Synergistic engineering on surface chemistry and morphology in TiCT MXene towards high rate and durable LiO batteries.

The lithium‑oxygen battery (LOB) has emerged as an appropriate candidate for next-generation power supply system, owing to the ultrahigh theoretical energy density (3480 Wh kg) and relatively low cost. However, some intrinsic challenges, including high redox overpotentials, limited rate capability, and poor cyclic life, continue to hinder the practical deployment of lithium‑ oxygen batteries. The fundamental limitations originate from sluggish oxygen reduction/evolution reaction (ORR/OER) kinetics and parasitic side reactions, which can be effectively mitigated by employing efficient cathode electrocatalysts.

Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor.

Lens epithelium, a fundamental biological structure pivotal for maintaining normal vision, can be disrupted, leading to the development of cataracts. The epithelial-mesenchymal transition has been proven to be the key factor of secondary cataract progression. However, the underlying mechanism of epithelial-mesenchymal transition in lens epithelial cells remains unclear.

Non-pharmacological therapies for quality of life in women with breast cancer: a protocol for a systematic review and network meta-analysis.

Introduction: Breast cancer (BC) is the most frequently diagnosed cancer worldwide. Both the disease itself and the side effects of its treatments significantly impair the quality of life (QoL) of women with BC. Non-pharmacological therapies (NPTs), including exercise therapies, mindfulness-based interventions, cognitive therapies, acupoint therapies, and other complementary therapies, are increasingly being employed to improve the QoL for women with BC.

Lipid nanoparticles for mRNA delivery in brain via systemic administration.

Efficient delivery of messenger RNA (mRNA) to the brain via systemic administration remains a challenge, primarily due to the blood-brain barrier. To address this challenge, we incorporated SR-57227, a ligand of serotonin [5-hydroxytryptamine type 3 (5-HT)] receptor, into the design of ionizable lipids to develop lipid nanoparticles (LNPs) for systemic mRNA delivery to the brain. OS4T LNP was identified as an optimized formulation based on multiple assays.

Deciphering the molecular signatures of tropical L. under cold stress: an integrated physiological and transcriptomic analysis.

Introduction: is a widely cultivated palm species with significant economic and medicinal value. However, is a tropical plant that is particularly susceptible to low temperatures.

Methods: This study integrates physiological profiling with transcriptomic sequencing to systematically investigate the cold-response mechanisms of .

Lactylation in radiosensitivity regulation: Mechanistic insights and recent advances.

Lactylation, as a novel post-translational modification, has gained a lot of attention in the biomedical field in recent years. Lactylation is not only related to cellular metabolism but also increasingly prominent in the tumor microenvironment, particularly in regulating radiation sensitivity. This review aims to explore the potential connection between lactylation modification and the regulation of radiation sensitivity.

Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions.

Introduction: Triple-negative breast cancer (TNBC) demonstrates poor prognosis due to its heterogeneity-related biological barrier, immunosuppressive tumor microenvironment (TME) and escape of cancer cells on immune surveillance. Exosomes are membrane-encased vehicles with properties of inter- and intra-cellular communication and regulation for therapeutic use, even as drug vehicles. M1 macrophage-derived exosomes (M1-Exos) can communicate with adjacent M2 macrophages and reprogram them to M1 subtypes to reshape TME.

Arbuscular mycorrhizal fungi enhance the tolerance of Casuarina equisetifolia to drought and salt stress under coral sand matrix conditions.

To evaluate the effects of arbuscular mycorrhizal fungi (AMF) on the stress tolerance of Casuarina equisetifolia in coral sand matrix, we inoculated seedlings with Funneliformis mosseae and Rhizophagus intraradices and subjected them to salt stress (SS) and drought stress (DS). The results indicated that AMF colonization significantly (p < 0.05) enhanced height (42-123 %), proline and soluble sugar concentrations, and the peroxidase and superoxide dismutase activities (0.

Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway.

Diabetic cataract (DC), a well-recognized complication in diabetic patients, can progress to blindness if not adequately managed, with currently limited therapeutic strategies. Icariin (ICA), a natural compound derived from Epimedium, has been demonstrated exhibiting anti-inflammatory and anti-oxidant, but its impact on diabetic cataracts remains elusive. In this study, we used both SRA01/04 cells and SD rats' model to explored the protective effects of ICA in cataract formation.

Survival Benefit of Surgical Staging Before Radiotherapy in Locally Advanced Cervical Cancer: A Pooled Analysis.

Lymph node metastasis significantly impacts prognosis and treatment in locally advanced cervical cancer (LACC). Surgical staging offers precise information on node involvement, though its survival benefit is debated. We pooled data from 9 cohort studies involving 2553 patients to evaluate the benefit of pre-treatment surgical staging in patients with locally advanced cervical cancer.

Gold nanotriangle-enhanced high-sensitive determination of alpha-fetoprotein via lateral flow immunoassay in serum.

The first visual lateral flow immunoassay (LFIA) is reported using gold nanotriangles (AuNTs) as labeling materials for high-sensitivity alpha-fetoprotein (AFP) detection in serum. Compared with traditional gold nanoparticles, the use of anisotropic AuNTs significantly reduces the detection limit of AFP due to larger surface area and strong localized surface plasmon resonance, which can reach 5 ng/mL in serum samples with naked eyes. Under optimized conditions, this method demonstrates excellent accuracy and reproducibility in both buffer and serum systems.

Manganese Nanomaterials: A Green Solution to Suppress in Rice.

Due to the environmental concerns surrounding widely used antimicrobial agents, the use of nanotechnology to suppress crop diseases has attracted increasing attention in the agricultural field. This paper investigated the inhibitory effects of manganese-based nanomaterials (NMs) on rice leaf blight. In vitro experiments showed that manganese oxide (MnO) NMs and manganese tetroxide (MnO) NMs directly inhibited (Xoo) with a maximum OD value of 0.

Activating lithium-ion storage performances of two-dimensional MSiN (M = Mo, W) monolayers: a theoretical prediction.

Two-dimensional materials MAZ (where M = Mo, W, V, Cr, Nb, Ta, Ti, Zr or Hf; A = Si or Ge; and Z = N, P, or As) have attracted increasing interest for their exceptional stability and mechanical strength. Therefore, it is vital to explore their lithium-ion (Li-ion) energy storage behavior for next-generation energy storage technologies. Herein, the potential of two synthesized MSiN (M = Mo, W) materials as Li-ion battery anodes was systematically investigated, and two effective ways were proposed to trigger their Li-ion storage performances through first-principles calculations.

Unlock the sustained therapeutic efficacy of mRNA.

mRNA therapies have emerged as a transformative class of medicines, offering immense potential across a diverse array of applications. This progress has been particularly evident in the wake of the success of lipid nanoparticle (LNP)-based mRNA vaccines during the COVID-19 pandemic. As these applications expand, the demand for sustained protein production has become increasingly critical.

Adipose Tissue-Derived Extracellular Vesicles Loaded with miR-141-3p Regulate Obesity-Induced Insulin Resistance by Targeting Glycogen Synthesis and Gluconeogenesis.

Purpose: Insulin resistance, a hallmark feature of type 2 diabetes and cardiovascular diseases, is critically influenced by liver-adipose tissue crosstalk, offering a novel therapeutic strategy for its management. Emerging evidence indicates that extracellular vesicles (EVs) secreted from adipose tissue serve as essential carriers of miRNA-mediated interorgan communication. This study aimed to investigate the regulatory effects of adipose tissue-derived EVs on obesity-induced hepatic insulin resistance and to elucidate the underlying molecular mechanisms by which EV-mediated signaling contributes to metabolic dysfunction.

Glycosylation as an intricate post-translational modification process takes part in glycoproteins related immunity.

Protein glycosylation, the most ubiquitous and diverse type of post-translational modification in eukaryotic cells, proteins are input into endoplasmic reticulum and Golgi apparatus for sorting and modification with intricate quality control, are then output for diverse functional glycoproteins that are utilized by cells to precisely regulate various biological processes. In order to maintain the precise spatial structure of glycoprotein, misfolded and unfolded glycoproteins are recognized, segregated and degraded to ensure the fidelity of protein folding and maturation. This review enumerates the role of five immune-related glycoproteins and reveals the relevance of glycosylation to their antigen presentation, immune effector function, immune recognition, receptor binding and activation, and cell adhesion and migration.

Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection.

Lipid nanoparticle-messenger RNA formulations have garnered significant attention for their therapeutic potential in infectious diseases, cancer and genetic disorders. However, effective mRNA delivery to the central nervous system (CNS) remains a formidable challenge. To overcome this limitation, a class of brain-targeting lipids (BLs) is developed by incorporating brain-targeting small molecules with amino lipids and formulated them with helper lipids to generate brain-targeting lipid nanoparticles (BLNPs) for mRNA delivery.

Comparative efficacy of non-pharmacological interventions on kinesiophobia in patients with chronic non-specific low back pain: a study protocol for a systematic review and network meta-analysis.

Introduction: Kinesiophobia is a significant factor which influences the prognosis of patients with chronic non-specific low back pain (CNLBP). The restriction of functional training can severely impede functional recovery and contribute to negative emotional states (including anxiety and depression) and a heightened risk of insomnia while exacerbating the economic burden on patients. Although several randomised controlled trials have evaluated the effects of various non-pharmacological interventions on kinesiophobia in CNLBP, their relative efficacy and potential adverse effects remain ambiguous.

Furan-Derived Lipid Nanoparticles for Transporting mRNA to the Central Nervous System.

Delivery of mRNA (mRNA) to the central nervous system (CNS) remains a significant challenge. Herein, we design a library of furan-derived lipids and, to our knowledge, for the first time, leverage the meningeal lymphatic vessels (MLVs) route to achieve efficient delivery of mRNA to the brain. These furan-derived lipids were engineered with different furan cores, functional groups, and tails.

BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner.

Retinal vascular diseases are typified by the proliferation of irregular and leaky microvessels, resulting in vision impairment. Although the etiology of retinal angiogenesis is not yet fully understood, it is evident that microglia play a pivotal role in promoting angiogenesis. In vivo, the METTL14 conditional knockout (cKO) mouse was constructed to investigate the role of METTL14 in oxygen-induced retinopathy (OIR).

[Remediation of Antimony-polluted Soil Using Iron Sulfide-modified Biochar and Stability Assessment After Remediation].

To investigate the remediation effects and mechanisms of iron sulfide-modified biochar （FeS-BC） on polluted soil surrounding an antimony smelting plant, soil from around a decommissioned antimony smelting plant in the Qinglong County, Guizhou Province, was used as the research subject. Through soil cultivation experiments, the effects of raw biochar （BC） and iron sulfide-modified biochar （FeS-BC） on the leaching toxicity, bioavailability, and speciation of antimony （Sb） in the soil were compared. The results showed that with an FeS∶BC mass ratio of 1∶5 and an addition rate of 7%, the average stabilization efficiency of Sb in soils with varying degrees of Sb pollution （G1-G6） reached 66.

Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation.

Shikonin (SHK) possesses extensive pharmacological effects including antimicrobial and anti-inflammatory properties for diabetic wound (DW), while its molecular mechanism remains to be clarified. In this study, we investigated the potential mechanisms of SHK in treating DW by combining network pharmacology and in vitro experiments. We obtained potential targets for SHK and DW from the publicly available database.

Nanomaterials-Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis.

The etiology of osteoporosis is rooted in the disruption of the intricate equilibrium between bone formation and bone resorption processes. Nevertheless, the conventional anti-osteoporotic medications and hormonal therapeutic regimens currently employed in clinical practice are associated with a multitude of adverse effects, thereby constraining their overall therapeutic efficacy and potential. Recently, nanomaterials have emerged as a promising alternative due to their minimal side effects, efficient drug delivery, and ability to enhance bone formation, aiding in restoring bone balance.

Enhancing antitumor immunity through chemotherapeutic-derived lipid nanoparticle-induced immunogenic cell death and CD40L/Flt3L mRNA-mediated dendritic cell activation.

Dendritic cells (DCs) are essential for inducing effective antitumor T cell responses. However, the immunosuppressive tumor microenvironment (TME) hinders DC recruitment and maturation, facilitating tumor progression and spread. This study investigates the synergistic potential of immunogenic cell death (ICD), triggered by chemotherapeutic-derived lipid nanoparticles (LNPs), in combination with Flt3L and CD40L mRNA delivery to enhance DC mobilization and activation, reprogram the TME, and ultimately promote robust antitumor T cell responses.

Effects of Hot Night Exposure on Human Semen Quality: A Multicenter Population-Based Study.

Objective: To explore and quantify the association of hot night exposure during the sperm development period (0-90 lag days) with semen quality.

Methods: A total of 6,640 male sperm donors from 6 human sperm banks in China during 2014-2020 were recruited in this multicenter study. Two indices (i.