Valley-Layer-Polarized Anomalous Hall Effect in a Two-Dimensional Multiferroic van der Waals Material.

Emerging phenomena such as the valley Hall effect and layer Hall effect, showing promise for next-generation electronics and valleytronic devices, have attracted considerable attention. However, most studies of the layer Hall effect have been restricted to antiferromagnetic or topological systems. Based on first-principles calculations, we establish a valley-layertronics framework and predict that two-dimensional ScI is a multiferroic material exhibiting substantial spontaneous valley polarization in both its monolayer (93.

Masked minds: The effects of wearing masks on malevolent creativity.

This research provides the first empirical investigation into how embodied experiences influence malevolent creativity. While prior studies have linked embodiment to general creativity, the impact of specific bodily states-such as mask-wearing-on malevolent creativity remains unexplored. Across two between-subjects experiments (Experiment 1: N = 100; Experiment 2: N = 100), we examined the psychological mechanisms underlying this effect.

A Novel Nomogram for Preoperative Prediction of Early Postoperative Mortality in Patients Undergoing Surgical Revascularization for Acute Myocardial Infarction.

Background: Despite advancements in surgical techniques, coronary artery bypass grafting (CABG) for patients with recent acute myocardial infarction (AMI) remains associated with relatively high mortality. Risk prediction in these patients is essential. The aim of this study was to develop a nomogram model to predict the early postoperative mortality in patients undergoing surgical revascularization for AMI based on preoperative clinical features.

Mechanisms and Management of Albumin-Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer.

Breast cancer incidence continues to rise globally, with molecular subtyping now playing a critical role in prognosis and treatment selection. The main subtypes-Luminal A, Luminal B, HER2-enriched, and triple-negative breast cancer (TNBC)-exhibit distinct clinical behaviors and treatment responses, with respective molecular characteristics. Chemotherapy plays a pivotal role in the comprehensive treatment of breast cancer, being widely used in neoadjuvant, adjuvant, and metastatic systemic therapy.

Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.

While metal exposures are linked to cardiovascular and renal diseases, their role in cardiorenal comorbidity remains poorly understood. Using the American Heart Association's Cardiovascular-Kidney-Metabolic Syndrome (CKM syndrome) framework, we combined population epidemiology and Adverse Outcome Pathway (AOP) analysis to explore how cadmium exposure influences CKM progression and advanced-stage outcomes. Data from 5865 adults aged 30-79 years in the National Health and Nutrition Examination Surveys (NHANES) were analyzed to investigate serum metal exposure patterns and CKM syndrome progression.

Label-free microfiber biosensor for ultrahigh sensitivity detection of TNF-α protein.

Rapid detection of low concentrations of tumor necrosis factor-α (TNF-α) plays an important role in medical diagnostics. This study proposed a fast, label-free single mode-tapered no core-single mode (STNCS) microfiber structure for the ultra-low concentration of TNF-α detection. The experimental results show that the proposed microfiber biosensors have good spectral stability (0.

The Effects of Rukangyin on the Biological Behavior and Hippo Signaling Pathway in MDA-MB-231 Breast Cancer Cells.

Introduction: This study aims to examine the impact of Rukangyin (RKY) and its components, LSQR and QTSS, on various cellular processes and signaling mechanisms in MDA-MB-231 triple-negative breast cancer (TNBC) cells.

Methods: Twenty-five Sprague-Dawley (SD) rats were randomly assigned to five groups according to the administered drugs, including the RKY group, LSQR group, QTSS group, fluorouracil group, and blank control group (n=5 in each group). The serum samples from each group were then used as a medicated medium for the culture of the TNBC cell line MDA-MB-231.

Integrated Omics Reveal Lindl.'s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways.

: Lindl. (DNL), a traditional dietary supplement, exhibits therapeutic potential for type 2 diabetes mellitus (T2DM), yet its mechanisms remain unclear. : T2DM was induced in / mice.

1,4-Dearomatization of Pyridines and Quinolines Enabled by the Carbodication Lewis Acid.

1,4-Dihydropyridines (DHPs) are valuable compounds in medicinal chemistry and organic synthesis. The most straightforward pathway for preparing 1,4-DHPs is the direct 1,4-reduction of pyridines and quinolines. However, existing strategies are not effective for pyridines with electron-withdrawing substituents at the C2 position.

The first report of load and congener group profile of short-chain chlorinated paraffins (SCCPs) in mackerel icefish Champsocephalus gunnari and painted notie Nototheniops larseni at South Georgia, Antarctic during winter.

Short-chain chlorinated paraffins (SCCPs), as a class of emerging persistent organic pollutants, with the capabilities of persistence, bioaccumulation, and long-distance transmissibility, listed in the Stockholm Convention, have received widespread attention in recent years. The study on SCCPs in Antarctica biota, however, are extremely limited, especially during the winter. In this study, we therefore for the first time examined SCCPs in two fish species, mackerel icefish Champsocephalus gunnari and painted notie Nototheniops larseni, with different life-history patterns but of both ecological importance at South Georgia during austral winter.

A U-shaped microfiber ring laser sensor for ultrasensitive detection of Ni ions.

As a common heavy metal pollutant, Ni necessitates a rapid, sensitive, and accurate detection method to mitigate its impact on human health and the environment. This study developed a U-shaped single mode-tapered four core-single mode (STFS) based fiber ring laser (FRL) sensor coated with Ni ion-imprinted chitosan (Ni-II-CS) for Ni detection. Experimental results demonstrate that the average spectral stability in deionized water is 0.

Energy optimization model of multi-energy system considering distributed photovoltaic coordinated carbon reduction.

Aiming at the problems of complex characteristics such as nonlinearity, multivariable, and strong coupling in the energy optimization process of thermal power plant station under the carbon reduction constraints due to the multiple types of equipment and large amount of operation data in the multi-energy system (MES), an energy optimization method of multi-energy system considering distributed photovoltaic coordinated carbon reduction is proposed in this paper. Firstly, the energy characteristic model of the MES in the production process of energy input, output and conversion is established. The interaction between various systems, equipment and other elements of the MES is deeply studied, and the energy characteristic analysis method of the MES is proposed.

Artificial Intelligence Algorithm Predicts Response to Immune Checkpoint Inhibitors.

Purpose: Cancer treatment has been revolutionized by immune checkpoint inhibitors (ICI). However, a subset of patients do not respond and/or they experience significant adverse events. Attempts to integrate reliable biomarkers of ICI response as part of standard care have been hampered by limited generalizability.

Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways.

Diabetic nephropathy (DN) exhibits profound spatial metabolic heterogeneity across kidney regions, yet how compartmentalized pathways drive disease progression remains poorly defined. A deeper understanding of the organizational spatial environment and metabolic pathways of diabetic kidney damage will provide new insights to develop new therapies. By integrating high-resolution spatial multi-omics and single-cell transcriptomics, we mapped region-specific metabolic dysregulation in diabetic kidneys, identifying glutathione metabolism, pentose phosphate, and glycolytic pathways as zonally disrupted in cortical and medullary regions.

Senescence in cancer.

Cellular senescence is a state of stable cell-cycle arrest induced by various intrinsic and extrinsic stressors, serving as a protective mechanism to prevent the proliferation of damaged cells. While this process is crucial for tissue homeostasis and tumor suppression, the progressive accumulation of senescent cells (SnCs) over time is implicated in age-related pathologies, including immune dysfunction and cancer. In oncology, senescence plays a paradoxical role: it can inhibit tumor development by halting the growth of potentially malignant cells, yet it may also facilitate tumor progression through the senescence-associated secretory phenotype (SASP).

Development of an Early-Warning Model for Predicting the Capecitabine-Induced Diarrhea.

Objective: Diarrhea is primary adverse effect of capecitabine (Cap) causing treatment discontinuation. The aim of this study was to construct an early-warning model for predicting the Cap-induced diarrhea.

Methods: A Cap-induced diarrhea model in mice was constructed in 36 mice, and the exposure levels of Cap and its five metabolites were quantified in plasma and colon and correlated their exposure levels to the diarrhea.

Association between endocrine disrupting chemicals exposure and the risk of all-cause mortality in individuals with diabetes mellitus or its complications: A prospective cohort study.

Objective: To investigate the association between exposure to endocrine disrupting chemicals (EDCs) and all-cause mortality in individuals with diabetes mellitus (DM) in U.S., including those with diabetic complications.

Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes.

Importance: Exposure to high altitudes elicits multiple adaptive mechanisms that intricately impact the entire body, causing deleterious health outcomes. However, high-altitude exposure effects on accelerated aging and aging-related changes remain uncertain.

Objective: To comprehensively assess the associations of high-altitude exposure with overall aging and related changes and to provide insights into the treatment and prevention of aging-associated deficits in populations living in high-altitude areas.

Fabrication of polydopamine-altered PCL/PLGA nanofibrous scaffolds on cerium to enhance cytocompatibility, microbial inhibition, and improved osteogenic properties for tissue regeneration in orofacial treatment.

Biodegradable scaffolds have significant potential for directed tissue regeneration in craniofacial and oral applications and bone regeneration. We designed an innovative cerium-altered/collagen-clacked polycaprolactone/poly-lactic-co-glycolic acid (PC/PL) electrospun scaffolds (PC/PL-PD-Ce-CL) to address the deficiencies of existing scaffold materials regarding osteogenic and antimicrobial characteristics. Novel scaffolds were developed by electrospinning a fundamental PCL/PLGA matrix, impregnating in situ reduction with cerium nanoparticles (CeNPs), applying a polydopamine coating, and clacking with collagen.

Analysis of Phthalate Monoesters and Bisphenols in Human Prostate Cancer Tissue and Urine.

A growing concern has been raised about human exposure to phthalates and bisphenols, while data is limited regarding the accumulation of these endocrine disrupting chemicals at the target tissue. In this study, a novel, simple, and sensitive method was successfully developed for the simultaneous determination of nine phthalate monoesters and nine bisphenols in human prostate tissue samples. A solid-liquid extraction procedure was applied following ultra-high performance liquid chromatography tandem mass spectrometry analysis.

A Preliminary Study on the Therapeutic Role of γδT Cells in Triple-Negative Breast Cancer.

This study was aimed to elucidate the cytotoxic effects of γδT cells on triple-negative breast cancer (TNBC) cells and assess their antitumor efficacy in a mouse xenograft model. Furthermore, the underlying mechanisms of γδT cell action on TNBC were explored. The study utilized three TNBC cell lines (MDA-MB-231, MDA-MB-468, and BT-549) as target cells, with γδT cells serving as effector cells.

Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis.

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their bioaccumulative nature. Reduced bone mineral density (BMD) is associated with an increased risk of developing osteoporosis. This pioneering study aims to assess the effects of different PFAS compounds on bone mineral.

Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients.

Amis: Chemotherapy-induced hepatotoxicity (CIH) is a significant concern in colorectal cancer (CRC) patients treated with the CAPEOX (capecitabine and oxaliplatin) regimen. Identifying predictive factors for CIH is crucial for clinical management.

Patients And Methods: This study analyzed colorectal tissue (CRT), plasma, and urine samples from CRC patients.

Revealing the role of bisphenol A on prostate cancer progression and identifying potential targets: A comprehensive analysis from population cohort to molecular mechanism.

Bisphenol A (BPA) is a widespread environmental pollutant whose exact effects on prostate cancer (PCa) progression remain understudied. This study aims to investigate the effect and underlying molecular mechanisms between BPA exposure and PCa in a comprehensive approach. The multicenter cohort study found that BPA exposure plays an important role in promoting biochemical recurrence and death of PCa.