Uric acid mediates the association of alpha-1 acid glycoprotein with gallstones in adult women in the United States.

Gallstones are a common biliary disorder whose pathogenesis may involve alpha-1-acid glycoprotein (AGP), an acute phase inflammatory protein. Serum uric acid (SUA) is the end product of purine metabolism and is associated with a variety of chronic diseases. We conducted a cross-sectional analysis of 1,652 adult women from the 2017-2020 NHANES database to explore the association between AGP levels and gallstone risk and the potential mediating role of SUA.

Normal-pressure-prepared chitosan carbonate liquid dressing: Spontaneous transformation into a pure chitosan water-resistant film and enhanced wound repair.

Liquid dressings are essential in wound care due to their excellent conformability and spontaneous film-forming properties. However, their application is hindered by two key challenges: strict biocompatibility requirements and the need for water-resistant film formation upon drying. Additionally, incorporating active repair functions is extremely difficult.

Use of extracorporeal membrane oxygenation in adult trauma patients with refractory acute cardiopulmonary failure: guideline from the Chinese society of extracorporeal life support 2025.

Background: Adult trauma patients with refractory acute cardiopulmonary failure suffer from high morbidity and mortality. In the past decade, a growing body of researches has shown survival benefits of extracorporeal membrane oxygenation (ECMO) in trauma patients who fail to respond to optimal damage control resuscitation (DCR), and there is an opportunity to formulate clinical practice guidelines to guide clinicians in implementing trauma ECMO at the bedside.

Methods: The Chinese Society of Extracorporeal Life Support (CSECLS) convened a domestic panel of interdisciplinary experts to develop this guideline, adhering to the principles of the World Health Organization (WHO) Manual for Guideline Development and the policy of conflict of interest.

The disproportionate burden of pulmonary arterial hypertension among the elderly: global, regional, and national trends from 1990 to 2021-findings from the 2021 global burden of disease study.

Objectives: Pulmonary arterial hypertension (PAH) is a chronic vascular disorder characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, leading to right ventricular failure. This condition imposes a substantial economic burden and significant health challenges globally. This study aimed to comprehensively analyze the global burden of PAH, with specific attention to vulnerable populations including the elderly, by evaluating gender, age (especially older age groups), region, country, and sociodemographic variables using data from the Global Burden of Disease Study (GBD) 2021.

An assessment of the impact of a new-type of doctor-nurse joint prenatal breastfeeding clinic attendance on women's breastfeeding duration and feeding-related breast problems: A cohort observational study.

To promote breastfeeding, a new-type of doctor-nurse joint prenatal breastfeeding clinic was carried out in Haidian District Maternal and Child Health Hospital, Beijing, China. Actual improvement in the duration of breastfeeding and feeding-related breast problems for women using these clinics remains unknown. This observational study assesses the impact of doctor-nurse joint prenatal breastfeeding clinic's interventions on breastfeeding duration and feeding-related breast problems in comparison with women who did not receive clinic services.

Suborbital- and millennial-scale monsoon variability during Pleistocene interglacials.

Observational and modeling results show that the frequency and amplitude of extreme climatic events have increased significantly in the context of global warming. However, whether abrupt climate changes intensified during past warm periods remains poorly constrained due to the lack of high-resolution geological records. Here, we report a 512-m predominantly lacustrine sedimentary record from the Weihe Basin (North China), revealing that lake levels fluctuated significantly on suborbital (half- and quarter-precession) and millennial timescales over the last 2 Ma.

Porphyrins and Their Derivatives in Cancer Therapy: Current Advances, Mechanistic Insights, and Prospective Directions.

Porphyrin and its derivatives are widely used in cancer therapy due to their strong photon absorption capabilities and moderate light stability. Due to their hydrophobic nature, porphyrins with tetrapyrrolic macrocycles ease self-aggregation in physiological conditions. Instead, exploiting the C4 symmetry structure for self-assembly is beneficial to improve the bioavailability of porphyrin and its derivatives.

Integrated proteomics and metabolomics to clarify the essential beneficial mechanisms of L-theanine in alleviating ISO-induced cardiac damage in mice.

L-theanine (L-Thea), a bioactive amino acid found in tea, demonstrates remarkable nutraceutical properties. Isoproterenol (ISO) has been utilized as a reliable and potent agent to induce heart failure (HF) in murine models. The aim of this study was to explore the mechanisms through which L-Thea alleviates ISO-induced cardiac damage via the examination of proteomic and metabolomic data.

[Crisis Transformation of the Coupling Effect of Building Carbon Reduction-Environmental Protection-Economic Development System in China].

Exploring the spatio-temporal evolution and coordinated developmental level of the building carbon reduction-environmental protection-economic development system and analyzing the risks and opportunities of building carbon emission management are crucial for achieving the goals of realizing carbon peak and carbon neutrality. A comprehensive evaluation index system and coupled coordinated development, state space, and crisis transformation degree models were constructed to study the coupling effects of the building carbon reduction-environmental protection-economic development system in China from 2010 to 2020. The results showed that： ① The comprehensive evaluation value of the environmental protection system increased steadily, from 0.

Portable DNA extraction integrated with LAMP-CRISPR/Cas12a technology for on-site detection of Salmonella Typhimurium.

The infection and outbreak of Salmonella typhimurium (S. typhimurium) highlight the need for developing a reliable on-site detection strategy fitting to various settings. However, due to the requirement of specialized instruments and trained personnel, traditional detection methods have to be implemented in laboratories and are not ideal for on-site applications.

Analysis of ABCG2 gene rs2231142 single nucleotide polymorphism and risk factors in hyperuricemia.

The relationship between the single nucleotide polymorphism (SNP) at the rs2231142 locus of the Adenosine triphosphate-binding cassette transporter G subfamily member 2 (ABCG2) gene and susceptibility to hyperuricemia (HUA) is to be investigated, alongside an analysis of the associated risk factors for HUA. Venous blood samples were obtained from 1612 patients diagnosed with HUA and 1770 individuals exhibiting normal uric acid (UA) levels. Deoxyribonucleic acid was isolated, followed by amplification of the target gene via polymerase chain reaction.

Molecule-rich solutions for achieving novel non-opioid analgesics.

Despite their efficacy, opioids have long been associated with risks of addiction, tolerance, and dependence, leaving an unmet clinical need for pain treatment. Efforts have been devoted to developing novel classes of pain-relieving medication that outperform current options in terms of pain relief, side-effect profiles, and potential for abuse, but with limited success. Recent advances in the neurobiology of pain have shed light on the potential of targeting non-opioid receptors involved in pain processing.

Polysaccharides Extracted from Old Stalks of L. Improve Nonalcoholic Fatty Liver by Increasing the Gut Butyric Acid Content and Improving Gut Barrier Function.

Nonalcoholic fatty liver disease (NAFLD) ranks among the most prevalent chronic liver diseases worldwide, yet effective treatments remain scarce. Old stalks of L. are rich in polysaccharides.

Primer Exchange Reaction with Cascade RNA Transcription for Highly Specific Detection of Exosomal miRNA and Liver Cancer Diagnosis.

Exosomal microRNAs (miRNAs) serve as dependable and noninvasive biomarkers for early cancer diagnosis. However, the accurate and feasible detection of exosomal miRNAs is often hindered by their low abundance and the requirement of specialized equipment for miRNA detection. In this study, we present a novel approach, termed rimer xchange eaction-based luorescence mission with ascade RNA aptamers ranscription (PERFECT) for the highly sensitive detection of exosomal miRNA.

Self-compassion and work engagement among clinical nurses: the mediating role of moral resilience.

Background: As the workload of clinical nursing continues to increase, the mental health of nurses has emerged as a critical area of concern. Self-compassion, moral resilience, and work engagement are essential components in enhancing the mental health of clinical nurses. Although it is well-established that self-compassion significantly contributes to improved work engagement, there remains a notable lack of research investigating the specific mechanisms through which self-compassion influences work engagement, particularly from the perspective of moral resilience.

Prognostic value of composite inflammatory markers in patients with chronic obstructive pulmonary disease: A retrospective cohort study based on the MIMIC-IV database.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease, and inflammation plays a key role in the pathogenesis of COPD. The aim of this study is to investigate the association between systemic immune inflammation index (SII), systemic inflammatory response index (SIRI),pan-immune inflammation value (PIV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) and all-cause mortality in patients with chronic obstructive pulmonary disease (COPD), and to evaluate the effect of composite inflammatory markers on the prognosis of COPD patients. We obtained data on COPD patients from the Medical Information Mart for Intensive Care (MIMIC) -IV database and divided patients into four groups based on quartiles of baseline levels of inflammatory markers, The primary outcomes were in-hospital and ICU mortality.

Ethical leadership and nurses' job performance: the mediating role of self-compassion.

Background: Ethical leadership is crucial in nursing management, and self-compassion is increasingly recognized as a significant factor influencing nurses' job performance. Although the link between ethical leadership and nurse job performance has been established, the specific mechanisms that underlie this relationship remain unclear. Additionally, there is a paucity of research examining the potential role of self-compassion in this context.

Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue.

The distribution and bioaccumulation of environmental pollutants are essential to understanding their toxicological mechanism. However, achieving spatial resolution at the subtissue level is still challenging. Perfluorooctanesulfonate (PFOS) is a persistent environmental pollutant with widespread occurrence.

Spatiotemporal transcriptome and metabolome landscapes of cotton somatic embryos.

Somatic embryogenesis (SE) is a developmental process related to the regeneration of tissue-cultured plants, which serves as a useful technique for crop breeding and improvement. However, SE in cotton is difficult and elusive due to the lack of precise cellular level information on the reprogramming of gene expression patterns involved in somatic embryogenesis. Here, we investigate the spatial and single-cell expression profiles of key genes and the metabolic patterns of key metabolites by integrated single-cell RNA-sequencing (scRNA-seq), spatial transcriptomics (ST), and spatial metabolomics (SM).

The mediating role of compassion fatigue between perceived organization support and caring behavior among outpatient nurses in China: a cross-sectional study.

Background: The caring behaviors of outpatient nurses play a crucial role in improving the quality of care in hospitals. Work resources and personal psychological resources have a significant impact on nurses' caring behavior. Previous research has shown that perceived organizational support and compassion fatigue are linked to nurses' caring behaviors.

The fall armyworm converts maize endophytes into its own probiotics to detoxify benzoxazinoids and promote caterpillar growth.

Background: The fall armyworm (FAW, Spodoptera frugiperda) threatens maize production worldwide, and benzoxazinoids (Bxs) are known as the main secondary metabolites produced by maize to defend against FAW. However, we do not yet know whether and in what ways certain endophytes in the digestive system of FAW can metabolize Bxs, thus enhancing the fitness of FAW when feeding on maize.

Results: Using Bxs as the sole carbon and nitrogen source, we isolated Pantoea dispersa from the guts of FAW.