Overcoming ACQ: DPA-modified TICT-type AIEgens for high-resolution and multilevel latent fingerprint visualization.

Latent fingerprints (LFPs), as critical carriers of personal identification information, present a long-standing challenge for high-resolution imaging in forensic science. Aggregation-induced emission luminogens (AIEgens), known for their superior luminescence in aggregated or high-viscosity environments, have emerged as ideal candidates for high-contrast fingerprint visualization. In this study, we designed a series of novel AIEgens by introducing diphenylamine (DPA) donor groups at the 3- and 11-positions of a quinazolinone core, effectively constructing twisted intramolecular charge transfer (TICT) systems.

The effects of tv/video viewing hours on later ADHD symptoms: a counterfactual analysis in longitudinal population-representative data.

Background: It has been proposed that early-life screen use can impact the development of attention deficit hyperactivity disorder (ADHD) symptoms. Some studies have supported a weak association between higher levels of screen time and ADHD symptoms; however, this association is vulnerable to confounding and a causal explanation remains controversial.

Methods: To help address confounding in this association, we conducted inverse probability of treatment weighting (IPTW) analyses in a large UK-representative longitudinal sample to examine the impact of TV/video viewing at age 3 on ADHD symptoms at age 5.

Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA: Novel Insight Into the Mechanism of Plaque Erosion.

Smoking is the only cardiovascular risk factor for plaque erosion. We found cigarette tar resulted in erosion-like lesion development in apolipoprotein E mice, with mural thrombosis, discontinuous endothelium, platelet activation, smooth muscle cell proliferation, and hyaluronic acid accumulation in the aorta. Single-cell transcriptomics revealed that genes relating to pyroptosis, platelet activation, and leukocytes adhesion were significantly increased in an endothelial cell subset.

Targeting KEAP1/NRF2 interaction with oleuropein ameliorates atherosclerosis by inhibiting macrophage ferroptosis.

Atherosclerosis (AS) is a chronic inflammatory arterial disease. Oleuropein (OL), extracted from olive leaves, has demonstrated broad cardioprotective properties. However, the effects of OL on AS remain to be fully elucidated.

GA-DELLA-OsMYB48-1 module-mediated regulation of inorganic phosphate uptake in rice.

Inorganic phosphate (Pi) is essential for plant growth and development, yet the regulatory role of gibberellic acid (GA) in Pi uptake in rice remains poorly understood. Here, we identified a major quantitative trait locus (QTL) for phosphorus and nitrogen concentrations, which corresponds to an allele of the Green Revolution gene Semi-Dwarf 1 (SD1), encoding GA20-oxidase, a key enzyme in GA biosynthesis. Through functional analyses of near-isogenic lines, genetic complementation, overexpression, and knockout transgenic lines, we demonstrated that SD1 enhances Pi uptake in rice.

Cyberbullying by Chinese Adolescents After Being Cyber-Victimized: How Does Moral Disengagement Affect This Process?

Cyberbullying among adolescents is a serious concern, warranting the attention of both researchers and practitioners. While cyber-victimization is considered one of the most important factors leading to cyberbullying perpetration, more investigation is needed on the underlying mediating mechanisms, especially from a developmental perspective. Based on the social information processing model, this study investigated the direction of the relationship between cyber-victimization and cyberbullying perpetration as well as the underlying developmental mechanisms of moral disengagement.

RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8.

RIPK1 (Receptor-interacting serine/threonine-protein kinase 1) is fundamental in regulating cell proliferation, programmed cell death, and inflammation. Within the TNF (tumor necrosis factor) signaling pathway, the kinase activity of RIPK1 is essential for determining cellular fate, promoting either apoptosis or necroptosis. Mutations disrupting RIPK1 kinase activity significantly impact cellular fate decisions, highlighting its importance in the TNF signaling cascade.

Brusatol Inhibits Esophageal Squamous Cell Carcinoma Tumorigenesis Through Bad-Mediated Mitochondrial Apoptosis Induction and Anti-Metastasis by Targeting Akt1.

Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy characterized by poor prognosis and a deficiency of effective therapies. Brusatol (Bru), a bioactive component derived from , exhibits potent anti-tumor activity. However, the pro-apoptotic and anti-metastatic effects of Bru in ESCC remain unclear.

Chromatin accessibility dynamics and transcriptional regulatory networks underlying the primary nitrogen response in rice roots.

Nitrogen (N) is essential for rice growth; however, the transcriptional regulation of the primary nitrogen response (PNR), characterized by the rapid upregulation of N uptake and assimilation genes upon N resupply, remains poorly understood. This study investigated the dynamics of the PNR in the roots of two rice cultivars (Zhenshan 97 and Nipponbare) via time-series Assay for Transposase-Accessible Chromatin using sequencing and RNA sequencing analyses within 2 h of ammonium nitrate resupply. Regulatory regions responsive to N induction were precisely identified.

Emerging role of the cGAS-STING pathway in cardiovascular diseases: biologic function, mechanisms and targeted therapy.

Currently, cardiovascular diseases (CVDs) represent a substantial threat to human health and wellness. Accumulating evidence has increasingly highlighted the pivotal role of the DNA-activated cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon gene (STING) pathway in the progression of CVDs. The enhanced type I interferon response and the release of pro-inflammatory mediators disrupt cellular redox balance and trigger various cell death modalities, potentially leading to the emergence of adverse events such as atherosclerosis.

Is emotion dysregulation in childhood a precursor to internalising problems in adolescence?

Internalising problems such as anxiety and depression affect a sizeable proportion of adolescents and show a peak age of onset around the transition to adolescence. Emotion regulation issues have been associated with internalising problems; however, it is less clear whether emotion regulation issues in childhood are a causal precursor to internalising problems in adolescence. The present study uses a counterfactual analysis approach in a large-scale UK representative study to assess whether emotion regulation issues at age 7 appear to have a causal impact on internalising problems at age 11,14, and 17, when accounting for confounding factors, including pre-existing internalising problems.

Associations between emotion malleability beliefs and emotion regulation processes in daily life.

Emotion malleability beliefs have been demonstrated to influence emotion regulation at the trait level. Contemporary theories propose that emotion regulation involves several stages: identifying the need to regulate, selecting strategies, and implementing those strategies. It remains unclear how emotion malleability beliefs relate to these stages in everyday life.

Recent advances in the roles of extracellular vesicles in cardiovascular diseases: pathophysiological mechanisms, biomarkers, and cell-free therapeutic strategy.

Cardiovascular diseases (CVDs) represent a profound challenge with inflammation playing a significant role in their pathophysiology. Extracellular vesicles (EVs), which are membranous structures encapsulated by a lipid bilayer, are essential for intercellular communication by facilitating the transport of specific bioactive molecules, including microRNAs, proteins, and lipids. Emerging evidence suggests that the regulatory mechanisms governing cardiac resident cells are influenced by EVs, which function as messengers in intercellular communication and thereby contribute to the advancement of CVDs.

Volatile aromatic substances analysis of different temperature stored 'Docteur Jules Guyot' pear ( L.).

During the post-ripening process of 'Docteur Jules Guyot' pear, the aroma of the fruit gradually becomes richer with increasing maturity. In this study, the volatile substances in 'Docteur Jules Guyot' pear fruits stored at room temperature (RT), low temperature (LT), and low temperature to room temperature (LT-RT) were identified and analyzed using solid-phase microextraction (SPME) with gas chromatography-mass spectrometry (GC-MS) at different ripening stages. The results showed that the volatile substances were mainly alcohols, aldehydes, esters, acids, ketones, alkanes, and terpenes.

1,2-Dichloroethane as a Gaseous Acetylene Source for the Rapid Assembly of Isoquinolino[1,2-]quinazolinone Scaffolds.

Reported herein is a novel ruthenium(II)-catalyzed [4 + 2] annulation of quinazolinones with 1,2-dichloroethane (DCE), resulting in a myriad of isoquinolino[1,2-]quinazolinone scaffolds. In this protocol, DCE serves not only as a solvent but also as an acetylene source. The fused quinazolinones undergo versatile transformations and provide a rapid and convenient way to access several important bioactive molecule analogues such as Rutecarpine, Euxylophoricine B and Euxylophoricine E.

GW806742X can induce mouse MLKL activation by directly promoting MLKL kinase like domain dimerization.

The dimerization of the MLKL kinase-like domain (KLD) is a crucial step for MLKL activation in necroptosis. In 2014, it was discovered that GW806742X can directly bind to the mouse MLKL KLD via surface plasmon resonance (SPR) (Kd = 9.3 μM), inhibiting TNF-induced membrane translocation of MLKL and necroptosis.

Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs.

Immunotherapies, including checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy, have revolutionized cancer treatment; however, many patients remain unresponsive to these treatments or relapse following treatment. CRISPR screenings have been used to identify novel single gene targets that can enhance immunotherapy effectiveness, but the identification of combinational targets remains a challenge. Here, we introduce a computational approach that uses sgRNA set enrichment analysis to identify cancer-intrinsic paralog pairs for enhancing immunotherapy using genome-wide screens.

Implications of the different submerged extent of typical sandbars to local DOM and SDOM during the pre-flood season in the middle reaches of Yangtze River.

In large rivers, sandbar evolution is mainly driven by changes in discharge, flow velocity, and sediment concentration in the water, which can shape the implications of local dissolved organic matter (DOM) and sediment dissolved organic matter (SDOM). After the completion of the Three Gorges Dam (TGD), the water level in the middle reaches of the Yangtze River changes rapidly during the year, and the submerged extent of the Yangtze River sandbars are significantly affected by the change in water level, so that when the water level rises to the defense level or higher, the sandbars may be completely submerged. As a result, different submerged extent such as periodically and long-term have occurred on the typical sandbars.

Bidirectional Relationships between Adolescent Aggression and Mental Health Conditions: Longitudinal Evidence from Secondary School Students in China.

A rising global concern, adolescent aggression has been linked to adolescents' mental health conditions, and vice versa. Although longitudinal relationships between the two have been studied, within-person associations between these variables, which are important for informing interventions, have not been adequately examined. To bridge that research gap, this study examined the within-person associations between aggression (i.

[Research progress on the role and mechanism of ferroptosis in heart diseases].

Cardiovascular disease remains the leading cause of death in China, with its morbidity and mortality continue to rise. Ferroptosis, a unique form of iron-dependent cell death, plays a major role in many heart diseases. The classical mechanisms of ferroptosis include iron metabolism disorder, oxidative antioxidant imbalance and lipid peroxidation.

LncRNA GAS5 Regulates Myometrial Cell Contractions in an m6A-Dependent Manner.

LncRNAs are engaged in signaling pathways in human physiological and pathological states. However, LncRNAs mediate the onset of human labor still remains unknown. RNA sequencing of lower segment myometrium (in labor vs.

Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque.

Background: Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to the progression of atherosclerosis (AS). Meanwhile, Spermine (Sp) could serve as an endogenous small molecule exhibiting a wide range of cardiovascular protective effects.

Methods: Zeolitic imidazolate framework-90 (ZIF90) nanoparticles were synthesized and utilized to create a novel delivery nanosystem encapsulated with Sp (CD16/32-ZIF90@Sp).