Predictors for Achieving Textbook Outcomes After Endoscopic Resection of Giant Submucosal Tumors in the Esophagus and Cardia.

Background And Aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate the predictors of TO for giant SMTs with a long diameter ≥ 7 cm or a transverse diameter ≥ 3.5 cm.

Design of multifunctional metasurface devices with tunable propagation properties.

The integration of terahertz (THz) technology with metasurfaces has attracted attention as it enables the fabrication of compact, high-performance, and tunable photonic devices. However, extensive investigation of metasurfaces was limited to a narrow THz range or manipulating a single mode of electromagnetic waves, absorption, reflection, or transmission, without achieving multi-band or broadband switching. This capability constrains metasurface adaptability in modern and reconfigurable systems.

Tube posterior tibial artery flow-through free flap for salvaging upper limbs with contaminated soft tissue defects and arterial injuries.

The tube posterior tibial artery flow-through free flap technique is proposed for salvaging upper limbs with severely contaminated or infected soft tissue defects and major arterial injuries. Between January 2016 and February 2024, six patients were treated using this method. This is a two-stage approach involving initial restoration of blood supply via a tube posterior tibial artery flow-through free flap, followed by delayed soft tissue coverage utilizing the unfolded tube flap after a series of wound debridements and vacuum sealing drainage treatments.

Percutaneous cannulated screw fixation vs open reduction and plate fixation for displaced intra-articular Sanders II and III calcaneal fracture: A two-center retrospective propensity-matched analysis.

Background: The optimal surgical strategy for treating displaced intra-articular calcaneal fractures remains controversial.

Purpose: The purpose of this retrospective cohort study was to compare the clinical and radiologic outcomes of percutaneous cannulated screw fixation versus open reduction and plate fixation via the sinus tarsi approach in patients with displaced intra-articular Sanders II or III calcaneal fractures.

Study Design: A retrospective analysis was performed on the records of patients with displaced Sanders II or III calcaneal fractures.

Correction: Identification of prognosis and therapy related intratumoral microbiome and immune signatures in gastric cancer.

[This corrects the article DOI: 10.3389/fimmu.2025.

Te Vacancy Defect Engineering on FeGeTe (001) Basal Planes for Enhanced Oxygen Evolution Reaction: A First-Principles Study.

Photocatalytic water splitting for hydrogen production is an attractive renewable energy technology, but the oxygen evolution reaction (OER) at the anode is severely constrained by a high overpotential. The two-dimensional vdW ferromagnetic material FeGeTe, with its good stability and excellent metallic conductivity, has potential as an electrocatalyst, but its sluggish surface catalytic reactivity limits its large-scale application. In this work, we adapted DFT calculations to introduce surface Te vacancies to boost OER performance of the FeGeTe (001) surface.

Clinical and genetic analysis of -Related cockayne syndrome: hepatic dysfunction as a biomarker, anhidrosis as a rare feature, and rehabilitation outcomes for ankle contractures.

Objectives: Cockayne syndrome (CS), a rare hereditary neurodegenerative disorder caused by pathogenic variants in (CSB) and (CSA), often clinically overlaps with cerebral palsy (CP), leading to misdiagnosis. This study evaluates the role of genetic testing in differential diagnosis, examines hepatic dysfunction as a biomarker of disease severity, and delineates clinical characteristics of CSA-related CS.

Methods: A retrospective case series of eight CSA-related CS patients was conducted.

[46,XY disorder of sex development caused by gene variants: a case report].

The patient was a boy aged 1 year and 9 months who presented with 46,XY disorder of sex development (DSD), with severe undermasculinization of the external genitalia. Laboratory tests and ultrasound examinations showed normal functions of Leydig cells and Sertoli cells in the testes. Genetic testing revealed a novel pathogenic heterozygous variant, c.

Effects of beer addition on the fermentation quality and flavor development of pickled peppers.

This study explored the effects of beer as a fermentation medium additive, with beer addition levels of 25 % and 50 %, on the fermentation quality and flavor development of pickled peppers. Beer addition resulted in higher pH, reducing sugar, and nitrite levels, as well as improved textural crispness, while reducing total acidity and salinity. Microbial community analysis indicated that Firmicutes, Proteobacteria, and Ascomycota were the dominant phyla.

Nanomedicines and stroke: Advantages in chronic inflammation treatment and neural regeneration.

Stroke can be categorized as ischemic and hemorrhagic on the basis of its origin. The pathophysiology following a stroke is complex, and is characterized by ongoing inflammation, neuronal injury, and the accumulation of reactive oxygen species in the brain, all of which reflect a dynamic process of change. This complexity hinders achievement of significant therapeutic outcomes with standard stroke treatment procedures, limiting post-stroke recovery.

ELF6 mutation suppresses the dwarf phenotype of Arabidopsis ino80 mutant by modulating cell cycle progression.

The chromatin-remodeling factor INO80 is conserved across eukaryotes and plays important roles in various biological processes. However, its upstream regulators remain unclear. This study aimed to identify new regulators of INO80 in Arabidopsis and to uncover its molecular mechanism in plant growth.

Deep learning model enables the discovery of a novel BET inhibitor YD-851.

BET inhibitor is a novel strategy in tumor therapy based on targeting epigenetic mechanism. In recent decades, dozens of clinical trials have been conducted to validate the potential efficacy of the first-generation BET inhibitors in refractory cancer and non-cancerous ailments. However, limited efficacy and significant toxicity were observed in clinical trials for treating solid tumors.

Integrating Single-Cell Transcriptomics and Machine Learning to Define an ac4C Gene Signature in Lung Adenocarcinoma.

Introduction: Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, faces challenges such as drug resistance and tumor heterogeneity. N4-acetylcytidine (ac4C) is an important RNA modification involved in cancer progression, but its role in lung adenocarcinoma remains unclear.

Methods: This study analyzed transcriptomic and single-cell RNA sequencing data from public databases to investigate the expression and clinical significance of ac4C-related genes in lung adenocarcinoma.

Revealing the pathogenesis of vasculitis induced by aggregation of cryoglobulins associated with the immune response through an study.

Cryoglobulinemic vasculitis (CryoVas) is the most common symptom of cryoglobulinemia. However, the mechanism by which cryoglobulins (CGs) induce vascular injury remains unclear. Herein, serum samples from patients with type I, II, and III cryoglobulinemia were analyzed, with healthy individuals as controls.

KadsuraChem: A Machine Learning-Powered LC-MS Database for Phytochemicals and Its Role in Compound Identification of .

plants, rich in bioactive dibenzocyclooctadienes and triterpenoids, are widely used in traditional medicine and the food industry. Previous LC-MS research identified only 25 dibenzocyclooctadienes from , with issues including isomer confusion and false positives. To overcome these hurdles, this study developed machine learning models based on 161 previously isolated dibenzocyclooctadienes and triterpenoids from to predict the retention times (RT) and fragmentation patterns of reference-standard-lacking compounds from or Schisandraceae.

Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy.

Introduction: Metabolic-associated fatty liver disease (MAFLD) has emerged as a global health crisis, which is characterized by hepatic lipid accumulation, inflammation, and fibrosis. Currently, effective therapeutic strategies for MAFLD are still scarce.

Methods: This study aimed to explore the hepatoprotective effects and underlying mechanisms of total flavones from Abelmoschus manihot (L.

Research Progress of Physiotherapy on Female Stress Urinary Incontinence: A Bibliometric Analysis.

Background And Purpose: Stress urinary incontinence (SUI) is characterized by the involuntary leakage of urine on physical activities or sneezing or coughing. Despite a considerable number of studies on physiotherapy for female SUI have been published, a bibliometric analysis that comprehensively quantifies and summarizes these studies is still lacking. Thus, the aim of this study is to summarize the current state of this area based on bibliometrics and to suggest future research trends.

Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes.

Background: Pancreatic cellular heterogeneity is fundamental to systemic metabolic regulation, yet its pathological remodeling in diabetes remains poorly characterized.

Methods: We integrated single-cell RNA sequencing with machine learning frameworks to decode pancreatic heterogeneity. Novel tools included PanSubPred (two-stage feature selection/XGBoost classifier) for multi-lineage annotation and PSC-Stat (XGBoost/Gini optimization) for stellate cell activation analysis.

Metabolomics analysis of dynamic quality changes in beef during low-voltage electrostatic field combined with partial freezing storage.

The quality and shelf life of beef are significantly affected by storage conditions, emphasizing the urgent need for efficient preservation technologies to extend shelf life and reduce waste. This study evaluated the quality changes of beef during storage under low-voltage electrostatic field (LVEF) combined with partial freezing and under partial freezing alone. The results showed that during the 0-24 day storage period, LVEF effectively slowed the increases in pH, thiobarbituric acid reactive substances, total volatile basic nitrogen, and total viable counts, maintained tenderness, and delayed protein oxidation.

Bioadhesive and antioxidant hydrogel by MoS-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration.

Tissue engineering has been used as a potential treatment strategy for articular cartilage regeneration, but current hydrogel scaffolds often fail to meet these criteria due to weak mechanical strength and unfavorable biocompatibility. Inspired by the metal ion-polyphenol redox system-initiated free radical polymerization (MPi-FRP), a novel molybdenum disulfide-tannic acid (MoS-TA) dual-catalytic system was used as an initiator for the free radical polymerization of methacrylated hyaluronate (HAMA) to synthesize a HAMA-MoS-TA (abbreviated as HAMA-M) nanocomposite hydrogel for cartilage repair under mild conditions. Compared to the pure HAMA hydrogel, HAMA-M hydrogels exhibited robust mechanical properties, and the adhesive strength was promoted for 81.

Pediatric sequential organ failure assessment for predicting outcomes in ECMO-bridged pediatric heart transplant recipients: experience from the largest pediatric heart transplant center in China.

Objective: Advanced heart failure in children sometimes requires mechanical circulatory support as a bridge to transplantation, with extracorporeal membrane oxygenation (ECMO) remaining a critical option despite its associated risks. The pediatric Sequential Organ Failure Assessment (pSOFA) may have potential in evaluating prognosis in ECMO-bridged candidates.

Methods: 188 Children underwent orthotopic heart transplantation in Union hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2018 and April 2025 were studied retrospectively, with 24 received ECMO assistance as a bridge to transplant.

Identification of prognosis and therapy related intratumoral microbiome and immune signatures in gastric cancer.

The impact of the intratumoral microbiome (ITM) on the treatment and prognosis of gastric cancer (GC) remains controversial. Our study analyzed the differential ITM in GC tissues and identified nine bacterial genera significantly associated with overall survival (OS), with seven as risk factors and two as protective factors. Three distinct clusters with varying survival outcomes were defined, demonstrating correlations with pathological stage and immune features.

ncRNA-mediated ITGB1 upregulation correlates with poor prognosis and tumor-immune infiltration in gastric cancer.

Background: Gastric cancer (GC) is a highly heterogeneous and complex disease. Recently, integrin β (ITGB) superfamily members have been shown to play crucial roles in the initiation and progression of various human cancers. However, the precise role and molecular mechanisms of ITGB1 in GC are yet to be fully elucidated.

Effect of Ultrasonic Treatment on the Quality of Pumpkin Juice Fermented by Yeast.

To investigate the effect of ultrasound on the quality of pumpkin juice fermented by yeast, ultrasound (power range 0-400 W, duration 10 min) was used to assist the yeast fermentation of pumpkin juice. The effects of ultrasound-assisted fermentation at different powers on the quality characteristics of pumpkin juice, such as the color, aroma components, carotenoid content, and antioxidant activity, were studied. The optimal combination of fermentation process parameters was determined as follows: a pumpkin juice content of 20 mL, fermentation temperature of 30 °C, fermentation time of 1 day, and inoculation amount of 3% (the mass-to-volume ratio of yeast to water).