Publications by authors named "Lang Cai"

This study is dedicated to fabricating rice bran protein particles (RBPPs) through a thermal-acid modification strategy and exploring their potential as Pickering emulsifiers. The results confirmed that compared with rice bran protein (RBP), RBPPs exhibited enhanced hydrophobicity, reduced interfacial tension, and favorable wettability (83.4 ± 5.

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With the increasing demand for healthy diets, low-fat foods have gradually become a hot issue. This study successfully prepared low-internal-phase and high-viscoelastic emulsion gels using the synergistic effect between buckwheat protein microgel (BPM) and carboxylated cellulose nanofibers (CNF). The effects of the ratio of BPM to CNF on the microstructure, stability, rheological properties, and 3D printing characteristics of the emulsion gels were investigated.

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Loss functions widely employed in medical image segmentation, e.g., Dice or Generalized Dice, treat each pixel of segmentation target(s) equally.

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Gap junction intercellular communication (GJIC) is essential for regulating the development of the organism and sustaining the internal environmental homeostasis of multi-cellular tissue. Fibroblast growth factor 8 (FGF8), an indispensable regulator of the skeletal system, is implicated in regulating chondrocyte growth, differentiation, and disease occurrence. However, the influence of FGF8 on GJIC in chondrocytes is not yet known.

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SDF-1α, the most common isoform of stromal cell-derived factor 1, has shown vital effects in regulating chondrocyte proliferation, maturation, and chondrogenesis. Autophagy is a highly conserved biological process to help chondrocytes survive in harsh environments. However, the effect of SDF-1α on chondrocyte autophagy is still unknown.

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is a neglected roundworm, which can cause debilitating disease in dogs and humans worldwide. Serum is an excellent material for monitoring the occurrence of many diseases. However, no information is available on the expression of microRNAs (miRNAs) in the serum of dogs infected with .

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Article Synopsis
  • - Toxocariasis is a neglected parasitic infection, primarily caused by a type of roundworm, affecting dogs, particularly Beagles, and its impact on lung lipid metabolism is not well understood.
  • - Researchers conducted a non-targeted lipidomic analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) on the lungs of Beagle dogs infected with the roundworm, identifying 1197 lipid species, with distinct changes observed at various time points post-infection.
  • - The study revealed specific lipid signatures associated with lung toxocariasis, providing insights into how these lipid alterations may relate to the disease's pathogenesis, enhancing our understanding of the interactions between the parasite and the dog's lungs.
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Gap junctional intercellular communication (GJIC) is indispensable for the maintenance of physiological balance in articular cartilage. Transforming growth factor-β3 (TGF-β3), an important growth factor of TGF-β superfamily, is well recognized to play a unique regulatory role in cartilage development and diseases. However, the role of TGF-β3 in GJIC in adult chondrocytes remains elusive.

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  • A previously overlooked zoonotic helminth causes significant health issues in both animals and humans, with the spleen's role in infection needing further investigation, particularly concerning microRNAs (miRNAs).
  • Researchers analyzed the spleen RNA from 18 Beagle puppies at different stages post-infection, identifying 20, 34, and 19 differentially expressed miRNAs (DEmiRNAs) at 24 hours, 96 hours, and 36 days post-infection, respectively.
  • The identified DEmiRNAs may be crucial in the immune response against the infection by regulating genes linked to inflammation and immune function, suggesting important changes in spleen miRNAs that could influence the disease's development (toxocariasis).
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  • - A lipidomic analysis was conducted on the liver of beagle dogs infected with a parasite, using advanced liquid chromatography-tandem mass spectrometry to assess lipid profiles at three different time points: 12 hours, 24 hours, and 36 days post-infection.
  • - The study identified six categories and 42 subclasses of lipids, noting significant changes in the abundance of hundreds of lipid species throughout the infection period, highlighting key lysophospholipids that may aid in parasite migration and development during early infection stages.
  • - Pathway analysis indicated major shifts in immune-inflammatory responses, with significant alterations in pathways related to B-cell receptor signaling and NF-kappa B, showcasing the importance of lipidomic profiling in understanding
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Article Synopsis
  • * Researchers analyzed RNA expression in the spleens of Beagle puppies at three different infection time points (24 hours, 96 hours, and 36 days post-infection) and found significant changes in long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs).
  • * The study identified numerous differentially expressed genes associated with immune responses, indicating that the changes in lncRNA and mRNA expression may relate to the disease's development and pathophysiology.
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Article Synopsis
  • Toxocara is a roundworm that can infect both humans and animals, leading to a condition known as toxocariasis, but the immune response in its definitive hosts is still not fully understood.
  • Researchers analyzed how infection affects the immune cells of Beagle dogs during the lung infection phase by using RNA sequencing technology, identifying over 2,100 differentially expressed genes.
  • The study found that several of these genes are involved in key immune signaling pathways, suggesting that the infection may weaken the immune function of the dogs' cells, which could help clarify how the parasite interacts with host immune responses.
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Objective: To explore the role of nasal mucosal lymphatic drainage in the pathogenesis of nasal polyps.

Methods: There were 25 cases in the experimental group who had nasal polyps (which was further divided into Malm-1, Malm-2, Malm-3 level 3 subgroups) and 6 cases in the control group, including thyroid cancer and laryngeal cancer patients who had normal nasal structure. The nasal polyps in the experimental group and the middle turbinate in the control group were injected with a radionuclide and a radionuclide imaging technique was used to image the nasal mucosal lymphatics.

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