A 3D Nanofiltration Array for Direct Plasma EV Purification with Label-Free SERS Detection toward Accurate Clinical Breast Cancer Staging.

Extracellular vesicles (EVs) have emerged as promising biomarkers in cancer diagnostics. However, rapid and nondestructive isolation of EVs from plasma remains challenging due to the presence of abundant interferents with smaller sizes (e.g.

A wearable SERS-microfluidic patch for continuous monitoring of kidney health-related biomarkers in sweat.

Non-invasive and real-time monitoring of biomarkers such as urea and uric acid (UA) in sweat is of great significance for comprehensive health management, especially for those with intense exercise routines or in need of continuous health tracking. However, common flexible sensors are typically designed for single measurement, which hinders the significant applications of continuous and on-demand health regulation. Here, a wearable patch utilizing surface-enhanced Raman spectroscopy (SERS) and manually manageable microfluidics has been proposed for on-demand assessment of urea and UA in sweat.

One-step detection of nanoplastics in aquatic environments using a portable SERS chessboard substrate.

Nanoplastics present a significant hazard to both the environment and human health. However, the development of rapid and sensitive analysis techniques for nanoplastics is limited by their small size, lack of specificity, and low concentrations. In this study, a surface-enhanced Raman scattering (SERS) chessboard substrate was introduced as a multi-channel platform for the pre-concentration and detection of nanoplastics, achieved by polydomain aggregating silver nanoparticles (PASN) on a hydrophilic and a punched hydrophobic PVDF combined filter membrane.