The Safety of Cadonilimab: A Systematic Review and Single-Arm Meta-Analysis.

Introduction: Cadonilimab (AK104) is a bispecific antibody that simultaneously targets programmed cell death-1 and cytotoxic T-lymphocyte antigen-4. It has received approval for the treatment of cervical cancer and gastric/gastroesophageal junction cancer. This meta-analysis aims to assess cadonilimab's safety profile.

Daphnetin alleviates renal inflammation, oxidative stress, and apoptosis in septic rats via the JAK2/STAT3 signaling pathway.

Acute kidney injury (AKI) induced by sepsis is a critical condition with high morbidity, posing a significant challenge in clinical settings. Daphnetin (DAP), a natural compound, has demonstrated anti-inflammatory and antioxidant properties in various diseases. This study aims to explore the specific role and underlying mechanism of DAP in sepsis-induced AKI.

Using WGCNA and transcriptome profiling to identify hub genes for salt stress tolerance in germinating soybean seeds.

Salinized soil can significantly hinder soybean growth, leading to a reduction in overall yield. To address this issue, identifying key genes related to salt tolerance in soybeans is essential for improving their resistance to salinity and ensuring sustainable development of soybean production. While current research predominantly focuses on salt tolerance during the seedling stage, there is still a lack of comprehensive studies on the genes involved in salt tolerance during the germination stage.

Asymmetric waveguide and compressively strained quantum well-enabled high-power, polarization-dependent 850 nm gain chip.

The development of high-power gain chips is crucial for advancing hybrid-integrated narrow-linewidth lasers, which face power limitations in emerging applications such as quantum sensing and atomic cooling. This study designed a high-power GaAs-based gain chip based on an asymmetric waveguide and compressively strained quantum wells for the 850 nm wavelength band. By applying the epitaxial structure and low-loss waveguide, a record continuous-wave output power of 114.

Prediction of 3D spatial distribution, driving factors, and risk for heavy metal(loid)s in sediment of Dongdagou River based on ensemble learning.

Sediments contaminated with heavy metal(loid)s can cause harm to the environment. This study proposed the use of machine learning methods to predict, classify, and identify the three-dimensional distribution of heavy metal(loid)s in sediment. Based on the 1423 sampling data from Dongdagou, a total of 8 metal(loid)s and 18 covariates were used to train and test the model.

Risk Factors for Physiologic Radiolucent Lines Under the Tibial Base Plate After Osteoarthritis With Primary Computer-Assisted Navigation TKA-A Nested Case-Control Study.

Background: Osteoarthritis (OA) is the most prevalent joint disease in the elderly population, and primary computer-assisted navigation total knee arthroplasty (CA-TKA) remains a critical therapeutic intervention for OA. The presence of physiologic radiolucent lines (RLLs) beneath the tibial base plate following CA-TKA carries significant long-term clinical implications and is regarded as a potential indicator of prosthetic loosening. However, the specific risk factors for RLL development in CA-TKA, despite its theoretical precision advantages, remain poorly understood.

Phosphoglycerate kinase 1 as a potential prognostic biomarker in papillary thyroid carcinoma.

Backgroud: Papillary thyroid carcinoma (PTC) represents a malignant epithelial tumor characterized with a preference for younger individuals. Despite its generally favorable prognosis, PTC still poses considerable challenges, particularly in regards to the propensity for distant metastasis. As a key enzyme in the glycolytic pathway, phosphoglycerate kinase 1 (PGK1) has been linked to the progression of various cancer types.

Identification and possible mechanisms of Kitasatospora purpeofusca conferring biocontrol potential against Rhizoctonia solani.

Rhizoctonia solani is a widespread and destructive plant pathogenic fungus that infects numerous important crops, including tobacco, where it causes tobacco target spot, a disease that severely impacts production. In this study, a strain ZZ-48, isolated from the rhizosphere soil of forests, exhibited strong antifungal activity with a 79.39 % inhibition rate against R.

Tissue-like Soft Dual-Network Hydrogel Patch with Instant/Tunable Adhesion and Microenvironment Modulation for Infected Wound Healing.

The disorganized microenvironment driven by bacterial infection is a key factor in delayed wound healing. Additionally, uncontrolled adhesion between dressings and wound sites inevitably occurs during long-term treatment, resulting in risks of wound exposure or secondary damage. Here, we designed a dual-network hydrogel patch (CHI(C)-F/N-A) based on an orthogonal cross-linking mechanism with instant/tunable adhesion properties and the function of synergistically modulating the microenvironment, which is designed to address these complex matters.

Biocontrol ability and possible mechanism of Bacillus velezensis LQ-03 against Colletotrichum scovillei, the pathogen of anthracnose on chili pepper.

Background: Pepper anthracnose caused by Colletotrichum scovillei is a destructive disease. Currently, anthracnose diseases are primary controlled using fungicides, but prolonged overuse of conventional chemical fungicides can adversely affect both the environment and human health. Thus, it is essential to explore safer alternative methods for controlling pepper anthracnose to mitigate environmental and food safety risks.

Negative correlation between level of self-reported antisocial personality disorder symptoms and neural responsiveness to looming threats.

Objective: Individuals with antisocial personality disorder (ASPD) exhibit an elevated risk for both threat/frustration-based reactive aggression and goal-directed aggression. This heightened risk may be associated with atypical neural responses to environmental threats. The objective of this study was to investigate neural responsiveness to threatening facial stimuli among individuals with varying levels of self-reported ASPD.

Dissociated neuronal cultures as model systems for self-organized prediction.

Dissociated neuronal cultures provide a powerful, simplified model for investigating self-organized prediction and information processing in neural networks. This review synthesizes and critically examines research demonstrating their fundamental computational abilities, including predictive coding, adaptive learning, goal-directed behavior, and deviance detection. A unique contribution of this work is the integration of findings on network self-organization, such as the development of critical dynamics optimized for information processing, with emergent predictive capabilities, the mechanisms of learning and memory, and the relevance of the free energy principle within these systems.

Specific changes in the levels of circulating cell-free mitochondrial DNA in the serum of patients with diabetic microangiopathy.

Introduction: Diabetic microangiopathy (DMAP) is a common chronic complication of diabetes. This study aimed to explore the early diagnostic value of the copy number and methylation level of cell-free mitochondrial DNA in the serum of patients with DMAP.

Methods: A total of 40 patients with simple diabetes (diabetes group) and 50 patients with DMAP (40 with diabetic nephropathy [DN group] and 10 with diabetic retinopathy [DR group]) were included in the study.

Bibliometric analysis of global research hotspots in ovarian cancer immunotherapy from 2014 to 2024 using CiteSpace.

Bibliometric analysis has been employed to systematically evaluate the research landscape and emerging trends in ovarian cancer immunotherapy over the past decade (2014-2024). A bibliometric analysis of 3,100 publications (including reviews articles and articles) on immunotherapeutic interventions for ovarian malignancies was conducted using the Web of Science Core Collection (2014-2024). Temporal publication trends, institutional collaboration networks, and emerging research foci were systematically examined via CiteSpace software.

Triple-optimization fiber-optic endotoxin-sensing strategy utilizing Limulus Amebocyte Lysate (LAL).

Rapid and reliable detection of lipopolysaccharide(LPS) is critical for the clinical management of sepsis. While the Limulus Amebocyte Lysate (LAL) assay remains the clinical gold standard for endotoxin detection, its heavy reliance on horseshoe crab blood has intensified ecological pressures as wild crab populations decline. Moreover, current alternatives still face challenges in sensitivity, speed, and reagent efficiency.

Nano-enzymatic functionalized dual network hydrogel promotes tendon repair by modulating the inflammatory cycle and cellular behavior.

Tendon injuries are prone to adhesions after repair, which in turn lead to limb dysfunction, which remains a major challenge in clinical treatment. Current research suggests that tendon injuries are affected by the accumulation of reactive oxygen species (ROS), inflammatory responses, and type III collagen deposition. These factors lead to an imbalance between extrinsic and intrinsic tendon healing and are the main reasons for the occurrence of peritendinous adhesions.

Performance of long-term continuous hydrological models in fluvial flow simulation in a large-scale river basin.

Hydrological models are an effective tool for the estimation of peak floods and runoff in planning water development and flood mitigation/adaptation. Continuous hydrologic modeling can determine the relationships between hydrologic processes and environmental changes over long time periods. Therefore, the selection of a theoretically robust and functionally reliable hydrological model is crucial for the effective management of flood risk within a basin.

SIRT7-Mediated MVP Desuccinylation Facilitates Tongue Squamous Cell Carcinoma Progression by Activating JAK2/STAT3 Pathway.

Major vault protein (MVP) plays a contributing role in multifarious cancers, and then its role in Tongue squamous cell carcinoma (TSCC) is uncomprehending. This study aimed to investigate the regulatory effect of MVP on malignant behavior of TSCC cells and its mechanism. We first pointed out the abnormal upregulation of MVP in tumor tissues by immunohistochemistry, western blot, and reverse transcription-quantitative polymerase chain reaction assays.

Design, synthesis, and biological evaluation of KDM5B degraders against hematologic malignancy cells.

Histone lysine-specific demethylase 5B (KDM5B) is frequently overexpressed in a wide range of tumors and is regarded as a promising target for drug development. Current drugs targeting KDM5B are primarily small-molecule inhibitors, which suffer from limitations such as poor selectivity and insufficient pharmacological efficacy. Targeted protein degradation (TPD) technology as an emerging drug development strategy has received extensive attention in recent years, that enables the catalytic elimination of the entire protein of interest, thereby disrupting both the enzymatic and non-enzymatic functions.

Elevated SNHG1 promotes invasion and migration of Cd(II)-transformed cells through Sox2, Rac1, and Slug.

Numerous studies have shown that exposure to cadmium [Cd(II)] contributes to the development of cancers in the lung and other organs. Cd(II) compounds are classified as confirmed human carcinogens; however, the mechanisms underlying Cd(II)-induced carcinogenesis remain poorly understood. Small nucleolar RNA host gene 1 (SNHG1), a long non-coding RNA (lncRNA), has been identified as an oncogene.