Research on influencer marketing strategies based on double-layer network game theory.

The breakthroughs in communication technologies, such as 5G, have significantly accelerated the popularity of high-traffic consumption entertainment activities, including short video live streaming and real-time broadcasting, making them one of the most prevalent social interaction methods today. It is the high activity level of such online engagements that has given rise to diversified online marketing business models, opening up new channels and opportunities for interactions between brands and consumers. This study focuses on the emerging "influencer marketing" strategy rooted in content marketing, employing double-layer network game theory to construct a dual-layer relationship network between "brands" and "influencers" and establish a game-theoretic mechanism between them.

Advancing drug-drug interactions research: integrating AI-powered prediction, vulnerable populations, and regulatory insights.

Drug-drug interactions (DDIs) pose a significant and intricate challenge in clinical pharmacotherapy, especially among older adults who often have chronic conditions that necessitate multiple medications. These interactions can undermine the effectiveness of treatments or lead to adverse drug reactions (ADRs), which in turn can increase illness rates and strain healthcare resources. Traditional methods for detecting DDIs, such as clinical trials and spontaneous reporting systems, tend to be retrospective and frequently fall short in identifying rare, population-specific, or complex DDIs.

Glioma cells produce soluble PD-L1 via the Wnt/β-catenin signaling pathway to suppress CD8+ T cell activity.

Soluble programmed death ligand 1 (sPD-L1) is emerging as a novel prognostic marker, potentially replacing PD-L1 for assessing prognosis and immunotherapy effectiveness. However, little is known about sPD-L1. This study aimed to assess sPD-L1's potential as a biomarker and explore its origin and biological function.

Genome-wide identification and expression analysis of the SiSWEET gene family in Setaria italica and functional characterization of the SiSWEET13a in Arabidopsis.

Sugar will eventually be exported transporters (SWEETs), an original family of sugar transporters that facilitate the cell membrane flux traversing and govern long-distance sugar distribution throughout plant development. SWEETs playvital roles in various developmental processes including phloem loading, pollen nutrition, seed filling, and pathogen nutrition. Although the SWEET family has been systematically reported in different organisms, research on foxtail millet (Setaria italica L.

Biomarkers associated with cancer-related anorexia in lung cancer: a scoping review.

Purpose: Anorexia is a frequent and serious symptom in patients with lung cancer, often leading to malnutrition and cachexia, and negatively affecting quality of life and survival. This scoping review systematically synthesizes current evidence on biomarkers associated with cancer-related anorexia (CRA) in lung cancer, aiming to clarify biological mechanisms and inform targeted interventions.

Methods: We performed a comprehensive literature search of studies evaluating the associations between CRA and various biomarkers in patients with lung cancer.

Current status of older people with chronic diseases adopting digital health technologies: A scoping review.

Background: Digital health technologies (DHTs) promise enhanced health for older people, yet the digital divide hinders adoption and utilization. This study aimed to identify DHTs that can help older people in chronic disease management, specifically the facilitators, barriers, needs, and scenarios.

Methods: We searched PubMed, Embase, Cochrane Library, Web of Science, Scopus, and IEEE for studies published in English between 2000 and 2024.

The change of soluble programmed cell death ligand-1 (sPD-L1): A new predictor of prognosis in hypopharyngeal squamous cell carcinoma patients treated with radiotherapy.

PurposeThe aim of this study was to evaluate the concentration of soluble programmed cell death ligand-1 (sPD-L1) in the plasma of hypopharyngeal squamous cell carcinoma (HSCC) patients before and after radiotherapy (RT) and to explore its correlation with prognosis.MethodsA total of 47 patients and 12 healthy individuals were enrolled. All blood samples were collected before RT and 35 blood samples were obtained after RT.

Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions.

Acute liver failure (ALF) represents a critical clinical syndrome marked by massive hepatocyte death and severe functional deterioration. While metabolic dysregulation is a recognized hallmark, the pathophysiological implications of iron metabolism disturbance in ALF progression remain poorly understood, which may unveil novel therapeutic targets. Using clinical samples and preclinical murine models, we identified ferroptosis as a predominant pathological feature in ALF-affected livers.

'Cell knife' for cancer: the clinician's perspective.

Boron Neutron Capture Therapy (BNCT), often referred to as the 'cell knife,' represents a binary, tumor-selective therapeutic modality that minimizes damage to surrounding healthy tissues. This review provides a comprehensive clinical perspective on BNCT, addressing the radiobiological mechanisms and summarizing related clinical trials, with a particular emphasis on glioma and head and neck cancers. Furthermore, the paper touches upon the synergistic potential of BNCT when integrated with other treatment modalities, such as proton and carbon ion radiotherapy, alternative neutron capture therapies, ultrasound, and immunotherapy.

Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway.

Background: Radiodermatitis (RD) is the primary acute adverse effect experienced by patients receiving radiotherapy (RT) for head and neck cancer (HNC). This study aimed to investigate the correlation between triglyceride (TG) levels and the severity of RD, as well as the underlying mechanisms involved.

Methods: Data were collected from 248 patients with locally advanced HNC treated with intensity-modulated radiation therapy (IMRT).

Peptide-based immuno-PET/CT monitoring of dynamic PD-L1 expression during glioblastoma radiotherapy.

Real-time, noninvasive programmed death-ligand 1 (PD-L1) testing using molecular imaging has enhanced our understanding of the immune environments of neoplasms and has served as a guide for immunotherapy. However, the utilization of radiotracers in the imaging of human brain tumors using positron emission tomography/computed tomography (PET/CT) remains limited. This investigation involved the synthesis of [F]AlF-NOTA-PCP2, which is a novel peptide-based radiolabeled tracer that targets PD-L1, and evaluated its imaging capabilities in orthotopic glioblastoma (GBM) models.

The quality and reliability of online video resources concerning patient education for migraine treatment in China Mainland: an electronic media-based study.

Background: Migraine is an extremely prevalent and disabling primary neurological disease worldwide. Although multiple forms of patient education for migraine management have been employed in the past decades, the quality and reliability of headache-related online videos targeting migraine patients remained unclear, particularly those in China. Therefore, in this study, our research team aimed to explore the overall quality and credibility of online videos concerning patient education on migraine treatment in China Mainland.

An Effective Single-Station Cooperative Node Localization Technique Using Multipath Spatiotemporal Information.

Precise cooperative node localization is essential for the application of multifunctional integrated radio frequency (RF) sensor networks in military and civilian domains. Most geometric localization methods commonly rely on observation data from multiple receiving nodes or anchor points with known positions and synchronized clocks, producing complex system architectures and high construction costs. To address this, our paper proposes an effective single-station cooperative node localization technique, where the observation station only requires two antennas for operation.

A three-dimensional marine plastic litter real-time detection embedded system based on deep learning.

Marine plastic pollution has emerged as a significant ecological and biological issue impacting global marine ecosystems. To develop real-time cleaning systems for marine plastic litter, we implemented a three-dimensional marine plastic litter real-time detection (3D-MPLRD) system that incorporates deep learning techniques. Specifically, image quality assessment and enhancement are applied to mitigate the adverse effects of harsh underwater conditions on image quality, thereby enhancing the training efficacy of models beyond that achieved by conventional approaches.

Super-enhancer-associated circPVT1 promotes malignancy of hepatocellular carcinoma via YBX1-mediated RRM2 activation.

Circular RNAs (circRNAs), the essential members of epigenetic reprogramming, are emerging as an appealing layer in hepatocellular carcinoma (HCC). Super-enhancers (SEs) are large clusters of transcriptional enhancers with the tremendous gene activation potential and are extensively investigated in cancer research. The present study explores and uncovers an SE-related circRNA circPVT1, identifying its biological functions and downstream mechanisms in HCC.

Acute radiation skin injury in stage III-IV head and neck cancer: scale correlates and predictive model.

Purpose: Active radiation skin injury (ARSI) has the highest incidence of acute adverse reactions caused by radiotherapy (RT) in patients with head and neck cancer (HNC). This study aimed to screen risk factors that can facilitate the identification of HNC patients at high risk of ARSI.

Methods: Data from 255 stage III-IV HNC patients who underwent intensity-modulated radiation therapy (IMRT) were collected.

Design and characterization of a self-matching photonic lantern for all few-mode fiber laser systems.

We model and demonstrate a self-matching photonic lantern (SMPL) device, which is designed to address the constraint of limited transverse modes generated by fiber lasers. The SMPL incorporates a FMF into the array at the input end of a traditional photonic lantern. The few-mode fiber at the output end is specifically configured to align with the few-mode fiber at the input, therefore named as SMPL.

Systematic investigation of TetR-family transcriptional regulators and their roles on lignocellulosic inhibitor acetate tolerance in .

TetR-family transcriptional regulators are widely distributed among bacteria and involved in various cellular processes such as multidrug and inhibitor resistance. is a industrial bacterium for lignocellulosic ethanol production. Although TetR-family regulators and their associated RND-family efflux pumps in have been identified to be differentially expressed under various inhibitors and stressful conditions, there are no systematic investigation yet.