Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Current status and influencing factors of blue carbon in seagrass beds: An extensive survey and comprehensive analysis in the Yellow and Bohai Seas, China.

Seagrass beds constitute a unique blue carbon ecosystem that mitigates climate change by capturing and sequestering CO over extended periods. Despite being recognized as potent carbon sinks, there is still limited information on the quantification, regional variability, and drivers influencing their blue carbon stocks. In this study, we established 108 sampling sites to estimate organic carbon (C), sediment accumulation rates (SARs), and carbon accumulation rates (CARs) across 13 seagrass beds located in the Yellow and Bohai Seas of China.

Escaping the Drug-Bias Trap: Using Debiasing Design to Improve Interpretability and Generalization of Drug-Target Interaction Prediction.

Considering the high cost associated with determining reaction affinities through in vitro experiments, virtual screening of potential drugs bound to specific protein pockets from vast compounds is critical in AI-assisted drug discovery. Deep-learning approaches have been proposed for predicting Drug-Target Interactions (DTIs). However, they have shown an overestimated accuracy due to the drug-bias trap, a challenge where traditional multimodal models overly rely on the drug branch while underutilizing protein information.

Isotopic evidence for spatial heterogeneity in trophic levels within benthic food webs across typical habitats along the coast of the eastern Laizhou Bay, China.

This study employed stable isotope analysis (δC and δN) to examine the trophic sources, nutritional levels of consumers, and ecological niches of macrobenthic organisms across four distinct habitats, including artificial reef area (ARA), marine protected area (MPA), bottom seeding proliferation area (BSPA), and seagrass bed (SGB) in Laizhou Bay during spring and autumn. The results indicate that in spring, the δC values of particulate organic matter (POM) (-23.44 ± 0.

Association between longitudinal trajectories of insomnia symptoms and subsequent cognitive decline: a prospective cohort study.

Background: Previous studies found that insomnia was an important risk factor for cognitive decline. However, previous studies only focused on baseline insomnia status, not taking into consideration the changes in insomnia status during follow-up. The study aimed to investigate the association between longitudinal trajectories of insomnia symptoms and subsequent cognitive decline.

A Multifaceted Approach Leads to Improved Linkage to HCV Therapy: A Multicenter Randomised Controlled Trial.

Aim: Hepatitis C virus (HCV) treatment rate was low in China. We aimed to evaluate a four-support approach in linking previous HCV RNA-positive patients to antiviral treatment.

Methods: We performed a randomised controlled trial (ChiCTR2200060858, https://www.

Integrated machine learning and single-cell analysis reveal the prognostic and therapeutic potential of SUMOylation-related genes in ovarian cancer.

Introduction: Ovarian cancer (OC) exhibits high mortality and chemoresistance rates, underscoring the urgent need for precise prognostic biomarkers and novel therapeutic targets. SUMOylation, crucial in cellular stress responses, is frequently dysregulated in various cancers. This study aims to characterize SUMOylation and its regulators in OC and identify potential biomarkers and therapeutic targets.

Rag2Mol: structure-based drug design based on retrieval augmented generation.

Artificial intelligence (AI) has brought tremendous progress to drug discovery, yet identifying hit and lead compounds with optimal physicochemical and pharmacological properties remains a significant challenge. Structure-based drug design (SBDD) has emerged as a promising paradigm, but the inherent data biases and ignorance of synthetic accessibility render SBDD models disconnected from practical drug discovery. In this work, we explore two methodologies, Rag2Mol-G and Rag2Mol-R, both based on retrieval-augmented generation to design small molecules to fit a 3D pocket.

Inhaled non-viral delivery systems for RNA therapeutics.

RNA-based gene therapy has been widely used for various diseases, and extensive studies have proved that suitable delivery routes greatly help the development of RNA therapeutics. Identifying a safe and effective delivery system is key to realizing RNA therapeutics' clinical translation. Inhalation is a non-invasive pulmonary delivery modality that can enhance the retention of therapeutic agents in the lungs with negligible toxicity, thereby improving patient compliance.

Molecular and physiological adaptations of Scartelaos histophorus to air exposure: Implications for amphibious fish survival.

Intertidal habitats present extreme environmental fluctuations, such as periodic air exposure that exposes aquatic organisms to desiccation, oxidative stress, and osmotic imbalance. Scartelaos histophorus, an amphibious fish, demonstrates exceptional physiological resilience in these dynamic ecosystems. This study investigates the physiological, histological, and transcriptomic responses of S.

Intensive oyster farming alters the microbial-regulated blue carbon storage in sediment.

Intensive oyster farming enhances the organic matter coupling from water to sediment through biodeposition, potentially contributing to carbon storage. Microbes play a key role in regulating biogeochemical cycling in the coastal sediment. However, their specific contributions to carbon storage under oyster farming remain poorly understood.

Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors.

Background: Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality globally. Traditional risk models, primarily based on established risk factors, often lack the precision needed to accurately predict new-onset major adverse cardiovascular events (MACE). This study aimed to improve prediction and risk stratification by integrating traditional risk factors with biochemical and metabolomic biomarkers.

Accelerometer-derived physical activity patterns and incident type 2 diabetes: a prospective cohort study.

Background: Emerging evidence suggests a significant relationship between the duration of physical activity (PA) and the incidence of type 2 diabetes (T2D). However, the association between the "weekend warrior" (WW) pattern-characterized by concentrated moderate-to-vigorous PA (MVPA) over one to two days-and T2D remains unclear.

Methods: This prospective cohort study aims to utilize device-measured PA data to investigate the associations between PA patterns and T2D.

Adaptation of Natural Killer Cells to Hypoxia: A Review of the Transcriptional, Translational, and Metabolic Processes.

As important innate immune cells, natural killer (NK) cells play an essential role in resisting pathogen invasion and eliminating transformed cells. However, the hypoxic microenvironment caused by disease conditions is an important physicochemical factor that impairs NK cell function. With the increasing prominence of NK cells in immunotherapy, there has been a surge of interest in developing biological means through which NK cells may overcome the inhibition caused by hypoxia in disease conditions.

Hypophysectomy, pituitary neuroadenolysis and pituitary radiosurgery for the treatment of refractory cancer pain: a historical review and mechanism investigation.

Refractory cancer pain affects 10-20% of patients with advanced malignancies and is not adequately controlled by opioids. The intrathecal therapy is an effective interventional procedure for referral, but the implanted infusion pumps are costly and the refilling requires technical expertise. Hypophysectomy, in its three stages-surgical, chemical, and radiosurgical-has emerged as an alternative for managing this pain.

Comparative analysis of certified emission reduction methodologies for methane emission reduction in China.

As one of the top emitters of methane (CH), China must take action to achieve its carbon neutrality goal. Programs to reduce CH emissions would benefit from the establishment of the China Certified Emission Reduction (CCER) trading market. However, studies investigating the impact of the CCER trading market on CH reduction remain limited.

Sex disparities in the risk of intracranial aneurysm rupture: a case-control study.

Background: There are sex disparities in the risk of ruptured intracranial aneurysm (IA), but which sex-specific factors are related to ruptured IA remains inconclusive.

Methods: Data from electronic medical records from two tertiary hospitals, collected between January 2012 and December 2019, were analyzed for this study. All IAs were confirmed by computed tomographic angiography or digital subtraction angiography.

Unraveling the impact of PFOA toxicity on Zostera marina using a multi-omics approach: Insights from growth, physiological, transcriptomic, and metabolomic signatures.

Perfluorooctanoic acid (PFOA), an anthropogenic organic pollutant known for its persistence, resistance to degradation, and toxicity, has raised significant concerns about its potential ecological impacts. Zostera marina, a common submerged seagrass species in temperate offshore areas, is highly vulnerable to pollutant stressors. However, the impact of PFOA on Z.

Development of a nomogram for individualized prediction of acute gastrointestinal injury in polytrauma patients.

Objective: Previous reports have indicated the occurrence of acute gastrointestinal injury (AGI) in critically ill individuals. Yet, there is limited information regarding the frequency and potential causes of AGI in individuals with polytrauma. The complicated diagnostic tools often mistaken and mislead the evaluation of AGI.

Risk Estimation of Deep Venous Thrombosis in Polytrauma Patients with Traumatic Brain Injury: A Nomogram Approach.

Background: Deep venous thrombosis (DVT), known to be a major factor in poor outcomes and death rates, is common after polytrauma with traumatic brain injury (TBI). In this study, a nomogram will be developed to predict the risk of DVT in polytrauma patients with TBI, since there is currently no specific and convenient diagnostic method.

Methods: A retrospective and observational trial was conducted between November 2021 and May 2023.

From trauma to chronicity: Understanding the incidence and early immune changes of chronic complications in polytrauma patients.

Objective: Polytrauma is a complex condition associated with poor outcomes and high mortality rates resulting from severe damage and complicated complications. This study sought to ascertain the incidence of chronic complications in polytrauma patients, as well as the early immune changes and risk factors.

Methods: A multicenter, prospective and observational cohort study was conducted at the emergency surgery or traumatic intensive care unit (TICU) of the Advanced Trauma Center from August 2020 to July 2023.

Single-cell transcriptome profiling of mA regulator-mediated methylation modification patterns in elderly acute myeloid leukemia patients.

Millions of people worldwide die of acute myeloid leukaemia (AML) each year. Although N6-methyladenosine (mA) modification has been reported to regulate the pathogenicity of AML, the mechanisms by which mA induces dysfunctional hematopoietic differentiation in elderly AML patients remain elusive. This study elucidates the mechanisms of the mA landscape and the specific roles of mA regulators in hematopoietic cells of elderly AML patients.

Integration of Genome-Wide Identification and Transcriptome Analysis of Class III Peroxidases in : Insight into Their Roles in Adventitious Roots, Heat Tolerance, and Petal Senescence.

As a plant-specific gene family, class III peroxidases (PODs) play an important role in plant growth, development, and stress responses. However, the POD gene family has not been systematically studied in . In this study, a total of 57 genes were identified in the genome.