Anterior Cervical Discectomy and Fusion Using Cages with Different Sized Windows: A Randomized Controlled Trial.

Study Design: Prospective randomized controlled trial.

Objectives: This study aimed to evaluate the subsidence rates of anterior cervical discectomy and fusion (ACDF) using polyetheretherketone (PEEK) cages with different window sizes.

Summary Of Background Data: PEEK cages used for ACDF procedures typically come with windows designed for filling with bone graft material.

Predictive efficacy of phantom-less calibration of computed tomography for cage subsidence after anterior cervical discectomy and fusion.

Purpose: Cage subsidence is a common complication after anterior cervical discectomy and fusion (ACDF). However, the predictive accuracy of conventional Hounsfield units (HU) for subsidence varies across studies. We aimed to develop a simple, phantom-less calibrated method for measuring bone mineral density (BMD) using preoperative cervical computed tomography (CT) and compared its predictive efficacy for cage subsidence with HU values.

Cadmium induces autophagy via IRE1 signaling pathway activated by Ca in GC-2spd cells.

Cadmium (Cd), an environmental toxicant, accumulates in the human body and damages the male reproductive system. To investigate the molecular mechanisms underlying Cd-induced reproductive toxicity, we used GC-2spd cells and treated them with CdCl. Additionally, we added 2-APB (an inhibitor of the IP3R) and STF-083010 (an inhibitor of IRE1) to investigate whether they could ameliorate Cd-induced reproductive toxicity.

Facet Distraction Distance Independently Predicts Cage Subsidence Following Anterior Cervical Discectomy and Fusion.

Objective: This study aimed to evaluate the relationship between facet distraction distance (FDD) and cage subsidence following anterior cervical discectomy and fusion (ACDF).

Methods: This retrospective study included patients who underwent ACDF for degenerative cervical disease at our institution between 2020 and 2023. Preoperative computed tomography scans were used to assess Hounsfield unit (HU) values, reflecting bone mineral density.

Posterior Hemivertebra Extended Resection Combined With Concave Anterior Column Reconstruction for Congenital Scoliosis.

Background: Posterior hemivertebra resection for hemivertebra deformities has been widely reported. However, achieving adequate correction of deformities through conventional hemivertebra resection remains technically challenging in older children. The authors developed a technique combining posterior hemivertebra extended resection with concave anterior column reconstruction.

Remodeling the Proinflammatory Microenvironment in Osteoarthritis through Interleukin-1 Beta Tailored Exosome Cargo for Inflammatory Regulation and Cartilage Regeneration.

Osteoarthritis (OA) presents a significant therapeutic challenge, with few options for preserving joint cartilage and repairing associated tissue damage. Inflammation is a pivotal factor in OA-induced cartilage deterioration and synovial inflammation. Recently, exosomes derived from human umbilical cord mesenchymal stem cells (HucMSCs) have gained recognition as a promising noncellular therapeutic modality, but their use is hindered by the challenge of harvesting a sufficient number of exosomes with effective therapeutic efficacy.

Monoaxial Screws Versus Polyaxial Screws Osteosynthesis for Unstable Atlas Fractures: A Retrospective, Comparative Study With a Minimum Follow-Up of 3 years.

Study Design: Retrospective cohort study.

Objective: The study aimed to compare the radiological parameters, clinical outcomes, and long-term effects of the posterior osteosynthesis with polyaxial screw-rod system and the monoaxial screw-rod system in the treatment of unstable atlas fractures.

Methods: We retrospectively analyzed the clinical data of 33 patients with posterior ORIF for unstable atlas fractures in our hospital from August 2013 to June 2020, with a minimum of 3 years of follow-up.

A facile Immunoregulatory Constructional Design by Proanthocyanidin Optimizing Directional Chitosan Microchannel.

Improving the interconnected structure and bioregulatory function of natural chitosan is beneficial for optimizing its performance in bone regeneration. Here, a facile immunoregulatory constructional design is proposed for developing instructive chitosan by directional freezing and alkaline salting out. The molecular dynamics simulation confirmed the assembly kinetics and structural features of various polyphenols and chitosan molecules.

Molecular co-assembled strategy tuning protein conformation for cartilage regeneration.

The assembly of oligopeptide and polypeptide molecules can reconstruct various ordered advanced structures through intermolecular interactions to achieve protein-like biofunction. Here, we develop a "molecular velcro"-inspired peptide and gelatin co-assembly strategy, in which amphiphilic supramolecular tripeptides are attached to the molecular chain of gelatin methacryloyl via intra-/intermolecular interactions. We perform molecular docking and dynamics simulations to demonstrate the feasibility of this strategy and reveal the advanced structural transition of the co-assembled hydrogel, which brings more ordered β-sheet content and 10-fold or more compressive strength improvement.

Design of a novel lateral mass screw-plate system for the treatment of unstable atlas fractures: a finite element analysis.

Background: Osteosynthesis of unstable atlas fractures preserves joint motion and therefore has a distinct advantage over a range of treatment procedures. To prevent the potential disadvantages associated with osteosynthesis, a new atlas lateral mass screw-plate (LMSP) system has been designed. However, the biomechanical role of using the LMSP system in atlas internal fixation is not known.

Silver Doping-Induced Luminescence Enhancement and Red-Shift of Gold Nanoclusters with Aggregation-Induced Emission.

A deep understanding on the luminescence property of aggregation-induced emission (AIE) featured metal nanoclusters (NCs) is highly desired. This paper reports a systematic study on enhancing the luminescence of AIE-featured Au NCs, which is achieved by Ag doping to engineer the size/structure and aggregation states of the Au -thiolate motifs in the NC shell. Moreover, by prolonging the reaction time, the luminescence of the as-synthesized AuAg NCs could be further tailored from orange to red, which is also due to the variation of the Au -thiolate motifs of NCs.