Decoding coal-induced pulmonary endothelial injury using single-cell omics.

Pulmonary endothelial injury is a critical factor in the pathogenesis and progression of coal pneumoconiosis. However, the precise mechanisms underlying this injury remain poorly understood. To address this, we established a coal pneumoconiosis mouse model by chronic intranasal coal dust exposure over 9 months.

FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation.

High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice.

An Olive Oil-Based High-Fat Diet Promotes Obesity-Driven Metastasis of Triple-Negative Breast Cancer.

Obesity is strongly associated with triple-negative breast cancer (TNBC). A better understanding of the molecular mechanisms driving obesity-induced TNBC progression could facilitate development of precision dietary intervention strategies. Here, we used murine models of obesity induced by different high-fat diets (HFDs) to examine their impact on TNBC progression.

Directed Structural Evolution of Nickel Nanoparticles into Atomically Dispersed Sites for Efficient CO Electroreduction.

Electrochemical CO reduction (CORR) to carbon monoxide (CO) offers a sustainable pathway for carbon utilization, yet challenges remain in terms of improving selectivity and activity. Herein, we report a Ni/NC catalyst synthesized via a milling - pyrolysis method, in which Ni particles anchored on nitrogen-doped carbon (NC) are electrochemically activated under an Ar atmosphere, leading to their structural evolution into single-atom Ni sites. After activation in Ar atmosphere, the current density nearly doubles (from ≈30 to ≈60 mA cm), and concurrently, the Faradaic efficiency of CO stays at ∼90% with the potential set to -0.

Quantifying aerosol and microbial exposure of healthcare workers in endoscopy suites: a time-based study.

Objectives: This study aimed to quantify aerosol and microbial exposure levels during different working hours, analyze temporal air pollution trends in the endoscopy suite, and provide evidence to optimize infection prevention strategies.

Methods: A portable laser particle counter and an airborne bacteria sampler were used to measure aerosol particle concentrations and microbial loads at four time points: before the commencement of work (baseline), and 1, 2, and 3 h after work initiation. Continuous data collection was conducted over 10 consecutive working days.

NONLINEAR GLOBAL FRÉCHET REGRESSION FOR RANDOM OBJECTS VIA WEAK CONDITIONAL EXPECTATION.

Random objects are complex non-Euclidean data taking values in general metric spaces, possibly devoid of any underlying vector space structure. Such data are becoming increasingly abundant with the rapid advancement in technology. Examples include probability distributions, positive semidefinite matrices and data on Riemannian manifolds.

Correction: Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung.

[This corrects the article DOI: 10.3389/fimmu.2025.

MSFI: Multi-timescale spatio-temporal features integration in spiking neural networks.

Dynamic vision sensors (DVS) asynchronously encode the polarity of brightness changes with high temporal resolution and a wide dynamic range, making them ideal for capturing temporal information. Spiking neural networks (SNNs) are well-suited for handling such event streams due to their inherent temporal information processing capability. However, existing SNNs only transmit membrane potential across timesteps, neglecting spatial dependencies and failing to extract complex temporal features.

Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery.

Background: Postoperative gastrointestinal recovery affects hospital stay time and patient's quality of life. Studies suggest that the use of dexmedetomidine during the perioperative period can promote post operational recovery of gastrointestinal function.

Aim: To evaluate the efficacy and safety of different doses of dexmedetomidine on postoperative gastrointestinal function recovery after laparoscopic colorectal surgery.

GDF15 Ameliorates Deoxynivalenol-Induced Anemia by Resolving Ribosomal Stress-Mediated Erythropoietic Arrest.

Deoxynivalenol (DON) is a prevalent trichothecene mycotoxin that contaminates global food supplies, posing significant health risks; however, targeted therapies against DON are scarce. Although DON-induced anemia is well-documented, the underlying mechanisms remain unclear. In this study, the effects of DON on erythropoiesis are examined in detail using complementary murine models and human primary erythroid cultures.

Latent profile analysis of empathy for pain and its associations with coping styles among nurses in China.

Objectives: This study sought to evaluate the prevalence of empathy for pain among nurses in Chinese hospitals through latent profile analysis, identify latent subgroups and their demographic characteristics and examine the relationship between different subgroups and coping styles.

Design: A multicentre cross-sectional study.

Setting: The study was conducted in 43 hospitals across Guangdong Province, China, comprising 36 general medical hospitals and 7 specialty hospitals.

Multi-omics analysis of immunologically relevant genes in multiple sclerosis to identify potential drug target.

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and immune dysregulation. Despite the established link with immune function, the genetic and pathological mechanisms connecting immune-related genes to MS remain incompletely understood.

Methods: We systematically integrated genome-wide association study (GWAS) data for various quantitative trait loci (QTLs) from public databases and literature, along with GWAS summary statistics for MS from IMSGC and FinnGen.

A novel sensitive electrode based on a chitosan/rGO/CuO composite for the detection of urea concentration.

Chitosan/reduced graphene oxide/copper oxide (CS/rGO/CuO) films were successfully deposited on a screen-printed electrode (SPE) surface by applying the electrodeposition technique and were utilized in detecting urea concentration using cyclic voltammetry (CV). The current study presents a novel sensitive electrode based on CS/rGO/CuO used to detect urea fertilizer. The characterization of the prepared samples was conducted using FTIR, XRD, and cyclic voltammetry.

Robotic ureteroplasty with lingual mucosa graft: a multi-institutional experience.

Background: The management of long proximal ureteral strictures poses a significant challenge, with traditional options such as renal autotransplantation or bowel interposition associated with substantial morbidity. This study explores the use of robotic ureteroplasty with lingual mucosal graft (RU-LMG) as a minimally invasive approach for treating complex ureteral strictures. We present a multi-institutional cohort to evaluate its effectiveness in managing proximal and mid-ureteral strictures.

Global, regional, and national temporal trend in burden of chronic respiratory diseases from 1990 to 2021: Findings from the Global Burden of Disease Study 2021.

Background: Chronic respiratory diseases (CRDs), including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD), and pulmonary sarcoidosis, continue to pose a significant global health challenge. This study aims to assess the global, regional, and national burden of CRDs from 1990 to 2021, using data from the Global Burden of Disease Study (GBD) 2021 to identify key trends and advise future public health strategies.

Methods: Data from the GBD 2021 were used to estimate the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of CRDs and their subtypes across 21 global regions and 204 countries and regions from 1990 to 2021.

Activity of upper-limb muscles during therapeutic climbing: a cross-sectional comparison between fractured and healthy individuals.

Background: Therapeutic climbing (TC) is an emerging physical therapy with demonstrated benefits for musculoskeletal rehabilitation, but its impact on upper-limb muscle activity remains unclear. Existing research predominantly focuses on healthy individuals, leaving muscle recruitment strategies in patients with upper-limb injuries largely unexplored. This study aims to investigate upper-limb muscle activity in patients with unilateral upper-limb injuries and healthy individuals across six TC exercises.

Decoding the Chemodiversity blueprint: Chromosome-scale genome assembly unveils photosynthesis-terpenoid coordination in Cinnamomum burmanni through genomic and miRNA regulatory networks.

The intricate interplay between photosynthetic efficiency and terpenoid biosynthesis in plants remains a pivotal yet underexplored area in secondary metabolism research. This study elucidates the physiological and molecular mechanisms underlying this synergy in Cinnamomum burmanni, a chemically diverse Lauraceae species, through a multi-omics approach. A high-quality chromosome-level genome of C.

Methicillin-Resistant (MRSA): Resistance, Prevalence, and Coping Strategies.

Increased antimicrobial resistance requires effective ways to overcome the global challenge of bacterial infections, including methicillin-resistant (MRSA). From the emergence of MRSA to its continued evolution, it is important to explore this pathogen from fresh perspectives and develop corresponding coping strategies to counter its growing threat. New coping strategies are continuously emerging, including but not limited to enhancing penetration capabilities or targeting their virulence.

Biodegradation of synthetic organic pollutants: principles, progress, problems, and perspectives.

Biodegradation plays a pivotal role in controlling environmental pollution. Naturally occurring microbes can degrade various environmental pollutants; however, the bioremediation of emerging pollutants resulting from the synthesis of recalcitrant organic compounds has not been sufficiently studied. These compounds pose significant environmental risks when released into soil and water bodies.

LncRNA Sirt1-AS Protects Against Cardiac Hypertrophy by Modulating Sirt1.

BackgroundLncRNAs are pivotal regulators in cardiovascular diseases. Sirt1-AS, a lncRNA, has been shown to play a role in cardiovascular diseases. This study aimed to explore the role of Sirt1-AS in cardiac hypertrophy and the underlying molecular mechanism.

Evaluation of a lifestyle intervention for women with gestational diabetes mellitus based on the medical internet of things: a randomized controlled trial with mid-sample verification.

Objective: To evaluate the effect of lifestyle intervention using a self-management model based on the medical Internet of Things (mIoT) for women with gestational diabetes mellitus (GDM).

Methods: 240 eligible participants were initially enrolled, with 225 completing the trial (116 in the intervention group, 109 in the control group) due to 15 dropouts (4 in the intervention, 11 in the control) caused by delivery at non-study hospitals. The control group regularly received the lifestyle interventions.

An audio tampering detection framework for low SNR conditions based on modified CZT.

Extracting the electric network frequency (ENF) from digital audio signals is a crucial means of forensic evidence. However, ENF signal extraction is susceptible to noise, making it challenging to establish a reliable matching relationship with the reference frequency database, especially under low signal-to-noise ratio (SNR) conditions. To solve this problem, an ENF extraction and tampering detection framework (ENF-ETD) for low SNR conditions is proposed in this article.

Enhancing the Solubility and Oral Bioavailability of Trimethoprim Through PEG-PLGA Nanoparticles: A Comprehensive Evaluation of In Vitro and In Vivo Performance.

Trimethoprim (TMP), a sulfonamide antibacterial synergist, is widely used in antimicrobial therapy owing to its broad-spectrum activity and clinical efficacy in treating respiratory, urinary tract, and gastrointestinal infections. However, its application is limited due to poor aqueous solubility, a short elimination half-life (t), and low bioavailability. In this study, we proposed TMP loaded by PEG-PLGA polymer nanoparticles (NPs) to increase its efficacy.

Asynchronous programmed cell death occurrence in the silk glands at pupation (Bombyx mori).

Silk glands are crucial for silk protein synthesis and secretion. However, the degeneration process takes place at pupation, as mediated by programmed cell death (PCD). The differences of PCD in the anterior silk gland (ASG) and middle silk gland (MSG) with different physiological functions remain unexplored.

Colchicine alleviates atherosclerosis combined with diabetes mellitus by targeting PIM2 and regulating the NF-κB signaling pathway.

Background: Coronary heart disease (CHD) is becoming increasingly prevalent worldwide due to the aging population. Although diabetes mellitus (DM) is an independent risk factor for the development of CHD, existing anti-atherosclerotic therapies do not adequately address the mechanism underlying the exacerbation of CHD in diabetic patients. Derived from the Colchicum autumnale plant, colchicine has recently gained recognition as a novel anti-inflammatory agent for CHD.