Artificial Electric Synapse of CuI-Based Memristor for Neuromorphic Emotion Recognition and Neural Networks.

Emotion classification is pivotal for advancing human-computer interaction, where it necessitates efficiently decoding complex dynamic signals. Traditional approaches, however, struggle to capture the temporal dependencies and nonlinear patterns intrinsic to emotional expressions. Herein, a novel CuI-based synaptic memristor is proposed, featuring reliable analog resistive switching and diverse biosynaptic plasticity, including EPSC, PPF, STM/LTM, LTP/LTD, and SRDP.

CdS/CZTSSe heterojunction synaptic memristor: Enabling efficient handwritten digit recognition.

Owing to the outstanding performance of memristors in brain-like parallel computing and data processing, especially in the efficient recognition of handwritten digits and complex patterns, they are regarded as key components for next-generation artificial intelligence systems. This study developed a memristor based on the P-N heterostructure CdS/Cu2ZnSn(S,Se)4 (CdS/CZTSSe). The results indicate that the Ag/CdS/CZTSSe/Mo memristor exhibits stable non-volatile bipolar resistive switching.

TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms.

TRIM21 is a highly efficient and versatile E3 ubiquitin ligase that plays a crucial role in targeted protein degradation through its specific binding capabilities. To investigate its role in chemically mediated degradation, we utilized two high-affinity binders identified from a DNA-encoded compound library (DEL) to design and synthesize several TrimTACs (TRIM21-based degraders) targeting BRD4. Degradation assays revealed that TrimTACs incorporating distinct TRIM21-binding moieties produced markedly different levels of BRD4 degradation.

Biosafety of hyperbranched polylysine and its regulatory effect on non-alcoholic fatty liver and gut microbiota.

Hyperbranched polylysine (HBPL) has shown broad-spectrum antibacterial activity and cell adhesion promoting effect, which are inherited mainly from its ε- and α-structures, respectively. Although the effectiveness of HBPL in wound anti-infection, tissue regeneration and surface modification has been thoroughly demonstrated, its systematic biosafety evaluation and influence on bacterial cohorts in the gut remain unknown. In this study, the biosafety of HBPL was systematically analyzed via endotoxin detection, cytotoxicity test, and acute systemic toxicity test (oral and intravenous injection).

An auxiliary role of deep neural network ophthalmic disease identification models in choosing medication treatment strategy.

To evaluated a Deep Neural Network (DNN)-based ophthalmic disease diagnosis framework in facilitating personalized medication treatment plans using a prospective, single-center, randomized controlled clinical trial design. 500 patients were randomly assigned to either a DNN-aided experimental group or a control group receiving standard physician-based treatment plans. The primary outcomes were medication selection accuracy, clinical efficacy (assessed by BCVA and CMT), patient compliance, and adverse reaction management.

Acute appendicitis in children: Two microbial states associated with clinical indicators and severity.

Background: Acute appendicitis (AA) is one of the most common abdominal emergencies worldwide. It is associated with dysbiosis and is usually classified clinically as either simple appendicitis (SA) or complicated appendicitis (CA) . The etiology and pathogenesis of AA remain incompletely understood.

Artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under LPS-induced inflammation.

Objective: The purpose of this study was to investigate the effects and mechanism of artemisinin (ART) on the proliferation, apoptosis, and inflammatory response of human dental pulp stem cells (HDPSCs) under lipopolysaccharide (LPS)-induced inflammation.

Methods: HDPSCs were isolated, cultured, and identified by flow cytometry and three-directional differentiation induction. A suitable concentration of LPS was selected to mimic the inflammatory condition in vitro.

Crystal Structural Editing: Novel Biaxial MgTeO Crystal as Zero-Order Waveplates.

Waveplates are important optical components to control the polarization of light. Currently, they are often fabricated from uniaxial crystals, and there is no report about waveplates based on the biaxial crystals. In this work, a novel biaxial crystal MgTeO with a structure constructed by 0D TeO groups is designed and grown as waveplate materials for the first time.

Multifunctional Artificial Electric Synapse of MoSe-Based Memristor toward Neuromorphic Application.

Research on memristive devices to seamlessly integrate and replicate the dynamic behaviors of biological synapses will illuminate the mechanisms underlying parallel processing and information storage in the human brain, thereby affording novel insights for the advancement of artificial intelligence. Here, an artificial electric synapse is demonstrated on a one-step Mo-selenized MoSe memristor, having not only long-term stable resistive switching characteristics (reset 0.51 ± 0.

Exploring the promoting effect of lanthanum passivation on the photovoltaic performance of CZTSSe solar cells.

The significant open-circuit voltage (VOC) deficit poses a major obstacle to enhancing the efficiency of Cu2ZnSn(S,Se)4 (CZTSSe) solar cells. Interface passivation emerges as a potent strategy to regulate carrier transport and boost performance. Here, we innovatively introduced rare-earth lanthanum (La) to passivate the absorber interface by directly treating the absorption layer surface with an aqueous La3+ ion solution.

Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs.

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) has emerged as a promising therapeutic target for cancer treatment. However, the current PIN1 inhibitors have shown limited efficacy in animal models, leaving the question of whether PIN1 is a proper oncologic target still unanswered. By screening a 1 trillion DNA-encoded library (DEL), we identified novel nonacidic compounds.

Multicolor Fully Light-Modulated Artificial Synapse Based on P-MoSe/PO Heterostructured Memristor.

Developing brain-inspired neuromorphic paradigms is imperative to breaking through the von Neumann bottleneck. The emulation of synaptic functionality has motivated the exploration of optoelectronic memristive devices as high-performance artificial synapses, yet the realization of such a modulatory terminal capable of full light-modulation, especially near-infrared stimuli, remains a challenge. Here, a fully light-modulated synaptic memristor is reported on a P-MoSe/PO heterostructure formed by a facile one-step selenization process.

Electrical-Light Coordinately Modulated Synaptic Memristor Based on TiC MXene for Near-Infrared Artificial Vision Applications.

Emerging optoelectronic memristive devices with high parallelism and low-power consumption have made neuromorphic computing hardware a tangible reality. The coordination of conductivity regulation through both electrical and light signals is pivotal for advancing the development of synaptic memristors with brainlike functionalities. Here, an artificial visual synapse is presented with the TiC MXene memristor which demonstrates not only the nonvolatile memory effect (Set/Reset: 0.

Superstrong, sustainable, origami wood paper enabled by dual-phase nanostructure regulation in cell walls.

Constructing a crystalline-amorphous hybrid structure is an effective strategy to overcome the conflict between the strength and toughness of materials. However, achieving such a material structure often involves complex, energy-intensive processing. Here, we leverage the natural wood featuring coexisting crystalline and amorphous regions to achieve superstrong and ultratough wood paper (W-paper) via a dual-phase nanostructure regulation strategy.

Wood Ion Pumps Enabled by Light-Responsive MoS-Decorated Nanocellulosic Channels.

Light-driven active ion transport discovered in nanomaterials (e.g., graphene, metal-organic framework, and MXene) implicates crucial applications in membrane-based technology and energy conversion systems.

Neural mechanisms for secondary suppression of emotional distractors: Evidence from concurrent electroencephalography-magnetoencephalography data.

Distractor suppression allows us to remain on-task in the presence of distractions by filtering task-irrelevant information from ongoing cognitive processing and responding. Electrophysiological studies have revealed that this key feature of selective attention is a dynamic process that involves at least two distinct stages of processing. Two important aspects of these processing stages remain unclear: Whether the processing of emotional distractors at an earlier stage is automatic, as reflected in the N2/early posterior negativity (EPN) component; and what functional-anatomical brain systems are recruited in each stage.

DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy.

Objective: DNA damage-inducible transcript 3 (DDIT3), as a downstream transcription factor of endoplasmic reticulum stress, is reported to regulate chondrogenic differentiation under physiological and pathological state. However, the specific involvement of DDIT3 in the degradation of condylar cartilage of temporomandibular joint osteoarthritis (TMJOA) is unclarified.

Design: The expression patterns of DDIT3 in condylar cartilage from monosodium iodoacetate-induced TMJOA mice were examined to uncover the potential role of DDIT3 in TMJOA.

Promoting effect of lanthanum doping on photovoltaic performance of CZTSSe solar cells.

A large open-circuit voltage (VOC) deficit is the major challenge hindering the efficiency improvement of Cu2ZnSn(S,Se)4 (CZTSSe) solar cells. Cation substitution, or doping, is usually an effective strategy to achieve carrier regulation and improve efficiency. In this work, we developed a rare-earth element lanthanum (La) doped CZTSSe thin-film solar cell by directly introducing La3+ ions into the CZTS precursor solution.

Versatile Cu2ZnSnS4-based synaptic memristor for multi-field-regulated neuromorphic applications.

Integrating both electrical and light-modulated multi-type neuromorphic functions in a single synaptic memristive device holds the most potential for realizing next-generation neuromorphic systems, but is still challenging yet achievable. Herein, a simple bi-terminal optoelectronic synaptic memristor is newly proposed based on kesterite Cu2ZnSnS4, exhibiting stable nonvolatile resistive switching with excellent spatial uniformity and unique optoelectronic synaptic behaviors. The device demonstrates not only low switching voltage (-0.

MoO Synaptic Memristor with Programmable Multilevel Conductance for Reliable Neuromorphic Hardware.

Memristor holds great potential for enabling next-generation neuromorphic computing hardware. Controlling the interfacial characteristics of the device is critical for seamlessly integrating and replicating the synaptic dynamic behaviors; however, it is commonly overlooked. Herein, we report the straightforward oxidation of a Mo electrode in air to design MoO memristors that exhibit nonvolatile ultrafast switching (0.

Attention affects the perception of self-motion direction from optic flow.

Many studies have demonstrated that attention affects the perception of many visual features. However, previous studies show conflicting results regarding the effect of attention on the perception of self-motion direction (i.e.

Alum/CpG adjuvant promotes immunogenicity of inactivated SARS-CoV-2 Omicron vaccine through enhanced humoral and cellular immunity.

The SARS-CoV-2 Omicron variant, which was classified as a variant of concern (VOC) by the World Health Organization on 26 November 2021, has attracted worldwide attention for its high transmissibility and immune evasion ability. The existing COVID-19 vaccine has been shown to be less effective in preventing Omicron variant infection and symptomatic infection, which brings new challenges to vaccine development and application. Here, we evaluated the immunogenicity and safety of an Omicron variant COVID-19 inactivated vaccine containing aluminum and CpG adjuvants in a variety of animal models.

Enhancing Inactivated Yellow Fever 17D Vaccine-Induced Immune Responses in Balb/C Mice Using Alum/CpG.

There are some concerns about the safety of live attenuated yellow fever vaccines (YF-live), particularly viscerotropic adverse events, which have a high mortality rate. The cellular production of the vaccine will not cause these adverse effects and has the potential to extend applicability to those who have allergic reactions, immunosuppression, and age. In this study, inactivated yellow fever (YF) was prepared and adsorbed with Alum/CpG.

The cross-linking and protective effect of artemisinin and its derivatives on collagen fibers of demineralized dentin surface.

Objective: To investigate the cross-linking and protective effect of artemisinin (ART), dihydroartemisinin (DHA), and artesunate (AST) on collagen fibers of demineralized dentin surface.

Methods: Molecular docking was used to predict potential interactions of ART, DHA, and AST with dentin type I collagen. Human third molars without caries were completely demineralized and treated with different solutions for 1 min.