Atomically Asymmetrical Ruthenium-Oxygen-Cobalt Sites Accelerate Oxygen Redox and Suppress Side Reactions for Stable Lithium-Oxygen Batteries.

Development of aprotic lithium-oxygen (Li-O) batteries suffers from slow cathode reaction kinetics, numerous side reactions, and large polarization, which are intimately related to the discharge product of LiO. Here, we designed and prepared a modified CoO nanoparticle with atomic Ru substitution at octahedral Co sites supported by carbon nanocages (RuCoO@HCNs) as a cathode catalyst. The asymmetrical octahedral Ru-O-Co units trigger a strong electron coupling effect, leading to charge redistribution and optimization of the d-orbital energy levels, thus facilitating oxygen activation and conversion into superoxide anions during discharging.

Global trends and prospects of endothelial keratoplasty from 2004 to 2023: a bibliometric analysis.

Background: Endothelial keratoplasty (EK) has revolutionized the treatment of corneal diseases by offering a less invasive alternative to traditional full-thickness keratoplasty. Over the past decades, EK techniques have evolved significantly, improving surgical outcomes, expediting recovery, and reducing postoperative complications. Nevertheless, challenges such as postoperative rejection and endothelial cell loss persist.

Decoding the Chemodiversity blueprint: Chromosome-scale genome assembly unveils photosynthesis-terpenoid coordination in Cinnamomum burmanni through genomic and miRNA regulatory networks.

The intricate interplay between photosynthetic efficiency and terpenoid biosynthesis in plants remains a pivotal yet underexplored area in secondary metabolism research. This study elucidates the physiological and molecular mechanisms underlying this synergy in Cinnamomum burmanni, a chemically diverse Lauraceae species, through a multi-omics approach. A high-quality chromosome-level genome of C.

An integrated research strategy based on "compound exogenous chemical substances-endogenous metabolites in disease": To explore the scientific basis of Modified Bazhen Yimu Gao in the treatment of primary dysmenorrhea.

Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is a common gynecological disease in women, which affects about 45 %-95 % of women. It exerts significant negative effects on the quality of life, learning and work efficiency of women. Modified Bazhen Yimu Gao (MBYG), a proprietary Chinese medicine preparation, has a medication history of 15 years.

A phosphoprotein gene RT-qPCR assay for detecting all lineages of peste des petits ruminants virus.

Peste des petits ruminants (PPR) is a highly contagious disease caused by peste des petits ruminants virus (PPRV). PPRV is classified into four lineages based on the nucleocapsid (N) or fusion (F) genes. We established a TaqMan quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) assay using a pair of primers and a probe based on the phosphoprotein (P) gene.

Detection of Lineage IV Peste Des Petits Ruminants Virus by RT-qPCR Assay via Targeting the Hemagglutinin Gene.

Peste des petits ruminants virus (PPRV) has been classified into four lineages based on the nucleocapsid and fusion genes, with lineage IV strains being the most widely distributed. In Africa, recent epidemiological data revealed that PPRV lineage IV is increasingly displacing other lineages in prevalence, suggesting a competitive advantage in viral transmission and adaptability. Moreover, a lineage IV strain was the only confirmed strain in Europe and Asia.

Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis.

Purpose: To evaluate the safety, feasibility, and effectiveness of exercise interventions aimed at improving the physical and/or mental health of patients with hematologic malignancies (HM) during chemotherapy.

Methods: We systematically searched nine electronic databases for studies from their inception up to February 2024. The review process strictly adhered to the Cochrane guidelines and followed the PRISMA checklist for reporting systematic reviews.

A new flavonol glycoside isolated from the stems and leaves of .

A new flavonol glycoside, namely astraside D, was isolated and characterised from the stems and leaves of (AMSL). Its structure was determined through comprehensive spectroscopic analysis, including HR-ESI-MS, 1D and 2D NMR. Building on our previous findings that AMSL alleviates memory impairment, we investigated the neuroprotective effect of astraside D on PC12 cells.

Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study.

Introduction: Syndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However, there are few researches about the relation of serum syndecan-1 with corona virus disease 2019 (COVID-19).

Perinatal Women's Perception of Maternal Health Information Quality on Digital Media: Scoping Review.

Background: Perinatal women are increasingly turning to digital media for maternal health information; however, concerns regarding the quality of this information persist. Understanding perinatal women's perceptions of information quality is essential for enhancing the effectiveness of information services.

Objective: This review aims to (1) identify the key features that perinatal women focus on when perceiving the quality of maternal health information on digital media and (2) summarize the quality issues with maternal health information on digital media that perinatal women have reported.

Iron Quantification Using Spectral CT-Based Material Decomposition Technique for Noninvasive Hepatic Fibrosis Staging: An Experimental Study.

Background: Accurate staging is crucial for effective treatment of hepatic fibrosis (HF). This study evaluates whether spectral CT-derived liver iron concentration (LIC) quantification correlates with HF stages and validates its efficacy in diagnostic staging.

Methods: One hundred seventy-five New Zealand white rabbits were included in the prospective study (35 normal controls; 140 HF models).

Activation of Rab7-mediated lipophagy is required for triptolide to induce ferroptosis in hepatic cells.

The aim of this study was to investigate the regulation of triptolide on Rab7-mediated lipophagy to elucidate the potential association between lipophagy and ferroptosis in triptolide-induced hepatotoxicity. Human normal liver HL7702 cells and C57BL/6J mice were treated with triptolide to establish in vitro and in vivo models. The results revealed that triptolide caused a severe hepatic cell damage in vitro and in vivo.

Gui-zhi-fu-ling-wan alleviates bleomycin-induced pulmonary fibrosis through inhibiting epithelial-mesenchymal transition and ferroptosis.

Background: Idiopathic pulmonary fibrosis (IPF) has a higher morbidity and poor prognosis. Gui-Zhi-Fu-Ling-Wan (GFW) is a traditional Chinese herbal formula which exerts anti-inflammatory and anti-oxidative effects. The goal was to determine the protective effect of GFW on bleomycin (BLM)-induced pulmonary fibrosis.

ACM-Assessor: An Artificial Intelligence System for Assessing Angle Closure Mechanisms in Ultrasound Biomicroscopy.

Primary angle-closure glaucoma (PACG), characterized by angle closure (AC) with insidious and irreversible progression, requires precise assessment of AC mechanisms for accurate diagnosis and treatment. This study developed an artificial intelligence system, ACM-Assessor, to evaluate AC mechanisms in ultrasound biomicroscopy (UBM) images. A dataset of 8482 UBM images from 1160 patients was retrospectively collected.

Neuroprotective triterpenoids from Astragalus membranaceus stems and leaves: Anti-inflammatory and anti-apoptotic mechanisms for memory improvement via in vivo and in vitro models.

Astragalus membranaceus is a versatile plant resource that can be used for both medicinal and food purposes. The stems and leaves of A.membranaceus (AMSL), which are by-products generated during the processing of its medicinal roots, are commonly reused as a feed additive for animals.

New steroidal saponins from Physochlainae Radix: Structures and anti-inflammatory efficacy.

Physochlainae Radix (PR), a crucial herbal medicine, has been widely utilized in the treatment of pulmonary disorders, such as asthma and bronchitis. In the present study, nine previously undescribed steroidal saponins, designated as infundilides A-I (1-9), were isolated from PR. These compounds exhibit unique structural features characterized by the presence of unusual hydroxymethyl or carboxyl substituents at the C-20 position.

Preparation, activity, and mechanistic insights of processed Polygala tenuifolia glycoprotein in ameliorating Alzheimer's disease.

This study examined the efficacy and mechanism of Polygala tenuifolia glycoprotein (ZPG) in alleviating Alzheimer's disease (AD) for clinical application. ZPG's effects were tested in scopolamine hydrobromide-induced AD mice using behavioral, histological, and biomarker investigations. Additionally, 16S rDNA sequencing and lipidomics revealed ZPG's impact on gut microbiota and lipid metabolism, supported by pathway enrichment and correlation analyses.

The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High-Resolution Live Cell Microscopy.

Mechanical strain substantially influences tissue shape and function in various contexts from embryonic development to disease progression. Disruptions in these processes can result in congenital abnormalities and short-circuit mechanotransduction pathways. Manipulating strain in live tissues is crucial for understanding its impact on cellular and subcellular activities, unraveling the interplay between mechanics and cells.

Associations of Serum Legumain with Severity and Prognosis Among Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients.

Background: A number of studies have demonstrated that legumain is engaged in the pulmonary diseases. Nevertheless, the role of legumain is indistinct in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The aim is to identify the correlation of serum legumain with AECOPD patients through a prospective cohort study.

Integrated transcriptomics and network pharmacology to reveal the mechanism of Physochlainae Radix in the treatment of asthma.

Background: Physochlainae Radix (PR), a valuable traditional Chinese medicine, has been historically applied for the treatment of bronchitis and asthma in clinic, yet its mechanisms have not been clearly elucidated.

Purpose: This study aims to reveal the underlying mechanisms of PR in treating asthma, employing transcriptomics and network pharmacology approaches.

Methods: To evaluate the therapeutic effects of PR on asthma, we established the asthmatic model in ICR mice by using OVA.

[Pharmacokinetics and anti-inflammatory activity of cannabidiol/ γ-polyglutamic acid-g-cholesterol nanomicelles].

In this study, the pharmacokinetic characteristics and tissue distribution of cannabidiol(CBD)/γ-polyglutamic acid-g-cholesterol(γ-PGA-g-CHOL) nanomicelles [CBD/(γ-PGA-g-CHOL)NMs] were investigated by pharmacokinetic experiments, and the effect of CBD/(γ-PGA-g-CHOL)NMs on the lipopolysaccharide(LPS)-induced inflammatory damage of cells was evaluated by cell experiments. CBD/(γ-PGA-g-CHOL)NMs were prepared by dialysis. The CBD concentrations in the plasma samples of male SD rats treated with CBD and CBD/(γ-PGA-g-CHOL)NMs were investigated, and the pharmacokinetic parameters were calculated and compared.