Dual Effects of a Combination of and Inflammation and Hyperuricemia.

This study developed an effective combination of and (SNE) and evaluated its anti-inflammatory and anti-hyperuricemic effects under conditions. First, the effect of SNE was tested on xanthine oxidase (XOD) activity. To investigate the anti-inflammatory effect of SNE, nitric oxide (NO) production was detected by Griess assay, and proinflammatory cytokines were measured by enzyme-linked immunosorbent assay in RAW264.

Pain-Free and Wireless Luminescent Microneedle Sensor Array for In Situ Monitoring Tissue Oxygenation Status in Diabetic Foot Ulcers.

Diabetic foot ulcers (DFUs) is a severe complication of diabetes, progressing insidiously at early stages but eventually leading to amputation. Therefore, to effectively bring DFUs under control, early diagnosis is crucial. Recent researches have shown that DFUs progression correlates with tissue oxygenation.

Research hotspots and trends in the interaction mechanisms of neuroinflammation and sleep disorders: A bibliometric analysis based on WOS.

This study aims to analyze the research hotspots and trends regarding neuroinflammation in sleep disorders over the past 30 years through bibliometric and review analyses. Relevant publications were sourced from the Web of Science Core Collection (WoSCC). We utilized VOSviewer and CiteSpace for the visualization and quantitative analysis of the literature to provide an objective presentation and predictions.

Communicating with two vehicles immediately ahead boosts traffic capacity sixfold in connected autonomous vehicle platoons.

Addressing urban congestion through enhanced traffic capacity has emerged as a critical objective for connected autonomous driving technologies. An irredundant communication connectivity topology is essential for ensuring the high efficiency and stability of the traffic system, which has not been fully validated due to the scarcity of real-world tests. Motivated by this fact, this paper deploys a connected autonomous vehicle platoon without relying on the information of a platoon leader to preserve the possibility of extending the platoon in future practical applications.

Modeling post-gastrula development via bidirectional pluripotent stem cells.

The absence of stem cells capable of efficiently generating both trophoblast and epiblast lineages has hindered precise recapitulation of embryonic development. Through high-content chemical screening, we established an (AS and LY) AL medium to generate mouse bidirectional pluripotent stem cells (BPSCs) characterized by concurrent expression of OCT4 and CDX2. Mouse BPSCs demonstrated highly plastic differentiation into trophoblast, epiblast and primitive endoderm (PrE) lineages in vitro within 48 h without exogenous inducing factors and efficiently contributed to embryonic and extraembryonic tissues in vivo.

Impact of left anterior descending lesion location on midterm outcomes in patients undergoing left internal mammary artery grafting: a five-year cohort study integrating quantitative flow ratio assessment.

Background: The prognostic value of coronary artery bypass grafting (CABG) may be suboptimal when guided solely by anatomical stenosis severity. Quantitative flow ratio (QFR), a computational angiography-derived hemodynamic assessment tool, offers functional insights; however, its prognostic interplay with lesion localization [proximal vs. mid-to-distal left anterior descending artery (LAD)] remains unclear.

Central glutathione mitigates obesity-induced social phobia: evidence from human and animal studies.

Objective: To explore the impact of obesity on social phobia and the therapeutic effect of the antioxidant glutathione on this disorder.

Methods: A total of 600 subjects were divided into an Obese Group and a Control Group. Four scales were utilized to determine social phobia, and magnetic resonance spectroscopy was applied to evaluate the central glutathione levels.

L-shaped association between fibrinogen to serum albumin ratio and all-cause mortality among critically ill children: a retrospective cohort study.

Background: While elevated fibrinogen-to-albumin ratio (FAR) correlates with all-cause mortality in adults, its prognostic value in pediatric intensive care units (PICUs) remains unclear. This study aimed to investigate the association between FAR and in-hospital all-cause mortality in critically ill pediatric patients.

Methods: We conducted a retrospective cohort study analyzing the PIC database from 2010 to 2018.

Association between coffee consumption and life expectancy: a prospective cohort study from NHANES 2001-2018.

Objective: To assess the association between coffee consumption and life expectancy among the US adults.

Design: Prospective cohort.

Setting: National representative survey in the United States, 2001-2018.

Thyroid hormones and cognitive function in chronic schizophrenia: a large-scale cross-sectional study.

Background: Cognitive dysfunction is a core symptom in chronic schizophrenia, yet the mechanisms underlying these impairments remain poorly understood. Thyroid hormones have been suggested to influence cognitive function in various psychiatric disorders, but their role in schizophrenia remains unclear. This study aimed to explore the relationship between thyroid hormone levels and cognitive performance in patients with chronic schizophrenia.

Effects of endoscopic minimally invasive surgery on olfactory function and quality of life in patients with chronic rhinosinusitis and nasal polyps.

Objective: To evaluate the efficacy of endoscopic minimally invasive surgery (EMIS) in improving olfactory function and quality of life among patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Methods: A cohort of 117 patients diagnosed with CRSwNP between January 2020 and June 2024 were included in this retrospective study. Patients were assigned to either a control group (n=50, treated with conventional endoscopic sinus surgery [ESS]) or a research group (n=67, treated with EMIS).

Development of nomogram model based on LASSO-Logistic regression for predicting postoperative undernutrition to complex anorectal malformation: a pilot exploratory study.

Background: Nutritional problems in patients with anorectal malformation (ARM) after anorectoplasty have not received sufficient attention. This study aimed to establish prediction model of postoperative undernutrition for patients with complex ARM.

Methods: Retrospective review of 104 patients with complex ARM was conducted with assessments of clinical data.

LUT-based end-to-end optical communication system for constellation shaping.

This paper presents a look-up table (LUT)-based end-to-end (E2E) optical communication system for constellation shaping. The LUT encoder enables efficient initialization and enhances the convergence performance of the E2E learning system. We explore geometric constellation shaping, probabilistic constellation shaping, as well as joint geometric and probabilistic constellation shaping (GeoPCS), with GeoPCS achieving the highest mutual information gain of 0.

[Hypoandrogenism and the mode of cell death in the penile cavernosum tissue of male rats].

Objective: To study the mode of cell death in the penile cavernosum tissue of male rats in the hypoandrogenic state.

Methods: We equally randomized 36 10-week-old SD male rats into six groups: 4-week sham-operation (4-wk SO), 8-week sham-operation (8-wk SO), 4-week castration (4-wk C), 8-week castration (8-wk C), 4-week castration + testosterone replacement (4-wk C+T), and 8-week castration + T replacement (8-wk C+T). The rats in the SO groups received incision of the scrotal skin with preservation of the testis and epididymis, those in the C groups underwent bilateral orchiectomy and epididymectomy, and those in the C+T groups were subcutaneously injected with T propionate at 3 mg/kg qd alt.

Bevacizumab-associated glomerular microangiopathy: a case report and literature review.

Here we present a case of bevacizumab-associated glomerular microangiopathy (Bmab-GMA), a rare and distinct glomerular pathology, in a middle-aged male patient who developed progressive renal impairment following adjuvant chemotherapy with bevacizumab for surgically resected lung adenocarcinoma. The patient presented with new-onset hypertension and mild elevation in serum creatinine. Renal biopsy revealed characteristic histopathological features, including pseudothrombotic deposits of periodic acid-Schiff (PAS)-positive hyaline material within glomerular capillaries on light microscopy, and subendothelial and mesangial electron-dense deposits with segmental widening of the subendothelial space on electron microscopy.

A predictive model for early detection of concomitant pulmonary embolism in patients with deep vein thrombosis immediately upon hospital admission.

Objective: To develop and validate a predictive model for the early identification of concomitant pulmonary embolism (PE) in patients with deep vein thrombosis (DVT) upon hospital admission.

Methods: We retrospectively collected data from a cohort of patients diagnosed with DVT, including baseline demographics, clinical characteristics, laboratory parameters, and imaging-based measurements of compression of the iliac vein to develop a predictive model. The least absolute shrinkage and selection operator regression, widely used in clinical decision-making algorithms for its ability to perform variable selection and regularization simultaneously, was used for variables selection.

A 20-year retrospective analysis of ocular and adnexal injuries resulting from animal attacks in Eastern China.

Background: This study aimed to assess the clinical characteristics, management strategies, and outcomes of ocular and adnexal injuries caused by animal attacks.

Methods: A retrospective analysis was conducted on patients hospitalized for animal-induced eye injuries at the Eye and ENT Hospital of Fudan University (2003-2023). This study was approved by the Ethics Committee of the Eye and ENT Hospital of Fudan University (Ref.

Copy number amplification of TTPAL promotes cholesterol biosynthesis and esophageal squamous cell carcinoma progression via elevating NSUN2-mediated m5C modification of SREBP2 mRNA.

Alterations in copy number are crucial genetic events in the development of esophageal squamous cell carcinoma (ESCC). Here, we show that Tocopherol alpha transfer protein-like (TTPAL) is highly amplified and frequently overexpressed in human ESCC. Using Ttpal-KO mouse mode, we demonstrate that TTPAL promotes ESCC cell proliferation and accelerates tumor development by driving cholesterol biosynthesis.

Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated HS-albumin thiol antioxidant network.

Acetaminophen (APAP) overdose is the leading cause of acute liver failure and a major global health issue. APAP hepatotoxicity is primarily driven by oxidative stress resulting from the depletion of hepatic glutathione (GSH). Given that hydrogen sulfide (HS) and albumin are crucial components of the thiol antioxidant system, we hypothesized they play a critical role in the body's defense against APAP-induced liver injury (AILI).

Associations of cadmium exposure within heavy metal combinations with osteoporosis risk: an analysis of NHANES data (2013-2014 and 2017-2018).

Background: Environmental pollution is widely acknowledged as a critical contributor to osteoporosis. Previous studies confirmed that heavy metal exposure is closely associated with decreased bone mineral density.

Objective: This study aimed to evaluate the relationship between cadmium (Cd) and the incidence of osteoporosis, and to explore the mediating role of inflammatory response and oxidative stress in the relationship.

Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification.

The limited regenerative capacity in adult mammalian heart is mainly attributed to the low cell cycle activity of cardiomyocytes. Achieving cardiomyocyte division is a challenging undertaking, as the contractile function, a major characteristic of cardiomyocytes, is not overall compatible with cell cycle progression. To dissect the relationship between sarcomeric contraction and proliferation in cardiomyocytes, we utilized Blebbistatin (Blebb), a Myosin II inhibitor commonly used for cardiomyocyte culture ex vivo, and revealed that Myosin inhibition by Blebb in cardiomyocytes resulted in enhanced cell cycle entry with cytokinesis failure, thus increasing polyploidy.

Oxidized Albumin Induces Renal Tubular Cell Death and Promotes the Progression of Renal Diseases Through Ferroptosis.

Oxidative stress plays a crucial role in disease pathogenesis. While reactive oxygen species (ROS) directly cause cellular injury, emerging evidence suggests oxidatively modified proteins like albumin may also contribute significantly to tissue damage. Although oxidized albumin (ox-Alb) is linked to renal pathology, the direct effects and mechanisms of ox-Alb on renal cell injury remain unclear.

Thermal ocular injury associated with retinal necrosis and vitreous inflammation: a case report.

Background: A case of thermal ocular injury associated with retinal necrosis and vitreous inflammation is reported.

Case Presentation: A 53-year-old man's right eye was hit by a heated screw, which embedded directly into the nasal orbit. Two weeks after the foreign body was removed, serious vitreous inflammation and a large yellow-white lesion on the nasal peripheral retina, which resembled a subretinal abscess, were observed.

Restoration of Oxacillin susceptibility in MRSA strains by NPPB.

Methicillin-resistant Staphylococcus aureus (MRSA) is a critical public health issue because of its resistance to multiple antibiotics, including β-lactams such as methicillin and oxacillin. To search for antibacterial sensitizers, we have investigated the synergistic antibacterial effects of the combination of the β-lactam antibiotic oxacillin and 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) against the MRSA strains. Checkerboard assays showed the synergistic antibacterial efficacy of NPPB combined with oxacillin against five MRSA strains.

Radial Support Force: A Key Player in Vena Cava Neointimal Hyperplasia.

Background: Neointimal hyperplasia (NIH) is a risk factor for inferior vena cava filter (IVCF) retrieval failures and damage to the inferior vena cava (IVC) wall post-retrieval. Unfortunately, the mechanical properties of IVCFs have not been evaluated and are not readily available from the manufacturer. This study aimed to investigate the correlations between radial support force (RSF) and NIH, and the release of tumor necrosis factor-alpha (TNF-α) during this process.