Integrating Multi-Omics Data Using Machine Learning to Explore New Therapeutic Targets for Acute Kidney Injury.

Renal ischemia-reperfusion (I/R) injury is an unavoidable complication associated with renal transplantation, and currently, there are no targeted therapeutic interventions. The objective of this study was to explore the molecular mechanisms that contribute to I/R-induced acute kidney injury (I/R-AKI) and to discover potential targets for effective renal safeguarding. Bioinformatics techniques were employed to analyse critical genes regulating I/R-AKI at the single-cell level and to develop diagnostic models.

Genome sequencing and population genomics provide insights into the demographic history, genetic load, and local adaptation of an endangered Tertiary relict.

Endangered Tertiary relict trees represent an exceptional evolutionary heritage with small and isolated populations, yet little is known about how demographic history, local adaptation, and genetic load have affected their long-term survival and extinction risk. We performed whole-genome sequencing and population genomic analyses on Ulmus elongata L. K.

Genomic Insights Into Local Adaptation Across Heterogeneous Understory Habitats and Climate Change Vulnerability.

Understanding adaptive evolution and survival risks in understory herbs is crucial for the effective conservation of biodiversity. How environmental gradients shape species local adaptation patterns is not well understood, nor is how populations of understory herbs respond to a changing climate. In this study, we conducted population genomic analyses of Adenocaulon himalaicum (Asteraceae) with a pan-East Asian distribution, representing a good model for dominant understory herbs to elucidate adaptation mechanisms in heterogeneous forest ecosystems.

METTL1 drives glioma progression by promoting N7-methylguanosine (m7G) modification of glycolysis-related enzyme PGK1.

Glioma is a common brain malignancy with a poor prognosis. N7-methylguanosine (m7G) modification is involved in cancer progression, and methyltransferase 1 (METTL1) is a m7G methyltransferase. Here, we aimed to study the role of METTL1 in glioma and the potential mechanism.

Toxic Effects of Povidone-Iodine on : Concentration-Dependent Responses in Oxidative Stress, Immunosuppression, and Recovery Potential.

Povidone-iodine (PVP-I), a widely used aquaculture disinfectant, remains poorly understood in terms of sublethal toxicity and damage reversibility. This study employed as the model organism to evaluate the acute toxicity and sublethal effects of PVP-I through a 4-day exposure experiment followed by a 7-day depuration period. Acute toxicity tests enabled the determination of 24-96 h median lethal concentrations (LC), with the 96 h LC being 5.

Prediction of 3D spatial distribution, driving factors, and risk for heavy metal(loid)s in sediment of Dongdagou River based on ensemble learning.

Sediments contaminated with heavy metal(loid)s can cause harm to the environment. This study proposed the use of machine learning methods to predict, classify, and identify the three-dimensional distribution of heavy metal(loid)s in sediment. Based on the 1423 sampling data from Dongdagou, a total of 8 metal(loid)s and 18 covariates were used to train and test the model.

Betulinic Acid Alleviates Acute Pancreatitis by Promoting SIRT1-PINK1-Mediated Mitophagy in Acinar Cells.

Betulinic acid (BA) has the potential to ameliorate acute pancreatitis (AP); however, the mechanisms have not been fully elucidated. This study aimed to identify the effect of BA on mitophagy and its mediated acetylation. Rat pancreatic acinar AR42J cells were treated with cerulein to simulate AP-induced injury, and then inflammation and mitophagy were evaluated after BA treatment.

Tale of one emergent game: Opinion formation in dynamical undirected hypergraphs.

Opinion dynamics in dynamical hypergraphs, mirroring the dynamical nature of high-order social interactions, are attracting increasing attention. Opinion dynamics on high-order interactions lead to non-trivial dynamical patterns compared with that on pairwise networks. How should we systematically understand the intrinsic differences between opinion dynamics in hypergraphs and that in networks? We establish a voter model in a dynamical hypergraph.

Hard-Soft-Acid-Base Management Enabled Bright and Stable Pure-Blue Perovskite Quantum Dot LEDs.

Light-emitting diodes (LEDs) based on perovskite quantum dots (QDs) have achieved external quantum efficiencies (EQEs) exceeding 20% at a practical luminance (>1000 cd m) for real-world applications in the green and red regions. However, the pure-blue perovskite QD LEDs still suffer from low efficiency at high luminance: the EQE of the reported best device at 600 cd m is below 7.0%.

Modular assembled biomimetic nanobubbles for synergistic therapy of ischemic stroke cascade modulation thrombo-inflammatory network.

Dynamic pathology-adaptive nanodelivery systems represent a promising frontier in acute ischemic stroke (AIS) therapy. Here, we report a thrombo-inflammatory cascade-targeted biomimetic nanobubble engineered through gas-liquid interfacial modular assembly of platelet membranes and immunomodulator fingolimod (FTY720). Molecular dynamics simulations uncovered a gas-liquid interfacial self-organization mechanism driving the ordered spatial distribution of platelet membrane lipid rafts and amphiphilic FTY720 to fabricate platelet membrane coated FTY720 nanobubble (PFNB).

Autophagy-induced NR2F1 activation promotes the apoptosis of lens epithelial cells and facilitates cataract-associated fibrosis through targeting STAT3.

Cataracts, a widely prevalent ocular pathology, engender visual impairment and emerge as a primary etiological factor contributing to ocular blindness. Substantial evidence substantiates that epithelial-mesenchymal transition stands prominently among the pivotal causative factors associated with this debilitating condition. However, the underlying mechanism remains unclear.

A bispecific antibody-drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial.

Research on patients with advanced esophageal squamous cell carcinoma (ESCC) who have progressed on immunotherapy remains limited. BL-B01D1 is a first-in-class antibody-drug conjugate consisting of an EGFR-HER3 bispecific antibody bound to a topoisomerase I inhibitor (Ed-04) payload via a cleavable linker. Here, we present safety and efficacy data from a phase 1 study of BL-B01D1, in 82 patients previously treated for ESCC.

A high-quality chromosome-level genome assembly and annotation of the giant freshwater prawn (Macrobrachium rosenbergii).

The giant freshwater prawn, Macrobrachium rosenbergii, is native to Southeast Asia and is used in aquacultural practices worldwide. It is considered advantageous because of its rapid growth, high nutritional value, and economic benefits. As one of the three major freshwater aquaculture shrimp sources in China, a high-quality genome resource is of great significance for promoting the germplasm improvement of varieties.

Hybrid-Dimensional Heterostructure Enables Efficient Near-Infrared Perovskite Quantum Dot Light-Emitting Diodes.

Perovskite quantum dots (QDs) have shown promise in light-emitting diodes (LEDs) in the visible color range. Nevertheless, the efficiency and luminance of perovskite QDs in the near-infrared region (NIR, >750 nm) remain an issue. One reason comes from the liable surface and dynamic ligand binding of the ionic nature of perovskite QDs.

The Role of EZH2 in Initiating Epigenetic Regulation of CRSwNP.

Purpose: Chronic rhinosinusitis with nasal polyps (CRSwNP) was a polygenic disease whose pathogenesis involved epigenetic mechanisms. This study aimed to analyze biomarkers and pathways associated with CRSwNP using RNA-sequencing and explore the role of key biomarkers in the inflammatory response through epigenetic regulation in nasal mucosal cells. Particularly on EZH2, a key epigenetic regulator and histone methyltransferase, to explore its potential for CRSwNP immunotherapy.

Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway.

Diabetic cataract (DC), a well-recognized complication in diabetic patients, can progress to blindness if not adequately managed, with currently limited therapeutic strategies. Icariin (ICA), a natural compound derived from Epimedium, has been demonstrated exhibiting anti-inflammatory and anti-oxidant, but its impact on diabetic cataracts remains elusive. In this study, we used both SRA01/04 cells and SD rats' model to explored the protective effects of ICA in cataract formation.

Association between prealbumin levels and pulmonary hypertension in peritoneal dialysis patients: a single-center retrospective cohort study.

Background: Pulmonary hypertension (PH) is common in peritonealdialysis (PD) patients and is associated with increased morbidity and mortality. However, the specific risk factors for PH and its prognostic impact remain underexplored, particularly in suburban populations. This study aimed to investigate the risk factors for PH and evaluate its impact on long-term all-cause and cardiovascular mortality in PD patients.

Real-time synthesis of twisted Gaussian Schell-model beams and their applications in suppressing the turbulence-induced scintillation and beam wander.

Twist phase is a unique degree of freedom in partially coherent optical fields, which produces photonic orbital angular momentum (OAM) similar to the vortex phase. In this Letter, we report a method for efficiently generating twisted Gaussian Schell-model (TGSM) beams using the Laguerre-Gauss (LG) mode decomposition via a digital micro-mirror device. By judiciously controlling the modal weight of each LG mode, we experimentally generate the high-quality TGSM beams in real time, only involving dozens of LG modes for superposition.

Effects of Dietary Astaxanthin on Growth, Coloration, Immunity, and Antioxidant Capacity in .

This study investigated the effects of astaxanthin (Ax) on the growth, body color, and immunity of . Four different concentrations of Ax (0, 50, 100, and 200 mg kg) were supplemented in the basal diet to assess their impact on the growth, coloration, immunity, and antioxidant capacity in . After 10 and 20 weeks of feeding, compared to the control group, the addition of 100 mg kg⁻ of Ax significantly increased the weight gain rate (WGR) and specific growth rate (SGR; < 0.

Amidation-Retarded Synthesis of Perovskite Quantum Dots with Low Defect Density and Enhanced Carrier Transport for Efficient Light Emitting Diodes and Solar Cells.

Perovskite quantum dots (PQDs) are promising for both solar cells (SCs) and light emitting diodes (LEDs) for their excellent optoelectronic characteristics and solution-processable fabrication. One of the general limitations for these two kinds of devices is that high defect density and poor charge transport, resulting from the unavoidable amidation-induced PbX precipitation at high reaction temperature. In this work, an amidation-retarded synthesis strategy is proposed to prevent the PbX precipitation and subsequent defect formation.

Clinical efficacy of percutaneous closure of patent foramen ovale in children diagnosed with migraine.

Objective: This retrospective analysis aimed to assess the clinical efficacy of patent foramen ovale (PFO) closure for the treatment of migraine in children.

Methods: Data from 35 children diagnosed with migraine and PFO (pre-intervention transthoracic echocardiography did not detect PFO in some, but saline contrast echocardiography was positive, indicating hidden PFO), admitted to Tianjin Children's Hospital for PFO closure between March 2020 and February 2024, were retrospectively collected and analysed. The efficacy of post-intervention pain relief was evaluated using an 11-point numerical rating scale (NRS-11), headache impact test-6 (HIT-6), and Paediatric Migraine Disability Assessment Score (PedMIDAS), migraine frequency, and duration of each migraine attack.

Evolution of the polarization state and OAM-resolved polarization of full Poincaré beams propagating in the atmosphere.

A detailed study is conducted on the polarization characteristics of full Poincaré beams (FPBs) propagating through atmospheric turbulence, including polarization state, degree of polarization, OAM-resolved Stokes parameters, and OAM-resolved degree of polarization. Analytical solutions for the cross-spectral density matrix and its corresponding coherence-orbital angular momentum (COAM) matrix are formulated. We show that the polarization distribution of the propagating FPBs in turbulence, at any transversal plane, still remains a stereographic projection of the Poincaré sphere but rotates with respect to its propagation axis.

β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation.

Ischemia‑reperfusion injury‑induced acute kidney injury (IRI‑AKI) involves inflammatory cell infiltration and increased apoptosis, although the potential association between these processes remains unclear. The aim of the present study was to assess the impact of β‑elemene treatment on the IRI‑AKI using both and models, reverse transcription‑quantitative PCR, western blot assays, hematoxylin and Eosin (H&E) staining, Immunohistochemical staining and TUNEL staining. β‑elemene significantly decreased morphological and pathological kidney inflammation in mice caused by IRI.

LncRNA AK020546 Alleviates Myocardial Ischemia-Reperfusion Injury via Suppressing METTL14/m6A/MST1 Axis-Mediated Ferroptosis.

Ferroptosis occurs after myocardial ischemia-reperfusion (I/R) injury. Long non-coding RNA (lncRNA) AK020546 possesses the effect of protecting the myocardium from I/R injury; however, the underlying mechanisms remain not fully understood. This study aimed to investigate the effect of AK020546 on ferroptosis in cardiomyocytes and underlying molecular mechanisms.

Associations among blood heavy metals, neurofilament light chains and cognition function in US adults: NHANES 2013-2014.

Background: Heavy metals could induce neurotoxicity, leading to cognitive function and motor deficiencies. Serum neurofilament light chain (sNfL) is a promising biomarker for neurological injury, and it may indicate nerve damage from heavy metals exposure. However, there's limited research exploring the associations among heavy metals, sNfL, and cognitive function in adults, and the existing findings are inconsistent.