Ethanol Infusion of the Vein of Marshall in Catheter Ablation of Persistent Atrial Fibrillation in Patients with Mitral Valve Replacement.

Background: The effectiveness of ethanol infusion of the vein of Marshall (EIVOM) for persistent atrial fibrillation (AF) in patients with mitral valve replacement (MVR) remains to be determined.

Objectives: This study investigated the effectiveness and safety of EIVOM in catheter ablation of persistent AF in patients with MVR.

Methods: This is a retrospective case-control study.

An HIV fusion-inhibitory lipopeptide provides robust post-exposure prophylaxis and prevents viral reservoir seeding in macaques.

LP-98 is a lipopeptide HIV fusion inhibitor showing strong treatment and pre-exposure prophylaxis efficacies in non-human primates. In this study, we further characterized its pharmacokinetics, long-lasting antiviral activity, and post-exposure prophylaxis (PEP) efficacy using 62 macaques. In cynomolgus macaques, LP-98 achieved high concentrations (C) with a half-life (T) of ∼31 h, and sustained an effective therapeutic concentration for two weeks post-injection.

MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy.

Chemoresistance is the leading cause of cancer-related death. How chemotherapy subjugates the cellular crosstalk in the tumour microenvironment to cause chemoresistance remains to be defined. Here we find chemotherapy enables immunosuppressive SDF1 endothelial niche to evade immunosurveillance in ovarian and breast cancers.

PRDX3 promotes nasopharyngeal carcinoma tumor growth by regulating PINK1/Parkin pathway-dependent lipid peroxidation and mitochondrial dysfunction.

Background: Nasopharyngeal carcinoma (NPC) is a challenging malignancy characterized by aggressive progression and limited therapeutic efficacy. Emerging evidence implicates peroxiredoxin 3 (PRDX3), a mitochondrial peroxidase, as a critical regulator of redox homeostasis and mitochondrial integrity. Given its role in modulating cell death through mitochondrial quality control, we investigated the therapeutic potential of targeting PRDX3 in NPC.

Effect of Oral Direct Factor Xa Inhibitors on the Prevalence of Hip Heterotopic Ossification following Arthroplasty for Acute Femoral Neck Fracture: A Propensity Score-Matched Cohort Study.

Background: Heterotopic ossification (HO) is a common complication following hip arthroplasty that can limit hip range of motion (ROM). Oral direct factor Xa (FXa) inhibitors are commonly used anticoagulants after arthroplasty; however, they have a high risk of local bleeding and hematoma formation, which are significant triggers for HO formation. To our knowledge, there is no evidence regarding whether FXa inhibitors will increase HO incidence following hip arthroplasty.

Decahedron-derived five-fold twin noble metal nanocrystals: Solution-phase synthesis, growth mechanism, and applications.

Five-fold twinned (FFT) noble metal nanocrystals have attracted considerable interest in nanoscience due to their unique structures. This review gives a comprehensive analysis on four common types of FFT noble metal NCs (Au, Ag, Pd, and Pt) synthesized in solution, covering both monometallic structures (e.g.

Acute kidney injury: pathogenesis and therapeutic interventions.

Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and heterogeneous, primarily attributed to metabolic disturbances arising from the disease itself and the administration of medications related to treatment. In recent years, AKI in cancer patients is highly concerned.

[Therapeutic mechanism of Compound Xuanju Capsule on erectile dysfunction].

Objective: To investigate the pharmacological mechanism of Compound Xuanju Capsule in the treatment of erectile dysfunction (ED) by using network pharmacology and molecular docking technology.

Methods: The active ingredients and targets of Compound Xuanju Capsule were screened using Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP). TTD, OMIM, DrugBank and GeneCards databases were used to obtain genes related to ED, and the union of the results was taken as the disease genes of ED.

Solar-Driven Interfacial Evaporation: Material Types, Structural Strategies, and Emerging Applications.

Solar-driven interfacial evaporation (SDIE) is an emerging eco-friendly and low-carbon technology and has been widely studied in the field of photothermal applications in recent years. With the attention and development of SDIE in innovation fields, new strategies, structures, and typical materials are gradually being developed and applied. Therefore, it is important to report on these latest developments.

Frequent use of online medical records: analysis of influence factors based on structural equation modeling.

The advent of electronic storage of medical records and the internet has led to an increase in the use of online medical records, thereby enhancing doctor-patient communication and facilitating medical treatment. Based on demographic and personal behavioral characteristics from the National Cancer Institute's 2019-2020 National Trends in Health Information Survey data, this study explored the characteristics and factors influencing the frequent use of online medical records and compared them with those that do not. By combining traditional statistical tests and two machine learning algorithms, eight variables were identified as key variables in the frequent use of online medical records.

Prognostic value and predictive model construction for patients undergoing laparoscopic radical prostatectomy based on the preoperative NPL-IRS score and prognostic nutritional index.

Objective: To explore the prognostic value of preoperative hematological indicators for prostate cancer (PCa) patients with laparoscopic radical prostatectomy (LRP) and construct a nomogram prediction model based on hematological indicators and clinicopathological characteristics.

Method: PCa patients who underwent LRP in Beijing Chaoyang Hospital from January 2017 to December 2022 were retrospectively analyzed. Clinicopathological data and blood indicators, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), red blood cell distribution width (RDW), prognosis nutritional index were compared between non-recurrence and recurrence groups.

Retrospective analysis of the impact of human papillomavirus infection in the male genital tract on sperm: from a single center.

Objective: This study primarily aimed to investigate human papillomavirus (HPV) infection in males and to evaluate its effect on semen parameters, fertility and partner HPV infection status.

Methods: A total of 624 men who visited the West China Second Hospital of Sichuan University between October 1, 2019, and September 30, 2023, were included. HPV DNA was detected in exfoliated cells from the male genitalia using polymerase chain reaction (PCR) and reverse membrane hybridization to analyze the relationship between HPV infection and semen parameters.

RESP2: An Uncertainty Aware Multi-Target Multi-Property Optimization AI Pipeline for Antibody Discovery.

Discovery of therapeutic antibodies against infectious disease pathogens presents distinct challenges. Ideal candidates must possess not only the properties required for any therapeutic antibody (e.g.

Associations Between Hematologic Parameters and All-Cause Death in Individuals With Cardio-Renal-Metabolic Multimorbidity: A National Cohort Study.

Background: Cardio-renal-metabolic multimorbidity is common and a major cause of death. This study investigates the associations between hematologic parameters and all-cause death, aiming to redefine complete blood count reference intervals for individuals with cardio-renal-metabolic multimorbidity.

Methods: The study cohort consisted of 4482 adults drawn from the National Health and Nutrition Examination Survey conducted between 1999 and 2018.

Coffee-Ring Suppression in Inkjet-Printed Perovskite Films Enabled by a Shape-Anisotropic Nanorod Solute Strategy.

Achieving uniform perovskite thin films via inkjet printing remains a significant challenge due to the pervasive coffee-ring effect. Here, we present a solute engineering strategy that incorporates shape-anisotropic perovskite nanorods into a single-solvent ink formulation, effectively suppressing coffee-ring formation and yielding ultraflat films with an average roughness (Ra) as low as 0.226 nm.

Enhanced catalytic oxidative depolymerization of lignin to aromatic compounds by activated carbon-supported polyoxometalate-ionic liquid catalysts.

Lignin, a major component in renewable plant biomass, serves as a potential source of high-value aromatic chemicals. However, efficiently decomposing lignin while maintaining its aromaticity for fossil fuel substitution remains a significant challenge. This study synthesized a [VimAm]Br@POM@AC catalyst, composed of a Keggin-type polyoxometalate (POM) modified by ionic liquid ([VimAm]Br) and supported on activated carbon (AC).

Tumors hijack macrophages for iron supply to promote bone metastasis and anemia.

Bone marrow is both a primary site for hematopoiesis and a fertile niche for metastasis. The mechanism of the common occurrence of anemia among patients with bone metastasis remains poorly understood. Here, we show that a specialized population of VCAM1CD163CCR3 macrophages, normally essential for erythropoiesis by transporting iron to erythroblasts, are highly enriched in the bone metastatic niche in mouse models.

CTRP3 mitigates sepsis-induced impairment of endothelial barrier function by suppressing pyroptosis in endothelial cells.

Acute lung injury significantly contributes to mortality in bacterial sepsis due to lung endothelial barrier destruction, leading to protein-rich lung edema, an influx of proinflammatory leukocytes, and persistent hypoxemia. CTRP3, an adipokine, reduces endothelial adhesion molecules Vcam-1 and Icam-1 and inhibits LPS-induced monocytic adhesion, highlighting its anti-inflammatory effects. This study investigates CTRP3's protective role in sepsis-induced acute lung injury, revealing reduced CTRP3 expression during sepsis, which worsens endothelial dysfunction.

Chain-Transported Hypercoordinated Chloroaluminate Electrolyte for Solid-State Aluminum-Ion Batteries.

Aluminum-ion batteries (AIBs) have garnered significant attention due to their high safety and environmental compatibility. However, their practical development has been hindered by conventional liquid electrolytes, which suffer from a narrow electrochemical stability window and interfacial instability. Here, we develop a hypercoordinated chloroaluminate electrolyte (HCCAE) for low-cost and long-life solid-state AIBs, featuring a chain-assisted ion transport mechanism.

Upgrading Coal Gangue Waste into Molecular Sieves for Sustainable Wastewater Purification.

The disposal and management of coal gangue (CG) waste from coal mining pose significant environmental pollution challenges. Here, we propose utilizing CG as raw material to synthesize CG-based NaA-type molecular sieves (CG@NaA MS) through a high-temperature alkali fusion combined with a hydrothermal process. This approach enables the sustainable treatment of copper ions and methylene blue (MB) in wastewater.

Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.

Background: Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches.

Methods: Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites.

Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.

Spinal V3 interneurons are glutamatergic neurons that are distributed among the dorsal, intermediate, and ventral spinal cord. They are involved in broad neural circuit connections in the central nervous system. Functionally, they play important roles in locomotion, such as the maintenance of robust and balanced gaits during walking.

A Data-Driven Mathematical Model for Clonorchiasis with Seasonality.

Clonorchiasis is a foodborne disease caused by parasites and transmitted to humans through intermediate hosts. Clonorchis sinensis parasitizes in the bile ducts of human liver and causes organ lesions. The cercariae and metacercaria of Clonorchis sinensis have seasonal variations and may be affected by high water temperature in summer.

Ultra-stable panchromatic luminescent BaMoO/CsPbX (X = Cl, Br, I) heterostructures by suppressing interfacial charge transfer.

Constructing perovskite heterostructures with restricted interface charge transfer is crucial for improving stability and optoelectronic performance, as well as expanding multifunctional applications. Herein, a one-step solvent-free thermal assisted epitaxial growth strategy is proposed to construct BaMoO/CsPbX (X = Cl, Br, I) heterostructures. Derived from the high lattice matching of 90.

Data-Driven Backstepping Control for a Class of Unknown Nonlinear Strict-Feedback Systems.

The tracking control problem for strict-feedback systems with unknown dynamics has been extensively studied. However, most existing control approaches require online approximation models and associated a priori assumptions. In order to avoid the necessity of deriving online models, this article proposes a data-driven backstepping control (DBC) approach for a class of strict-feedback systems with unknown dynamics.