Interactive dynamic scalp acupuncture enhances brain functional connectivity in bilateral basal ganglia ischemic stroke patients: a randomized controlled trial.

Aim: This randomized controlled trial investigated the effects of interactive dynamic scalp acupuncture (IDSA) on brain functional connectivity density (FCD) in patients with bilateral basal ganglia ischemic stroke (BBGIS), focusing on its potential to enhance motor recovery.

Methods: Seventy BBGIS patients (aged 45-75 years, 1-3 months post-stroke, Brunnstrom stage II-V) and 40 age-and sex-matched healthy controls (HCs) were enrolled. Resting-state functional MRI (rs-fMRI) assessed baseline FCD differences between groups, with regions showing significant alterations correlated to Fugl-Meyer Assessment (FMA) scores selected as seed points.

Carbon Supports Regulated the Performances of Copper Catalysts for H Production through Microwave-Initiated Methanol Steam Reforming.

To tackle the storage challenges for distributed hydrogen applications, the microwave-initiated methanol steam reforming (MSR) process was deployed to increase the flexibility and energy efficiency of the MSR hydrogen production. As the key, a series of carbon-supported CuZn catalysts were systematically investigated to reveal the impacts of dielectric properties, conductivity, and dispersion on the catalytic performance under microwave irradiation. In addition to the excellent dielectric properties and conductivity exhibited by the carbon supports, the efficient dispersion of active species will dominate the catalytic activity, which was evidenced by the fact that the graphite supported CuZnG-40 is less active than the carbon nanotube supported and well dispersed CuZnCNTs-10, even with CuZnG-40 presenting superior conductivity and dielectric properties.

[Analysis of situations prone to insufficient spaces in tooth surface preparation with the fixed-depth groove method].

Objectives: Digitally collect data on the preparation space of the molar occlusal surface for full crown restoration and analyze the minimum preparation spaces and areas prone to insufficient preparation.

Methods: A total of 846 molars (excluding third molars) designated for repair with zirconium dioxide crowns were selected. All molars were prepared by using the fixed-depth groove method under visual guidance.

Celastrol Induces Ferroptosis by Regulating CERKL to Exert Anti-Gastric Cancer Effect.

Gastric cancer is a significant global health issue. Celastrol, a natural compound, has shown antitumor potential, but its molecular mechanism in gastric cancer remains unclear. In this study, we treated HGC-27 cells with celastrol and employed CCK8, colony formation, and Transwell assays, revealing its inhibitory effect on cell proliferation and migration.

Nursing for conical telescopic crown prosthodontics in treating periodontitis accompanied by dentition defects.

Objective: We aimed to investigate the nursing technique and outcomes of conical telescopic crown prosthodontics for patients with periodontitis accompanied by dental defects.

Methods: One hundred patients with chronic periodontitis and dental problems from January 2018 to August 2020 were enrolled. They were randomly assigned to an observation group (n=50) and a control group (n=50).

The tomato SBP-box protein SlCNR negatively regulates genes involved in fruit cutin deposition.

Cutin serves as the foundational structure of the plant cuticle and plays a crucial role in determining fruit development and quality. However, the transcriptional regulation of cutin deposition by fruit-specific transcription factors remains largely unknown. This study delves into the regulatory role of the tomato (Solanum lycopersicum) SBP-box protein Colorless Non-Ripening (SlCNR), primarily expressed in fruits, in cutin formation.

Artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under LPS-induced inflammation.

Objective: The purpose of this study was to investigate the effects and mechanism of artemisinin (ART) on the proliferation, apoptosis, and inflammatory response of human dental pulp stem cells (HDPSCs) under lipopolysaccharide (LPS)-induced inflammation.

Methods: HDPSCs were isolated, cultured, and identified by flow cytometry and three-directional differentiation induction. A suitable concentration of LPS was selected to mimic the inflammatory condition in vitro.

Knowledge, Attitude, and Practice Regarding Digital Dental Technologies Among Dentists in Jiangsu Province.

: The aim of this study was to explore the knowledge, attitude, and practice (KAP) with regard to digital dental technologies among dentists in Jiangsu province. : This web-based cross-sectional study enrolled dentists in Jiangsu province during June, 2023. A web-based questionnaire was used to collect the demographic characteristics of the participants and KAP regarding digital dental technologies.

White Fluorescent Carbon Dots for Specific Fe Detection and Imaging Applications.

In recent years, carbon dots (CDs) with fluorescence imaging function have been widely used in biomedicine, electronic manufacturing and environmental monitoring. However, monochromatic fluorescence is often limited by the application environment and loses its effectiveness. Here, we carefully designed white fluorescent CDs (WF-CDs) by solvothermal method, which is used for fluorescence imaging applications under different environmental conditions.

Carbon-supported Fe single atom nanozymes with long-lasting ROS generation and high NIR photothermal performance for synergistic cancer therapy.

Synergistic therapy combining photothermal therapy (PTT) and chemodynamic therapy (CDT) has proven to be a highly effective strategy for cancer treatment. However, PTT heavily relies on the accumulation of therapeutic agents at the tumor site. The peroxidase (POD) activity of common catalysts can be rapidly exhausted during the accumulation process, prior to laser intervention, thereby diminishing the synergistic enhancement effect of the combined therapy.

NIR-II Responsive Fe-Doped Carbon Nanoparticles for Photothermal-Enhanced Chemodynamic Synergistic Oncotherapy.

Phototherapy has demonstrated substantial development because in the second near-infrared (NIR-II) window it has a larger tissue penetration and fewer adverse consequences. In this work, a particular kind of NIR-II responsive Fe-doped carbon nanoparticles (FDCNs) is synthesized using a one-pot hydrothermal method for combined photothermal and chemodynamic therapy. The mesoporous nanostructure of FDCN, which has a size distribution that exceeds 225 nm, allows for effective acidification.

Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells via the DEGS1/S1P signaling pathway.

Celastrol (Cel) shows potent antitumor activity in various experimental models. This study examined the relationship between Cel's antivascular and antitumor effects and sphingolipids. CCK-8 assay, transwell assay, Matrigel, PCR-array/RT-PCR/western blotting/immunohistochemistry assay, ELISA and HE staining were used to detect cell proliferation, migration and invasion, adhesion and angiogenesis, mRNA and protein expression, S1P production and tumor morphology.

The cross-linking and protective effect of artemisinin and its derivatives on collagen fibers of demineralized dentin surface.

Objective: To investigate the cross-linking and protective effect of artemisinin (ART), dihydroartemisinin (DHA), and artesunate (AST) on collagen fibers of demineralized dentin surface.

Methods: Molecular docking was used to predict potential interactions of ART, DHA, and AST with dentin type I collagen. Human third molars without caries were completely demineralized and treated with different solutions for 1 min.

Huoxue Tongluo decoction combined with acupuncture in the treatment of lumbar disc herniation and its effect on JOA and VAS scores.

Background: Lumbar disc herniation (LDH) is a common clinical disease of the skeletal system, and its prevalence has been on a rise.

Objective: To evaluate the efficacy of Huoxue Tongluo decoction plus acupuncture in the treatment of lumbar disc herniation and its effectiveness in improving the functional recovery of the patients' affected joints and mitigating their pain.

Methods: In this prospective study, 110 patients with lumbar disc herniation enrolled in our Hospital from June 2019 to June 2021 were collected and randomized to receive either conventional treatment (control group) or Huoxue Tongluo Decoction plus acupuncture (study group).

Scoring consistency of standard patients and examiners in the developed dental objective structured clinical examination system.

Objective: To investigate the role of standard patients (SPs) and examiners as assessors for scoring in the dental objective structured clinical examination (OSCE) system and to evaluate the scoring differences between them.

Methods: We developed the doctor-patient communication and clinical examination station in the OSCE system. The examination time of this station was 10 min, and the examination institution wrote the script and recruited SPs.

Antibacterial one-step self-etching dental adhesive with silver nanoparticles synthesized in situ.

Objectives: The objective of this study is to value the long-term antibacterial capability and adhesive properties of one-step self-etching dental adhesive containing silver nanoparticles (AgNPs) synthesized in situ.

Methods: One-step self-etching adhesives with various weight percentages of silver 2-ethylhezanoate (0%, 0.05%, 0.

In situ immobilization of silver nanocrystals in carbon nanoparticles for intracellular fluorescence imaging and hydroxyl radicals detection.

Silver nanoparticles (Ag NPs) have attracted extensive research interest in bioimaging and biosensing due to their unique surface plasmon resonance. However, the potential aggregation and security anxiety of Ag NPs hinder their further application in biomedical field due to their high surface energy and the possible ionization. Here, binary heterogeneous nanocomplexes constructed from silver nanoparticles and carbon nanomaterials (termed as C-Ag NPs) were reported.

Simultaneous Determination of Amphenicols and Metabolites in Animal-Derived Foods Using Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry.

Amphenicols are widely used to prevent and treat animal diseases. However, amphenicol residues accumulate in livestock and poultry and harm consumers. We hypothesized that one can combine solid-phase extraction (SPE) with ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to simultaneously determine amphenicols and metabolites in pork, beef, lamb, chicken, and their products and meet government regulations for maximum residue limits.

Moxibustion for primary dysmenorrhea: A protocol for evidence-based clinical practice guideline.

Background: Primary dysmenorrhea (PD) is a common gynecological disease characterized by lower abdominal pain. Moxibustion as a traditional Chinese treatment, can effectively treat PD with few adverse reactions. Nowadays, there is still no standard guideline for moxibustion treatment of PD, so related clinical practice guidelines need to be developed.

Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window.

Graphene quantum dots (GQDs) are considered emerging nanomaterials for photothermal therapy (PTT) of cancer due to their good biocompatibility and rapid excretion. However, the optical absorbance of GQDs in shorter wavelengths (<1000 nm) limits their overall therapeutic efficacies as photothermal agent in the second near infrared window (1000-1700 nm, NIR-II). Herein, we report a type of GQDs with strong absorption (1070 nm) in NIR-II region that was synthesized via a one-step solvothermal treatment using phenol as single precursor by tuning the decomposition of hydrogen peroxide under a high magnetic field with an intensity of 9T.

Synthesis and biomedical applications of graphitic carbon nitride quantum dots.

Graphitic carbon nitride quantum dots (g-CNQDs) have attracted much attention for biomedical applications by virtue of their good biocompatibility, stable fluorescence, high quantum yield, and nontoxicity. On the basis of understanding the intrinsic properties and structural features in the intriguing system, enormous efforts have been devoted to optimizing synthetic methods and structures of g-CNQDs. A vast number of studies have also been pursued to discuss the potential applications of g-CNQDs in biomedical areas for biosensing, bioimaging, drug delivery and theranostics.

[Influence of the dentin smear layer trait on the bond strength of the self-adhesive resin cements].

Objective: This work aimed to evaluate the influence of smear layer on the bonding effectiveness and durability of the self-adhesive resin cements to dentin.

Methods: A total of 48 fresh caries-free third molars with exposed dentin surface were divided into two groups. The dentin surfaces were treated using a standard grit diamond bur (group A) or further polished using a fine grit diamond bur (group B) and then bonded with either of the two self-adhesive resin cements, namely, Clearfil SA Cement (CSA, Kuraray) and Multilink Speed (MS, Ivoclar Vivadent).

NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy.

Herein, we present a light-switchable drug delivery system based on chitosan-gated carbon-based nanocarriers (CGC NCs) that exhibit a loading capacity for doxorubicin as high as ∼89.65 wt% and controlled on/off release with/without NIR irradiation. In vitro and in vivo results show that the CGC NCs manifest high efficacy for cancer therapy through a synergistic effect of combined chemo-photothermal treatment.

Application of OSCE for Stage Assessment in Standardized Training for Oral Residents.

The aim of this study was to establish and implement an objective structured clinical examination (OSCE) for stage assessment in standardized training for oral residents, evaluating its validity and suitability. An OSCE was established for stage assessment of 158 residents in a program in Jiangsu Province, China. Its validity and suitability were evaluated using indices such as reliability and discrimination coefficients of assessment results.