The Safety of Cadonilimab: A Systematic Review and Single-Arm Meta-Analysis.

Introduction: Cadonilimab (AK104) is a bispecific antibody that simultaneously targets programmed cell death-1 and cytotoxic T-lymphocyte antigen-4. It has received approval for the treatment of cervical cancer and gastric/gastroesophageal junction cancer. This meta-analysis aims to assess cadonilimab's safety profile.

Armed Conflict and Pregnancy Termination: Evidence from Burkina Faso.

The mental and physical toll of conflict-related stressors-such as safety concerns, food insecurity, and loss of income-may have significant and deleterious impacts on birth outcomes among pregnant women. Armed conflict disrupts people's lives, often limiting access to essential resources and healthcare services (e.g.

Predictive value of core-fucosylated low-molecular-weight kininogen levels in patients with liver fibrosis: A prospective study.

Background: Core-fucosylated low-molecular-weight kininogen (LMWK-Fc) levels are significantly elevated in patients with liver fibrosis and cirrhosis.

Aim: To assess the value of LMWK-Fc as a diagnostic biomarker for liver fibrosis.

Methods: Our study included 132 healthy people and 132 patients with liver fibrosis.

Effects of beer addition on the fermentation quality and flavor development of pickled peppers.

This study explored the effects of beer as a fermentation medium additive, with beer addition levels of 25 % and 50 %, on the fermentation quality and flavor development of pickled peppers. Beer addition resulted in higher pH, reducing sugar, and nitrite levels, as well as improved textural crispness, while reducing total acidity and salinity. Microbial community analysis indicated that Firmicutes, Proteobacteria, and Ascomycota were the dominant phyla.

Lipid-based nanocarriers and their potential for incorporation into active edible films/coatings: highlighting nanocochleates as novel and promising nanocarriers.

This review highlights the potential of lipid-based nanocarriers, particularly nanocochleates, in enhancing edible films/coatings for food packaging. While direct application of bioactives poses risks such as uncontrolled release and sensitivity to environmental factors, lipid-based nanocarriers like nanocochleates offer improved stability, higher loading capacity, and controlled release. Originally used in pharmaceuticals, nanocochleates are now being explored in the food industry, promising significant benefits for active edible coatings.

Silk Sericin-Dihydromyricetin Covalent Complexes: Interaction Mechanisms, Structural Characteristics, and Functional Properties.

Dihydromyricetin (DMY) at varying concentrations (0-20%) was used to modify silk sericin (SS), thereby enhancing sericin's interfacial and functional properties. SS forms covalent complexes with DMY, as evidenced by the red shift of the ultraviolet absorption peak and fluorescence quenching, along with a decrease in free amino and sulfhydryl contents. Fourier transform infrared (FTIR) spectroscopy, H NMR spectra, and molecular docking results further corroborated the predominant covalent binding.

Integrated untargeted and targeted metabolomics to reveal the mechanisms of herbal medicine HLXLD on Alzheimer's disease.

Huo-Luo-Xiao-Ling-Dan (HLXLD), a Chinese herbal medicine consisting of 11 herbs, has been shown to be effective in alleviating cognitive and memory impairment in Alzheimer's disease (AD). However, the underlying mechanisms require further investigation. This study aimed to clarify potential therapeutic mechanisms of HLXLD in the treatment of AD from a metabolic perspective.

Chromatin accessibility analysis reveals functional cis-regulatory regions related to fruit development and domestication in tomato.

Non-coding DNA sequences harbor vast regulatory programs that ensure the precise spatiotemporal control of gene expression, which is essential for proper plant development and trait formation. Chromatin accessibility analysis could identify functional DNA regions within the extensive non-coding sequences and infer regulatory elements, serving as a crucial approach to unravel the mysteries of non-coding DNA sequences. Tomato fruit, a fleshy organ, provides a special system for studying fruit development and trait formation.

Design, synthesis, and pharmacological evaluation of novel M muscarinic receptor positive allosteric modulators for schizophrenia treatment.

The muscarinic acetylcholine M receptor (M mAChR) has emerged as a promising target for schizophrenia treatment. M positive allosteric modulators (PAMs) can enhance endogenous acetylcholine signaling by binding to the allosteric site of the receptor. Compared with M agonists, the regulation of M mAChR function by PAMs is more precise and has fewer off-target effects.

Power spectrum curve compensation method for image quality enhancement in high-throughput gene sequencing.

In high-throughput gene sequencing, the quality of sequencing images is critical for the accuracy of subsequent base calling. However, during practical sequencing processes, the time delay integration (TDI) camera's push-scan imaging often leads to significant degradation of image quality along the push-scan direction. Addressing the current limitations in TDI image restoration research for gene sequencing, this study establishes an imaging spectrum model of sequencing images based on MGI's ultra-high-throughput sequencer.

Rate of abnormal renal function index and related risk factors in patients with chronic hepatitis B.

Background: Patients with chronic hepatitis B (CHB) require long-term antiviral therapy. The effects of different antiviral drugs on kidney function are unclear. There is a lack of effective markers for monitoring early renal impairment.

METTL3 mediates m6A methylation modification of ULBP2 and affects the progression of cervical cancer.

Background: Cervical cancer (CC) is one of the most prevalent malignancies in women, posing a significant challenge globally. However, the precise molecular mechanism regulating CC progression through methyltransferase-like protein 3 (METTL3) and UL16 Binding Protein 2 (ULBP2) remains largely unknown.

Methods: Bioinformatic analysis was used to identify the effect of ULBP2 expression in CC tissues.

Construction of a risk prediction model for falls in elderly lung cancer patients with sarcopenia.

Background: To explore the risk factors associated with falls in elderly lung cancer patients with sarcopenia, construct a predictive model, and validate its performance.

Methods: This cross-sectional study involved 316 lung cancer patients with sarcopenia who were hospitalized in the oncology, thoracic surgery, and respiratory medicine departments of a tertiary hospital in Jiangxi Province between January 2023 and December 2023. Data were collected through questionnaires and physical measurements.

Perceived Neighborhood Disorder, Health Behaviors, and Inflammation Among Older Adults: A Mediation Analysis.

ObjectivesThis study investigates whether neighborhood disorder has indirect effects on inflammation via health behaviors and whether the pathways vary by race and ethnicity.MethodsThe study sample came from the Health and Retirement Study in 2014 and 2016. Inflammation level was assessed with C-reactive protein.

Tantalum doping triggered electronic reconfiguration of cobalt phosphide for efficient and stable overall seawater splitting.

The design of pre-catalysts is crucial for constructing highly durable and active seawater oxidation catalysts. In this work, a Ta-CoP catalyst for overall seawater splitting was successfully synthesized via an orbital electron interaction strategy, where Tantalum (Ta) was selected as the doping element, which enables strong interaction with the d-orbital electrons of cobalt (Co). Ta doping significantly alters the coordination environment of Co, leading to a notable increase in the charge density within the Co(P) bond.

Integrative fMRI and multiomics reveal neuroprotective mechanisms of Astragalus membranaceus in sleep deprivation-induced depression.

Background: Sleep deprivation (SD) is a significant public health concern and a risk factor for neuropsychiatric disorders, including depression. SD disrupts the gut-brain axis, causing dysbiosis and neuroinflammation. Astragalus membranaceus (AST) exhibits antidepressant and anti-inflammatory properties, including modulation of the gut microbiota; however, its neuroprotective effects on SD-induced neuropsychiatric disturbances remain largely unexplored.

Early replacement of re-induction therapy following failed intensive induction treatment enhances the therapeutic efficacy of newly diagnosed AML.

20-30% of newly diagnosed Acute myeloid leukemia(AML) patients fail to achieve complete response (CR) following intensive induction chemotherapy. This retrospective study aimed to evaluate the efficacy of reinduction regimens in improving CR rates among newly diagnosed AML patients who did not achieve partial response(PR) after initial intensive induction therapy. We conducted a retrospective analysis of 175 newly diagnosed AML patients aged 18-60 years, treated at the First Affiliated Hospital of China Medical University between January 2020 and March 2024.

Tailored Gas-Solid Interfacial Selectivity of Porous Polyionic Liquid Monoliths for High-Efficiency PM Interception and Accurate CO Sieving.

The high intrinsic viscosity of liquid-state ionic liquids (ILs) significantly impedes their application in the coseparation of CO and PM from flue gas, as this attribute leads to diminished adsorption capacity and substantial energy consumption. Herein, we present a direct phase transition synthesis strategy that enables single-step conversion of ILs from liquid to solid states through radical polymerization, thereby fabricating monolithic imidazolium-based porous polyionic liquids (VEs) with charge-pore synergy for efficient flue gas separation. The three-dimensional hierarchical porous networks within monolithic VEs feature internal high-flux mass transfer channels, enhancing permeation efficiency under Knudsen diffusion and Fick's law.

sp. nov., a Novel Actinomycete Isolated from Naidong, Xizang (Tibet), China.

The exploration of from extreme environments presents a particularly compelling avenue for novel compound discovery. A Gram-positive, pink-pigmented strain designated HC307 was isolated from a soil sample collected in Xizang (Tibet), China. The exploration of from extreme environments presents a particularly compelling avenue for novel compound discovery.

Discovery of THB Derivates as Ferroptosis Inhibitors for the Treatment of Acute Kidney Injury by Targeting VDAC.

Acute kidney injury (AKI), a clinical syndrome marked by high morbidity and mortality, remains a significant challenge due to the lack of effective therapeutic options. The accumulation of Fe and reactive oxygen species (ROS) in injured renal cells, which triggers ferroptosis, play a key driver in the pathogenesis of AKI. In this study, tetrahydroberberine (THB), a natural product, was identified as a ferroptosis inhibitor that targeted the voltage-dependent anion channel (VDAC).

Enhancement of stability and controlled release of phycocyanin via W/O/W double emulsions prepared with propylene glycol alginate and whey protein isolate.

The effectiveness of phycocyanin (PC) is limited by its poor stability. Herein, we evaluated the protective effect and release of PC from double emulsions (DEs) stabilized by propylene glycol alginate (PGA), whey protein isolate (WPI), and a WPI-PGA (WP) complex. Results showed that WP complex was formed via hydrogen bonding, as well as hydrophobic and electrostatic interactions.

Phycocyanin-butterfly pea (Clitoria ternatea L.) anthocyanin nanoparticles as novel high internal phase Pickering emulsion stabilizers with antioxidant and UV shielding properties.

Protein-based high internal phase Pickering emulsions (HIPPEs) possess versatile functionalities and extensive applications. However, the structural fragility of native proteins limits their direct use. Herein, butterfly pea anthocyanin (BPACN) was utilized to modify phycocyanin (PC), enhancing its interfacial properties and antioxidant capacity.

A study of the relationship between EEG and situation awareness of forklift drivers in task scenarios with different complexities.

Situation awareness (SA) loss in forklift operations is a major human error source. Accurately assessing the SA levels of forklift drivers is essential. While physiological sensors such as electroencephalography (EEG) have been proposed to measure SA, the EEG-SA relationship remains unclear.