A prospective case-control study: Analysis of the analgesic effect of acetaminophen-mannitol injection after endoscopic lumbar discectomy.

ObjectiveTo investigate the analgesic effects of acetaminophen-mannitol injections after endoscopic lumbar discectomy.MethodsThis is a prospective case-control study involving 60 patients who were randomly selected from those who underwent endoscopic lumbar discectomy for lumbar disc herniation or lumbar spinal stenosis at Sanshui District People's Hospital of Foshan between April and September 2024. Two groups were formed by randomly assigning patients, with each group containing 30 individuals.

[Effects of Focused Solution Model Nursing on quality of life and negative emotions of prostate cancer patients].

Objective: To analyze the effects of the Focused Solution Model Nursing intervention on quality of life, negative emotions of the patients with prostate cancer. Methods： A total of 82 prostate cancer patients who were diagnosed and treated at the General Hospital of Eastern Theater Command between September 2022 and September 2024 were included and randomly divided into study group and control group by the method of random number table, with 41 patients in each group. The patients in the study group were treated with Focused Solution Model Nursing intervention.

Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Preservation of ALYREF Phase Separation Mitigates Doxorubicin-Induced Cardiomyocyte DNA Damage and Cardiotoxicity.

The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. ALYREF, a nuclear protein that preserves genomic stability through interactions with intranuclear components or as an m⁵C-binding regulator of mRNA maturation and export, has not been previously implicated in DOX-induced cardiotoxicity (DIC). Here, the role and underlying mechanisms of ALYREF in the pathogenesis of DIC are investigated.

Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans.

Here, we define cognitive resilience as slower or faster cognitive decline after we regress out the effects of common brain neuropathologies. Its understanding could provide important insights into the biology underlying cognitive health, enabling the development of more effective strategies to prevent cognitive decline and dementia. However, this requires the development of a practical method to quantify resilience and measure it in living individuals, as well as identifying heterogenous pathways associated with resilience in different individuals.

Spatial yield gains in empty-row optimized rice-crab co-culture are linked to -driven nitrogen compensation in border rows.

Introduction: The rice-crab coculture system is ecologically sustainable with efficient resource utilization, but the soil nitrogen cycling mechanisms underlying yield limitations in different coculture models remain unclear. Here, we aimed to identify yield-limiting factors by comparing rice productivity between the conventional rice-crab coculture model (CK) and an optimized model (12 rows cultivated-1 row empty, ERC-12). We hypothesized that ERC-12 enhances crab activity in empty rows, thereby stimulating nifH-mediated soil nitrogen fixation to offset yield losses caused by reduced planting density.

Nanofibrous dressings incorporating a synergistic antibacterial-anti-inflammatory effect for infected wound healing.

Bacterial infections and chronic inflammation disrupt wound immune homeostasis and impair healing progression. Herein, we report a novel nanofibrous dressings that exhibits a synergistic antibacterial-anti-inflammatory effect through the integration of the physical barrier properties of electrospun nanofibers, the antimicrobial activity of biomacromolecule polylysine (PLys), and the anti-inflammatory and antioxidant effects of natural macromolecule tannic acid (TA). Using poly(L-lactide-co-ε-caprolactone) (PLCL) as the base biomaterial, sequential surface modification with TA and PLys enhanced wettability and introduced a positive surface charge, yielding a dressing with exceptional cytocompatibility and potent antimicrobial activity against Staphylococcus aureus.

Screening of SGLT2 inhibitors based on virtual screening and cellular experiments.

This study aims at find hit compounds as SGLT2 inhibitors through the methods of virtual screening, biological experiment, Structural similarity search and molecular docking. Computer-aided drug design techniques were used to build modelling of quantitative construct validity relationships. Three-dimensional pharmacophore model and the principle of drug properties were used to screen the compounds.

Postponed childbearing: a cross-sectional study of differences between subjective and objective factors.

Background: To investigate the factors influencing postponed childbearing in women, focusing on the differences between subjective and objective factors.

Methods: This study included 1,128 women who were recruited from three hospitals between January and December 2023. Participants with a prior history of mental health disorders or those who chose not to participate were excluded from the study.

Clinicopathological Features and Pathogenesis of Thymoma Complicated with Alopecia Areata: A Multicenter, Matched Case Analysis.

Background: Thymoma is a malignant tumor originating from the thymic epithelium and can be associated with over 100 paraneoplastic syndromes (PNSs). Due to the low incidence of thymoma and the relative rarity of alopecia areata (AA) as an associated autoimmune disease, patients with thymoma combined with AA are relatively uncommon in clinical practice. As a result, the clinicopathological features and pathogenesis of such patients have been rarely investigated.

Development of triazole-based positron emission tomography ligands targeting glutaminyl cyclases (QCs) in the brain.

Glutaminyl cyclases (QCs), including secreted sQC and Golgi-resident gQC, catalyze pyroglutamate formation and play a crucial role in Alzheimer's disease (AD). Here, we present the development of two triazole-cored QC-targeting PET ligands, [F]SEN177 ([F]8) and [F]QP5020 ([F]9). Compound 9 displayed superior binding potency toward both sQC and gQC with IC values of 30.

Recent advances in small molecules targeting the METTL3.

-methyladenosine (mA) is the most prevalent internal modification of eukaryotic mRNA, playing a crucial role in the regulation of gene expression. Methyltransferase-like 3 (METTL3), a key catalytic component of the mA methyltransferase complex, is primarily responsible for the deposition of mA on target RNA. Recent studies have revealed that METTL3 contributes to diverse pathological processes, particularly tumorigenesis, through both mA-dependent and independent mechanisms.

Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults: An Autopsy Study.

Background And Objectives: Cerebral amyloid angiopathy (CAA) is the accumulation of β-amyloid (Aβ) in the walls of small vessels in the leptomeninges and cortex and is a risk factor of intracerebral hemorrhage and dementia, but its underlying mechanism is unknown. We examined cortical proteins in relation to CAA to elucidate the molecular mechanisms underlying CAA.

Methods: Data were collected from participants of 5 community-based cohorts of older adults.

Correlation of serum uric acid with cancer: a systematic evaluation and dose-response meta-analysis of 43 cohort studies.

Objective: The association between serum uric acid (SUA) and cancer incidence and mortality remains controversial. In addition, increasing attention has been paid to its potential role in cancer prognosis. Therefore, this study aimed to investigate the correlation between SUA and cancer incidence, mortality, and prognosis through a meta-analysis.

Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.

Ethnopharmacological Relevance: Dachengqi Decoction (DCQD), a traditional formula from Treatise on Exogenous Febrile Disease, purges heat and preserves Yin. Previous studies indicate its efficacy against sepsis-associated liver injury (SALI), but its active components and mechanism remain unclear.

Aim Of The Study: To elucidate the effective components and mechanism of DCQD on SALI through network pharmacology and experimental validation.

Design and optimization of high-precision integrated experimental environments for large scientific facilities.

This study focuses on designing a high-precision laboratory for the Shenzhen superconducting soft x-ray free electron laser, addressing the stringent control requirements for temperature, humidity, and airflow that exceed conventional design methods. Using computational fluid dynamics simulation, we optimize airflow and temperature distribution to meet standards of 23 ± 0.1 °C, 37.

Association between prior hospitalization and nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) in community-dwelling U.S. adults: Evidence from NHANES.

While institution-based studies have established an association between prior hospitalization and methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage, this relationship remains unevaluated in community-dwelling adults explicitly excluded from institutionalized populations. The objective of this study was to investigate the potential relationship between prior hospitalization and MRSA nasal carriage in adults residing in non-institutionalized community settings. This cross-sectional analysis included 9512 community-dwelling U.

Mixed Pathologies and Cognitive Outcomes in Persons Considered for Anti-Amyloid Treatment Eligibility Assessment: A Community-Based Study.

Background And Objectives: Despite the capability of anti-amyloid monoclonal antibodies to lower β-amyloid (Aβ) brain levels, there is thus far limited clinical efficacy on cognitive outcomes. Among individuals with mild cognitive impairment (MCI) or mild-stage dementia, the cognitive impact of other brain pathologies may limit efficacy of anti-amyloid drugs. This study examined the burden and cognitive associations of mixed brain pathologies among autopsied persons who would have been considered as patients to undergo anti-amyloid treatment eligibility assessment.

A surgical strategy-based nomogram for primary pulmonary mucoepidermoid carcinoma.

Background: Primary pulmonary mucoepidermoid carcinoma (PMEC) is a rare malignancy with no standardized prognostic tools. This study aimed to investigate whether specific surgical approaches significantly impact survival outcomes and to develop an accurate predictive nomogram incorporating surgical variables.

Methods: Using the SEER database (2004-2020), we identified 225 PMEC patients.

Dujieqing decoction suppresses multiple myeloma growth by inhibiting the Wnt/β-catenin pathway.

Objective: To explore the therapeutic potential of the Dujieqing (DJQ) decoction for multiple myeloma (MM) and elucidate its mechanism of action.

Methods: RPMI8226 cells were treated with DJQ-containing serum (DJQ-CS) and a Wnt/β-catenin pathway inhibitor, XAV-939. Cell counting kit-8 assay was used to examine cell viability, and flow cytometry was performed to examine apoptosis.

Influence mechanisms of particle concentration and oil content on the formation and stability of rice bran protein-based Pickering emulsion.

This study is dedicated to fabricating rice bran protein particles (RBPPs) through a thermal-acid modification strategy and exploring their potential as Pickering emulsifiers. The results confirmed that compared with rice bran protein (RBP), RBPPs exhibited enhanced hydrophobicity, reduced interfacial tension, and favorable wettability (83.4 ± 5.

Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study.

Calcific aortic valve stenosis (CAVS) is steadily rising worldwide with no effective pharmacological agents available. Observational studies implicated dyslipidaemia as a risk factor for CAVS. Whether dyslipidaemia is causative for CAVS and the therapeutic potential of different lipid-modifying drug targets for CAVS treatment remains unclear.

Light-stimulated smart thermo-responsive constructs for enhanced wound healing: A streamlined command approach.

Efficient reconstruction of severe cutaneous wounds necessitates the orchestration of effective cell-mediated matrix remodeling and robust protection against microbial invasion. Herein, we engineered a near-infrared light (NIR)-stimulated, thermo-responsive bilayer system based on a drug-loaded hydrogel with a thermal-responsive temperature of ∼42 °C as the matrix layer and an antibacterial nanofibrous mat as the top layer. The matrix layer integrates basic fibroblast growth factor (bFGF)-loaded thermosensitive gelatin (Gel) hydrogel with polydopamine-Cu coated short nanofibers (P@SF).