Prematurity, Neonatal Complications, and the Development of Childhood Hypertension.

Importance: Preterm children face a higher risk of cardiovascular conditions, including hypertension. However, studies have not isolated the associations of prematurity with cardiovascular conditions from the associations of subsequent complications with cardiovascular conditions, especially among those admitted to a neonatal intensive care unit (NICU).

Objective: To investigate prospective associations of prematurity and NICU complications with childhood hypertension while accounting for prenatal and perinatal factors.

Environmental risks from impacts of industrial solid wastes applied on agricultural land in China: a comprehensive overview.

With the rapid development of industrialization in China, more and more industrial solid wastes (ISWs) are generated in industrial production processes. Under the pressure for safe disposals or utilization of ISWs as resources, and the demand for soil pollution remediation in China, there have been attempts to incorporate ISWs into agricultural land as soil amendments, while the environmental impacts of ISWs applied on agricultural land have aroused great concerns. This paper presents a comprehensive overview regarding the environmental risks from impacts of 7 types of ISWs (including blast furnace slag, steel slag, magnesium slag, coal-fired flue gas desulfurization gypsum, phosphogypsum, calcium carbide slag, and ammonia-soda residue) applied on agricultural land.

The STUB1-TPIT axis regulates the secretion of adrenocorticotrophic hormone in cushing disease.

Background: Cushing's disease (CD) is a clinical syndrome caused by excessive secretion of adrenocorticotropic hormone (ACTH) from a pituitary corticotroph adenoma, resulting in adrenal cortical hyperplasia and overproduction of cortisol. The T-box transcription factor (TPIT) is crucial for regulating ACTH secretion in pituitary corticotroph adenomas. This study aims to explore the ubiquitin-mediated degradation of TPIT and identify potential pharmaceutical agents for treating CD.

Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.

Randomized double-blind trials have shown that probiotic mixtures significantly increase high-density lipoprotein (HDL) levels and reduce the risk of cardiovascular disease mortality in end-stage renal disease (ESRD) patients. Meta-analysis with prospective cohort studies further confirms that elevated HDL is a protective factor for ESRD outcomes. In severe renal injury models, including 5/6 nephrectomy and apolipoprotein E-deficient ( ) mice, probiotics restored cardiac function, mirroring the cardioprotective effects seen in humans.

Blood plasma trimethylamine N-oxide and related metabolites and asthenozoospermia odds: a hospital-based matched case-control study in China.

Study Question: Are blood plasma trimethylamine N-oxide (TMAO) and related metabolites linked to the odds of asthenozoospermia?

Summary Answer: Increased blood plasma TMAO levels were positively associated with the odds of asthenozoospermia, while elevated levels of choline and L-carnitine were related to reduced asthenozoospermia odds, implying that TMAO and its related metabolites might play an important role in the development of asthenozoospermia.

What Is Known Already: Sperm motility and concentration are profoundly impaired by excessive reactive oxygen species (ROS). A positive correlation has been established between ROS levels and TMAO, which is regarded as a key regulatory factor for initiating mitochondrial ROS production.

Risk Factor Analysis of Transient Ischaemic Attack for Moyamoya Disease after a First Combined Revascularization Surgery.

Objective: This study aims to elucidate the characteristics and risk factors for transient ischaemic attack (TIA) after the combined revascularization surgical procedure for first diagnosed Moyamoya disease (MMD) patients.

Methods: This retrospective study involved 129 patients with MMD who underwent their first combined revascularization with the FLOW 800 system at multiple centers from April 2019 to July 2023. Patients were divided into TIA and non-TIA groups according to whether TIA occurred within 6 months post-revascularization.

Effects of Esketamine on Post-Partum Depression in Patients With Different Personality Types Undergoing Caesarean Section: Randomised Controlled Trial.

Background: As an intravenous general anaesthetic, esketamine has rapid and evident antidepressant effects and therefore helps prevent post-partum depression (PPD). This study aimed to observe the effect of intraoperative esketamine application on patients with PPD undergoing caesarean section and to explore whether this effect varies among patients with different personality types.

Methods: A total of 280 patients who underwent elective caesarean section under spinal anaesthesia were randomly divided into esketamine and control groups.

Coupling Mechanism of Methane Production and Carbon Fixation Regulated by Artificial Humic Acid in Paddy Soils: Insights into Microbial Communities and Metabolic Pathways.

The impact of artificial humic acid (HA) under varying water management conditions on the interactions between carbon metabolic pathways in rice soils remains unclear. Therefore, this study employed incubation experiments using HA-treated soil columns under continuous flooding (CF) and alternating wet-dry (AWD) to explore the relationship between CH production and CO fixation. The results demonstrate that HA significantly increased CH emissions, with a 102.

Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale.

While previous studies have examined the role of individual micronutrients in autism spectrum disorder (ASD), limited evidence exists on how maternal dietary patterns during pregnancy relate to broader social and communication outcomes. This study aimed to assess the association between adherence to a Mediterranean-style diet during pregnancy and measures of social impairment in a racially diverse, prospective birth cohort. We analyzed 821 mother-child pairs from the Boston Birth Cohort, including 52 children with an ASD diagnosis.

Incidence and risk factors investigation of chylous leakage following thoracic or lumbar vertebrectomy: a single‑center, retrospective analysis of 545 patients.

Objective: Thoracic or lumbar vertebrectomy is a complex spinal surgical procedure associated with considerable invasiveness and a high incidence of complications, including the infrequent chylous leakage. This study seeks to document the incidence of chylous leakage following thoracic or lumbar vertebrectomy and to investigate the risk factors associated with this complication, thereby offering insights into its prevention and management.

Methods: A retrospective analysis was performed with patients who underwent thoracic or lumbar vertebrectomy at our institution between July 2016 and March 2024.

Complexity analysis of a closed-loop supply chain for power battery recycling under government subsidies.

Considering government subsidies for new energy electric vehicle manufacturers, the study will construct a static game model to analyze the optimal strategies of decision-makers from the perspectives of manufacturers and retailers. It will analysis the impact of key model parameters such as government subsidy criteria, the fund returns rate and market size on optimal strategy selection. Additionally, a dynamic game model will be developed to investigate the complex behavior characteristics of decision-makers, as well as the influence of different behaviors on their complex benefits.

Prenatal Per- and Polyfluoroalkyl Substance Exposures and Longitudinal Blood Pressure Measurements in Children Aged 3 to 18 Years: Findings From a Racially and Ethnically Diverse US Birth Cohort.

Background: Prenatal per- and polyfluoroalkyl substance (PFAS) exposures may influence offspring blood pressure (BP), but long-term studies in diverse populations remain limited.

Methods: Participants were from the Boston Birth Cohort. We measured PFAS in maternal plasma collected 24 to 72 hours after delivery and extracted children's BP from medical records.

SHengXIaN-QuYu DEcoction in the Treatment of Heart Failure with Reduced and Mildly-Reduced Ejection Fraction (SHINE-HF): rationale and design for a multicenter randomized controlled trial.

Background: Although contemporary guideline-directed medical therapy (GDMT) for heart failure (HF) with reduced ejection fraction (HFrEF) and heart failure with mildly-reduced ejection fraction (HFmrEF) has been shown to significantly improve prognosis, patients with these conditions still face considerable residual risk, and their quality of life (QoL) remains severely compromised. ShengXian-QuYu (SXQY) Decoction is a widely prescribed complementary and alternative medicine (CAM) therapy for HF in clinical practice. However, there is currently no robust evidence supporting its efficacy in HFrEF and HFmrEF, and its potential adverse effects have yet to be fully elucidated.

Unraveling the Causal Association Between Circulating Copper Levels and Erectile Dysfunction: A Comprehensive Analysis via Bidirectional Two Sample Mendelian Randomization Study.

Erectile dysfunction (ED) is a prevalent condition severely impacting men's quality of life. While micronutrient balance is critical for sexual health, observational studies on micronutrient and ED remain inconclusive. The objective of this study was to evaluate the causal role of circulating levels of copper and other micronutrients in ED risk by Mendelian randomization (MR).

Radiographical changes and clinical prognosis after cervical laminectomy with posterior instrumented fusion for degenerative cervical myelopathy.

Study Design: A retrospective cohort study.

Objective: The aim of the study is to investigate the radiographic changes of the spinal canal, intervertebral foramina, and spinal cord after cervical laminectomy with posterior instrumented fusion (LF), and to determine the correlation with the length of decompression levels, clinical symptoms, and C5 palsy (C5P). LF is an effective procedure for the treatment of cervical stenosis caused by various reasons.

Muscle-derived factor alleviated cognitive impairment caused by intestinal ischemia-reperfusion.

Intestinal ischemia/reperfusion (II/R) is a common and grave clinical event, with high morbidity and mortality which can cause cerebral dysfunctions. There are no ideal prevention and treatment measures yet. The present study aimed to determine whether muscle-derived factors can alleviate gut-associated cerebral dysfunctions (GACD) following II/R.

High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a frequently encountered disorder characterized by voiding symptoms and pelvic or perineal pain. Proinflammatory T helper 17 (Th17) cells are essential for triggering the development of CP/CPPS. High-salt diet (HSD) consumption has been found to cause an accumulation of sodium chloride in peripheral organs, inducing autoimmune responses via the Th17 cell axis.

Maternal pre-pregnancy overweight/obesity, in-utero exposure to toxic heavy metals, and offspring age at peak height velocity: A prospective birth cohort study.

Introduction: Research on in-utero heavy metal exposure shows inconsistent results on offspring pubertal timing. We aim to contribute to understanding the association between heavy metal exposures and age at peak height velocity (APHV), an indicator of pubertal timing, and to investigate the joint associations of heavy metal concentrations and previously known risk factors.

Methods: We included 956 mother-child dyads from the Boston Birth Cohort.

Integration of proteomics with prospective birth cohort to elucidate early life origins of cardiometabolic diseases: rationale, study design, lab assay, and quality control.

There is growing evidence that the plasma proteome provides insights into personal health status at different stages of life. However, limited data are available on high-throughput proteomic studies in pediatric populations, especially, using prospective birth cohorts. We launched a proteomics study in 990 children from a US predominantly urban, low-income, multi-ethnic prospective Boston Birth Cohort (BBC, referred as "BBC proteomics study"), which aimed to leverage proteomics to investigate the biological pathways underlying the link between preterm birth and child long-term cardiometabolic health.

Arterial Stiffness, Central Blood Pressure, and the Risk of Incident Stroke in Hypertensive Adults.

Background And Aims: Whether hypertensive patients with elevated arterial stiffness and central systolic blood pressure (cSBP) are exposed to higher stroke risk is unclear.

Methods: A total of 6663 participants without a history of cardiovascular disease were enrolled in this study. cSBP was measured noninvasively using the A-Pulse CASPro device; carotid-femoral pulse wave velocity (cfPWV) was collected using a Pulse Pen device.

Climatic features of wind field and their impact on local air quality in Taiyuan Basin.

Taiyuan Basin has long been considered as one of the most air-polluted regions in China, closely related to its enclosed terrain and local climatic conditions. In this study, the wintertime climatic characteristics of the wind field and the corresponding boundary layer structure were investigated for their potential impact on local air quality in Taiyuan Basin, utilizing long-term Weather Research and Forecasting model simulations from 2015 to 2020. Prevailing southwesterly wind in this basin was revealed.

MIKC-Type MADS-Box Gene Analysis Reveals the Role of in Bud Dormancy Transition in Herbaceous Peony.

The MIKC-type MADS-box (MIKC) gene family is essential for controlling various plant developmental processes, including flowering time and dormancy transitions. Although the MIKC gene family has been widely studied across different plants, its characterization and functional study in herbaceous peony remain limited. In this study, 19 Pall.

Maternal exposure to per- and polyfluoroalkyl substances and epitope level antibody response to vaccines against measles and rubella in children from the Boston birth cohort.

Background: Previous studies suggest that per- and polyfluoroalkyl substances (PFAS) may act as immune suppressants. However, research about the impact of PFAS exposure on antibody responses to the measles, mumps, rubella (MMR) vaccine is limited and inconsistent.

Methods: This report includes 748 mother-child pairs from the Boston Birth Cohort, with 8 PFAS compounds measured in maternal plasma shortly after delivery.

Acid-responsive engineered bacteria with aberrant In-Situ anti-PD-1 expression for post-ablation immunotherapy of hepatocellular carcinoma.

Local thermal ablation (TA) can not only reduce the tumor burden of hepatocellular carcinoma (HCC) but also stimulate the host anti-tumor immune response, offering a promising avenue for combination with immune checkpoint blockade (ICB). However, tumor recurrence and ICB resistance are associated with residual tumor masses caused by incomplete TA treatment. Thus, adjuvant therapy that can accurately eliminate residual HCC tumors post-TA is expected to improve prognosis.

Exploring the mechanism of action of succinic acid in ovarian cancer via single-cell sequencing of the tumor immune microenvironment.

Background: The main treatments for ovarian cancer are surgery, chemotherapy, radiotherapy, and targeted therapy. Targeted therapy is a new treatment method that has emerged in recent years and relies on specific molecular targets to treat cancer. Succinic acid is a key intermediate product in the tricarboxylic acid cycle.