Effects of combined aerobic and resistance exercise on arterial stiffness in middle-aged and older men with dysglycemia and dyslipidemia: A 12-week intervention study.

Background: The aim of this study was to evaluate the effects of 12-week combined aerobic and resistance exercise program on vascular function in individuals with dysglycemia and dyslipidemia.

Methods: Participants aged 45-69 years with a Body Mass Index (BMI) < 35 kg/m and abnormal blood glucose or lipid levels were included. All participants performed two aerobic training sessions and one resistance training session per week for 12 weeks.

Non-Contact Dipole Moment Electric Modulation Achieving High Performance Near-Infrared Organic Photodetectors.

Near-infrared (NIR) detectors, serving as critical technological nodes bridging microscopic molecular recognition and macroscopic intelligent perception, meet the demands of cutting-edge technologies such as multispectral imaging. Organic semiconductor materials demonstrate unique advantages for NIR organic photodetectors (OPDs) due to their precisely tunable bandgaps, solution processability, flexibility compatibility, and biocompatibility. However, the narrow-bandgap intrinsic characteristics required for NIR response inevitably lead to carrier concentration surge that exponentially increases dark current, while hot carriers undergo phonon scattering relaxation that suppresses carrier collection.

High-Performance Thick-Film All-Polymer Solar Cells Enabled by a Blade-Coating Process Assisted by a Direct Nonuniform Electric Field.

The incorporation of thick active layers (>300 nm) is an essential requirement for wide-scale industrial production of organic solar cells (OSCs). However, it is still challenging to achieve efficient thick film devices, in particular for all-polymer OSCs, which are generally considered the most stable type of OSCs. In this study, a simple yet effective method is introduced by using a direct current (DC) field to manipulate the morphology of bulk heterojunction (BHJ) films within all-polymer OSCs during a blade coating process.

Ammonia-induced dispersion and proliferation of Actinobacillus pleuropneumoniae biofilms.

Biofilm is a common status of bacteria persistent inside the host. Its dispersion can cause reactivation of bacteria, leading to disease outbreak. This study investigated ammonia's effects on Actinobacillus pleuropneumoniae, an important porcine respiratory pathogen.

A slot region in the magnetosphere of Jupiter.

Understanding the balance between charged particle acceleration and loss is central to radiation belt research. Jupiter's Galilean moons orbit within its intense radiation environment and can act both as sources and sinks of energetic particles. Using observations from the Juno spacecraft, we identify large-scale depletions of energetic electrons along Europa's orbit.

Machine Learning-Driven Prediction Models for Brodalumab Therapeutic Effect and Response Speed in Plaque Psoriasis.

Purpose: Biologic therapies have transformed plaque psoriasis treatment, but patient responses remain variable, neces+sitating machine prediction model for personalized therapy.

Patients And Methods: Transcriptomic and clinical data from moderate-to-severe psoriatic patient biopsies were sourced from GSE117468. Differential gene analysis identified Brodalumab treatment-associated genes.

Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis.

Approximately 30-40% of patients with diabetes develop diabetic kidney disease (DKD). Identifying decisive factors for DKD initiation is crucial. Here, we observed that glomerular podocytes in male and female patients with DKD and db/db mice specifically displayed BCAA catabolic defects.

Kirkendall Effect-Driven Interface Engineering Facilitates Water Dissociation for Dual-Site HO Electrosynthesis Simultaneously at the Anode and Cathode.

The direct integration of renewable energy into HO electrosynthesis systems offers a promising strategy to minimize energy losses and costs. Due to the intermittency of renewable energy, the dual-site catalysts must efficiently enable both the two-electron oxygen reduction reaction (2e ORR) and water oxidation reaction (2e WOR). The Kirkendall effect was employed to engineer interfaces and construct a NiZnO─C catalyst with exposed (100) facets.

Scarf osteotomy combined with akin osteotomy for the treatment of patients with moderate hallux valgus: a retrospective study combining plantar pressure testing and gait analysis.

Background: Hallux Valgus (HV) not only results in deformities in the appearance of the foot but also induces pain and difficulties in walking, significantly affecting the quality of life of patients. This study utilises three-dimensional (3D) scanners and wearable gait sensors to precisely measure foot arch indices, plantar pressure distribution, and gait parameters, aiming to comprehensively assess the efficacy of Scarf osteotomy in conjunction with Akin osteotomy, thus providing scientific evidence for clinical treatment.

Methods: This retrospective study comprised a cohort of 60 patients diagnosed with moderate HV who underwent a Scarf osteotomy in conjunction with an Akin osteotomy during the period from December 2021 to December 2022.

Synergistic effects of PM components and ozone exposure on lung function in young adults: A cohort study in Shandong, China.

Exposure to fine particulate matter (PM) components and ozone (O) is associated with reduced lung function. This study aimed to examine the interaction effects of PM components and O on lung function in young adults. A cohort study involving 1697 participants was conducted in Shandong Province, China from September 2019 to November 2020.

An Ultrasensitive Four-Response Ratiometric Electrochemical Homogeneous Biosensor Based on a Positive MOF Biomaterial for Direct Diagnosis of Breast Cancer Types in Human Serum.

Continued development of high-performance, low-cost, in vitro diagnostic tools is critical for cancer diagnosis and therapeutic prognosis. Herein, we propose a four-response ratiometric electrochemical homogeneous biosensor based on positive MOF biomaterial for detection of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), and cell proliferation index (Ki67) protein biomarkers, and for simultaneous diagnosis of 10 types of breast cancer directly in human serum using a single electrode within one system. The principle of this specific four-response ratiometric electrochemical biosensor relied on neutral red (NR), tolonium blue (TB), tetramethylbenzidine (TMB), and malachite green (MG) loaded on the surface of UiO-66-NH.

Morphological observation and transcriptome profiling of axillary buds with different identities in response to gibberellin in woodland strawberry.

In strawberry plants, axillary buds can develop into short branches (branch crowns) that form inflorescences or long branches (runners) that produce daughter plants for vegetative propagation. Gibberellin (GA) is the key hormone promoting runner outgrowth, but the underlying mechanisms remain unclear. The woodland strawberry (Fragaria vesca) variety 'Hawaii 4' (H4) develops both branch crowns and runners depending on the internal or external factors, whereas 'Yellow Wonder' (YW) exclusively produces branch crowns.

Gradient-Asymmetric WPU-CNT@BiTe Film for Flexible Tactile Sensor with Decoupled Bending-Thermal Sensing Capacity.

Flexible tactile sensors equipped with multimodal decoupling capabilities are essential for the advancement of intelligent robotics. However, these sensors face challenges related to signal interference and limitations in single-variable detection. Drawing inspiration from the multilayered architecture and perception ability of biological skin, this study presents the development of an asymmetric gradient WPU-CNT@BiTe film via a gravity-induced self-sedimentation strategy, which integrates piezoresistive and thermoelectric effects, facilitating a dual-mode decoupled sensing capacity.

Exploring cadmium-binding proteins in Japanese scallops Mizuhopecten yessoensis: isolation and characterization.

Scallops (Mizuhopecten yessoensis) accumulate abnormal levels of cadmium (Cd) in their bodies; however, the chemical form of Cd in vivo remains unclear. In this study, Cd concentrations in various scallop tissues were measured, revealing that Cd predominantly accumulated as a water-soluble component within the midgut gland. High-performance liquid chromatography combined with the post-column tetraphenylporphyrin tetrasulfonic acid (TPPS) experiment revealed that the molecular weight of the Cd-binding substances was approximately 44 kDa.

A bioequivalent cornea cross-linking method using photo-initiators LAP and visible light.

Although cell-encapsulating hydrogels are of tremendous interest in regenerative medicine, few of them have been used in clinics and rarely used natural extracellular matrices as polymer precursors. One successful example is to use riboflavin (RF)/ultraviolet A (UVA) to cross-link corneal collagen, which has been used in clinics to halt disease progression in patients with corneal ectatic diseases. However, high-energy UVA and its action on RF cause tissue damage, particularly irreversible endothelium loss, and thus standard RF/UVA protocol may have limitations in treating patients at the advanced stage with thin cornea.

Artificial Intelligence-Assisted Visualized Microspheres for Biochemical Analysis: From Encoding to Decoding.

ConspectusAs an essential branch of chemical science, biochemical analysis is widely applied in disease diagnosis, food safety testing, environmental monitoring, and other fields. Artificial intelligence (AI) technology has substantially advanced biochemical analysis, enabling the prediction and extraction of key information from large volumes of image data; these tasks were previously unattainable, particularly in visualized single-microsphere counting for biosensing assays. By modification of different biorecognition molecules, encoded microspheres of various colors and sizes can serve as ideal optical multiprobes.

Separation of lignin from bamboo using type IV deep eutectic solvents for enhancing the antioxidant properties of chitosan films.

To promote the functionalization of chitosan-based films, lignin separated from Moso bamboo using type IV deep eutectic solvents (DESs; FeCl/glycerol (Gly), AlCl/Gly, and CuCl/Gly) was incorporated into chitosan to prepare lignin/chitosan composite films. For comparison, lignin pretreated with an aqueous NaOH solution was prepared and used for forming a film. The systematic characterization of lignin samples and lignin/chitosan composite films was performed using advanced analytical techniques.

Normal-pressure-prepared chitosan carbonate liquid dressing: Spontaneous transformation into a pure chitosan water-resistant film and enhanced wound repair.

Liquid dressings are essential in wound care due to their excellent conformability and spontaneous film-forming properties. However, their application is hindered by two key challenges: strict biocompatibility requirements and the need for water-resistant film formation upon drying. Additionally, incorporating active repair functions is extremely difficult.

Factors Associated With Digital Addiction: Umbrella Review.

Background: Digital addiction, affecting a significant portion of the population, particularly young people, is linked to psychological issues and social problems, making its prevention and management a crucial public health issue.

Objective: This umbrella review aimed to comprehensively analyze the factors influencing digital addiction by re-evaluating the methodologies and evidence quality of existing meta-analyses.

Methods: Databases including PubMed, Web of Science, the Cochrane Library, and Embase were systematically searched for reviews and meta-analyses related to factors associated with digital addiction up to September 24, 2024.

Myofibrillar protein and sunflower pectin complex for oil-in-water emulsion: Characteristics, interactions, and mechanisms.

Protein-polysaccharide combinations that result in the formation of electrostatic complexes or coacervates have been the focus of extensive food studies. In this study, complexes based on myofibrillar protein and sunflower pectin with three degrees of esterification (78.46 %, 69.

Isolation, genomic characterization and biocontrol potential of the lytic Pectobacterium phage Pcc_P10 against soft rot of pepper fruits.

Pectobacterium carotovorum (PBC) is a major plant pathogen responsible for soft rot disease in peppers, and its prevention and control remain highly challenging. In this study, a novel lytic phage targeting Pectobacterium carotovorum subsp. carotovorum (PCC), designated as Pcc_P10, belonging to the Pektosvirus genus within the Autographiviridae order, was isolated and characterized.

An imidazolium dication affords a stable UWY-like zeolite and enables a subtle structure direction towards EMM-17.

Zeolites with interconnected medium (10Ring) and large (12R) pores, such as the framework type, hold significant potential for catalysis but may suffer from instability due to a high germanium content required for their synthesis. Addressing this limitation, we report the synthesis of HPM-9, a novel -like germanosilicate zeolite, utilizing 1,1'-(1,8-octanediyl)bis(3-methylimidazolium) (8BMI) as the organic structure-directing agent (OSDA) in fluoride media. HPM-9 achieves significantly lower germanium content (Ge = Ge/(Ge + Si) down to 0.

A longitudinal metabolomics study on blood mercury and depressive symptoms.

Mercury exposure may increase the risk of depression. This study examined associations between blood mercury, depressive symptoms (PHQ-9), and metabolomic pathways in Chinese young adults. Fasting venous blood samples and questionnaire data (N = 477) were collected from the Chinese undergraduate cohort study in 2019 and 2021.

Mating-induced DNA replication factor minichromosome maintenance protein 10 promotes oogenesis in Plutella xylostella.

During oogenesis, the cell cycle becomes arrested during the DNA replication phase and resumes after mating facilitating crucial processes, including vitellogenesis and chorion formation. However, the molecular mechanisms regulating oogenesis in Plutella xylostella (L.) remain largely unexplored.

Integrated evaluation and optimization of acid fracturing effectiveness in carbonate reservoirs: Experimental insights and field validation.

The development of carbonate reservoirs is confronted with significant challenges, including pronounced heterogeneity and suboptimal porosity-permeability characteristics. These challenges are particularly acute in low-porosity, low-permeability complex media, where acid fracturing often exhibits limited effectiveness. To address these issues, this study systematically evaluates post-acid fracturing effectiveness in carbonate reservoirs, aiming to provide robust scientific and technical guidance for stimulation optimization.