Immune-Mediated Bone Loss: A Mendelian Randomization and NHANES-Based Study of Viral Infections and Osteoporosis.

Introduction: Osteoporosis is a major risk factor for fractures, yet the contribution of immune responses to its pathogenesis remains poorly understood. This study investigates whether common viral infections, including Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and varicella-zoster virus (VZV), contribute to osteoporosis through immune-mediated pathways.

Methods: We performed two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) summary data and complemented this with observational analyses from the NHANES 2003-2004 cycle.

Case Report: An integrative approach to psychotherapy for the mother of a daughter with bulimia nervosa.

Caregivers is a crucial factor in recovery and psychological intervention of individuals with eating disorders which are often-overlooked. This study explores the role of integrative therapy in promoting the psychological development of the mother of a daughter with bulimia nervosa, improving family structure, and facilitating the patient's recovery. A 43-month, 54-session intervention was conducted with the mother of a woman with eating disorder using an integrative therapy approach primarily based on Bowen family systems therapy, drawing, and narrative therapy.

Donanemab immunogenicity in participants with early symptomatic Alzheimer's disease.

Introduction: Donanemab is an immunoglobulin G1 antibody that targets an N-terminal truncated form of amyloid beta present in mature plaques. Treatment-emergent (TE) anti-drug antibodies (ADAs) were quantified in donanemab-treated participants from two pivotal clinical trials, and effects of TE ADAs on donanemab pharmacokinetics, efficacy, and safety were assessed.

Methods: Data were pooled from the phase 2 TRAILBLAZER-ALZ (NCT03367403) and phase 3 TRAILBLAZER-ALZ 2 trials (NCT04437511).

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis.

Objective: To systematically assess the impact of TCE on the efficacy of interventions targeting motor symptoms and mobility in people with Parkinson's disease.

Methods: a computerized search was performed for randomized controlled trials assessing TCE intervention for motor symptoms and mobility in Parkinson's disease patients across PubMed, Web of Science, Embase, Cochrane Library, EBSCO, China National Knowledge Infrastructure (CNKI), WanFang data, and VIP database, covering the period from the inception of the databases to January 2025.

Results: fourteen publications encompassing 833 Parkinson's disease patients were incorporated into the literature.

Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from .

Chizhiaroterpenoids A-C (-), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (), 6/6/6/6/7 (), and 6/6/6/5/6 () ring systems, were isolated from . Their biosynthetic pathways were proposed. and suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice.

Efficacy and safety of utidelone in pretreated patients with metastatic breast cancer in China: a multicenter, real-world study.

Background: Utidelone (UTD1), a genetically engineered epothilone derivative, has been approved in China for use in combination with capecitabine in treating metastatic breast cancer (MBC) patients previously treated with anthracyclines or taxanes.

Objectives: To evaluate the real-world efficacy and safety of UTD1 in Chinese patients with MBC and to explore potential predictors of therapeutic effectiveness.

Design: A multicenter, retrospective, real-world study.

Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.

Bone defect repair is a complex physiological process, starting with early modulation by the inflammatory immune system, and involves multiple physiological events, including angiogenesis, osteogenic differentiation, and mineralization. Biomaterial can regulate inflammatory responses through relevant immune cells in the local immune microenvironment of the implant-bone interface which is a hot topic in the field of regenerative medicine. Currently, Mg regulates immune cells in the bone microenvironment to promote osteogenesis and angiogenesis mainly focuses on macrophages,but there is relatively little research on T cells.

Effects of traditional Chinese exercises on the rehabilitation of patients with chronic heart failure: A -analysis.

The systematic -analysis was conducted to evaluate the clinical efficacy of Traditional Chinese Exercises (TCE) in the rehabilitation of patients with chronic heart failure (CHF). The findings provide evidence-based support for the implementation of non-pharmacological interventions in the management of CHF. A systematic search of PubMed, Web of Science, Cochrane Library, and Embase (up to November 2024) identified RCTs evaluating Traditional Chinese Exercise (TCE) for chronic heart failure rehabilitation.

IGFBP6 orchestrates anti-infective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression.

The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights, with our multi-center cross-age cohort study identifying insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis, prognosis, and mortality risk evaluation. Mechanistically, IGFBP6 engages in IGF-independent binding to prohibitin2 (PHB2) on epithelial cells, driving PHB2 tyrosine phosphorylation during sepsis. This process disrupts STAT1 phosphorylation, nuclear translocation, and its recruitment to the CCL2 promoter, ultimately impairing CCL2 transcription and macrophage chemotaxis.

A 3D Nanofiltration Array for Direct Plasma EV Purification with Label-Free SERS Detection toward Accurate Clinical Breast Cancer Staging.

Extracellular vesicles (EVs) have emerged as promising biomarkers in cancer diagnostics. However, rapid and nondestructive isolation of EVs from plasma remains challenging due to the presence of abundant interferents with smaller sizes (e.g.

Chromosome-level genome assembly of the caddisfly Stenopsyche angustata (Insecta: Trichoptera).

Stenopsyche angustata, a species within the diverse order Trichoptera, is widely distributed across freshwater environments and exhibits unique ecological traits that make it an ideal subject for studying adaptive evolution. In this study, we employed Illumina second-generation sequencing, PacBio third-generation sequencing, along with high-throughput chromosome conformation capture (Hi-C) technologies to generate raw sequencing data and construct chromosome-level genome assemblies of S. angustata.

Design of library intelligent lighting system based on deep learning.

Aiming at the problems of low intelligence and energy waste in the current university library lighting system, this paper designs an intelligent lighting solution based on sub-area autonomy control. The improved YOLOv5 human target detection algorithm and the human spatial localization algorithm based on multilayer perceptron are used. The introduction of a coordinate attention mechanism and depth-separable convolution into the YOLOv5 backbone network, along with the optimization of the bounding box regression loss function, resulted in a mean average precision (mAP) of 91.

Repressing epigenetic regulation enhances exogenous gene expression in the macroalga Pyropia yezoensis (Rhodophyta).

Pyropia yezoensis, an economically valuable macroalga, occupies a pivotal position in evolutionary history as a red alga, making it an ideal model organism for investigating the evolution of photosynthesis. However, efficient genetic manipulation in P. yezoensis, particularly the stable expression of exogenous genes, presents substantial challenges.

Decoding adenomyosis pathogenesis using an assembloid model.

Adenomyosis remains a challenging gynecological disorder to investigate due to the absence of in vitro models that accurately replicate endometrial tissue dynamics across the menstrual cycle. To address this gap, we established an endometrial assembloid model that faithfully mimics cycle-dependent endometrial responses and captures key cellular and molecular hallmarks of adenomyosis, including ectopic lesion- specific epithelial and stromal heterogeneity. Single-cell transcriptomics revealed that ectopic epithelial cells shift toward a luminal- dominant, glandular-deficient transcriptional profile during the secretory-like phase.

Mn Single-Atom Photocatalyst Enables Efficient Photocatalytic Reduction of CO.

Photocatalytic conversion of CO into fuels with HO as a proton source is recognized as a promising strategy for CO utilization. However, past efforts have mainly been devoted to the CO reduction reaction and overlooked essential water dissociation that provides a proton source. Herein, the Mn/PCN-N photocatalyst with Mn-N coordination by incorporating Mn single atoms into a polymeric carbon nitride (PCN) framework endowed with nitrogen vacancies (N) is developed for CO photoreduction.

sTLR9 on maternal Circulating immune cells as a negative regulatory phenotype during pregnancy.

TLR9 is an intracellular receptor that can also be localized to the cell surface, called sTLR9. sTLR9 is thought to have a negative immunomodulatory effect, which is conductive to the maintenance of immune tolerance. Since pregnancy is a physiological process accompanied with inflammation experienced by pregnant women while maintaining immune tolerance to the fetus, the change in sTLR9 of immune cells during pregnancy are worth studying.

MiR-29a-loaded nanoparticles alleviate inflammatory bowel disease via Sgk1/Foxo3a axis.

Inflammatory bowel disease (IBD) is an autoimmune disease with a long course, numerous complications, and high disability, and its incidence continues to grow worldwide. microRNA-29a (miR-29a) has the potential to regulate inflammation and fibrosis. However, identifying the targets and designing suitable delivery vectors remain major obstacles in the development of miRNA-based drugs.

Modeling post-gastrula development via bidirectional pluripotent stem cells.

The absence of stem cells capable of efficiently generating both trophoblast and epiblast lineages has hindered precise recapitulation of embryonic development. Through high-content chemical screening, we established an (AS and LY) AL medium to generate mouse bidirectional pluripotent stem cells (BPSCs) characterized by concurrent expression of OCT4 and CDX2. Mouse BPSCs demonstrated highly plastic differentiation into trophoblast, epiblast and primitive endoderm (PrE) lineages in vitro within 48 h without exogenous inducing factors and efficiently contributed to embryonic and extraembryonic tissues in vivo.

Stabilized FeC catalyst with K-Mg dual promotion for robust CO hydrogenation to high-value olefins.

Iron carbide catalysts, particularly the FeC phase, hold significant potential for efficient CO hydrogenation to olefins, yet stabilizing this phase under reactive conditions remains a major challenge. Herein, we report a robust and efficient synthesis of nearly phase-pure FeC catalysts derived from Prussian blue analogues, whose stability is significantly enhanced by strategically incorporating K and Mg promoters. Comprehensive characterization reveals that K accelerates the carbonization process and markedly enhances olefin selectivity, whereas Mg effectively suppresses water-induced oxidation, preserving the structural integrity of the FeC phase.

MicroRNA319-TCP19-IAA3.2 Module Mediates Lateral Root Growth in .

MicroRNA319 (miR319) and its targets TEOSINTE-BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors are well-characterized regulators of leaf and flower development, yet their role in root development remains elusive. Here, we demonstrated that overexpression of led to a decrease in the number and density of lateral roots in poplar, while repressing by short tandem target mimics (STTM) promoted lateral root (LR) development. The auxin signaling repressors and were upregulated in -OE plants but downregulated in -STTM plants.

Investigation of Novel Therapeutic Targets for Rheumatoid Arthritis Through Human Plasma Proteome.

: Rheumatoid arthritis (RA) is an autoimmune disease that remains incurable. An increasing number of proteomic genome-wide association studies (GWASs) are emerging, offering immense potential for identifying novel therapeutic targets for diseases. This study aims to identify potential therapeutic targets for RA based on human plasma proteome.

The impact of high-intensity exercise on patients with depression: a systematic review and meta-analysis of randomized controlled trials.

Objective: This study systematically evaluated the effectiveness of high-intensity exercise as an intervention for patients with depression through meta-analysis.

Methods: Relevant studies were retrieved from PubMed, Embase, Cochrane, and Web of Science up to June 30, 2025. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated.

Exploring the Biosynthetic Potential of Microorganisms from the South China Sea Cold Seep Using Culture-Dependent and Culture-Independent Approaches.

Cold seep ecosystems harbor unique microbial communities with potential for producing secondary metabolites. However, the metabolic potential of cold seep microorganisms in the South China Sea remains under-recognized. This study employed both culture-dependent and culture-independent approaches, including 16S rRNA amplicon sequencing and metagenomics, to investigate microbial communities and their potential for secondary metabolite production in the South China Sea cold seep.

Pilot-scale integration of micron-sized powder carriers and a hydrocyclone separator enhances nutrient removal in wastewater treatment.

Activity, abundance, and synergy of functional microorganisms are pivotal for wastewater treatment. Here, we developed a micron-medium biofilm composite sludge system, integrating powder carriers and a hydrocyclone separator to enhance functional bacterial enrichment and micro-granule formation. Powder carriers acted as bridges between zoogloea, facilitating coexistence of micro-granules (~115.