Chelerythrine alleviates inflammation and angiogenesis in a mouse rosacea model via suppressing the NF-κB/p38 MAPK/STAT3 pathways.

Introduction: Rosacea is a chronic inflammatory skin condition marked by excessive M1 macrophage polarization and angiogenesis, resulting in erythema and tissue inflammation. Despite available treatments, many patients experience recurrent flare-ups. This study explores chelerythrine, a bioactive component of Phellodendri Chinensis Cortex, for its therapeutic potential in rosacea through modulation of NF-κB, p38 MAPK and STAT3 signaling, inflammation, and vascular regulation.

DFT Calculation-Assisted Design of Precursors for Nucleophilic 2-Amino Allyl Cations and Their Application in [3 + 2] Cycloaddition with Electron-Deficient Alkenes.

In this work, we developed nucleophilic 2-aminoallyl cations guided by DFT calculations. Computational insights enabled a comprehensive analysis of factors governing N-nucleophilicity and an accurate prediction of cycloaddition reactivity with electron-deficient alkenes. Notably, this study represents the first asymmetric [3 + 2] cycloaddition of amino-allyl cations with exocyclic double bonds, enabling the efficient synthesis of -pyrrolidines with excellent diastereoselectivities and enantioselectivities.

Benefit-harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlled trials.

Background: Although intensive blood pressure control is recommended by major guidelines, its overall benefit-harm balance remains uncertain. In particular, it is unclear how net clinical benefit varies by blood pressure target and patient characteristics. We aimed to quantify the benefit-harm trade-offs of intensive blood pressure control versus standard blood pressure control.

Relationship Between Chronic Inflammatory Indicators and Diabetic Peripheral Neuropathy in Hospitalized Elderly Patients with Type 2 Diabetes.

Purpose: Investigate the correlation between chronic inflammatory indicators and DPN in hospitalized elderly patients with Type 2 diabetes mellitus (T2DM), and to build a prediction model to provide scientific basis for early identification of high-risk groups.

Patients And Methods: Clinical data of 270 elderly T2DM patients hospitalized in the People's Hospital of Ningxia Hui Autonomous Region from January 2021 to December 2024 were selected and classified into a diabetic peripheral neuropathy group (DPN, n=163) and a non-diabetic peripheral neuropathy group (NDPN, n=107) depending on the presence of DPN. Clinical features, biochemical indicators and peripheral blood inflammatory indicators (PLR, NLR, MLR, SII, SIRI) of patients were collected, and a predictive model was constructed by logistic regression analysis.

Burden trends and risk factors for prostate cancer from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021.

Objectives: Prostate cancer (PCa) is one of the most common malignancies in males worldwide. Therefore, conducting the latest and comprehensive assessment of PCa is important.

Research Design And Methods: Average annual percent change for age-standardized rate trend was calculated by Joinpoint.

Mechanistically Engineered Heterojunction From Spent LFP for Efficient Oxygen Evolution Electrocatalysis.

The large-scale retirement of LiFePO (LFP) batteries demands sustainable strategies for material recovery and functional repurposing. However, the inert micrometer-scale morphology and electronically stable lattice of spent LFP hinder its direct catalytic reuse. Herein, we present a structure-guided strategy that upcycles spent LFP into a high-performance oxygen evolution reaction (OER) electrocatalyst.

Microwave-Enhanced Catalytic Performance of Benzene Oxidation on MOF-Derived Mn/Ce-Co Oxides.

Microwave-assisted processing has shown tremendous promise in accelerating chemical reactions and reducing energy consumption through targeted dielectric heating. This study develops MOF-derived Mn-Co and Ce-Co oxide catalysts for energy-efficient benzene oxidation via microwave catalysis. The MnCo spinel oxides (particularly MnCo11-400) exhibit superior microwave absorption and catalytic activity due to enhanced oxygen mobility and tailored dielectric properties.

Mechanically Compliant and Impedance Matching Hydrogel Bioelectronics for Low-Voltage Peripheral Neuromodulation.

In neural biointerfacing technologies, mitigating the mismatch in mechanical and impedance attributes between neural tissues and bioelectronics remains a central challenge for achieving high-efficacy neuromodulation. Here, full-hydrogel bioelectronics that demonstrate superior mechanical compliance and impedance matching with 3D peripheral nerves, allowing for low-voltage vagus nerve stimulation, are reported. By precisely tuning the dimensional parameters through 3D printing, the hydrogel bioelectronics, initially in a 2D planar form in a dehydrated state, can curl spontaneously around nerves and form a seamless interface.

Postbiotic-Mediated Obesity Reduction via Bioactive Peptide ETLVK and Gut Microbiota in HFD Mice.

Although () TCCC11824 (CGMCC 8198) has shown antiobesity effects, its active components remained unclear. This study reveals that the TCCC11824 crushed supernatant (LpS) exerts broad antiobesity activities in high-fat diet (HFD)-induced obese mice. LpS significantly improved blood lipid profiles, reduced hepatic injury, and suppressed inflammation in liver and epididymal fat.

Construction of A Novel 5-Dye Fluorescent Multiplex System With 30 Y-STRs for Patrilineal Relationship Prediction.

Nowadays, Y chromosome short tandem repeats (Y-STRs) are widely used in forensic medicine practice, which has great significance for ancestry tracing, male lineage evolution, and male paternal relatives. Rapidly mutating Y-STRs (RM Y-STRs) have been shown to have greater potential to distinguish males from males in the patrilineal line. Therefore, a novel 5-dye fluorescent multiplex system with 30 Y-STRs was developed and optimized to screen out more RM Y-STRs and fasting mutating Y-STRs (FM Y-STRs).

Association Between Family Upbringing Environment and Mobile Phone Dependence Syndrome in Middle School Students - Guangzhou City, Guangdong Province, China, 2023.

What Is Already Known About This Topic?: Smartphones have consistently served as the primary device for internet access among younger populations. Recent research demonstrates that more than 25% of Chinese adolescents experience smartphone addiction. This study aims to examine the association between family upbringing environment and Mobile Phone Dependence Syndrome (MPDS) among middle school students in Guangzhou.

Study on the pore structure evolution and microscopic seepage characteristics of coal under high pressure air blasting.

The pore structure in coal seams has a significant impact on the occurrence and migration characteristics of coalbed methane. The High Pressure Air Blasting (HPAB) is one of the main feasible technologies to improve the efficiency of unconventional gas extraction. Currently, there is little research on the visualization of the evolution of pore structure and seepage characteristics in coal under HPAB, resulting in unclear understanding of the formation of 3D pore network structure in coal under HPAB, the interconnection of pores and fissures, and the mechanism of gas seepage and diffusion under HPAB.

Lipid nanoparticles for mRNA delivery in brain via systemic administration.

Efficient delivery of messenger RNA (mRNA) to the brain via systemic administration remains a challenge, primarily due to the blood-brain barrier. To address this challenge, we incorporated SR-57227, a ligand of serotonin [5-hydroxytryptamine type 3 (5-HT)] receptor, into the design of ionizable lipids to develop lipid nanoparticles (LNPs) for systemic mRNA delivery to the brain. OS4T LNP was identified as an optimized formulation based on multiple assays.

Red and blue light differentially regulate carbon metabolism and stem elongation in soybean cultivars with contrasting lodging resistance under shade: A multi-omics perspective.

This study employed soybean cultivars 'Henong 60' (lodging-resistant) and 'Heinong 48' (lodging-prone) to investigate the effects of red and blue light on plant height, stem chloroplast ultrastructure, cell wall composition, non-structural carbohydrate (NSC) content, and sugar metabolism-related enzyme activities under 70 % and 100 % shading. Integrated proteomics and metabolomics elucidated carbon allocation pathways during blue light-regulated stem development. Results demonstrated that blue light, compared to red light, significantly inhibited plant height, with stronger inhibition under 100 % shading.

CT-based radiomics model for noninvasive prediction of progression-free survival in high-grade serous ovarian carcinoma: a multicenter study incorporating preoperative and postoperative clinical factors.

Objective: To investigate the potential of combining radiomics with clinicoradiological features in predicting progression-free survival (PFS) after the surgery of high-grade serous ovarian carcinoma (HGSOC).

Methods: In this retrospective multicenter study, a total of 195 patients with pathologically confirmed HGSOC who underwent cytoreductive surgery followed by platinum-based chemotherapy were included from two institutions (train cohort, n = 134; test cohort, n = 61). From the train cohort, univariate and multivariate Cox proportional hazards regression analyses systematically evaluated associations between clinicoradiological features and PFS, culminating in a clinical prediction model for stratifying progression risk.

LPA antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities.

Activated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung interstitial section. Therefore, fibroblasts are one of the most targeted cells for treating idiopathic pulmonary fibrosis (IPF).

LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment.

Background: Endometrial cancer (EC), a leading gynecologic malignancy, demonstrates a rising global incidence that imposes significant clinical and socioeconomic burdens. While the RNA-binding protein LIN28B has been reported to promote the progression of EC, its mechanistic role in driving tumor progression and immune modulation remains poorly characterized. This study specifically investigates whether LIN28B promotes EC progression through MYC upregulation and its influence on tumor immune microenvironment remodeling.

Plasma proteomics-based risk scores for psoriasis prediction: a novel approach to early diagnosis.

Introduction: Psoriasis is a chronic immune-mediated inflammatory skin disease with a significant global burden. Current risk assessment lacks integration of proteomic data with genetic and clinical factors. This study aimed to develop a plasma proteomics-based risk score (ProtRS) to improve psoriasis prediction.

An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria-Tetanus-Acellular Pertussis, Type b, and ACYW135 Meningococcal Conjugate Vaccine in Murine and Rat Models.

: The combined diphtheria-tetanus-acellular pertussis (three-component), type b (Hib, conjugate), and ACYW135 meningococcal (conjugate) vaccine (DTaP-Hib-MCV4) offers a promising alternative to single-component vaccines, potentially simplifying immunization schedules and improving vaccination coverage. : We evaluated the safety, immunogenicity, and protective efficacy of DTaP-Hib-MCV4 in animal models. Acute and long-term toxicity studies were conducted in Sprague-Dawley (SD) rats with equal numbers of male and female animals.

Evaluating the generalizability and transferability of acoustic leak detection models for water distribution networks.

Acoustic Leak Detection (ALD) plays a pivotal role in ensuring the operational safety of water distribution networks (WDNs). However, the cross-domain deployment of single-scenario ALD models is significantly hindered by environmental heterogeneity (pipe materials and diameters, etc.) and data scarcity in practical WDNs.

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination.

Aortic aneurysm and dissection (AAD) are life-threatening cardiovascular diseases with limited effective medical treatments. Protein phosphatase 2A (PP2A), the most abundant serine/threonine phosphatase in eukaryotes, is pivotal in regulating intracellular signaling. This study investigates the role of PP2A in the pathogenesis of AAD.

Utility-Based Dose Selection for Stereotactic Body Radiation Therapy in Hepatocellular Carcinoma.

Purpose: Stereotactic body radiation therapy (SBRT) planning for hepatocellular carcinoma (HCC) typically prescribes the maximum dose associated with an acceptable risk of toxicity, relying on implicit trade-offs between efficacy and toxicity. To make this trade-off quantitative, we developed a utility-based approach to dose selection for SBRT in HCC and studied the expected effects on clinical outcomes.

Methods And Materials: Using a multi-institutional cohort of SBRT-treated patients, we developed predictive models for local progression, competing mortality, and liver toxicity, defined as an increase of 0.

Anti-Inflammatory Secondary Metabolites from sp. NX-S-6.

Five new natural products, including two sorbicillinoids (-), one indolinone alkaloid (), one tetracyclic steroid (), and one α-pyrone derivative (), were identified from the endophytic sp. NX-S-6, together with thirteen known natural products. The structures of new compounds were unambiguously elucidated by comprehensive spectroscopic analyses (NMR, MS), as well as electronic circular dichroism (ECD) calculation.

Contrasting Phylogeographic Patterns of Sandy vs. Rocky Sympatric Sister Species of Supralittoral Isopods in Chile.

Sister taxa that have diverged and persisted in sympatry have likely been exposed to the same general environmental changes throughout their evolutionary history and may thus exhibit similar phylogeographies. Here, we compare the phylogeographic patterns of two sister species of isopods (genus ) that have broadly overlapping distributions but distinct habitat preferences in the supralittoral zone of Chile. The dynamic geoclimatic history of this region during the Quaternary has been implicated in shaping the evolutionary histories of other coastal taxa.