Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.

Background: Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches.

Methods: Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites.

High-Value Conversion of Biomass-Derived Chemicals by In Situ Construction of Ni(OH)/CeVO@NF Catalysts Enriched with Oxygen Vacancies.

2,5-Furandicarboxylic acid (FDCA), synthesized via selective oxidation of 5-hydroxymethylfurfural (HMF), is a structural analog to petroleum-derived terephthalic acid (PTA) and a key precursor for renewable polyesters like polyethylene furanoate (PEF). Recent advances in electrocatalytic HMF oxidation (HMFOR) enable efficient synthesis under mild conditions, aligning with renewable energy integration. In this work, catalysts with oxygen-rich vacancies by growing Ce, V bimetallic-dopsynthesizeded Ni(OH) nanosheets in situ on nickel foam for electrocatalytic HMF oxidation to FDCA are prepared.

"One Rocket, Multiple Satellites": Natural Small Molecule Nanocarriers With In-Situ Nanosphere-to-Nanofiber Transition for Combined Chemo/PDT/Anti-Angiogenic Antitumor Therapy.

Drug delivery based on dynamic morphological transformation represents the cutting-edge strategy at the forefront of chemotherapy, integrating individual advantages that depend on the delivery stage and spatially resolved morphology. However, developing a tumor-specific, in vivo morphologically transformable small-molecule drug delivery system to achieve enhanced drug accumulation and photodynamic therapy (PDT) efficacy remains challenging. In this study, a multifunctional PDT formulation using natural small molecules as nanocarriers is developed, combining a tumor-targeting photosensitizer and anti-angiogenic therapy.

Metabolic Mechanism of Qizhi Capsule for Treating Hyperlipoidemia Based on Chinmedomics Strategy.

To elucidate the active ingredients, and mechanism of action of Qizhi Capsules (QZC), a traditional Chinese patent medicine for the treatment of hyperlipidemia (HP). A high-fat diet-induced HP rat model was used to evaluate the therapeutic effect of QZC. Then, we integrated metabolomics, serum pharmacochemistry, network pharmacology, and molecular docking strategies for investigation.

Superior High-Temperature Energy Storage Performance in All-Organic Composite Dielectrics Achieved by Synergistic Regulation of Free Volume and Charge Distribution.

Developing polymer dielectrics with stable high-temperature energy storage performance remains a pivotal challenge for next-generation electrical systems. However, the exponentially increasing conduction loss at elevated temperatures results in a decline in both energy storage density and efficiency. Herein, a cross-scale synergistic regulation strategy that integrates mesoscale free volume and molecular-scale charge trap, effectively addressing the issue of free volume collapse and space charge accumulation under thermal-electric coupling stress is proposed.

Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.

The utilization of mesenchymal stem cells (MSCs) serves as an encouraging strategy for treating liver fibrosis. However, precise mechanisms are not completely understood. Recently, small extracellular vesicles (sEVs) have emerged as major paracrine effectors mediating the anti-fibrotic effects of MSCs.

Nuclear Magnetic Resonance Based Metabolomics-A Rising Star in Traditional Chinese Medicine Research.

Metabolomics, a promising field in the realm of omics, focuses on the investigation of alterations and patterns in the composition and abundance of metabolites generated by organisms under perturbation, directly linking measurable chemical reactions with biological events. Its research philosophy aligns harmoniously with the holistic perspective and syndrome differentiation and treatment principles of traditional Chinese medicine (TCM). Consequently, metabolomics has garnered unparalleled attention and has been widely applied in various fields of TCM research such as disease diagnosis, effective constituents and mechanism related with efficacy.

Definition and validation of recompensation in patients with primary biliary cholangitis-related decompensated cirrhosis treated with ursodeoxycholic acid: Based on the BAVENO VII criteria.

Background And Objectives: Few studies have provided real-world data on the biochemical response, risk assessment, and prognosis of patients with primary biliary cholangitis (PBC)-related decompensated cirrhosis undergoing ursodeoxycholic acid therapy. The objective of this study is to define recompensation in this patient population based on the BAVENO VII criteria.

Methods: This retrospective analysis included 170 patients with cirrhosis who presented with ascites, hepatic encephalopathy, and/or variceal bleeding as their initial decompensating events at Xijing Hospital from 2006 to 2023.

N,O-Alternant Belt[3]arene Utilized for Construction of Multi-Color Supramolecular TADF Materials and Highly Selective Detection of 2-Cyanopyrazine.

In this work, 3,6-dimethoxycalix[3]acridine (3,6-DMO-C[3]A), as a new macrocyclic arene, was synthesized and then applied to the construction of a new kind of N,O-alternant belt[3]arene (NOAB[3]A) by the conversion approach from macrocycle to belt. NOAB[3]A has a regularly hexagonal structure and electron-rich cavity, and it can be successfully utilized as an electron donor to construct supramolecular thermally activated delayed fluorescence (STADF) materials with multi-color emissions by its complexation with electron acceptors with different electron-deficient abilities. Notably, due to the formation of STADF accompanied by fluorescence enhancement and redshift when NOAB[3]A combines with the cyanide-containing aromatic compounds, the belt[3]arene can also be directly used for highly selective, sensitive, and visual detection of 2-cyanopyrazine (2-CP) vapor at trace level.

METTL3 mediates mA methylation of ADAM17 to Downregulate ACE2-Ang-(1-7) axis and promote progression of hypertension.

Introduction: Features of hypertension include imbalance between vascular relaxation and constriction along with vascular remodeling caused by endothelial dysfunction, further increasing peripheral resistance and blood pressure (BP). While N-methyladenosine (mA) modifications of RNA mediated by methyltransferase-like 3 (METTL3) regulates certain endothelial function, its roles and mechanisms in hypertension remain unknown.

Objectives: This study was to examine roles of METTL3-mA and its regulating targets on BP, cardiovascular function, and remodeling in hypertensive mice.

Application of 32P Radioactive Patch in Keloid Treatment.

Keloid, as a benign fibroblastic disease of the skin, is the result of excessive proliferation of fibroblasts and abnormal deposition of collagen during the process of skin trauma repair. Clinically, this disorder presents as a fibrous proliferation that protrudes beyond the surface of the skin beyond the margins of the original injury, affecting both function and aesthetics. In clinical treatment, the P radioactive patch is a well-established and effective treatment based on the biological effect of β-rays, which can penetrate keloid tissue, induce apoptosis of fibroblasts in the keloid, impede cell proliferation, and inhibit excessive collagen synthesis and deposition, and eventually achieve the desired therapeutic effect after a period of treatment.

Lignin-derived self-assembled 2D N-doped carbon nanosheets as effective oxygen-redox electrocatalysts for rechargeable zinc-air batteries.

Two-dimensional (2D) carbon nanomaterials are widely used in electrocatalytic reactions due to their enhanced electron mobility and excellent structural stability. Nevertheless, the complexity of its synthesis process limits its large-scale application. In this study, layered porous 2D lignin-derived carbon nanosheets were successfully synthesized using various salts as templates combined with an antisolvent technique.

Uniaxial compressive strength of cemented coal gangue backfill based on response surface methodology.

Cemented Coal Gangue Backfill (CCGB) plays a pivotal role in sustainable mining practices, as its uniaxial compressive strength (UCS) directly dictates backfill stability, mining safety, and operational efficiency. However, existing research has yet to fully elucidate how key mix proportion parameters synergistically influence UCS across different curing stages, leaving a critical gap in optimizing CCGB performance. This study addresses this limitation by systematically investigating the factors governing CCGB's UCS under varied mix designs.

The relationship between high school English learners' anxiety and their smartphone addiction: evidence from a daily diary approach.

Background: The issue of smartphone addiction among high school English learners is becoming more and more significant in this era of information technology, and it is directly associated with their anxiety.

Methods: To examine the correlation between high school English learners' anxiety level and the severity of smartphone addiction, the anxiety and smartphone addiction levels of high school English learners were explored. SPSS 26 and MPLUS 8.

Label-free microfiber biosensor for ultrahigh sensitivity detection of TNF-α protein.

Rapid detection of low concentrations of tumor necrosis factor-α (TNF-α) plays an important role in medical diagnostics. This study proposed a fast, label-free single mode-tapered no core-single mode (STNCS) microfiber structure for the ultra-low concentration of TNF-α detection. The experimental results show that the proposed microfiber biosensors have good spectral stability (0.

ZrS as a saturable absorber for the -cut Tm:YAP laser.

Zirconium disulfide () has gained significant interest as a two-dimensional semiconductor material due to its remarkable nonlinear optical performance. This study fabricated a saturable absorber (SA) via liquid-phase exfoliation, and its nonlinear optical properties were evaluated using the I-scan technique. For the first time, to our knowledge, was employed as an SA to realize a stable 1934 nm passively Q-switching Tm:YAP laser with modulation functionality.

Case Report: Genetic predisposition to low-dose NSAID-induced liver injury in real-world China.

Non-steroidal anti-inflammatory drug (NSAID)-induced liver injury represents approximately 10% of reported drug-induced liver injury (DILI) cases, predominantly through idiosyncratic mechanisms. While epidemiological data are largely derived from Western populations with high NSAID utilization, China exhibits lower use of NSAIDs due to cultural preferences and the widespread use of traditional therapies. During the 2022-2023 Omicron outbreak in China, we observed a surge in DILI cases coinciding with increased NSAID use.

Assessing genetic causal relationship between milk fat content and chronic kidney disease: a two-sample Mendelian randomization study.

This study investigates the genetic causal relationship between milk fat content and chronic kidney disease (CKD) using publicly available genome-wide association study (GWAS) data. Single nucleotide polymorphisms (SNPs) significantly associated with milk fat content were identified following rigorous quality control procedures. A two-sample Mendelian randomization (MR) approach was used to analyze the relationship between three milk fat levels and CKD risk.

Energy-landscape analysis of brain network dynamics in a multi-center Alzheimer's disease and mild cognitive impairment cohort.

Convergent dynamic functional connectivity studies have demonstrated their potential as a hallmark for capturing the impairments in brain function associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, understanding whole-brain dynamics patterns remains limited, hampering the understanding of cognitive impairment and symptomatology for AD and MCI. An energy-landscape analysis was conducted to investigate brain dynamics across seven large-scale networks in 516 normal controls (NC), 404 AD patients, and 441 MCI participants from a multi-center cohort.

Potential candidate genes influencing meat production phenotypic traits in sheep: a review.

This review examines the genetic basis of meat production phenotypic traits in sheep, addressing the challenge of enhancing carcass and meat quality to meet global demand. The article identifies key potential genes associated with vertebral traits, body size, muscle development, and fat deposition across diverse sheep breeds worldwide. Through comprehensive analysis of recent literature (2018-2025), the study synthesizes findings from genome-wide association studies, candidate gene approaches, and transcriptomic analyses.

Structural MRI-based Computer-aided Diagnosis Models for Alzheimer Disease: Insights into Misclassifications and Diagnostic Limitations.

Purpose To examine common patterns among different computer-aided diagnosis (CAD) models for Alzheimer's disease (AD) using structural MRI data and to characterize the clinical and imaging features associated with their misclassifications. Materials and Methods This retrospective study utilized 3258 baseline structural MRIs from five multisite datasets and two multidisease datasets collected between September 2005 and December 2019. The 3D Nested Hierarchical Transformer (3DNesT) model and other CAD techniques were utilized for AD classification using 10-fold cross-validation and cross-dataset validation.

Autophagy-to-Apoptosis Conversion Mediated by GIMAP7 Exhibit Anti-RSV Action.

RSV is a notable respiratory pathogen. GIMAP7, an essential member of the immune protein family, might mitigate RSV infection. The aim of this project is to determine GIMAP7's function during RSV infection and evolve drugs targeting it.

The Role of TGF-β Signaling Pathway in Determining Small Ruminant Litter Size.

The transforming growth factor-beta (TGF-β) superfamily plays a crucial role in regulating female reproductive traits, particularly litter size, in small ruminants, such as sheep and goats. This review comprehensively examines the molecular mechanisms through which TGF-β superfamily members-including bone morphogenetic proteins (), growth differentiation factor 9 (), inhibin ( and ), and associated signaling genes-influence ovarian follicular development, ovulation rate, and ultimately, litter size. We synthesize recent findings on polymorphisms in key genes, such as , , and family genes, across diverse sheep and goat breeds worldwide.

Plumbagin targets the GLUT1/MMP-2 axis to inhibit oral squamous cell carcinoma progression.

Aim: This study aimed to investigate the clinicopathological characteristics and prognostic value of GLUT1 in oral squamous cell carcinoma (OSCC) and the effect of plumbagin (PLB) on inhibiting OSCC invasion and metastasis through the GLUT1/Matrix Metalloproteinase 2 (MMP2) axis pathway.

Materials And Methods: One hundred and twenty human OSCC specimens were collected. Immunohistochemistry was performed to analyze the expression, clinicopathological characteristics, and prognostic value of GLUT1 in these specimens.