Development of New Spiro Insecticides against White-Backed Planthoppers with Multitarget Impact.

The invasive white-backed planthopper (WBP) poses a severe threat to global rice crop security, and most populations have developed significant resistance to neonicotinoids. Although these species remain sensitive to mesoionic triflumezopyrim (TFM), both neonicotinoids and TFM are hazardous to pollinating insects. Herein, we disclose a series of new spirocompounds designed via isosteric ring replacement of scaffold hopping.

Design and Synthesis of Indole-Containing Tetrahydrothiazolo[3,2-]pyrimidine Mesoionics against Hemipteran Pests.

Mesoionic insecticides have emerged as promising pest nAChR modulators devoid of cross-resistance with neonicotinoids, demonstrating exceptional efficacy against sap-feeding insects. Nevertheless, the tetrahydrothiazolo[3,2-]pyrimidine structure remains underexplored within this chemotype. Here, we report an indole-based scaffold hopping of tetrahydrothiazolo[3,2-]pyrimidine, which leads to the development of a series of novel mesoionics.

New Mesoionic Pyrido[1,2‑] Pyrimidines Containing Oxime Esters against with Better Safety to Pollinating Insects.

The selectivity of pesticides for harmful insects versus beneficial organisms has long been a critical issue in agriculture. Pyrido-[1,2-] pyrimidine mesoionics have been widely demonstrated to effectively control a diverse range of insect pests. However, many of their analogues have exhibited high toxicity to bees.

Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis.

Purpose: To evaluate the safety, feasibility, and effectiveness of exercise interventions aimed at improving the physical and/or mental health of patients with hematologic malignancies (HM) during chemotherapy.

Methods: We systematically searched nine electronic databases for studies from their inception up to February 2024. The review process strictly adhered to the Cochrane guidelines and followed the PRISMA checklist for reporting systematic reviews.

Impact of Fluxapyroxad and Mefentrifluconazole on Microbial Succession and Metabolic Regulation in Rice Under Field Conditions.

This study systematically evaluated the residual behavior of fluxapyroxad (FXP) and mefentrifluconazole (MFZ) in rice-soil systems, alongside their soil and metabolic impacts. Analytical methods validated via linear regression (0.0001-0.

Celastrol Induces Ferroptosis by Regulating CERKL to Exert Anti-Gastric Cancer Effect.

Gastric cancer is a significant global health issue. Celastrol, a natural compound, has shown antitumor potential, but its molecular mechanism in gastric cancer remains unclear. In this study, we treated HGC-27 cells with celastrol and employed CCK8, colony formation, and Transwell assays, revealing its inhibitory effect on cell proliferation and migration.

Three-dimensional MRI-CT image fusion technique as an innovative strategy for dissolution and removal of facial fillers in specific portions.

Objectives: We explored the potential use of MRI-CT three-dimensional (3D) reconstruction in the extraction of facial fillers.

Methods: In this investigation, pre and postoperative MRI-CT 3D reconstructions were performed on a cohort of 28 patients who underwent filler removal therapy. The efficiency of filler removal in critical facial regions was quantitatively assessed, and patient satisfaction was evaluated using a standardized Likert scale.

A Systematic Profiling of the Components of Kukeya Tablets, a Traditional Ethnic Medicine Prescription, by Ultra-High-Performance Liquid Chromatography-Quadrupole/Orbitrap High-Resolution Mass Spectrometry.

Kukeya tablets (KYs), a traditional ethnic medicine prescription, are widely used to treat migraines and eye ailments in China. Despite their extensive clinical use, current knowledge on their therapeutic material basis is limited to a few major compounds, whereas certain minor ones have rarely been investigated. This study was conducted to screen and characterize the chemical components of KYs.

2,4-Epibrassinolide Regulates Polysaccharide Substance Biosynthesis after Field Application to .

This study investigated the effects of 2,4-epibrassinolide (EBR) residues on quality. The residues decreased from 0.164 to 0.

Triptolide's impact on ACER1 signaling: Inducing autophagy for triple-negative breast cancer suppression.

Given the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (Her-2) in triple-negative breast cancer (TNBC) cells, the efficacy of targeted therapies is limited. In this study, we uncovered that triptolide (TP) effectively suppresses the migration and invasiveness of MDA-MB-231 cells by activating autophagic pathways. Western blotting analysis revealed that TP significantly reduced the expression levels of p62 protein, while simultaneously markedly increasing the expression levels of LC3B-II, BNIP3, BNIP3L, ATG5, and ULK1 proteins, strongly suggesting an enhancement of autophagic activity in the cells.

Measuring the Work Relative Value of Common Nursing Items for the General Departments of Tertiary Hospitals: A Descriptive Study.

Aim(s): This study aims to evaluate the workload of clinical nurses by measuring the work relative value (work RVU) of common nursing items based on the resource-based relative value scale in China.

Background: Various single measurements have been employed to measure the nursing workload, but no comprehensive method has yet to be developed in China.

Methods: A descriptive study was conducted to construct a common item set for nursing work in general wards on the basis of the 2019 History Information System nursing database from Class A tertiary hospitals to identify the time associated with each service.

A systemic study of cyenopyrafen in strawberry cultivation system: Efficacy, residue behavior, and impact on honeybees (Apis mellifera L.).

The pesticide application method is one of the important factors affecting its effectiveness and residues, and the risk of pesticides to non-target organisms. To elucidate the effect of application methods on the efficacy and residue of cyenopyrafen, and the toxic effects on pollinators honeybees in strawberry cultivation, the efficacy and residual behavior of cyenopyrafen were investigated using foliar spray and backward leaf spray in field trials. The results showed that the initial deposition of cyenopyrafen using backward leaf spray on target leaves reached 5.

Residue analysis and dietary risk assessment of picoxystrobin in potato (), citrus fruit ( Blanco), and Kimura et Migo.

Picoxystrobin is a systemic fungicide widely used on potato, citrus fruit, and . To provide information for the risk assessment of potato, citrus, and , field experiments combined with QuEChERS and HPLC-MS/MS were performed to detect picoxystrobin. Picoxystrobin had good linearity ( > 0.

Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells via the DEGS1/S1P signaling pathway.

Celastrol (Cel) shows potent antitumor activity in various experimental models. This study examined the relationship between Cel's antivascular and antitumor effects and sphingolipids. CCK-8 assay, transwell assay, Matrigel, PCR-array/RT-PCR/western blotting/immunohistochemistry assay, ELISA and HE staining were used to detect cell proliferation, migration and invasion, adhesion and angiogenesis, mRNA and protein expression, S1P production and tumor morphology.

Residue analysis and dietary risk assessment of abamectin in fresh corn, bitter melon, and Fritillaria.

To clarify the residue behavior and possible dietary risk of abamectin in fresh corn, bitter melon, and Fritillaria, a method was developed for the simultaneous determination of abamectin residues in fresh corn, bitter melon, and Fritillaria by QuEChERS (quick, easy, cheap, effective, rugged, safe) ultra-performance liquid chromatography-tandem mass spectrometry. The mean recovery of abamectin in fresh corn, bitter melon, and Fritillaria was 86.48%-107.

Residue Analysis and Dietary Risk Assessment of Pymetrozine in Potato ( L.) and (Ramat).

Pymetrozine is used on potato () and () to obtain greater yield and quality. However, pesticide use carries the potential for residues to remain and be detected on harvested crops. Therefore, the aim of this study was to estimate pesticide residues in and products that are commercially available for human consumption and to assess the associated dietary risks.

Trifloxystrobin induced developmental toxicity by disturbing the ABC transporters, carbohydrate and lipid metabolism in adult zebrafish.

The environmental risks of trifloxystrobin (TR) have drawn attention because of its multiplex toxicity on aquatic organisms, but few studies have paid close attention to its chronic toxicity at environmental concentrations. In present study, histopathology, metabolomics and transcriptomics were comprehensively performed to investigate the toxic effects and biological responses on adult zebrafish after exposure to 0.1, 1 and 10 μg/L TR for 21 d.

[Prenatal diagnosis and genetic analysis of three fetuses with duodenal atresia or stenosis].

Objective: To explore the genetic basis for three fetuses with duodenal atresia or stenosis detected by ultrasonography.

Methods: Clinical data of three fetuses identified at the Women's Hospital Affiliated to Zhejiang University School of Medicine between January 2021 and August 2022 were collected. Umbilical cord blood and amniotic fluid samples of the fetuses and peripheral blood samples of their parents were collected and subjected to G-banded chromosomal karyotyping and single nucleotide polymorphism array (SNP array) analysis.

Construction and validation of a risk prediction model for perianal infection in patients with haematological malignancies during chemotherapy: a prospective study in a tertiary hospital in China.

Objectives: Perianal infection is a serious complication in patients undergoing chemotherapy for haematological malignancies. Therefore, we aimed to develop a predictive model to help medical staff promptly screen patients at a high risk of perianal infection during chemotherapy.

Design: This was a single-centre prospective observational study.

Discovery of Novel Isoxazoline Derivatives Containing Diaryl Ether against Fall Armyworms.

With the continuous evolution of insect resistance, it is a tremendous challenge to control the fall armyworm () with traditional insecticides. To solve this pending issue, a series of novel isoxazoline derivatives containing diaryl ether structures were designed and synthesized, and most of the target compounds exhibited excellent insecticidal activity. Based on the three-dimensional quantitative structure-activity relationship (3D-QSAR) model analysis, we further optimized the molecular structure with compound obtained and tested for its activity.

Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides against .

Isoxazoline structures are widely found in natural products and are rich in biological activities. This study discloses the development of a series of novel isoxazoline derivatives by introducing acylthiourea fragments to access insecticidal activity. All synthetic compounds were examined for their insecticidal activity against , with results showing moderate to strong activity.