Effectiveness of nonpharmacological interventions for menopause-related insomnia: A systematic review and Bayesian network meta-analysis.

Background: Nonpharmacological therapies are widely used to improve the sleep quality of menopausal women experiencing insomnia. It is necessary to clarify which of the nonpharmacological therapies studied in randomized controlled trials are most effective and comprehensively evaluate their impacts.

Method: We conducted a systematic search across PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the Web of Science from their inception until May 25, 2025.

Association between the Chinese Dietary Inflammatory Index and risk of gastric cancer: a case-control study in Southeastern China.

Objective: This study aimed to investigate the association between the Chinese Dietary Inflammatory Index (CHINA-DII) and the risk of gastric cancer (GC) among adults in Fujian Province of China.

Methods: A 1:1 matched case-control study was conducted between July 2023 and November 2024. A total of 336 newly diagnosed GC cases were recruited from the Union Hospital, and 336 sex-matched healthy controls were enrolled from communities in Fujian Province.

Improved WOA-DBSCAN Online Clustering Algorithm for Radar Signal Data Streams.

For the pulsed data streams emitted by multiple signal sources that generate aliasing, traditional density clustering algorithms have the problems of poor clustering effect, heavy reliance on manual experience to set the parameters, and the need to carry out density clustering every time new data are input, resulting in a huge amount of computation. Therefore, an online density clustering algorithm based on the improved golden sine whale optimization is proposed. First, by adding new parameters to the density clustering algorithm, the neighborhood is changed from a single parameter Eps to a joint decision of the parameters Eps and θ, which avoids cross-cluster expansion by more flexibly delimiting the neighborhood range.

Effects of Glycopyrronium Bromide as an Adjuvant Treatment in the Prevention of Nausea and Vomiting After Abdominal, Thyroid, and Breast Surgery: A Multicenter Randomized Controlled Trial.

Background: Effective methods for the prevention of postoperative nausea and vomiting remain to be found. Building upon previous evidence, we examined whether glycopyrrolate bromide had a preventive effect on nausea and vomiting when used as an adjuvant treatment.

Methods: In 11 participating hospitals, patients who were scheduled to receive gynecological (n=123), gastrointestinal (n=201), thyroid (n=93), and breast surgery (n=51) under general anesthesia and received postoperative opioids were randomly allocated to receive 4 mg dexamethasone and 4 mg tropisetron (Group C) or 4 mg dexamethasone and 4 mg tropisetron combined with 0.

Mass spectrometry-based metabolomic and lipidomic profiling stratifies stages of diabetic retinopathy.

Aims: Diabetic retinopathy is a metabolic complication of diabetes. This study aimed to elucidate metabolic and lipidomic alterations associated with diabetic retinopathy progression and identify biomarkers for its diagnosis and staging.

Methods: We analyzed serum profiles of 962 molecules, including 653 lipids and 309 polar small metabolites, from 167 individuals: 45 without retinopathy, 69 with non-proliferative diabetic retinopathy of varying severity, and 53 with proliferative diabetic retinopathy.

Establishment of a mouse model of Sjögren syndrome-related interstitial lung disease.

Sjögren syndrome-related interstitial lung disease (SS-ILD) is a severe complication associated with significant morbidity and mortality. Despite its clinical importance, the underlying pathogenesis remains poorly understood, and effective therapeutic strategies are limited. The development of a reliable animal model for SS-ILD is crucial for elucidating disease mechanisms and facilitating the discovery of novel treatments.

Structural stability and thermal transport properties of CaSiOmonolayer.

Thermoelectric materials exhibit significant potential for efficiently converting temperature differentials into electrical energy. Recent advancements in material science and nanotechnology continue to drive improvements in thermoelectric performance and broaden their range of applications. Here, we carry out extensive structure searches of two dimensional (2D) CaSiOmonolayer by CALYPSO structural prediction method and first-principles calculations.

An interpretable CT-based deep learning model for predicting overall survival in patients with bladder cancer: a multicenter study.

Predicting the prognosis of bladder cancer remains challenging despite standard treatments. We developed an interpretable bladder cancer deep learning (BCDL) model using preoperative CT scans to predict overall survival. The model was trained on a cohort (n = 765) and validated in three independent cohorts (n = 438; n = 181; n = 72).

Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis.

Cholecystectomy represents the most prevalent biliary surgical procedure for gallbladder abnormalities. Growing evidence suggests that cholecystectomy is associated with an elevated risk of colorectal cancer. However, the underlying mechanism remains elusive.

Multimodal Fusion Framework Based on Low-rank Interaction for Tumor Prognostic Prediction.

To improve the overall survival rate of cancer patients, we propose an innovative approach named Multimodal Fusion Framework based on Low-rank Interaction (MF2LI), which aims to overcome the current limitations of relying solely on single-modal data prediction and the excessive complexity of fusion. By harnessing low-rank multimodal fusion (LMF) and optimal weight integration (OWI), MF2LI maximizes the integration of pathological images and genomic data. The model incorporates a parallel decomposition strategy, reducing complexity and facilitating fusion based on the contributions of each component.

Ultra-fast line-field swept source scanning optical coherence elastography.

The drawbacks of repeated excitations and long imaging time in wave-based optical coherence elastography limited its application in ophthalmology. In this study, we put forward a swept source scanning optical coherence elastography (SSS-OCE) system based on the wavelength-dependence scanning technique. A dispersive element was employed to achieve ultra-fast line scanning from swept light source.

Twist deformation response of a holographic volume grating in flexible photopolymer.

Twist deformation of flexible photopolymer using a diffraction spectrum of a holographic volume grating is explored. Twist deformation can be categorized into transverse shear and macroscopic twist deformations. At a small twist angle, the transverse shear deformation can be considered as a tiny unit of twist deformation.

Investigating the correlation between IDO1/PD-L1 expression or co-expression and EGFR/KRAS gene mutations in advanced NSCLC.

Lung cancer was frequently diagnosed at advanced stages (III/IV) and exhibited poor 5-year survival due to limited treatment efficacy. While immunotherapy and targeted therapies had advanced care, drug resistance persisted as a critical challenge. Our study revealed significant IDO1/PD-L1 co-expression in NSCLC.

Passive social media use and depression among college students during public health emergencies: a chain mediation approach.

Introduction: Despite growing evidence linking passive social media use to depression during public health emergencies, the underlying psychological mechanisms remain unclear. This study investigates the impact of passive social media use on depression among college students during the COVID-19 pandemic, specifically examining the mediating roles of vicarious traumatization and fear of missing out (FoMO).

Methods: A structured survey was conducted among 322 college students.

Preparation of branched starch by α-amylase and thermophilic glycogen branching enzyme modification.

Maltogenic α-amylase (MA, EC 3.2.1.

Risk factors and predictive model for mortality in acute myocardial infarction with ventricular septal rupture at high altitudes.

Background: Acute myocardial infarction (AMI) combined with ventricular septal perforation (VSR) is still a highly fatal condition in the era of reperfusion therapy. The incidence rate has decreased to 0.2%-0.

Acute myocardial infarction with ventricular septal rupture: Clinical characteristics, prognosis factors, and treatment strategies.

This review comprehensively examines acute myocardial infarction with ventricular septal rupture (VSR), a rare yet lethal complication. We analyze its epidemiological, pathophysiological, clinical, and therapeutic aspects, emphasizing innovative strategies like bioabsorbable occluders and tissue engineering to reduce complications and improve prognosis. The integration of artificial intelligence and big data analytics for treatment decision-making and personalized surgical timing models is highlighted as transformative.

Atomic Trajectories of a Bimolecular Reaction Visualized by Ultrafast Electron Diffraction.

Bimolecular reactions are ubiquitous in chemistry, but it is exceptionally difficult to resolve the motion of atoms for such processes on the ultrafast time scales that the breaking and creation of chemical bonds occur. Detecting small changes in atom positions requires high temporal and spatial resolution and reliable signal-to-noise characteristics. Here, we have exploited solid-state alignment to track a photoinduced bimolecular disproportionation reaction that transforms two pairs of adjacent triiodide anions (I) into the metastable tetraiodide molecule and the diiodide fragment.

Evaluation of the Reliability and Validity of a Food Frequency Questionnaire Using Three-Day 24-Hour Dietary Recalls: A Study in Fujian, China.

This study aimed to evaluate the reliability and validity of a Food Frequency Questionnaire (FFQ) designed for use in epidemiological studies among populations in Fujian, China. From September to December 2023, adults aged 18 years and above residing in Fujian Province, southeastern China, were recruited via online survey promotion. Participants completed the FFQ twice with a one-month interval and also completed a 3-day 24 h dietary recall (3d-24HDR), covering two weekdays and one weekend day, during the same period.

Treatment of relapsed or refractory Hodgkin's lymphoma with lenalidomide combined with PD-1 monoclonal antibody: a case report and literature review.

The current standard treatment for relapsed or refractory Hodgkin's lymphoma involves salvage chemotherapy followed by high-dose chemotherapy and sequential autologous stem cell transplantation. However, for patients who cannot tolerate intense chemotherapy or do not meet the conditions for autologous stem cell transplantation, there is a need to explore new treatment options. We report a case of an elderly patient with multiple relapses of classical Hodgkin's lymphoma who experienced repeated disease progression despite undergoing multiple lines of treatment including novel agents such as CD30 monoclonal antibody and PD-1 monoclonal antibody.

Bombyx mori Jun gene is involved in endoreplication of silk gland cells by regulating S-phase cell cycle genes.

Endoreplication as a variant of the cell cycle is an important avenue of development and reproduction for organisms. Endoreplication-induced polyploid cells are pivotal in ensuring the normal size and function of tissues and organs. However, it is becoming increasingly evident that a multitude of signaling pathways exert regulatory effects on endoreplication, and the regulatory network still needs further clarification.

Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions.

Introduction: Triple-negative breast cancer (TNBC) demonstrates poor prognosis due to its heterogeneity-related biological barrier, immunosuppressive tumor microenvironment (TME) and escape of cancer cells on immune surveillance. Exosomes are membrane-encased vehicles with properties of inter- and intra-cellular communication and regulation for therapeutic use, even as drug vehicles. M1 macrophage-derived exosomes (M1-Exos) can communicate with adjacent M2 macrophages and reprogram them to M1 subtypes to reshape TME.

Mechanistic insights into electronic modulation of binuclear iron-based zeolites for selective oxidation of methane to methanol.

Conceptually, direct methane-to-methanol (DMTM) conversion represents an efficient approach for methane (CH) valorization, which is thermodynamically feasible at ambient temperature. However, this process consistently faces a conversion-selectivity trade-off. Particularly, when employing dioxygen (O) as the oxidizing agent, an additional compromise arises between O activation and the generation of reactive oxygen species necessary for CH activation.

Multivariate analysis of soil particle size distribution and Spatial correlation with soil moisture characteristics in different vegetation types of Mu Us Sandy Land.

In this paper, the fractal mechanism of soil improvement by vegetation was revealed by analyzing the soil characteristics under four typical vegetation types: Salix cheilophila, Caragana korshinskii, Hippophae rhamnoides, and Corethrodendron fruticosum in Mu Us Sandy Land. The results showed that (1) the soil of each vegetation type was mainly composed of sand (> 90%), and the content of clay and silt was less than 10%. CF had the least heterogeneity of soil particles in the 0-120 cm soil layer, HR was uniformly distributed in the 120-200 cm soil layer, and the change trend of particle composition in the 140-200 cm soil layer was consistent.