 or more anatomical sites, without involvement of a large vessel obstruction or vasculitis. We report the case of an older adult female who developed septic shock and disseminated intravascular coagulation (DIC) postoperatively, complicated by the onset of SPG.

Patient Concerns: A 66-year-old female was transferred to the intensive care unit for postoperative management. She subsequently developed septic shock and DIC. On the 10th day of admission, acral necrosis was observed in both feet.

Diagnoses: Septic shock complicated by DIC and SPG.

Interventions: Upon intensive care unit admission, the patient received ongoing organ support and anti-infection therapy. Phentolamine was applied via wet compresses to both feet.

Outcomes: Due to anastomotic leakage and multiple organ failure, the patient's family chose to discharge her from the hospital.

Lessons: In cases of SPG, prevention is more important than treatment. Early correction of underlying conditions and identification of risk factors can improve patient outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384844PMC
http://dx.doi.org/10.1097/MD.0000000000044099DOI Listing

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