Fully Erasable Amphibious Adhesives Derived from Soybean Oil with Record-High Underwater Adhesion Strength.

Developing amphibious adhesives that combine high adhesion strength with on-demand erasability in both dry and wet environments remains a significant challenge. In this study, biomass-derived, amphibious, and erasable adhesives are fabricated by grafting 3-aminobenzoic acid and 3-aminobenzeneboronic acid onto epoxidized soybean oil (ESO), yielding ESO-Am adhesives. These adhesives are dynamically cross-linked with boroxines, hydrogen bonds, and hydrogen-bonded hydrophobic nanodomains.

Enhancing the output of cellulose-based triboelectric nanogenerators via dual interfacial polarization effects.

Cellulose-based triboelectric nanogenerators (TENGs) have garnered significant attention in wearable electronics due to their biodegradability and abundant availability. However, the near-electroneutrality of cellulose hinders its advancement and broader application in high-performance TENGs. In this study, the triboelectric polarity of cellulose nanofibers (CNF) is modified by grafting different functional groups, wherein the incorporation of polar sulfonic acid groups enhances the deep trap density on the surface of CNF by an order of magnitude, reduces charge dissipation rates, and increases surface potential by nearly 200 % compared to untreated CNF.

Glycyrrhetinic acid functionalized polyamidoamine dendrimers for targeted gene delivery in liver cancer.

Gene therapy holds significant promise for the treatment of liver cancer. However, the development of safe and efficient gene delivery systems remains a critical challenge. Cationic polymers are widely utilized as gene carriers due to their high transfection efficiency, yet their application is often hindered by cytotoxicity and lack of target specificity.

Prognostic value and predictive model construction for patients undergoing laparoscopic radical prostatectomy based on the preoperative NPL-IRS score and prognostic nutritional index.

Objective: To explore the prognostic value of preoperative hematological indicators for prostate cancer (PCa) patients with laparoscopic radical prostatectomy (LRP) and construct a nomogram prediction model based on hematological indicators and clinicopathological characteristics.

Method: PCa patients who underwent LRP in Beijing Chaoyang Hospital from January 2017 to December 2022 were retrospectively analyzed. Clinicopathological data and blood indicators, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), red blood cell distribution width (RDW), prognosis nutritional index were compared between non-recurrence and recurrence groups.

Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels.

Volume-regulated anion channels (VRACs) are large-pore channels present in nearly all vertebrate cells, playing key roles in cell volume regulation and autocrine/paracrine signaling. Here, we identify the ubiquitously expressed puromycin-sensitive aminopeptidase (PSA) as a binding partner of the obligatory VRAC subunit SWELL1 (also known as LRRC8A) and report the cryo-electron microscopy structure of the SWELL1-PSA complex. Three PSA molecules associate with a single SWELL1 hexamer, coupling adjacent leucine-rich repeat (LRR) domains into local dimers.

Resveratrol primed adipose stem cell-derived exosomes alleviate intestinal ischemia reperfusion injury by regulating macrophage polarization.

Background: Intestinal ischemia/reperfusion injury (IRI) is a severe clinical condition associated with high morbidity and mortality. Despite advances in understanding the pathophysiology of IRI, effective therapeutic strategies remain limited. Adipose stem cell (ADSC)-derived exosomes (Exo) have been proven to be appropriate candidates for IRI through the anti-inflammatory effects.

Continuous Proton Channels in Vanadium Hexacyanoferrate Enable All-Round Improved Ultra-Low-Temperature Energy Conversion.

Proton-based batteries emerge as a promising candidate for low-temperature energy conversion and storage, yet their practical implementation is constrained by cathode performance limitations. Herein, [Fe(CN)] vacancies-mediated vanadium hexacyanoferrate (VFeCN-VHCF) with contiguous proton channels is pioneered as a proton cathode material for all-round improved ultra-low-temperature energy conversion. Through operando characterization and density functional theory calculations, we reveal that the [Fe(CN)] vacancies induce the formation of V═O bonds, which serve as the active sites to store protons and endow V-VHCF to reach a high capacity.

Identifying hundredfold carbon emission gaps in multiple resource recycling routes of construction waste via process and hybrid life cycle assessment.

Resource recycling of construction waste can be an effective substitute for the production of building materials, significantly reduce environmental pollution and ecological damage while lowering carbon emissions. However, existing studies lack a comprehensive and accurate comparison of different recycling processes, making it difficult to fully and accurately determine the associated carbon reduction potential. In this paper, process life cycle assessment (LCA) and hybrid LCA models are used to calculate carbon emissions from resource recycling of construction waste.

FedCoSR: Personalized Federated Learning With Contrastive Shareable Representations for Label Heterogeneity in Non-IID Data.

Heterogeneity arising from label distribution skew and data scarcity can cause inaccuracy and unfairness in IC applications that heavily rely on distributed computing. To deal with it, this article proposes a novel PFL algorithm, named federated contrastive shareable representations (FedCoSRs), to facilitate knowledge sharing among clients while maintaining data privacy. Specifically, the parameters of local models' shallow layers and typical local representations are both considered as shareable information for the server and are aggregated globally.

Dynamic surgery video summarization with balancing informativeness and diversity.

Surgery video summarization can help medical professionals quickly gain the insight into the surgical process for the surgical education and skill evaluation. However, existing methods are unable to efficiently summarize information to satisfy medical professionals. Since it is challenging to summarize the video while balancing the information richness and diversity.

The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma.

Background: This study aimed to determine the prognostic significance of inflammation markers for patients with oral squamous cell carcinoma (OSCC) and sought to analyze the reasons behind it and its value for clinical guidance.

Methods: This study enrolled 624 patients with OSCC who were surgically treated in our hospital. Clinical baseline data and peripheral blood routine/biochemical parameters were collected within 1 week before surgery.

A combined model integrating deep learning, radiomics, and clinical ultrasound features for predicting mutation in papillary thyroid carcinoma with Hashimoto's thyroiditis.

Objective: This study aims to develop an integrated model that combines radiomics, deep learning features, and clinical and ultrasound characteristics for predicting mutations in patients with papillary thyroid carcinoma (PTC) combined with Hashimoto's thyroiditis (HT).

Methods: This retrospective study included 717 thyroid nodules from 672 patients with PTC combined with HT from four hospitals in China. Deep learning and radiomics were employed to extract deep learning and radiomics features from ultrasound images.

In vitro identification and in vivo metabolic profiling of chemical constituents in seeds.

seeds (MOS), recognized as a nutritionally valuable food, are rich in diverse bioactive compounds and widely utilized for disease prevention and adjunctive therapy. However, their in vitro chemical constituents and in vivo blood-absorbed/metabolized components remain underexplored. This study pioneered the application of UPLC-Q-Exactive Orbitrap-MS to characterize MOS-derived compounds in vitro and in vivo, concurrently elucidating major constituents' fragmentation pathways via mass spectrometry.

Unlocking the potential: Exploring the application of bioactive peptides in aquaculture.

Bioactive peptides (BAPs), typically comprising two to 20 amino acids, are widely acknowledged for their distinctive biological functions. They can be broadly classified as endogenous or exogenous peptides. Integrating BAPs into feed is now deemed an efficacious nutritional strategy to enhance the resilience of farmed aquatic species against stress-induced damage and pathogen infections.

Comparative Evaluation of Focused Ultrasound Ablation Combined with Curettage and Transvaginal Repair in the Management of Cesarean Scar Pregnancy: A Retrospective Comparative Study.

Background: Cesarean scar pregnancy (CSP) is an uncommon and potentially life-threatening form of ectopic pregnancy characterized by embryo implantation within the scar tissue of a prior cesarean delivery.

Objective: The aim of this study is to compare clinical outcomes between focused ultrasound ablation surgery (FUAS) combined with suction curettage under hysteroscopic guidance and transvaginal debridement and repair surgery (TDRS) in the treatment of CSP.

Methods: A retrospective analysis was conducted on 78 patients with CSP and treated between 2017 and 2023.

Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure.

Background And Objective: Emerging evidence indicates that inflammation regulates cardiac remodeling and heart failure (HF). IL12β is a subunit for proinflammatory cytokines IL12 and IL23. However, the effect of IL12β inhibition on HF development and the underlying mechanism is not understood.

Mechanistic insights into the T6SS of multi-drug-resistant and its role in competition and pathogenesis.

, an opportunistic pathogen, often encodes Type VI Secretion System (T6SS) genes. However, the specific functions of T6SS, particularly in the context of clinical strains, remain poorly understood. In this study, we characterize a multi-drug-resistant strain, AH54, which possesses a complete and functional T6SS, composed of a structural cluster and two homologous auxiliary clusters (Aux1 and Aux2).

Climate warming reshapes seasonal flowering but stabilizes species interactions in a Tibetan alpine grassland.

Climate warming commonly drives asymmetric shifts in flowering phenology among species, potentially disrupting plant-plant interactions and threatening ecosystem stability. However, the mechanisms driving these species-specific phenological responses, and the extent to which resulting asynchrony destabilizes interspecific interactions, remain poorly understood. Using a 3-yr in situ warming experiment in a Tibetan alpine grassland, we monitored seasonal flowering patterns of 29 species and quantified interaction potentials across 812 species pairs from their flowering-time overlap.

Impact of Temporary Atezolizumab and Bevacizumab Interruption on Survival in Advanced HCC: An IMbrave150 Analysis.

Background: Atezolizumab (Atez) combined with bevacizumab (Bev) is the recommended first-line treatment for unresectable hepatocellular carcinoma (HCC). This study investigated the association of temporary Atez and Bev interruptions with clinical outcomes using IMbrave150 trial data.

Patients And Methods: Patient-level data from the phase 3 IMbrave150 (NCT03434379) trial were analyzed.

Non-Contact Dipole Moment Electric Modulation Achieving High Performance Near-Infrared Organic Photodetectors.

Near-infrared (NIR) detectors, serving as critical technological nodes bridging microscopic molecular recognition and macroscopic intelligent perception, meet the demands of cutting-edge technologies such as multispectral imaging. Organic semiconductor materials demonstrate unique advantages for NIR organic photodetectors (OPDs) due to their precisely tunable bandgaps, solution processability, flexibility compatibility, and biocompatibility. However, the narrow-bandgap intrinsic characteristics required for NIR response inevitably lead to carrier concentration surge that exponentially increases dark current, while hot carriers undergo phonon scattering relaxation that suppresses carrier collection.

Bacterial Acetyltransferase Effector AopP2 Primes Effector-Triggered Immunity in Watermelon by Acetylating a Conserved Transcription Factor.

Bacterial fruit blotch (BFB), caused by Paracidovorax citrulli (Pc), threatens global watermelon production, yet genetic resistance remains scarce. This study investigates the potential of non-adapted interaction triggered by Paracidovorax avenae (Pa), a maize pathogen, to combat BFB in watermelon. We demonstrate that Pa strain ATCC 19860 elicits a hypersensitive response (HR) in watermelon via its type III secretion system (T3SS), inducing effector-triggered immunity (ETI).

Histone H3K27 acetylation mediated by KAT8 maintains antiviral trained immunity in shrimp induced by inactivated white spot syndrome virus.

Shrimp aquaculture is critically important for global food security, but viral diseases like white spot syndrome virus (WSSV) cause devastating economic losses, highlighting the urgent need for effective disease control strategies. While trained immunity has been observed in invertebrates like shrimp after exposure to pathogens, the underlying molecular mechanisms remain elusive. Here we reveal that lysine acetyltransferase KAT8-mediated histone H3K27ac is critical for antiviral defense in shrimp Marsupenaeus japonicus.

Federated Metadata-Constrained iRadonMAP Framework with Mutual Learning for All-in-One Computed Tomography Imaging.

With the increasing use of computed tomography (CT), concerns about radiation dose have grown. Deep-learning-based methods have shown great promise in improving low-dose CT image quality while further reducing patient dose. However, most deep-learning-based methods are trained on vendor-specific CT datasets with varying imaging conditions and dose levels, which results in poor generalizability across vendors due to marked data heterogeneity.

Maternal uniparental disomy of chromosome 15 with concurrent paternal non-chromosome 15 marker chromosome: a rare presentation of prader-willi syndrome.

Background: Prader-Willi Syndrome (PWS) is a complicated genetic disorder demonstrating a variety of clinical phenotypes. Using molecular cytogenetics approaches to detect the deletions of the paternal 15q11-q13 region and maternal uniparental disomy of chromosome 15 plays an important role in the prenatal diagnosis of PWS.

Case Presentation: A pregnant woman with advanced maternal age underwent amniocentesis.

Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.

Background: The hematopoietic ecosystem comprises both cellular components such as hematopoietic stem cells (HSCs) and immune cells as well as non-cellular components including iron. Systemic iron overload, which leads to serious complications and affects both patients' quality of life and overall survival, is a common clinical challenge in patients with acute myeloid leukemia (AML). We previously elucidated the direct effects of iron overload on AML cells.