Serum metabolomic characteristics and their predictive value for ninety-day prognosis in patients with acute-on-chronic liver failure.

Background: Acute-on-chronic liver failure (ACLF) is characterized by severe metabolic disturbances; however, the specific metabolomic features and their predictive value on 90-day prognosis remain unclear.

Aim: To identify serum metabolomic changes in patients with ACLF with different prognoses to support clinical prediction of outcomes and treatment decisions.

Methods: This non-interventional, observational case-control study enrolled 58 patients with ACLF.

[Effect of Polyethylene Microplastics on Physiological Property and Vanadium Accumulation of Maize （ L.） Seedlings Under Vanadium Stress].

This study sought to elucidate the impact of polyethylene microplastics （PE） applied externally on the physiological traits, antioxidant activity, and vanadium （V） accumulation in maize （ L.） seedlings subjected to V stress. The maize variety used for this work was MY73, and V-stress was induced by cultivating seedlings in a soil culture setup with 150 mg·kg of V incorporated into each pot.

Risk factors and predictive model for mortality in acute myocardial infarction with ventricular septal rupture at high altitudes.

Background: Acute myocardial infarction (AMI) combined with ventricular septal perforation (VSR) is still a highly fatal condition in the era of reperfusion therapy. The incidence rate has decreased to 0.2%-0.

Acute myocardial infarction with ventricular septal rupture: Clinical characteristics, prognosis factors, and treatment strategies.

This review comprehensively examines acute myocardial infarction with ventricular septal rupture (VSR), a rare yet lethal complication. We analyze its epidemiological, pathophysiological, clinical, and therapeutic aspects, emphasizing innovative strategies like bioabsorbable occluders and tissue engineering to reduce complications and improve prognosis. The integration of artificial intelligence and big data analytics for treatment decision-making and personalized surgical timing models is highlighted as transformative.

Additive-Free EDA Photochemical Arylative Trifluoromethylation of Enamides with Trifluoromethyl Benzothiazole Sulfones.

An additive-free trifluoromethylation-heteroarylation of enamides with trifluoromethyl heteroaryl sulfones via EDA photochemistry is reported. Under visible-light irradiation, diverse enamides and sulfones undergo efficient difunctionalization to afford CF-heteroaryl amides in moderate to excellent yields, without the need for photocatalysts or additives. Mechanistic studies support the formation of a photoexcited EDA complex that triggers C-S bond cleavage, generating CF and heteroaryl anions.

[Mechanism of immediate administration of Angong Niuhuang Pills in intervention of traumatic brain injury based on metabolomics and transcriptomics].

This study integrates metabolomics and transcriptomics to explore the immediate effects of Angong Niuhuang Pills(ANP) in intervening traumatic brain injury(TBI) in rats. A TBI model was successfully established in rats using the optimized Feeney free-fall impact technique. Rats were randomly divided into sham operation(sham) group, model(Mod) group, positive drug(piracetam) group, ANP low-dose(ANP-L) group, and ANP high-dose(ANP-H) group according to a random number table.

Enhancing clinical problem-solving skills in cardiology nursing interns: A randomized controlled study of case-based learning and task-driven learning.

Aim: To assess the effectiveness of integrating Case-Based Learning (CBL) with Task-Driven Learning (TDL) in the clinical education of nursing interns specializing in cardiology.

Background: Traditional lecture-based learning (LBL) may not adequately prepare nursing interns for clinical problem-solving in cardiovascular specialties. Combining CBL with TDL methodologies could potentially enhance theoretical understanding and practical application skills.

Association of anti-PD-1 therapy with severe radiation-induced oral mucositis: A retrospective cohort study and validation in the CONTINUUM trial.

Background: The association of immune checkpoint inhibitors (ICIs) with radiation-induced oral mucositis (RIOM), a common and debilitating complication that affects the treatment tolerance of head and neck cancer patients, remains unclear.

Methods: In this multicenter retrospective cohort study, 840 eligible patients with locoregionally advanced nasopharyngeal carcinoma (NPC) were included, with propensity score matching (PSM) creating two comparison groups based on the receipt of anti-programmed cell death 1 (anti-PD-1) therapy. Additionally, individual patient data from 197 NPC patients in the CONTINUUM trial (NCT03700476) were used for validation.

Antitumor effects of human antithymocyte globulin on peripheral T cell lymphoma via complement-dependent and -independent cytotoxicity in xenograft mouse models.

Peripheral T cell lymphomas (PTCL) is a group of non-Hodgkin lymphomas characterized by substantial molecular heterogeneity, rapid progression, poor therapeutic response, and unfavorable outcomes. In recent clinical studies, antithymocyte globulin (ATG)-based allogeneic hematopoietic stem cell transplantation (allo-HSCT) has markedly improved the prognosis and survival of patients with PTCL. This study aimed to explore whether ATG has toxic effects on PTCL cells and evaluate whether ATG combined with chemotherapy has a synergistic antitumor effect.

[Diversity and Ecological Network Characteristics of Planktonic Bacterial Communities in Raohe River].

Planktonic bacteria play a vital role in the material cycling and energy flow of river ecosystems. However， little is known about the diversity and co-existence network relationship of riverine planktonic bacteria under multiple stressors. This study investigated the impact of nutrients， heavy metals， and antibiotics on the planktonic bacterial diversity and co-existence relationship in Raohe River， the classic river entering Poyang Lake， as well as its two tributaries， Changjiang and Le'an Rivers.

Concurrent or subsequent lymphomatous effusion in large B-cell lymphoma portends a dismal prognosis: A multi-institutional study.

Objective: Rare large B-cell lymphomas (LBCLs) present with concurrent or subsequent lymphomatous effusion (solid-effusion LBCL, SE-LBCL), which may have an inferior prognosis compared with their noneffusion counterpart. In addition, the relationship between SE-LBCL and human herpesvirus 8-negative effusion-based LBCL (EB-LBCL) remains unclear.

Methods: We collected 141 cases of SE-LBCL and a control cohort of 101 cases of stage IV solid-only LBCL.

Ras homolog enriched in brain 1 regulates β cell mass and β cell function mTORC1/AMPK/Notch1 pathways.

Background: The identification of key regulators of β cell mass and function is crucial in developing effective therapeutic interventions for diabetes. Ras homolog enriched in brain 1 (Rheb1), an upstream binding protein of mTOR, is a potential therapeutic target for β cell in diabetes, while the underlying mechanisms remains unknown.

Aim: To assess the effect and potential mechanism of Rheb1 on β cell mass and function.

A novel perspective on dissemination: somatic metastasis of germ cell tumors from the central nervous system.

Purpose: Primary germ cell tumors (GCTs) of the central nervous system are rare malignancies, with somatic metastasis being even less common. This study aims to propose a novel classification framework for dissemination patterns in CNS GCTs.

Methods: A group of 4 patients with somatic metastasis were identified among 284 germ cell tumors.

Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein Regulating Its Intracellular Trafficking.

Objective: To reveal the effects and potential mechanisms by which synaptic vesicle glycoprotein 2A (SV2A) influences the distribution of amyloid precursor protein (APP) in the trans-Golgi network (TGN), endolysosomal system, and cell membranes and to reveal the effects of SV2A on APP amyloid degradation.

Methods: Colocalization analysis of APP with specific tagged proteins in the TGN, ensolysosomal system, and cell membrane was performed to explore the effects of SV2A on the intracellular transport of APP. APP, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) expressions, and APP cleavage products levels were investigated to observe the effects of SV2A on APP amyloidogenic processing.

Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients.

Background: Ferritin is one of the major intracellular iron storage proteins and is implicated in the pathophysiological processes of many inflammatory diseases, but its function in community-acquired pneumonia (CAP) was unclear. The purpose of this study was to evaluate the expression of ferritin and analyze the relationship of serum ferritin with CAP.

Methods: Severe CAP patients and age- and gender-matched healthy participants were recruited for the study.

Comparative transcriptomic analysis of loquat floral fragrance and hormone synthesis regulation across developmental stages in petals and stamens.

Introduction: Loquat is a native plant in China that blooms at low temperatures in early winter, and the floral fragrance volatiles from the petals and stamens of loquats' flowers are attractive to wild pollinators like Chinese honeybees. Thus, it was necessary to reveal the biosynthesis of floral fragrance and hormone regulation involved in the insect pollination of loquats' flowers.

Methods: Here, the volatile contents of petals and stamens were significantly higher than those of other parts of the loquat flower through the analysis of GC, and a key loquat flowers' compound 4-methoxybenzaldehyde has the highest content among all volatile components.

Adenosine triphosphate-induced cell death in heart failure: Is there a link?

Heart failure (HF) has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology. Adenosine triphosphate (ATP)-induced cell death represents a novel form of regulated cell deaths, marked by cellular energy depletion and metabolic dysregulation stemming from excessive ATP accumulation, identifying its uniqueness compared to other cell death processes modalities such as programmed cell death and necrosis. Growing evidence suggests that ATP-induced cell death (AICD) is predominantly governed by various biological pathways, including energy metabolism, redox homeostasis and intracellular calcium equilibrium.

Examination of the functions and mechanism of in mediating paclitaxel resistance in cervical squamous carcinoma cells.

Objective: To evaluate the mechanism of Kielin/chordin-like protein () in the resistance of cervical cancer cells to paclitaxel.

Method: A cervical squamous carcinoma cell line (SiHa) with knockout was constructed and treated with paclitaxel. Key cell functions were assessed by colony formation assay, measurement of cell proliferation by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and FACS-based detection of apoptosis.

Natural anti-neuroinflammatory inhibitors from .

Eleven compounds were isolated from the -butanol extract of Lour, including one undescribed lignan, curlignan-4---D-glucopyranoside (), and ten known compounds (). Their structures were characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D and 2D NMR), mass spectrometry (MS), and electronic circular dichroism (ECD). The inhibitory effects of these compounds on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia were evaluated.

Research on the antecedent configuration of work safety information disclosure of listed companies in high-risk industries in China.

In order to ascertain the conditions and pathways to improve the quality of work safety information disclosure of listed companies in high-risk industries in China, this study collated 222 listed companies in high-risk industries in China as valid samples, and used the fuzzy set qualitative comparative analysis (fsQCA) method to analyze the mixed effects of seven conditional variables. Seven kinds of substantive disclosure configurations and six kinds of symbolic disclosure configurations of work safety information were obtained. The results showed that any single condition is inadequate to drive enterprises to effectively disclose work safety information.