Pseudo-Jahn-Teller Effect-Regulated Structural Distortion in WNbO Triggering Highly Stable and Fast-Charge Lithium Storage.

WNbO with a ReO shear structure offers high lithium storage capacity but suffers from poor electron/ion transport. Hence, exploring an effective strategy aimed at enhancing intrinsic conductivity while maintaining a robust crystal framework is a significant challenge for advancing WNbO as a promising anode. Here, a pseudo-Jahn-Teller effect-driven local structural distortion regulation strategy is demonstrated in WNbO through quantifying Cu occupancy at Nb sites in NbO octahedra.

Ferrocene-functionalized indium-oxo cluster nanozyme for the detection of hydrogen peroxide and ascorbic acid.

Nanozymes are a class of nanomaterials with intrinsic enzyme-like properties, which overcome the limitations of natural enzymes, such as poor stability, high cost, and difficulty in storage, thus achieving rapid development. Herein, the enzyme-like activity of ferrocene-functionalized indium-oxo cluster (TPP)[InFcDCA(µ-O)(µ-OCH)(Cl)], named [InFc], was analyzed. The obtained [InFc] cluster has good peroxidase-like activity, which can catalyze the reaction of 3,3',5,5'-tetramethylbenzidine (TMB), o-phenylenediamine (OPD), and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) with HO.

Design of a Lattice-Reinforced Shape Memory Alloy Actuator for Underwater Soft Robots.

Throughout the development of soft robots, shape memory alloy (SMA) actuators have received considerable attention due to their inherent advantages, such as high power-to-weight ratio, low driving voltage, and high response speed. This study presents a lattice-reinforced SMA actuator with improved response speed and increased deformation range. The SMA wires are used to drive the actuator to achieve bending, while the high elastic wire's elasticity is used to achieve recovery.

Anterior Cervical Discectomy and Fusion Using Cages with Different Sized Windows: A Randomized Controlled Trial.

Study Design: Prospective randomized controlled trial.

Objectives: This study aimed to evaluate the subsidence rates of anterior cervical discectomy and fusion (ACDF) using polyetheretherketone (PEEK) cages with different window sizes.

Summary Of Background Data: PEEK cages used for ACDF procedures typically come with windows designed for filling with bone graft material.

Predictive efficacy of phantom-less calibration of computed tomography for cage subsidence after anterior cervical discectomy and fusion.

Purpose: Cage subsidence is a common complication after anterior cervical discectomy and fusion (ACDF). However, the predictive accuracy of conventional Hounsfield units (HU) for subsidence varies across studies. We aimed to develop a simple, phantom-less calibrated method for measuring bone mineral density (BMD) using preoperative cervical computed tomography (CT) and compared its predictive efficacy for cage subsidence with HU values.

Fullerene-derivative-induced hilly morphology for high-speed flexible organic electrochemical transistors.

Coupled ionic/electronic transport endows organic electrochemical transistors (OECTs) with high transconductance but slow response, limiting their applications in real-time signal processing due to time delays. Strategies to accelerate the response of OECTs without compromising their amplification capabilities remain elusive, primarily due to the conflicting dynamics of ionic and electronic transport. Herein, we present a universal method that blends semiconducting polymers with the fullerene derivative PCBM to create separate electronic and ionic transport phases.

Alveolar macrophages maintain tissue localization and gain enhanced anti-tumor activity in Lewis lung carcinoma-reprogrammed lung microenvironment.

The role of alveolar macrophages (AMs) in lung carcinogenesis has been extensively studied, yielding significant insights. However, the status of AMs in tumor-bearing lungs remains incompletely characterized. Using orthotopic Lewis Lung Carcinoma (LLC) mouse models, we found that tumors induced an inflammatory extra-tumoral lung microenvironment (ETLME), distinct from the immunosuppressive tumor microenvironment (TME).

Association between triglyceride glucose-body mass index and acute kidney injury and renal replacement therapy in critically ill patients with sepsis: analysis of the MIMIC-IV database.

Background: Previous studies have linked kidney damage to insulin resistance (IR), yet the association between triglyceride glucose-body mass (TyG-BMI) index, a reliable marker of IR, and acute kidney injury (AKI) remains unclear.

Methods: Patient data were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. AKI was set as the primary endpoint, and renal replacement therapy (RRT) was set as the secondary endpoint to represent the progression of AKI.

Predicting arsenic bioaccessibility: A global data-driven machine learning approach and its implication for reducing carbon emissions.

Site-specific arsenic (As) bioaccessibility data can improve the accuracy of health risk assessments, but direct measurements are costly and time-consuming. Even when available, measured values such as the mean still yield remediation targets below natural background levels, limiting their practical use. Existing predictive models, including linear regressions and some machine learning (ML) approaches, often rely on artificially spiked or limited field-aged samples with high As concentrations, reducing their generalizability.

Pyrethroids in sediments and wastewater treatment plant-derived biosolids from Ireland.

Pyrethroids are widely used synthetic insecticides. This study reports the occurrence, distribution, and ecotoxicological risks of eight pyrethroids in sediments and biosolids from wastewater treatment plants (WWTPs) across Ireland. A total of 120 sediment samples were collected along with 3 biosolids samples from each of seven WWTPs (n = 21).

Implantation of integrated magnetically levitated biventricular assist devices (DuoCor) - a single center clinical experience.

Background: End-stage heart failure remains a major global health challenge with high mortality. While heart transplantation is the gold-standard treatment, the scarcity of donor hearts necessitates alternative therapies. Left ventricular assist devices effectively support patients with end-stage left heart failure, but no mature biventricular assist devices (BiVAD) currently exist for those with biventricular failure.

Effects of suturing of the mediastinal pleura on lessening pleural effusions after lobectomy in patients with non-small cell lung cancer.

Background: Lobectomy in patients with non-small cell lung cancer (NSCLC) results in empty spaces filled up with gases and superfluous pleural effusions. This study aimed to evaluate the effects of suturing of the mediastinal pleura (SMP) on reducing pleural effusion after lobectomy.

Methods: Medical records of 529 patients with NSCLC who underwent right lung lobectomy and systematic mediastinal lymph node dissection (SMLD) were retrospectively reviewed, including 131 who underwent SMP and 324 in the control group.

Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in .

The methylotrophic yeast () is a pivotal heterologous protein production platform, yet inefficient secretory trafficking hinders its industrial scalability. We addressed this limitation through the systematic engineering of early secretory pathways to enhance extracellular yields for three phylogenetically distinct proteins: fungal α-amylase (AmyA), bacterial β-glucanase (BgA), and human serum albumin (HSA). By integrating secretory peptide engineering with 3' untranslated region (3' UTR) optimization, cotranslational ER translocation efficiency improved, elevating extracellular activity by 1.

Multiplexed MALDI fingerprints for rapid detection of spontaneous bacterial peritonitis.

Background: The efficient diagnosis of spontaneous bacterial peritonitis (SBP) has been hindered by the low sensitivity of current clinical indicators. A rapid and accurate detection method for SBP is essential to enable early diagnosis and prompt intervention.

Methods: Given the critical role of specialized metabolites in bacterial infections, we combined matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with partial least squares discriminant analysis (PLS-DA) to directly analyze intact protein and specialized lipid fingerprints in ascitic fluid, in order to effectively distinguish spontaneous bacterial peritonitis (SBP) from noninfected ascites.

Deep reinforcement learning model for Multi-Ship collision avoidance decision making design implementation and performance analysis.

This paper proposes a novel multi-ship collision avoidance decision-making model based on deep reinforcement learning (DRL). The model addresses the critical challenge of preventing ship collisions while maintaining efficient navigation in complex maritime environments. Our innovation lies in the integration of a comprehensive state representation capturing key inter-ship relationships, a reward function that dynamically balances safety, efficiency, and COLREGs compliance, and an enhanced DQN architecture with dueling networks and double Q-learning specifically optimized for maritime scenarios.

Improvement of Anti-Collision Performance of Concrete Columns Using Bio-Inspired Honeycomb Column Thin-Walled Structure (BHTS).

In recent years, frequent vehicle-bridge pier collision accidents have posed a serious threat to people's economic and life security. In order to avert the impairment of reinforced concrete bridge piers (RCBPs) under the impact of vehicles, three kinds of Mg-Al alloy AlSi10Mg anti-collision structures designed by selective laser melting (SLM) printing were tested by the numerical simulation method in this study: an ultra-high performance concrete (UHPC) anti-collision structure, a bio-inspired honeycomb column thin-walled structure (BHTS) buffer interlayer, and a UHPC-BHTS composite structure were used to reduce the damage degree of RCBPs caused by vehicle impact. In accordance with the prototype configuration of the pier, a scaled model with a scale ratio of 1:10 was fabricated.

Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway.

Spinal Cord Injury (SCI) is a severe disorder of the central nervous system, typically caused by trauma or disease, which significantly impacts the quality of life of affected individuals. Secondary inflammation following spinal cord injury is a critical factor influencing prognosis, making the exploration of the inflammatory microenvironment crucial for the treatment of SCI. Xanthoxylin, a small organic molecule extracted from plants, has demonstrated notable anti-inflammatory effects.

Enhancer RNA-mediated transcriptional regulatory programs reveal the malignant progression of glioma.

To systematically investigate the molecular and pathological mechanisms of enhancer RNA (eRNA)-mediated transcriptional regulation in glioma recurrence and progression, transcriptomic, regulatome, and genomic data were integrated to analyze eRNA behavior in lower-grade gliomas (stages II/III) and glioblastomas (stage IV). Most eRNAs exhibited dynamic expression during glioma progression, regulated by master transcription factors (TFs) and affected by genomic mutations. The constructed perturbed TF-mediated eRNA-promoter regulatory landscape revealed that rewiring eRNA-promoter networks contributed to glioma malignancy.

Mechanism and application of phenyllactic acid on the control of yogurt post-acidification caused by Lactobacillus bulgaricus.

Excessive post-acidification can adversely affect taste acceptance and shorten yogurt shelf life. Herein, the inhibitory effect of phenyllactic acid (PLA) on yogurt post-acidification was investigated using Lactobacillus bulgaricus as indicator. The results demonstrated that PLA effectively inhibited L.

Potential of C-X-C-Chemokine-Receptor-Type-4-Directed PET/CT Using [¹⁸F]AlF-NOTA-QHY-04 in Identifying Molecular Subtypes of Small Cell Lung Cancer.

Objective: Molecular subtyping of small-cell lung cancer (SCLC) has major implications for prognostic relevance and treatment guidance. This study aimed to explore the feasibility of a novel tracer targeting C-X-C-chemokine-receptor-type-4 (CXCR4) for distinguishing different SCLC subtypes.

Materials And Methods: Thirty-five patients with pathologically confirmed SCLC were enrolled in this prospective study.

Current Landscape in the Management of Aortic Stenosis.

Aortic stenosis (AS) poses significant risks to patient survival and quality of life. The management of AS extends beyond restoring valve function to encompass lifelong disease management. While curative treatments exist, advancements in therapeutic approaches and prosthetic valve technology continue to evolve.

Pathogenic characterization and mechanism of sequence type 4 Cronobacter sakazakii derived from milk-based infant and baby foods.

Background: Cronobacter sakazakii can cause severe infections in premature infants and neonates through the consumption of contaminated milk-based foods. However, the pathogenesis of sequence type 4 (ST4) C. sakazakii remains to be fully elucidated.

Species diversity and spatial pattern of heritage trees in Taiyuan.

Heritage trees are key to maintaining biodiversity, supporting ecosystem services, and preserving cultural heritage. This study investigates the species composition, spatial distribution patterns, and conservation needs of heritage trees in ancient Taiyuan city in Northern China, focusing on their cultural-ecological significance and urbanization threats. Using redundancy analysis, we surveyed 4737 heritage trees across ten urban core, suburban and rural districts and nine habitat types and calculated their importance values, species diversity indices, and statistical associations with key socio-demographic and environmental factors.

Effects of fertilizer reduction on yield and nitrogen utilization in maize-soybean intercropping system.

To investigate the characteristics of nitrogen utilization in maize-soybean intercropping system under reduced fertilization, we conducted a spilt-plot experiment, with maize monoculture, soybean monoculture and maize-soybean intercropping as the main plot, and no fertilization, reduced fertilization (by 20%) and conventional fertilization as the sub-plot. We examined the effects of different cropping patterns and fertilization rates on crop nitrogen accumulation, nitrogen translocation, soil nitrogen content and yield. The results showed that nitrogen accumulation of intercropped maize and soybean under reduced fertilization was reduced at different growing stages.