Identification and characterization of the first G8P[1] sheep rotavirus strain in China: Genetic similarity to human rotavirus and zoonotic potential.

Rotavirus (RV) is a major cause of gastroenteritis in both humans and many mammals, including livestock. However, information regarding RV in sheep remains limited, particularly in China. This study reports the first isolation and characterization of the G8-P[1]-I2-R2-C2-M2-A11-N2-T6-E2-H3 type sheep RV strain (GS13) in China.

Prognostic impact of Fusobacterium nucleatum on survival in colorectal cancer: A systematic review and meta-analysis.

Recent studies have demonstrated a significant correlation between Fusobacterium nucleatum (F. nucleatum) and colorectal cancer. However, the prognostic significance of this microorganism in patients with colorectal cancer remains unclear.

Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.

Allergic rhinitis (AR), a globally prevalent immune-mediated inflammatory condition, is still an incurable disease. In the present study, we have validated the impact of the Kelch-like ECH associated protein 1 (Keap1)-related oxidative stress and inflammatory response in clinical AR patient peripheral blood and nasal swab samples, emphasizing the biological relevance of Keap1 and AR. Targeting Keap1 -nuclear factor erythroid 2-related factor 2 (Nrf2) related anti-oxidative stress may be effective for AR intervention.

Research on influencer marketing strategies based on double-layer network game theory.

The breakthroughs in communication technologies, such as 5G, have significantly accelerated the popularity of high-traffic consumption entertainment activities, including short video live streaming and real-time broadcasting, making them one of the most prevalent social interaction methods today. It is the high activity level of such online engagements that has given rise to diversified online marketing business models, opening up new channels and opportunities for interactions between brands and consumers. This study focuses on the emerging "influencer marketing" strategy rooted in content marketing, employing double-layer network game theory to construct a dual-layer relationship network between "brands" and "influencers" and establish a game-theoretic mechanism between them.

Ultrathin Hf-MOF with Dinitrogen Chelating Sites Stabilizing and Inducing Generation of Single-Rod CsBiBr Nanocrystals for Efficient Photocatalytic CO Reduction.

The ordered growth of semiconductor quantum dots (QDs) in confined environments remains a critical challenge in photocatalysis. Herein, CsBiBr (CBB) QDs were covalently anchored as single-rod nanocrystals (SRNCs) within Hf-based metal-organic framework (MOF) nanosheets (Hf-bpy, Hbpy = 2,2'-bipyridine-5,5'-dicarboxylic acid), forming a series of host-guest photocatalysts CBB@Hf-bpy. By modulation of the thickness of MOF nanosheets, the length of CBB SRNCs was effectively shortened to 18 nm, exhibiting strong quantum confinement effects.

Insights into microplastic exposure routes in the earthworm (Eisenia fetida): Gut and skin.

The uptake of microplastics (MPs) by terrestrial invertebrates poses potential threats to soil ecosystems. This study investigated the uptake of polypropylene MPs in Eisenia fetida, focusing on two exposure routes (gut and skin) and key influencing factors (particle size and concentration). A 50-day uptake-elimination experiment was conducted using four MP concentrations (0.

Application of three-dimensional fluorescence spectral characterization and chemometrics in the analysis of traceability of Paeoniae Radix Rubra.

Natural products are treasure troves of resources that the environment has given upon humans and are directly linked to human health and well-being. Extracting natural products from medicinal plants is the material basis for treating various diseases but the natural product content of the same medicinal plant can vary due to environmental conditions, which may exert an influence on the therapeutic outcome. Since the existing identification methods for the origin of medicinal plants are cumbersome, it is necessary to find a easy, quick, and accurate way to trace the origins of medicinal plants and ensures the quality of natural products.

Targeted therapies induced depigmentation: a review.

Skin depigmentation or vitiligo-like depigmentation (VLD) is one of the most prevalent cutaneous adverse events during targeted therapies for cancers or autoimmune diseases. The depigmentation is usually with high mental burden and affect the disease treatment, some of which are even clinical markers for good prognosis. This study aimed to explore the underlying immunopathologic mechanisms of VLD induced by targeted therapy for cancer and autoimmune disease as well as vaccine, such as immune checkpoint inhibitors (e.

Impact of left anterior descending lesion location on midterm outcomes in patients undergoing left internal mammary artery grafting: a five-year cohort study integrating quantitative flow ratio assessment.

Background: The prognostic value of coronary artery bypass grafting (CABG) may be suboptimal when guided solely by anatomical stenosis severity. Quantitative flow ratio (QFR), a computational angiography-derived hemodynamic assessment tool, offers functional insights; however, its prognostic interplay with lesion localization [proximal vs. mid-to-distal left anterior descending artery (LAD)] remains unclear.

Moiré Patterns of Two-Dimensional Covalent Organic Framework Single Crystals Created by Superstacking.

Two-dimensional (2D) covalent organic frameworks (COFs) are useful due to their molecular and crystalline features. However, the knowledge of the interlayer stacking of 2D COFs remains limited. Here, we report a 2D COF, COF-400, exhibiting an unprecedented ABCD stacking mode.

Causal association between different types of ametropia and risk of diabetic retinopathy: a two-sample Mendelian randomization study.

Objective: To investigate the causal link between ametropia and diabetic retinopathy, as well as to offer genetic support for the association between these two conditions.

Methods: This study employed a methodology involving the utilisation of genome-wide association studies data that are publicly accessible. Specifically, single nucleotide polymorphisms (SNPs) that exhibit a strong association with ametropia were employed as instrumental variables, and a two-sample Mendelian randomization (MR) approach was employed to examine the causal relationship between different types of ametropia and diabetic retinopathy.

Population Pharmacokinetic Model of Pegbing in Healthy Subjects and Chronic Hepatitis B Patients.

Pegbing (peginterferon alpha-2b) is a polyethylene glycol-modified interferon α-2b injection that has demonstrated favorable efficacy and safety profiles in the treatment of chronic hepatitis B (CHB). This study aimed to develop a population pharmacokinetic (PopPK) model of Pegbing in both healthy subjects and CHB patients and to investigate the influence of covariates on its pharmacokinetic behavior. Pharmacokinetic data were obtained from a Phase I trial in healthy volunteers and a Phase II trial in CHB patients.

Ferroelectric/Antiferroelectric HfZrO Artificial Synapses/Neurons for Convolutional Neural Network-Spiking Neural Network Neuromorphic Computing.

Brain-inspired neuromorphic computing offers significant potential for efficient and adaptive computational platforms. Emerging ferroelectric and antiferroelectric HfZrO devices provide key roles in convolutional neural network (CNN) and spiking neural network (SNN) computing with unique polarization switching characteristics. Here, we present ferroelectric/antiferroelectric HfZrO devices to realize functions of artificial synapse/neurons by element doping engineering.

Room-temperature self-healing waterborne glassy polyurethane a disordered hydrogen bonding network.

In an era driven by carbon neutrality and circular economy imperatives, the development of glassy polymers that intrinsically self-heal at room temperature is highly desirable for energy-efficient and sustainable applications, while these properties typically demand opposing degrees of polymer network mobility. Here, we report a waterborne glassy polyurethane that features a high density of disordered hydrogen bonds, and shows both significant mechanical performance (a Young's modulus of 1.5 GPa and a yield strength of 39.

Macular vascular density changes in different stages of chronic primary angle-closure glaucoma.

Objective: This study aims to investigate differences in macular vascular density (MVD) between individuals with chronic primary angle-closure glaucoma (CPACG) and healthy controls, as well as to evaluate cross-sectional changes in MVD at various stages of CPACG.

Method: This is a retrospective study based on the epidemiological survey of eye diseases in the local community, including 47 eyes of CPACG subjects (20 eyes at the early stage and 27 eyes at the middle-to-severe stages). All subjects underwent optical coherence tomography angiography (OCTA) imaging to detect MVD, as well as macular retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness.

Venous hemodynamics during blood flow restriction exercise: Impact of cuff type and arm position.

Purpose: Blood flow restriction (BFR) training is an exercise training modality to accelerate fatigue in exercising limbs by restricting blood flow. Although arterial inflow has been studied, its impact on venous hemodynamics remains unclear. This study examined the effects of cuff type and arm position on venous hemodynamics during BFR exercise.

SLC6 transporters as pharmacological targets in depression: Molecular mechanisms and therapeutic strategies.

Depression is one of the leading causes of disability globally. Maintaining neurotransmitter homeostasis is essential not only for the prevention but also for the effective treatment of psychiatric disorders, particularly depression. Solute carrier 6 (SLC6) transporters, as key membrane proteins associated with the neurotransmitter reuptake pathways at the presynaptic membrane of the central nervous system, mediate neurotransmitter reuptake through Na and Cl dependent co-transport.

Robust A-site Cation Engineering for Stable 2D High-n Tin Perovskite Homologs with Bridged Lasing Emission Gaps.

Two-dimensional high-n halide perovskites (e.g., n  = 3) offer a unique platform for stable, efficient optoelectronics by synergizing improved stability with bulk-like carrier transport.

Downregulation of miR-127-5p promotes idiopathic epiretinal membrane development via GLUL-mediated Müller cell activation.

Idiopathic epiretinal membrane (iERM) represents a fibrocellular proliferation on retinal surface associated with vision loss, with underlying molecular mechanisms that remain undefined. The current work aimed to assess miR-127-5p for its role in the regulation of retinal Müller cell activity in iERM. We analyzed miRNA expression profiles in vitreous samples from iERM patients and controls.

The Effect of Yupingfeng Polysaccharides on Immune Performance and Intestinal Microbiota in Goslings.

This study evaluated the effects of Yupingfeng polysaccharides (YPF-P) on production performance, immune response, and intestinal health in goslings. A total of 240 one-day-old healthy male goslings were randomly assigned to four groups, each with six replicates of ten goslings. The Control group (Control) was fed a basal diet, while the experimental groups received the basal diet supplemented with 200 mg/kg (YPFPI), 400 mg/kg (YPFPII), and 600 mg/kg (YPFPIII) of YPF-P.

Interactions between gut microbiota and cardiovascular drugs: effects on drug therapeutic effect and side effect.

There exists a complex relationship between gut microbiota and cardiovascular diseases (CVD). On one hand, the plasma levels of various metabolites produced by gut microbiota, such as trimethylamine n-oxide (TMAO), short-chain fatty acid (SFCA), bile acid (BA), are closely related to the occurrence and development of CVD. On the other hand, CVD can affect gut microbiota, leading to gut microbiota dysbiosis or metabolic changes.

Partial femoral head replacement: a new innovative surgical technique for precise minimally invasive treatment of association research circulation osseous stage III femoral head necrosis.

Background: Association Research Circulation Osseous (ARCO) stage III is the last chance for joint preservation in patients with osteonecrosis of the femoral head (ONFH). As the femoral head has collapsed at this stage, existing hip-preserving surgical treatments show limited success. We aimed to introduce a new surgical technique called partial femoral head replacement for the treatment of ARCO III femoral head necrosis and to evaluate its safety and efficacy.

A quantitative figure of merit for battery SEI films and their use as functional solid-state electrolytes.

As a key passivation film that governs battery operation, the solid electrolyte interphase (SEI) has long been credited for enabling high-performance batteries or blamed for their eventual death. However, qualitative descriptions of the SEI often found in the literature (e.g.

Super-resolution femtosecond electron diffraction reveals electronic and nuclear dynamics at conical intersections.

Conical intersections play a pivotal role in excited-state quantum dynamics. Capturing transient molecular structures near conical intersections remains challenging due to the rapid timescales and subtle structural changes involved. We overcome this by combining the enhanced temporal resolution of mega-electron-volt ultrafast electron diffraction with a super-resolution real-space inversion algorithm, enabling visualization of nuclear and electronic motions at conical intersections with sub-angstrom resolution, surpassing the diffraction limit.

Retrospective long-term surgical results of internal limiting membrane-sparing vitrectomy for pediatric optic disc pit maculopathy.

Background: Pediatric optic disc pit maculopathy (ODPM) is a rare condition that threatens children's visual development. Current treatments, such as pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling, are effective but controversial in pediatric cases due to potential complications. The efficacy and safety of ILM-sparing vitrectomy in pediatric ODPM patients remain underexplored.