The self-assessment of critical thinking disposition and the needs for training: a cross-sectional survey of clinical nurses.

Background: Critical thinking is essential for nurses' clinical decision-making and the delivery of safe, high-quality care, and is shaped by their critical thinking disposition. However, nurses demonstrate negative critical thinking dispositions, with limited evidence available on influencing factors and training needs.

Objective: This study aims to investigate nurses' critical thinking dispositions, identify influencing factors, and explore their relationship with training needs.

[Research progress in pharmacological activities and pharmacokinetics of geniposidic acid].

Geniposidic acid(GA), a natural iridoid, exists in the roots, stems, leaves, flowers, bark, fruits, and seeds of medicinal plants of Rubiaceae, Eucommiaceae, and Plantaginaceae. Modern pharmacological studies have revealed that GA has multiple pharmacological activities, including organ-protective, anti-inflammatory, antioxidative, anti-osteoporosis, anti-neurodegenerative, and anti-cardiovascular effects. GA can enhance cell/organism defenses by upregulating key anti-inflammatory and antioxidant cytokines, while downregulating key node proteins in pro-inflammatory signaling pathways such as AhR and TLR4/MyD88, thereby exerting pharmacological effects such as organ protection.

Insulin injection knowledge, attitude, and practice of community nurses in a mountainous area of southwest Zhejiang in China: a multi-center cross-sectional study.

Background: Suboptimal insulin injection is widely used to treat Chinese patients with diabetes, with most patients being treated in primary care institutions. However, research on community nurses' knowledge, attitude, and practice concerning insulin injection in less developed areas of China is extremely scarce.

Objective: To investigate the knowledge, attitude, and practice of community nurses concerning insulin injection in a mountainous area of southwest, Zhejiang, China.

The osteogenic effect of 3D-printed bone grafting guides in PAOO: a retrospective cohort study.

Background: Periodontally accelerated osteogenic orthodontics (PAOO) effectively increases alveolar bone volume and broadens orthodontic treatment options. However, bone grafting during PAOO faces challenges such as graft displacement, membrane collapse, and insufficient coronal bone regeneration. This study aimed to evaluate whether 3D-printed digital bone grafting guides could improve graft stability and alveolar bone regeneration compared with conventional PAOO.

Comprehensive analysis of the sucrose nonfermenting 1-related protein kinase 2 gene family in broomcorn millet (Panicum miliaceum L.) under abiotic stress conditions.

Background: Sucrose nonfermenting 1-related protein kinase 2 (SnRK2) proteins constitute a family of plant-specific serine/threonine kinases that play critical roles in mediating abscisic acid (ABA) signaling and responses to abiotic stresses, including drought and salinity. Nevertheless, systematic bioinformatics analysis and expression profiling of the SnRK2 gene family in broomcorn millet (Panicum miliaceum L.) have not yet been reported.

Causal relationship between multiple types of food intake and myopia: a Mendelian randomization study.

Aim: To investigate the causal relationship between dietary intake and myopia using Mendelian randomization (MR) analysis.

Methods: Genome-wide association study (GWAS) data from the IEU Open GWAS database were utilized to examine associations between myopia and various dietary factors. MR analysis, incorporating both univariable and multivariable approaches, assessed the impact of food intake on myopia risk through five analytical methods, with inverse variance weighted (IVW) serving as the primary reference.

Mobilome-mediated transcriptional activation of biosynthetic gene clusters and its impact on strain competitiveness in food fermentation microbiomes.

Background: Microbial interactions are critical for maintaining the stability of food fermentation microbiomes, and mobile genetic elements (MGEs) significantly influence these interactions by horizontal gene transfer events. Although MGEs are known to facilitate horizontal gene transfer, their distribution among microorganisms and specific effects on microbial interactions remain poorly understood.

Results: We analyzed 590 metagenomic and 42 metatranscriptomic samples from food fermentations, recovering 1133 metagenome-assembled genomes (MAGs).

P2IFormer: A Multi-Granularity Patch-to-Image Embedding Model for Fault Diagnosis of High-Speed Train Axle-Box Bearings.

The axle-box bearing is a critical load-bearing component in high-speed trains and is prone to failure under long-term heavy-duty operation, affecting both operational efficiency and safety. Current deep-learning-based fault diagnosis methods face two key challenges: difficulty in capturing temporal features across multiple scales simultaneously, and limited capability in modeling local sequential patterns. To address these issues, we propose P2IFormer, a fault diagnosis model based on multi-granularity patch-to-image embedding.

Diagnostic performance of "pons chocolate chip sign" in heterozygous HTRA1-related cerebral small vessel disease.

Background And Purpose: Heterozygous HTRA1-related cerebral small vessel disease (hHTRA1-CSVD) presents diagnostic challenges due to its clinical and imaging similarities with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and sporadic cerebral small vessel disease (CSVD). Recently, the "chocolate chip sign" around the midbrain has been proposed as a potential imaging marker for hHTRA1-CSVD. However, the diagnostic value of similar findings around the pons remains unclear.

Machine Learning-Driven Prediction Models for Brodalumab Therapeutic Effect and Response Speed in Plaque Psoriasis.

Purpose: Biologic therapies have transformed plaque psoriasis treatment, but patient responses remain variable, neces+sitating machine prediction model for personalized therapy.

Patients And Methods: Transcriptomic and clinical data from moderate-to-severe psoriatic patient biopsies were sourced from GSE117468. Differential gene analysis identified Brodalumab treatment-associated genes.

Ion exchange-based magnetic micro-cleaners harness multiple effects to enhance antibiotics removal.

The widespread misuse of antibiotics has created significant environmental and public health concerns due to their persistence in aquatic ecosystems. Therefore, effective strategies for antibiotics removal are urgently needed. Here we propose an ion-exchange-based magnetic micro-cleaner to enhance antibiotic removal from contaminated water bodies through multiple effects.

Effects of swimming training on cecum microorganisms and metabolites in rats with high fat diet.

Swimming is a whole-body aerobic exercise that has preventive and therapeutic effects on chronic metabolic diseases triggered by a high-fat diet. SPF grade rats (n = 48) were selected. They were divided into 4 groups (GB, GY, ZY and ZB) with 12 rats in each group.

Chronic inflammation and cognitive frailty in older adults: A narrative review.

Cognitive Frailty (CF) is a clinical syndrome characterized by the co-occurrence of physical frailty and cognitive impairment in the absence of dementia. This geriatric condition has emerged as a significant contributor to compromised health status and diminished quality of life among aging populations, yet its underlying pathological mechanisms remain incompletely elucidated. Chronic low-grade inflammation, recognized as a hallmark of biological aging, has been implicated in the pathogenesis of multiple age-related diseases, including hypertension, diabetes, panvascular diseases, and cerebrovascular disorders.

HIV-Tat and vascular endothelium: implications in the HIV associated brain, heart, and lung complications.

Following the advent of antiretroviral therapy (ART), neurological, cardiovascular, and pulmonary comorbidities emerged as major challenges in treating non-infectious complications in people living with HIV. Despite effective ART, HIV viral proteins can persist in circulation even in individuals with negligible viral loads, potentially contributing to cellular and tissue-level stress, inflammation, and related health complications. Most of the HIV protein: Tat (Trans activator of Transcription), expressed in HIV-infected cells, is actively secreted and exerts its pathological effects on non-infected cells, particularly impacting the vascular endothelium.

Clinical Characteristics and Outcomes of Oncologic Surgical Emergencies: A Retrospective Study.

Background: Oncologic surgical emergencies (OSEs) are increasing, with rising cancer incidences and prolonged patient survival. However, prior OSEs studies have been limited by a narrow focus. This study aimed to determine whether a five-category classification for OSEs can effectively guide clinical decision-making based on patient outcomes.

Risk stratification for Pseudomonas LRTI in immunocompromised patients: A LASSO-logistic regression model with clinical implications.

This retrospective cohort study examined 28-day mortality predictors among 177 immunocompromised adults with acute Pseudomonas aeruginosa lower respiratory tract infections (LRTIs) over a 6-year observational period. LASSO regression followed by logistic regression analysis was used to screen 19 clinical and laboratory variables. To evaluate the predictive performance of the model, ROC analysis was performed.

ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance.

Background: The urea cycle and pyrimidine synthesis occur mainly in the liver and undergo opposite changes during hepatocarcinogenesis. Argininosuccinate synthase 1 (ASS1) and carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) are key enzymes in the urea cycle and pyrimidine synthesis, respectively, and compete for the common substrate, aspartate. Moreover, ASS1 is lowly expressed in certain cancers, while CAD is highly expressed.

Dihydroartemisinin decreases pre-existing neutralizing antibodies against adeno-associated virus in challenged mice.

Introduction: The high prevalence of pre-existing neutralizing antibodies (NAbs) against adeno-associated virus (AAV) poses a major obstacle to in vivo gene therapy. Current immunosuppressive (IS) strategies, such as corticosteroids, are limited by toxicity and adverse effects. To explore safer alternatives, we evaluated dihydroartemisinin (DHA), a synthetic derivative of artemisinin inspired by traditional Chinese medicine (TCM), as a potential IS agent.

Synergistic effects of commensals and phage predation in suppressing colonization by pathogenic Vibrio parahaemolyticus.

Colonization resistance is a fundamental mechanism by which microbiomes suppress pathogen invasion; however, the ecological and mechanistic determinants of its efficacy remain incompletely understood. Here, we constructed a defined microbial consortium and employed in vivo shrimp infection models to investigate the synergistic interaction between commensal microbes and a pathogen-specific phage in suppressing the pathogen Vibrio parahaemolyticus. Our in vitro experiment revealed that combining key taxa, particularly with phage integration, markedly enhanced pathogen exclusion.

Large-scale protein interactome reveals lineage-specific genes driving plant-parasitic nematode adaptive innovations.

Mounting evidence suggests that lineage-specific genes drive phenotype diversity. Plant-parasitic nematodes (PPNs), among the most destructive plant pathogens, have evolved innovated traits required for plant parasitism, yet the genetic basis remains unclear. Here, we identify PPN lineage-specific genes (PPNLSGs) and analyze the large-scale protein interactome of their encoded proteins (PPNLSPs).

Effects of beer addition on the fermentation quality and flavor development of pickled peppers.

This study explored the effects of beer as a fermentation medium additive, with beer addition levels of 25 % and 50 %, on the fermentation quality and flavor development of pickled peppers. Beer addition resulted in higher pH, reducing sugar, and nitrite levels, as well as improved textural crispness, while reducing total acidity and salinity. Microbial community analysis indicated that Firmicutes, Proteobacteria, and Ascomycota were the dominant phyla.

Attention-Guided Residual Spatiotemporal Network with Label Regularization for Fault Diagnosis with Small Samples.

Fault diagnosis is of great significance for the maintenance of rotating machinery. Deep learning is an intelligent diagnostic technique that is receiving increasing attention. To address the issues of industrial data with small samples and varying working conditions, a residual convolutional neural network based on the attention mechanism is put forward for the fault diagnosis of rotating machinery.

Migration Safety of Perfluoroalkyl Substances from Sugarcane Pulp Tableware: Residue Analysis and Takeout Simulation Study.

The rapid growth of plant-based biodegradable tableware, driven by plastic restrictions, necessitates rigorous safety assessments of potential chemical contaminants like per- and polyfluoroalkyl substances (PFASs). This study comprehensively evaluated PFAS contamination risks in commercial sugarcane pulp tableware, focusing on the residues of five target PFASs (PFOA, PFOS, PFNA, PFHxA, PFPeA) and their migration behavior under simulated use and takeout conditions. An analysis of 22 samples revealed elevated levels of total fluorine (TF: 33.

Lewis Acidity-Governed Ion Exchange and Record Birefringence in A'[Ag(POF)].

Four monofluorophosphates, A'[Ag(POF)] (A' = Ag, K, Rb, NH ), with layered sandwich structures were synthesized. Systematic characterization reveals that the Lewis acidity gradient of A' cations (Ag > Rb ≈ K > NH ) governs their distinct ion-exchange kinetics, where Ag substitution requires 7 days for Rb/K but 14 days for NH . The density functional theory (DFT) calculations demonstrate that optical anisotropy primarily stems from the alignment of P─F bonds in [POF] tetrahedra, as well as the alignment of dipole moment of [Ag(1)O] tetrahedra.