Silencing of METTL14 attenuates experimental intracerebral hemorrhage by suppressing TFRC-mediated ferroptosis.

Ferroptosis is emerging as a pathological mechanism of intracerebral hemorrhage (ICH), and inhibiting ferroptosis contributes to improving prognosis. N6-methyladenosine (m6A) methylation is a common RNA modification that is involved in disease progression. This study aimed to explore the effect of METTL14, a m6A transmethylase, on ferroptosis and the molecular mechanism, and identify its role in ICH progression.

Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma.

Objectives: The combination of dynamic-contrast-enhanced-magnetic-resonance-imaging (DCE-MRI) with the apparent-diffusion-coefficient (ADC) holds significant value for predicting tumor pathological outcomes. This study pioneers the combined application of DCE-MRI and ADC parameters to evaluate their utility in differentiating histopathological grades of adenoid cystic carcinoma (ACC).

Methods: Retrospective diagnosis of 23 ear and temporal ACC patients was confirmed based on surgical pathology from March 2020 to April 2024.

Dialysis dependence is associated with poor prognosis in multiple myeloma: a multicenter retrospective cohort study.

Background: Patients with multiple myeloma (MM) and renal impairment (RI), particularly those requiring dialysis, have historically experienced poor outcomes. Despite advancements in targeted therapies, the prognosis of dialysis-dependent MM and factors influencing dialysis independence remain unclear.

Objectives: This study aimed to provide a comprehensive analysis of the clinical manifestations and treatment outcomes of dialysis-dependent MM patients in China, and to explore the factors associated with dialysis independence and long-term survival.

Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.

Randomized double-blind trials have shown that probiotic mixtures significantly increase high-density lipoprotein (HDL) levels and reduce the risk of cardiovascular disease mortality in end-stage renal disease (ESRD) patients. Meta-analysis with prospective cohort studies further confirms that elevated HDL is a protective factor for ESRD outcomes. In severe renal injury models, including 5/6 nephrectomy and apolipoprotein E-deficient ( ) mice, probiotics restored cardiac function, mirroring the cardioprotective effects seen in humans.

Comparison of the efficacy and adverse events between argon-helium cryoablation and microwave ablation for non-small cell lung cancer: a propensity score matching study.

Background: Microwave ablation (MWA) and argon-helium cryoablation (AHC) have emerged as widely utilized therapeutic modalities for non-small cell lung cancer (NSCLC) globally, prompting increasing research focus on the comparative clinical characteristics and prognostic outcomes associated with these two ablation techniques. This study aimed to explore the clinical characteristics and prognosis of MWA and AHC in the treatment of NSCLC.

Methods: A total of 125 cases of NSCLC treated in the Beijing University of Chinese Medicine Dongzhimen Hospital were retrospectively analysed.

Betulinic Acid Alleviates Acute Pancreatitis by Promoting SIRT1-PINK1-Mediated Mitophagy in Acinar Cells.

Betulinic acid (BA) has the potential to ameliorate acute pancreatitis (AP); however, the mechanisms have not been fully elucidated. This study aimed to identify the effect of BA on mitophagy and its mediated acetylation. Rat pancreatic acinar AR42J cells were treated with cerulein to simulate AP-induced injury, and then inflammation and mitophagy were evaluated after BA treatment.

Socioeconomic gradients in cancer survivorship mortality pathways and interventions.

This commentary examines socioeconomic disparities in mortality among cancer survivors, drawing insights from a cohort study demonstrating that unhealthy lifestyles mediate 13.5%-28.7% of socioeconomic status (SES)-related mortality differences.

Mitochondrial cardiovascular diseases: molecular mechanisms, multi-omics exploration and therapeutic strategies.

Background: Recent research highlights that abnormal mitochondrial function is a key feature in several cardiovascular diseases (CVDs), including aortic dissection, aortic aneurysm, atherosclerosis, pulmonary hypertension, and heart failure. We propose a novel concept termed mitochondrial cardiovascular diseases (Mito-CVDs) to define these conditions, which involve heart and vascular disorders directly driven by mitochondrial impairments, with the aim of highlighting the critical role of mitochondria in CVDs.

Aim Of Review: This review aims to explore the complex relationship between mitochondrial impairments and Mito-CVDs, offering insights into potential molecular mechanisms and therapeutic strategies to address these diseases.

A multi-stage training and deep supervision based segmentation approach for 3D abdominal multi-organ segmentation.

Accurate X-ray Computed tomography (CT) image segmentation of the abdominal organs is fundamental for diagnosing abdominal diseases, planning cancer treatment, and formulating radiotherapy strategies. However, the existing deep learning based models for three-dimensional (3D) CT image abdominal multi-organ segmentation face challenges, including complex organ distribution, scarcity of labeled data, and diversity of organ structures, leading to difficulties in model training and convergence and low segmentation accuracy. To address these issues, a novel multi-stage training and a deep supervision model based segmentation approach is proposed.

Hydroxy-pendant tetrazole as the cage group for photoactivatable push-pull fluorophores.

Photoactivatable fluorophores enable selective fluorescence activation within a defined region of interest at a precisely controlled time point. This high degree of spatiotemporal control over fluorescence emission facilitates advanced imaging modalities and super-resolution microscopy techniques, allowing real-time monitoring of dynamic processes and nanoscale visualization of structural features. The development of photocage groups is the general and most popular strategy for designing photoactivatable fluorophores.

Lactoferrin combined with Coenzyme Q10 ameliorate sarcopenia in an aging mouse model induced by D-galactose.

Sarcopenia is an age-related condition with a slow and prolonged decrease in muscular mass, strength, and function. As the population ages, the frequency of sarcopenia rises, and aggressive prevention methods and effective treatment options are in urgent need. Here, we explore the hypothesis that nutritional interventions can ameliorate skeletal muscle aging in mice affected by sarcopenia, and the aforementioned hypothesis was validated through histopathological characterization and behavioral experiments.

The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis.

Liver sinusoidal endothelial cells (LSECs) are essential for maintaining liver function by actively sensing nutrients and producing angiocrine factors. LSECs also regulate systemic iron metabolism by secreting bone morphogenetic proteins (BMPs), key modulators of systemic iron homeostasis. However, the mechanism by which LSECs sense iron to regulate iron metabolism remains unclear.

Metabolic Features and Nutritional Interventions in Chronic Diseases.

Metabolic dysfunction is closely linked to the pathogenesis and progression of various chronic diseases [...

Dietary Supplement Use Is Associated with Select Serum Nutrient Biomarkers among Postmenopausal Women: Results from a Controlled Feeding Study.

Background: Dietary supplement use is common among older adults; however, the association between supplement use and corresponding nutrient biomarkers in this population is less well understood.

Objectives: This study aimed to determine whether older women using dietary supplements had higher serum concentrations of corresponding biomarkers and whether those using multiple supplement sources of the nutrient had incrementally higher serum nutrient concentrations.

Methods: Participants from the Women's Health Initiative enrolled in a 2-wk feeding study (n = 153).

Interpretable machine learning model integrating contrast-enhanced CT environmental radiomics and clinicopathological features for predicting postoperative recurrence in lung adenocarcinoma: a retrospective pilot study.

Purpose: This study aims to develop an interpretable predictive model combining contrast-enhanced CT (CECT) radiomics features with clinicopathological parameters to assess 3-year recurrence risk after surgery for lung adenocarcinoma (LA).

Methods: A retrospective cohort of 350 LA patients (126 recurrence, 224 non-recurrence) from Xiangyang NO.1 People's Hospital (2016-2023) was included.

Magnetic nanosystems modified with natural polyphenol for white wine stability via efficient haze protein removal.

Protein haze is a significant concern for the white wine industry, impacting sensory quality, stability, and consumer experience. The predominant treatment currently employed in production is bentonite, which leads to high costs and significant wine production losses, while also adsorbing certain aroma and flavor compounds. Therefore, there is a need for cost-effective and efficient methods that do not compromise the wine's flavor and aroma.

KAT2A knockdown induces microglia M2 polarization by succinylation of PRDX3 after traumatic brain injury.

Objectives: Neuroinflammation, a secondary injury following traumatic brain injury (TBI), is closely associated with microglial polarization. Emerging evidence suggests that succinylation plays a critical role in brain injury, yet its regulatory mechanisms remain unclear. Here, we investigated the role of KAT2A, a key succinyltransferase, in modulating microglial polarization.

Uncharted factors in emergency laparotomy outcomes: a call for holistic assessment.

The recent study by Thu et al. investigating the interplay between frailty, sarcopenia, and physical status in patients undergoing emergency laparotomy (EmLap) provides valuable insights into preoperative risk stratification. The authors' efforts to disentangle these complex factors in predicting mortality are commendable, particularly their emphasis on frailty and poor physical status as independent prognostic markers.

Fe Triggers Endocytosis of Carrier Proteins in Mammalian Cells.

Human serum albumin (HSA) plays an indispensable role as a carrier of endogenous and exogenous substances in vivo. The efficiency of endocytosis determines the transport capacity. However, the potential for enhancing the efficiency of HSA endocytosis remains largely unknown.